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    ZNF775 zinc finger protein 775 [ Homo sapiens (human) ]

    Gene ID: 285971, updated on 14-Nov-2024

    Summary

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    Official Symbol
    ZNF775provided by HGNC
    Official Full Name
    zinc finger protein 775provided by HGNC
    Primary source
    HGNC:HGNC:28501
    See related
    Ensembl:ENSG00000196456 AllianceGenome:HGNC:28501
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable DNA binding activity and metal ion binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in colon (RPKM 2.3), brain (RPKM 1.7) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ZNF775 in Genome Data Viewer
    Location:
    7q36.1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (150379330..150398630)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (151557672..151576951)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (150076419..150095718)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986858 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:150044724-150044956 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18775 Neighboring gene REPIN1 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26823 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:150065484-150066288 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:150066289-150067094 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:150067095-150067899 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26824 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26825 Neighboring gene replication initiator 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26826 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18778 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26827 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:150078931-150079888 Neighboring gene ZNF775 antisense RNA 1 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:150080845-150081800 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:150083270-150083842 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:150083843-150084413 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:150085648-150086246 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:150096281-150096868 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:150096869-150097456 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:150097787-150098311 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:150098312-150098835 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:150098842-150099517 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:150099518-150100192 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:150100193-150100867 Neighboring gene zinc finger domain-containing protein LOC728743 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18779 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:150103235-150103743 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26828 Neighboring gene uncharacterized LOC124901773 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18780

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. A GO catalogue of human DNA-binding transcription factors. Lovering RC, et al. Biochim Biophys Acta Gene Regul Mech, 2021 Nov-Dec. PMID 34673265
    2. DCAF8, a novel MuRF1 interaction partner, promotes muscle atrophy. Nowak M, et al. J Cell Sci, 2019 Sep 6. PMID 31391242
    3. Assessment of community efforts to advance network-based prediction of protein-protein interactions. Wang XW, et al. Nat Commun, 2023 Mar 22. PMID 36949045, Free PMC Article
    4. E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins. Khanna R, et al. FEBS J, 2018 Jun. PMID 29676528
    5. A directed protein interaction network for investigating intracellular signal transduction. Vinayagam A, et al. Sci Signal, 2011 Sep 6. PMID 21900206

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC33584

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 775

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173680.4 → NP_775951.2  zinc finger protein 775

      See identical proteins and their annotated locations for NP_775951.2

      Status: VALIDATED

      Source sequence(s)
      AC073111, AW402889, BC015152, DB472309
      Consensus CDS
      CCDS43678.1
      UniProtKB/Swiss-Prot
      Q8IY24, Q96BV0
      Related
      ENSP00000330838.5, ENST00000329630.10
      Conserved Domains (3) summary
      COG5048
      Location:275 → 524
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:448 → 468
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:121 → 146
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      150379330..150398630
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047420221.1 → XP_047276177.1  zinc finger protein 775 isoform X1

    2. XM_047420224.1 → XP_047276180.1  zinc finger protein 775 isoform X2

      UniProtKB/Swiss-Prot
      Q8IY24, Q96BV0

    3. XM_047420222.1 → XP_047276178.1  zinc finger protein 775 isoform X1

    4. XM_047420223.1 → XP_047276179.1  zinc finger protein 775 isoform X1

    5. XM_047420220.1 → XP_047276176.1  zinc finger protein 775 isoform X1

    6. XM_047420225.1 → XP_047276181.1  zinc finger protein 775 isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      151557672..151576951
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054357930.1 → XP_054213905.1  zinc finger protein 775 isoform X1

    2. XM_054357931.1 → XP_054213906.1  zinc finger protein 775 isoform X1

    3. XM_054357932.1 → XP_054213907.1  zinc finger protein 775 isoform X1

    4. XM_054357933.1 → XP_054213908.1  zinc finger protein 775 isoform X2

    5. XM_054357934.1 → XP_054213909.1  zinc finger protein 775 isoform X3

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96BV0.2 GenPept UniProtKB/Swiss-Prot:Q96BV0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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