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    RGMB repulsive guidance molecule BMP co-receptor b [ Homo sapiens (human) ]

    Gene ID: 285704, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RGMBprovided by HGNC
    Official Full Name
    repulsive guidance molecule BMP co-receptor bprovided by HGNC
    Primary source
    HGNC:HGNC:26896
    See related
    Ensembl:ENSG00000174136 MIM:612687; AllianceGenome:HGNC:26896
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DRAGON
    Summary
    RGMB is a glycosylphosphatidylinositol (GPI)-anchored member of the repulsive guidance molecule family (see RGMA, MIM 607362) and contributes to the patterning of the developing nervous system (Samad et al., 2005 [PubMed 15671031]).[supplied by OMIM, Apr 2009]
    Expression
    Ubiquitous expression in brain (RPKM 10.1), skin (RPKM 10.1) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See RGMB in Genome Data Viewer
    Location:
    5q15
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (98768632..98796494)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (99271925..99299789)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (98104336..98132198)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene CTBP2 pseudogene 4 Neighboring gene DEAD-box helicase 18 pseudogene 4 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:98102871-98103612 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:98103613-98104353 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:98106065-98106565 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22835 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:98109729-98110228 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22836 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr5:98114818-98116017 Neighboring gene RGMB antisense RNA 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:98175311-98175811 Neighboring gene uncharacterized LOC105379099 Neighboring gene casein kinase 1 alpha 1 pseudogene 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Repulsive guidance molecule b inhibits neurite growth and is increased after spinal cord injury. Liu X, et al. Biochem Biophys Res Commun, 2009 May 15. PMID 19324014
    2. Repulsive guidance molecule B inhibits metastasis and is associated with decreased mortality in non-small cell lung cancer. Li J, et al. Oncotarget, 2016 Mar 29. PMID 26910889, Free PMC Article
    3. Repulsive guidance molecule B (RGMB) plays negative roles in breast cancer by coordinating BMP signaling. Li J, et al. J Cell Biochem, 2012 Jul. PMID 22415859
    4. Repulsive guidance molecules lock growth differentiation factor 5 in an inhibitory complex. Malinauskas T, et al. Proc Natl Acad Sci U S A, 2020 Jul 7. PMID 32576689, Free PMC Article
    5. RGMB enhances the suppressive activity of the monomeric secreted form of CTLA-4. Sekiya T, et al. Sci Rep, 2019 May 6. PMID 31061392, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RNF4~RGMb~BMP6 axis required for osteogenic differentiation and cancer cell survival.
      Title: RNF4~RGMb~BMP6 axis required for osteogenic differentiation and cancer cell survival.
    2. RGMB enhances the suppressive activity of the monomeric secreted form of CTLA-4.
      Title: RGMB enhances the suppressive activity of the monomeric secreted form of CTLA-4.
    3. Repulsive guidance molecules lock growth differentiation factor 5 in an inhibitory complex.
      Title: Repulsive guidance molecules lock growth differentiation factor 5 in an inhibitory complex.
    4. Our results demonstrate that RGMB is an important inhibitor of non-small cell lung cancer metastasis and that low RGMB expression is a novel predictor or a poor prognosis.
      Title: Repulsive guidance molecule B inhibits metastasis and is associated with decreased mortality in non-small cell lung cancer.
    5. Data show that Dragon expression was increased in colon cancer tissues compared to control tissues in CAC mouse model and in human patients.
      Title: Dragon (repulsive guidance molecule b, RGMb) is a novel gene that promotes colorectal cancer growth.
    6. RGMB was down-regulation in non-small cell lung cancer.
      Title: Study on expression of lncRNA RGMB-AS1 and repulsive guidance molecule b in non-small cell lung cancer.
    7. Study highlights the potential importance of RGMb in propagating pro-angiogenic effects of HGF and BMP-7.
      Title: Tumour angiogenesis and repulsive guidance molecule b: a role in HGF- and BMP-7-mediated angiogenesis.
    8. two RGMB ectodomains conformationally stabilize the juxtamembrane regions of two NEO1 receptors in a pH-dependent manner.
      Title: Structure of the repulsive guidance molecule (RGM)-neogenin signaling hub.
    9. current data firstly revealed that RGMB may act as a negative regulator in breast cancer through BMP signaling
      Title: Repulsive guidance molecule B (RGMB) plays negative roles in breast cancer by coordinating BMP signaling.
    10. The expression of RGMA, RGMB and RGMC was evident in most examined prostate cancer cell lines, and also in the prostate cancer tissues
      Title: Repulsive guidance molecules, novel bone morphogenetic protein co-receptors, are key regulators of the growth and aggressiveness of prostate cancer cells.
    Submit: New GeneRIF Correction See all GeneRIFs (11)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study in NSAID-induced acute urticaria/angioedema in Spanish and Han Chinese populations.
    EBI GWAS Catalog
    Variants in several genomic regions associated with asperger disorder.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ90406, MGC86970, DKFZp434P228

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables coreceptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in BMP signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in BMP signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cell adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum-Golgi intermediate compartment ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in membrane raft IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    repulsive guidance molecule B
    Names
    DRG11-responsive axonal guidance and outgrowth of neurite
    RGM domain family, member B
    repulsive guidance molecule family member b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012761.3 → NP_001012779.2  repulsive guidance molecule B isoform 2

      See identical proteins and their annotated locations for NP_001012779.2

      Status: VALIDATED

      Source sequence(s)
      AC008522, AK054622, BC020513, BC067736
      Consensus CDS
      CCDS47251.1
      UniProtKB/TrEMBL
      J3KNF6
      Related
      ENSP00000308219.7, ENST00000308234.11
      Conserved Domains (2) summary
      pfam06534
      Location:267 → 441
      RGM_C; Repulsive guidance molecule (RGM) C-terminus
      pfam06535
      Location:95 → 262
      RGM_N; Repulsive guidance molecule (RGM) N-terminus

    2. NM_001366508.1 → NP_001353437.1  repulsive guidance molecule B isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC008522
      Consensus CDS
      CCDS93751.1
      UniProtKB/Swiss-Prot
      D6R9A0, Q6NW40, Q8NC92
      Related
      ENSP00000423256.1, ENST00000513185.3
      Conserved Domains (2) summary
      pfam06534
      Location:226 → 400
      RGM_C; Repulsive guidance molecule (RGM) C-terminus
      pfam06535
      Location:54 → 221
      RGM_N; Repulsive guidance molecule (RGM) N-terminus

    3. NM_001366509.1 → NP_001353438.1  repulsive guidance molecule B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC008522
      Consensus CDS
      CCDS47251.1
      UniProtKB/TrEMBL
      J3KNF6
      Conserved Domains (2) summary
      pfam06534
      Location:267 → 441
      RGM_C; Repulsive guidance molecule (RGM) C-terminus
      pfam06535
      Location:95 → 262
      RGM_N; Repulsive guidance molecule (RGM) N-terminus

    4. NM_001366510.1 → NP_001353439.1  repulsive guidance molecule B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC008522
      Consensus CDS
      CCDS47251.1
      UniProtKB/TrEMBL
      J3KNF6
      Conserved Domains (2) summary
      pfam06534
      Location:267 → 441
      RGM_C; Repulsive guidance molecule (RGM) C-terminus
      pfam06535
      Location:95 → 262
      RGM_N; Repulsive guidance molecule (RGM) N-terminus

    5. NM_001366511.1 → NP_001353440.1  repulsive guidance molecule B isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC008522
      Conserved Domains (2) summary
      pfam06534
      Location:266 → 440
      RGM_C; Repulsive guidance molecule (RGM) C-terminus
      pfam06535
      Location:94 → 261
      RGM_N; Repulsive guidance molecule (RGM) N-terminus

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      98768632..98796494
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047417124.1 → XP_047273080.1  repulsive guidance molecule B isoform X1

    2. XM_047417125.1 → XP_047273081.1  repulsive guidance molecule B isoform X3

      UniProtKB/Swiss-Prot
      D6R9A0, Q6NW40, Q8NC92

    3. XM_011543345.3 → XP_011541647.1  repulsive guidance molecule B isoform X2

      See identical proteins and their annotated locations for XP_011541647.1

      UniProtKB/TrEMBL
      J3KNF6
      Conserved Domains (2) summary
      pfam06534
      Location:267 → 441
      RGM_C; Repulsive guidance molecule (RGM) C-terminus
      pfam06535
      Location:95 → 262
      RGM_N; Repulsive guidance molecule (RGM) N-terminus

    4. XM_011543346.3 → XP_011541648.1  repulsive guidance molecule B isoform X4

      Conserved Domains (2) summary
      pfam06534
      Location:185 → 364
      RGM_C; Repulsive guidance molecule (RGM) C-terminus
      pfam06535
      Location:13 → 180
      RGM_N; Repulsive guidance molecule (RGM) N-terminus

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      99271925..99299789
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054352457.1 → XP_054208432.1  repulsive guidance molecule B isoform X1

    2. XM_054352458.1 → XP_054208433.1  repulsive guidance molecule B isoform X4

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_173670.2: Suppressed sequence

      Description
      NM_173670.2: This RefSeq was permanently suppressed because there is insufficient support for the alternate terminal exon represented by this transcript.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6NW40.3 GenPept UniProtKB/Swiss-Prot:Q6NW40

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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