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    PAK3 p21 (RAC1) activated kinase 3 [ Homo sapiens (human) ]

    Gene ID: 5063, updated on 14-Nov-2024

    Summary

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    Official Symbol
    PAK3provided by HGNC
    Official Full Name
    p21 (RAC1) activated kinase 3provided by HGNC
    Primary source
    HGNC:HGNC:8592
    See related
    Ensembl:ENSG00000077264 MIM:300142; AllianceGenome:HGNC:8592
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ARA; bPAK; MRX30; MRX47; OPHN3; PAK-3; XLID30; PAK3beta; beta-PAK
    Summary
    The protein encoded by this gene is a serine-threonine kinase and forms an activated complex with GTP-bound RAS-like (P21), CDC2 and RAC1. This protein may be necessary for dendritic development and for the rapid cytoskeletal reorganization in dendritic spines associated with synaptic plasticity. Defects in this gene are the cause of a non-syndromic form of X-linked intellectual disability. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2017]
    Expression
    Biased expression in brain (RPKM 8.0), pancreas (RPKM 3.0) and 11 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See PAK3 in Genome Data Viewer
    Location:
    Xq23
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (110944397..111227361)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (109392559..109675560)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (110187625..110470589)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:109911493-109912258 Neighboring gene M6PR pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29856 Neighboring gene chordin like 1 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:110065211-110065764 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20942 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:110187999-110188834 Neighboring gene OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:110207796-110208396 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:110254037-110254537 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20943 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29857 Neighboring gene NANOG hESC enhancer GRCh37_chrX:110438658-110439159 Neighboring gene FCF1 pseudogene 4 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chrX:110489468-110490667 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chrX:110498437-110498970 Neighboring gene glutamate dehydrogenase 1 pseudogene 9 Neighboring gene calpain 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. PAK signalling in neuronal physiology. Kreis P, et al. Cell Signal, 2009 Mar. PMID 19036346
    2. X-linked mild non-syndromic mental retardation with neuropsychiatric problems and the missense mutation A365E in PAK3. Gedeon AK, et al. Am J Med Genet A, 2003 Aug 1. PMID 12884430
    3. A comparative expression analysis of four MRX genes regulating intracellular signalling via small GTPases. Kohn M, et al. Eur J Hum Genet, 2004 Jan. PMID 14673471
    4. Regulation of the Cool/Pix proteins: key binding partners of the Cdc42/Rac targets, the p21-activated kinases. Feng Q, et al. J Biol Chem, 2002 Feb 15. PMID 11741931
    5. PAK and other Rho-associated kinases--effectors with surprisingly diverse mechanisms of regulation. Zhao ZS, et al. Biochem J, 2005 Mar 1. PMID 15548136, Free PMC Article

    See all (93) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PAK3 Exacerbates Cardiac Lipotoxicity via SREBP1c in Obesity Cardiomyopathy.
      Title: PAK3 Exacerbates Cardiac Lipotoxicity via SREBP1c in Obesity Cardiomyopathy.
    2. Porocarcinomas with PAK1/2/3 fusions: a series of 12 cases.
      Title: Porocarcinomas with PAK1/2/3 fusions: a series of 12 cases.
    3. PAK3 is a key signature gene of the glioma proneural subtype and affects its proliferation, differentiation and growth.
      Title: PAK3 is a key signature gene of the glioma proneural subtype and affects its proliferation, differentiation and growth.
    4. The intellectual disability PAK3 R67C mutation impacts cognitive functions and adult hippocampal neurogenesis.
      Title: The intellectual disability PAK3 R67C mutation impacts cognitive functions and adult hippocampal neurogenesis.
    5. Loss of Smad4 promotes aggressive lung cancer metastasis by de-repression of PAK3 via miRNA regulation.
      Title: Loss of Smad4 promotes aggressive lung cancer metastasis by de-repression of PAK3 via miRNA regulation.
    6. Prognostic significance of PAK family kinases in acute myeloid leukemia.
      Title: Prognostic significance of PAK family kinases in acute myeloid leukemia.
    7. PAK3 mutations responsible for severe intellectual disability and callosal agenesis inhibit cell migration.
      Title: PAK3 mutations responsible for severe intellectual disability and callosal agenesis inhibit cell migration.
    8. Synaptic actin stabilization protein loss in Down syndrome and Alzheimer disease.
      Title: Synaptic actin stabilization protein loss in Down syndrome and Alzheimer disease.
    9. Further delineation of the phenotype of PAK3-associated x-linked intellectual disability: Identification of a novel missense mutation and review of literature.
      Title: Further delineation of the phenotype of PAK3-associated x-linked intellectual disability: Identification of a novel missense mutation and review of literature.
    10. Integration of hepatitis B virus DNA into p21-activated kinase 3 (PAK3) gene in HepG2.2.15 cells.
      Title: Integration of hepatitis B virus DNA into p21-activated kinase 3 (PAK3) gene in HepG2.2.15 cells.
    Submit: New GeneRIF Correction See all GeneRIFs (29)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Intellectual disability, X-linked 30
    MedGen: C0796237 OMIM: 300558 GeneReviews: Not available
    		Compare labs

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • DKFZp686E11117

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables MAP kinase kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables SH3 domain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity EXP
    Inferred from Experiment
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity TAS
    Traceable Author Statement
    more info
    		  
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in axonogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to organic cyclic compound IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in dendrite development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in dendritic spine morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in dendritic spine morphogenesis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in ephrin receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of actin filament polymerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of axonogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of postsynapse organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in stimulatory C-type lectin receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    involved_in synapse organization TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in postsynaptic density IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase PAK 3
    Names
    adriamycin resistance-associated
    oligophrenin-3
    p21 (CDKN1A)-activated kinase 3
    p21 protein (Cdc42/Rac)-activated kinase 3
    NP_001121638.1
    NP_001121639.1
    NP_001121640.1
    NP_001121644.1
    NP_001121645.1
    NP_001311254.1
    NP_001311255.1
    NP_001311256.1
    NP_001311257.1
    NP_001311258.1
    NP_001311259.1
    NP_001311260.1
    NP_001311261.1
    NP_001311262.1
    NP_001311263.1
    NP_002569.1
    XP_005262189.1
    XP_005262190.1
    XP_006724717.1
    XP_006724718.1
    XP_011529264.1
    XP_011529270.1
    XP_011529271.1
    XP_011529273.1
    XP_016885046.1
    XP_016885047.1
    XP_016885048.1
    XP_016885049.1
    XP_016885052.1
    XP_047298102.1
    XP_047298103.1
    XP_047298104.1
    XP_047298105.1
    XP_047298106.1
    XP_054183121.1
    XP_054183122.1
    XP_054183123.1
    XP_054183124.1
    XP_054183125.1
    XP_054183126.1
    XP_054183127.1
    XP_054183128.1
    XP_054183129.1
    XP_054183130.1
    XP_054183131.1
    XP_054183132.1
    XP_054183133.1
    XP_054183134.1
    XP_054183135.1
    XP_054183136.1
    XP_054183137.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_008288.2 RefSeqGene

      Range
      156907..288077
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001128166.3 → NP_001121638.1  serine/threonine-protein kinase PAK 3 isoform a

      See identical proteins and their annotated locations for NP_001121638.1

      Status: REVIEWED

      Source sequence(s)
      AK290504, AK315284, AL031117, BC117353, DB563607
      Consensus CDS
      CCDS14554.1
      UniProtKB/TrEMBL
      B2RCU6
      Related
      ENSP00000410853.1, ENST00000446737.5
      Conserved Domains (2) summary
      cd06656
      Location:248 → 544
      STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
      pfam00786
      Location:69 → 126
      PBD; P21-Rho-binding domain

    2. NM_001128167.3 → NP_001121639.1  serine/threonine-protein kinase PAK 3 isoform a

      See identical proteins and their annotated locations for NP_001121639.1

      Status: REVIEWED

      Source sequence(s)
      AK290504, AL031117, BC117353, DB563607
      Consensus CDS
      CCDS14554.1
      UniProtKB/TrEMBL
      B2RCU6
      Related
      ENSP00000401982.1, ENST00000425146.5
      Conserved Domains (2) summary
      cd06656
      Location:248 → 544
      STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
      pfam00786
      Location:69 → 126
      PBD; P21-Rho-binding domain

    3. NM_001128168.3 → NP_001121640.1  serine/threonine-protein kinase PAK 3 isoform b

      See identical proteins and their annotated locations for NP_001121640.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) represents use of an alternate promoter and contains two alternate in-frame exons compared to variant 1. The encoded isoform (b, also known as ab) is longer than isoform a.
      Source sequence(s)
      AL031117, AL117326, AL357774
      Consensus CDS
      CCDS48151.1
      UniProtKB/TrEMBL
      B2RCU6
      Conserved Domains (2) summary
      cd06656
      Location:284 → 580
      STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
      pfam00786
      Location:69 → 162
      PBD; P21-Rho-binding domain

    4. NM_001128172.2 → NP_001121644.1  serine/threonine-protein kinase PAK 3 isoform c

      See identical proteins and their annotated locations for NP_001121644.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) has a shorter 5' UTR and contains an alternate in-frame exon compared to variant 1. It encodes isoform c which is longer than isoform a.
      Source sequence(s)
      AK290504, AL031117, AM943852, BC117353, DB563607
      Consensus CDS
      CCDS48152.1
      UniProtKB/TrEMBL
      B2RCU6
      Related
      ENSP00000389172.1, ENST00000417227.5
      Conserved Domains (2) summary
      cd06656
      Location:269 → 565
      STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
      pfam00786
      Location:69 → 147
      PBD; P21-Rho-binding domain

    5. NM_001128173.3 → NP_001121645.1  serine/threonine-protein kinase PAK 3 isoform d

      See identical proteins and their annotated locations for NP_001121645.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) represents use of an alternate promoter and contains alternate in-frame exon compared to variant 1. It encodes isoform d (also known as b) which is longer than isoform a.
      Source sequence(s)
      AL031117, AL117326, AL357774
      Consensus CDS
      CCDS48153.1
      UniProtKB/Swiss-Prot
      A8K389, B1GX77, B1GX78, B1GX79, O75914, Q5JWX1, Q5JWX2, Q7Z2D6, Q7Z2E4, Q7Z3Z8, Q8WWK5, Q8WX23, Q9P0J8
      UniProtKB/TrEMBL
      B2RCU6
      Conserved Domains (2) summary
      cd06656
      Location:263 → 559
      STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
      pfam00786
      Location:69 → 141
      PBD; P21-Rho-binding domain

    6. NM_001324325.2 → NP_001311254.1  serine/threonine-protein kinase PAK 3 isoform a

      Status: REVIEWED

      Source sequence(s)
      AL031117, AL117326, AL356578, AL357774
      Consensus CDS
      CCDS14554.1
      UniProtKB/TrEMBL
      B2RCU6
      Conserved Domains (2) summary
      cd06656
      Location:248 → 544
      STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
      pfam00786
      Location:69 → 126
      PBD; P21-Rho-binding domain

    7. NM_001324326.2 → NP_001311255.1  serine/threonine-protein kinase PAK 3 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) represents use of an alternate promoter compared to variant 1.
      Source sequence(s)
      AL031117, AL117326, AL357774
      Consensus CDS
      CCDS14554.1
      UniProtKB/TrEMBL
      B2RCU6
      Conserved Domains (2) summary
      cd06656
      Location:248 → 544
      STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
      pfam00786
      Location:69 → 126
      PBD; P21-Rho-binding domain

    8. NM_001324327.2 → NP_001311256.1  serine/threonine-protein kinase PAK 3 isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (17) represents use of an alternate promoter compared to variant 1.
      Source sequence(s)
      AL031117, AL117326, AL357774
      Consensus CDS
      CCDS48153.1
      UniProtKB/Swiss-Prot
      A8K389, B1GX77, B1GX78, B1GX79, O75914, Q5JWX1, Q5JWX2, Q7Z2D6, Q7Z2E4, Q7Z3Z8, Q8WWK5, Q8WX23, Q9P0J8
      UniProtKB/TrEMBL
      B2RCU6
      Conserved Domains (2) summary
      cd06656
      Location:263 → 559
      STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
      pfam00786
      Location:69 → 141
      PBD; P21-Rho-binding domain

    9. NM_001324328.2 → NP_001311257.1  serine/threonine-protein kinase PAK 3 isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (18) represents use of an alternate promoter compared to variant 1.
      Source sequence(s)
      AL031117, AL117326, AL357774
      Consensus CDS
      CCDS48153.1
      UniProtKB/Swiss-Prot
      A8K389, B1GX77, B1GX78, B1GX79, O75914, Q5JWX1, Q5JWX2, Q7Z2D6, Q7Z2E4, Q7Z3Z8, Q8WWK5, Q8WX23, Q9P0J8
      UniProtKB/TrEMBL
      B2RCU6
      Related
      ENSP00000262836.4, ENST00000262836.6
      Conserved Domains (2) summary
      cd06656
      Location:263 → 559
      STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
      pfam00786
      Location:69 → 141
      PBD; P21-Rho-binding domain

    10. NM_001324329.2 → NP_001311258.1  serine/threonine-protein kinase PAK 3 isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (19) represents use of an alternate promoter compared to variant 1.
      Source sequence(s)
      AL031117, AL117326, AL357774
      Consensus CDS
      CCDS48153.1
      UniProtKB/Swiss-Prot
      A8K389, B1GX77, B1GX78, B1GX79, O75914, Q5JWX1, Q5JWX2, Q7Z2D6, Q7Z2E4, Q7Z3Z8, Q8WWK5, Q8WX23, Q9P0J8
      UniProtKB/TrEMBL
      B2RCU6
      Related
      ENSP00000361080.1, ENST00000372010.5
      Conserved Domains (2) summary
      cd06656
      Location:263 → 559
      STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
      pfam00786
      Location:69 → 141
      PBD; P21-Rho-binding domain

    11. NM_001324330.2 → NP_001311259.1  serine/threonine-protein kinase PAK 3 isoform a

      Status: REVIEWED

      Source sequence(s)
      AL031117, AL117326, AL356578, AL357774
      Consensus CDS
      CCDS14554.1
      UniProtKB/TrEMBL
      B2RCU6
      Conserved Domains (2) summary
      cd06656
      Location:248 → 544
      STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
      pfam00786
      Location:69 → 126
      PBD; P21-Rho-binding domain

    12. NM_001324331.2 → NP_001311260.1  serine/threonine-protein kinase PAK 3 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (21) represents use of an alternate promoter compared to variant 1.
      Source sequence(s)
      AL031117, AL117326, AL357774
      Consensus CDS
      CCDS14554.1
      UniProtKB/TrEMBL
      B2RCU6
      Conserved Domains (2) summary
      cd06656
      Location:248 → 544
      STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
      pfam00786
      Location:69 → 126
      PBD; P21-Rho-binding domain

    13. NM_001324332.2 → NP_001311261.1  serine/threonine-protein kinase PAK 3 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (22) represents use of an alternate promoter compared to variant 1.
      Source sequence(s)
      AL031117, AL117326, AL357774
      Consensus CDS
      CCDS14554.1
      UniProtKB/TrEMBL
      B2RCU6
      Conserved Domains (2) summary
      cd06656
      Location:248 → 544
      STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
      pfam00786
      Location:69 → 126
      PBD; P21-Rho-binding domain

    14. NM_001324333.2 → NP_001311262.1  serine/threonine-protein kinase PAK 3 isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (23) represents use of an alternate promoter compared to variant 1.
      Source sequence(s)
      AL031117, AL117326, AL357774
      Consensus CDS
      CCDS48153.1
      UniProtKB/Swiss-Prot
      A8K389, B1GX77, B1GX78, B1GX79, O75914, Q5JWX1, Q5JWX2, Q7Z2D6, Q7Z2E4, Q7Z3Z8, Q8WWK5, Q8WX23, Q9P0J8
      UniProtKB/TrEMBL
      B2RCU6
      Conserved Domains (2) summary
      cd06656
      Location:263 → 559
      STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
      pfam00786
      Location:69 → 141
      PBD; P21-Rho-binding domain

    15. NM_001324334.2 → NP_001311263.1  serine/threonine-protein kinase PAK 3 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (24) represents use of an alternate promoter compared to variant 1.
      Source sequence(s)
      AL031117, AL117326, AL357774
      Consensus CDS
      CCDS14554.1
      UniProtKB/TrEMBL
      B2RCU6
      Conserved Domains (2) summary
      cd06656
      Location:248 → 544
      STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
      pfam00786
      Location:69 → 126
      PBD; P21-Rho-binding domain

    16. NM_002578.5 → NP_002569.1  serine/threonine-protein kinase PAK 3 isoform a

      See identical proteins and their annotated locations for NP_002569.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) represents use of an alternate promoter compared to variant 1.
      Source sequence(s)
      AK290504, AL031117, BC117353, DA022842, DA957724, DB563607
      Consensus CDS
      CCDS14554.1
      UniProtKB/TrEMBL
      B2RCU6
      Related
      ENSP00000361077.4, ENST00000372007.10
      Conserved Domains (2) summary
      cd06656
      Location:248 → 544
      STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
      pfam00786
      Location:69 → 126
      PBD; P21-Rho-binding domain

    RNA

    1. NR_136740.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10) represents use of an alternate promoter and contains a distinct, shorter 3' end, compared to variant 1. This variant is represented as non-coding because the it lacks a large portion of the coding region found in variant 1.
      Source sequence(s)
      AL357774

    2. NR_136741.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11) represents use of an alternate promoter and contains a distinct, shorter 3' end, compared to variant 1. This variant is represented as non-coding because the it lacks a large portion of the coding region found in variant 1.
      Source sequence(s)
      AL357774

    3. NR_136742.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (12) represents use of an alternate promoter and contains a distinct, shorter 3' end, compared to variant 1. This variant is represented as non-coding because the it lacks a large portion of the coding region found in variant 1.
      Source sequence(s)
      AL357774

    4. NR_136743.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (13) represents use of an alternate promoter and contains a distinct, shorter 3' end, compared to variant 1. This variant is represented as non-coding because the it lacks a large portion of the coding region found in variant 1.
      Source sequence(s)
      AL357774

    5. NR_136744.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (14) represents use of an alternate promoter and contains a distinct, shorter 3' end, compared to variant 1. This variant is represented as non-coding because the it lacks a large portion of the coding region found in variant 1.
      Source sequence(s)
      AL357774

    6. NR_136745.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (15) represents use of an alternate promoter and contains a distinct, shorter 3' end, compared to variant 1. This variant is represented as non-coding because the it lacks a large portion of the coding region found in variant 1.
      Source sequence(s)
      AL357774

    7. NR_136746.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (16) represents use of an alternate promoter and contains a distinct, shorter 3' end, compared to variant 1. This variant is represented as non-coding because the it lacks a large portion of the coding region found in variant 1.
      Source sequence(s)
      AL357774

    8. NR_136747.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (25) represents use of an alternate promoter and contains an alternate exon in the 3' region compared to variant 1.
      Source sequence(s)
      AL031117, AL117326, AL357774

    9. NR_136748.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) is shorter at the 5' end and contains an alternate exon in the 3' region compared to variant 1.
      Source sequence(s)
      AL031117, AL357774, BC143544

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      110944397..111227361
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047442148.1 → XP_047298104.1  serine/threonine-protein kinase PAK 3 isoform X4

    2. XM_047442149.1 → XP_047298105.1  serine/threonine-protein kinase PAK 3 isoform X4

    3. XM_017029557.2 → XP_016885046.1  serine/threonine-protein kinase PAK 3 isoform X2

      UniProtKB/Swiss-Prot
      A8K389, B1GX77, B1GX78, B1GX79, O75914, Q5JWX1, Q5JWX2, Q7Z2D6, Q7Z2E4, Q7Z3Z8, Q8WWK5, Q8WX23, Q9P0J8
      UniProtKB/TrEMBL
      B2RCU6
      Conserved Domains (2) summary
      cd06656
      Location:263 → 559
      STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
      pfam00786
      Location:69 → 141
      PBD; P21-Rho-binding domain

    4. XM_011530968.3 → XP_011529270.1  serine/threonine-protein kinase PAK 3 isoform X1

      See identical proteins and their annotated locations for XP_011529270.1

      UniProtKB/TrEMBL
      B2RCU6
      Conserved Domains (3) summary
      smart00220
      Location:283 → 530
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06647
      Location:275 → 530
      STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
      pfam00786
      Location:69 → 139
      PBD; P21-Rho-binding domain

    5. XM_011530969.2 → XP_011529271.1  serine/threonine-protein kinase PAK 3 isoform X1

      See identical proteins and their annotated locations for XP_011529271.1

      UniProtKB/TrEMBL
      B2RCU6
      Conserved Domains (3) summary
      smart00220
      Location:283 → 530
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06647
      Location:275 → 530
      STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
      pfam00786
      Location:69 → 139
      PBD; P21-Rho-binding domain

    6. XM_017029559.2 → XP_016885048.1  serine/threonine-protein kinase PAK 3 isoform X3

      UniProtKB/TrEMBL
      B2RCU6
      Conserved Domains (3) summary
      smart00220
      Location:268 → 515
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06647
      Location:260 → 515
      STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
      pfam00786
      Location:69 → 124
      PBD; P21-Rho-binding domain

    7. XM_017029563.2 → XP_016885052.1  serine/threonine-protein kinase PAK 3 isoform X7

      UniProtKB/TrEMBL
      B2RCU6
      Related
      ENSP00000428921.1, ENST00000518291.6
      Conserved Domains (2) summary
      cd06656
      Location:284 → 580
      STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
      pfam00786
      Location:69 → 162
      PBD; P21-Rho-binding domain

    8. XM_047442147.1 → XP_047298103.1  serine/threonine-protein kinase PAK 3 isoform X3

    9. XM_011530962.2 → XP_011529264.1  serine/threonine-protein kinase PAK 3 isoform X1

      See identical proteins and their annotated locations for XP_011529264.1

      UniProtKB/TrEMBL
      B2RCU6
      Conserved Domains (3) summary
      smart00220
      Location:283 → 530
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06647
      Location:275 → 530
      STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
      pfam00786
      Location:69 → 139
      PBD; P21-Rho-binding domain

    10. XM_047442146.1 → XP_047298102.1  serine/threonine-protein kinase PAK 3 isoform X3

    11. XM_005262132.3 → XP_005262189.1  serine/threonine-protein kinase PAK 3 isoform X1

      See identical proteins and their annotated locations for XP_005262189.1

      UniProtKB/TrEMBL
      B2RCU6
      Conserved Domains (3) summary
      smart00220
      Location:283 → 530
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06647
      Location:275 → 530
      STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
      pfam00786
      Location:69 → 139
      PBD; P21-Rho-binding domain

    12. XM_005262133.4 → XP_005262190.1  serine/threonine-protein kinase PAK 3 isoform X3

      See identical proteins and their annotated locations for XP_005262190.1

      UniProtKB/TrEMBL
      B2RCU6
      Conserved Domains (3) summary
      smart00220
      Location:268 → 515
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06647
      Location:260 → 515
      STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
      pfam00786
      Location:69 → 124
      PBD; P21-Rho-binding domain

    13. XM_006724654.3 → XP_006724717.1  serine/threonine-protein kinase PAK 3 isoform X1

      See identical proteins and their annotated locations for XP_006724717.1

      UniProtKB/TrEMBL
      B2RCU6
      Conserved Domains (3) summary
      smart00220
      Location:283 → 530
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06647
      Location:275 → 530
      STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
      pfam00786
      Location:69 → 139
      PBD; P21-Rho-binding domain

    14. XM_017029558.2 → XP_016885047.1  serine/threonine-protein kinase PAK 3 isoform X3

      UniProtKB/TrEMBL
      B2RCU6
      Conserved Domains (3) summary
      smart00220
      Location:268 → 515
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06647
      Location:260 → 515
      STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
      pfam00786
      Location:69 → 124
      PBD; P21-Rho-binding domain

    15. XM_006724655.3 → XP_006724718.1  serine/threonine-protein kinase PAK 3 isoform X1

      See identical proteins and their annotated locations for XP_006724718.1

      UniProtKB/TrEMBL
      B2RCU6
      Conserved Domains (3) summary
      smart00220
      Location:283 → 530
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06647
      Location:275 → 530
      STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
      pfam00786
      Location:69 → 139
      PBD; P21-Rho-binding domain

    16. XM_017029560.2 → XP_016885049.1  serine/threonine-protein kinase PAK 3 isoform X3

      UniProtKB/TrEMBL
      B2RCU6
      Conserved Domains (3) summary
      smart00220
      Location:268 → 515
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06647
      Location:260 → 515
      STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
      pfam00786
      Location:69 → 124
      PBD; P21-Rho-binding domain

    17. XM_011530971.3 → XP_011529273.1  serine/threonine-protein kinase PAK 3 isoform X6

      Conserved Domains (2) summary
      pfam00786
      Location:69 → 139
      PBD; P21-Rho-binding domain
      cl21453
      Location:262 → 292
      PKc_like; Protein Kinases, catalytic domain

    18. XM_047442150.1 → XP_047298106.1  serine/threonine-protein kinase PAK 3 isoform X5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      109392559..109675560
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054327159.1 → XP_054183134.1  serine/threonine-protein kinase PAK 3 isoform X4

    2. XM_054327160.1 → XP_054183135.1  serine/threonine-protein kinase PAK 3 isoform X4

    3. XM_054327152.1 → XP_054183127.1  serine/threonine-protein kinase PAK 3 isoform X2

      UniProtKB/Swiss-Prot
      A8K389, B1GX77, B1GX78, B1GX79, O75914, Q5JWX1, Q5JWX2, Q7Z2D6, Q7Z2E4, Q7Z3Z8, Q8WWK5, Q8WX23, Q9P0J8

    4. XM_054327151.1 → XP_054183126.1  serine/threonine-protein kinase PAK 3 isoform X1

    5. XM_054327150.1 → XP_054183125.1  serine/threonine-protein kinase PAK 3 isoform X1

    6. XM_054327156.1 → XP_054183131.1  serine/threonine-protein kinase PAK 3 isoform X3

    7. XM_054327162.1 → XP_054183137.1  serine/threonine-protein kinase PAK 3 isoform X7

    8. XM_054327158.1 → XP_054183133.1  serine/threonine-protein kinase PAK 3 isoform X3

    9. XM_054327149.1 → XP_054183124.1  serine/threonine-protein kinase PAK 3 isoform X1

    10. XM_054327154.1 → XP_054183129.1  serine/threonine-protein kinase PAK 3 isoform X3

    11. XM_054327146.1 → XP_054183121.1  serine/threonine-protein kinase PAK 3 isoform X1

    12. XM_054327153.1 → XP_054183128.1  serine/threonine-protein kinase PAK 3 isoform X3

    13. XM_054327147.1 → XP_054183122.1  serine/threonine-protein kinase PAK 3 isoform X1

    14. XM_054327155.1 → XP_054183130.1  serine/threonine-protein kinase PAK 3 isoform X3

    15. XM_054327148.1 → XP_054183123.1  serine/threonine-protein kinase PAK 3 isoform X1

    16. XM_054327157.1 → XP_054183132.1  serine/threonine-protein kinase PAK 3 isoform X3

    17. XM_054327161.1 → XP_054183136.1  serine/threonine-protein kinase PAK 3 isoform X6

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O75914.2 GenPept UniProtKB/Swiss-Prot:O75914

    Gene LinkOut

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