GATA3 GATA binding protein 3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: GATA3provided by HGNC
Official Full Name: GATA binding protein 3provided by HGNC
Primary source: HGNC:HGNC:4172
See related: Ensembl:ENSG00000107485 MIM:131320; AllianceGenome:HGNC:4172
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: HDR; HDRS
Summary: This gene encodes a protein which belongs to the GATA family of transcription factors. The protein contains two GATA-type zinc fingers and is an important regulator of T-cell development and plays an important role in endothelial cell biology. Defects in this gene are the cause of hypoparathyroidism with sensorineural deafness and renal dysplasia. [provided by RefSeq, Nov 2009]
Expression: Biased expression in skin (RPKM 54.6), urinary bladder (RPKM 20.0) and 7 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 10p14

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	10	NC_000010.11 (8045333..8075198)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	10	NC_060934.1 (8046004..8076094)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	10	NC_000010.10 (8096651..8117161)

Chromosome 10 - NC_000010.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HER2 overexpression in urothelial carcinoma with GATA3 and PPARG copy number gains.
Title: HER2 overexpression in urothelial carcinoma with GATA3 and PPARG copy number gains.
Increased level of GATA3-AS1 long non-coding RNA is correlated with the upregulation of GATA3 and IL-4 genes in multiple sclerosis patients.
Title: Increased level of GATA3-AS1 long non-coding RNA is correlated with the upregulation of GATA3 and IL-4 genes in multiple sclerosis patients.
Association of GATA3 expression in triple-positive breast cancer with overall survival and immune cell infiltration.
Title: Association of GATA3 expression in triple-positive breast cancer with overall survival and immune cell infiltration.
Recurrent GATA3 P409Afs*99 Frameshift Extension Mutations in Sweat-gland Carcinoma With Neuroendocrine Differentiation.
Title: Recurrent GATA3 P409Afs*99 Frameshift Extension Mutations in Sweat-gland Carcinoma With Neuroendocrine Differentiation.
Analysis of GATA3 and FOXA2 expression suggests that downregulation of genes involved in the maintenance of a mature yolk sac tumor phenotype may underlie sarcomatoid transformation.
Title: Analysis of GATA3 and FOXA2 expression suggests that downregulation of genes involved in the maintenance of a mature yolk sac tumor phenotype may underlie sarcomatoid transformation.
Expression of BCL2, TP53, FOXA1, and GATA3 in pTa bladder cancer recurrence.
Title: Expression of BCL2, TP53, FOXA1, and GATA3 in pTa bladder cancer recurrence.
The androgen receptor interacts with GATA3 to transcriptionally regulate a luminal epithelial cell phenotype in breast cancer.
Title: The androgen receptor interacts with GATA3 to transcriptionally regulate a luminal epithelial cell phenotype in breast cancer.
Deregulation of miR-1245b-5p and miR-92a-3p and their potential target gene, GATA3, in epithelial-mesenchymal transition pathway in breast cancer.
Title: Deregulation of miR-1245b-5p and miR-92a-3p and their potential target gene, GATA3, in epithelial-mesenchymal transition pathway in breast cancer.
HepPar1 and GATA-3 Expression in Neuroendocrine Neoplasms: A Potential Trap for Pathologic Diagnosis: Erratum.
Title: HepPar1 and GATA-3 Expression in Neuroendocrine Neoplasms: A Potential Trap for Pathologic Diagnosis: Erratum.
ARID5B, IKZF1, GATA3, CEBPE, and CDKN2A germline polymorphisms and predisposition to childhood acute lymphoblastic leukemia.
Title: ARID5B, IKZF1, GATA3, CEBPE, and CDKN2A germline polymorphisms and predisposition to childhood acute lymphoblastic leukemia.

Submit: New GeneRIF Correction See all GeneRIFs (433)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Hypoparathyroidism, deafness, renal disease syndrome MedGen: C1840333 OMIM: 146255 GeneReviews: Not available	Compare labs

Copy number response

Description
Copy number response Triplosensitivity No evidence available (Last evaluated 2020-06-24) ClinGen Genome Curation Page Haploinsufficency Sufficient evidence for dosage pathogenicity (Last evaluated 2020-06-24) ClinGen Genome Curation PagePubMed

EBI GWAS Catalog

Description
A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci. EBI GWAS Catalog EBI GWAS CatalogPubMed
A genome-wide association study of Hodgkin's lymphoma identifies new susceptibility loci at 2p16.1 (REL), 8q24.21 and 10p14 (GATA3). EBI GWAS Catalog EBI GWAS CatalogPubMed
A meta-analysis of Hodgkin lymphoma reveals 19p13.3 TCF3 as a novel susceptibility locus. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genetics of rheumatoid arthritis contributes to biology and drug discovery. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide diet-gene interaction analyses for risk of colorectal cancer. EBI GWAS Catalog EBI GWAS CatalogPubMed
Identification of susceptibility loci for colorectal cancer in a genome-wide meta-analysis. EBI GWAS Catalog EBI GWAS CatalogPubMed
Meta-analysis of genome-wide association studies identifies six new Loci for serum calcium concentrations. EBI GWAS Catalog EBI GWAS CatalogPubMed
Variation at 10p12.2 and 10p14 influences risk of childhood B-cell acute lymphoblastic leukemia and phenotype. EBI GWAS Catalog EBI GWAS CatalogPubMed
Variation at 3p24.1 and 6q23.3 influences the risk of Hodgkin's lymphoma. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Nef	nef	Amino acids 19-26 of HIV-1 Nef mediate the binding of Nef to murine GATA-1 and GATA-3 in vitro, suggesting Nef may act as a nuclear regulatory factor through binding to human GATA-1 and GATA-3	PubMed

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

G20258 (e-PCR)
- UniSTS:11781

A005A11 (e-PCR)
- UniSTS:11782

SHGC-34122 (e-PCR)
- UniSTS:65804

RH17471 (e-PCR)
- UniSTS:65805

GATA3_1519 (e-PCR)
- UniSTS:277271

RH78856 (e-PCR)
- UniSTS:2362

D10S2148 (e-PCR)
- UniSTS:71540

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA binding	TAS Traceable Author Statement more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISA Inferred from Sequence Alignment more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IMP Inferred from Mutant Phenotype more info	PubMed
enables E-box binding	IDA Inferred from Direct Assay more info	PubMed
enables HMG box domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables histone methyltransferase binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables interleukin-2 receptor binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific double-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables transcription cis-regulatory region binding	IDA Inferred from Direct Assay more info	PubMed
enables transcription coactivator binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within T cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in T cell receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in T-helper 2 cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in TOR signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in anatomical structure formation involved in morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in anatomical structure morphogenesis	TAS Traceable Author Statement more info	PubMed
involved_in aortic valve morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in axon guidance	IEA Inferred from Electronic Annotation more info
involved_in canonical Wnt signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in cardiac right ventricle morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in cartilage development	IEA Inferred from Electronic Annotation more info
involved_in cell fate commitment	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell fate determination	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell maturation	IEA Inferred from Electronic Annotation more info
involved_in cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in cellular response to BMP stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to interferon-alpha	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to interleukin-4	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to tumor necrosis factor	IEP Inferred from Expression Pattern more info	PubMed
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in cochlea development	IEA Inferred from Electronic Annotation more info
involved_in defense response	TAS Traceable Author Statement more info	PubMed
involved_in developmental growth	IEA Inferred from Electronic Annotation more info
involved_in ear development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic hemopoiesis	IEA Inferred from Electronic Annotation more info
involved_in embryonic organ development	IBA Inferred from Biological aspect of Ancestor more info
involved_in erythrocyte differentiation	IEA Inferred from Electronic Annotation more info
involved_in humoral immune response	IEA Inferred from Electronic Annotation more info
involved_in immune system development	IBA Inferred from Biological aspect of Ancestor more info
involved_in in utero embryonic development	IEA Inferred from Electronic Annotation more info
involved_in inflammatory response	ISS Inferred from Sequence or Structural Similarity more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in inner ear morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in kidney development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lens development in camera-type eye	IEA Inferred from Electronic Annotation more info
involved_in lymphocyte migration	IDA Inferred from Direct Assay more info	PubMed
involved_in macrophage differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in male gonad development	ISS Inferred from Sequence or Structural Similarity more info
involved_in mast cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in mesenchymal to epithelial transition	IDA Inferred from Direct Assay more info	PubMed
involved_in mesonephros development	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell motility	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cell proliferation involved in mesonephros development	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of endothelial cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of negative regulation of epithelial to mesenchymal transition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of interleukin-2 production	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of mammary gland epithelial cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of type II interferon production	IEA Inferred from Electronic Annotation more info
involved_in nephric duct formation	ISS Inferred from Sequence or Structural Similarity more info
involved_in nephric duct morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuron migration	IEA Inferred from Electronic Annotation more info
involved_in norepinephrine biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in otic vesicle development	IEA Inferred from Electronic Annotation more info
involved_in parathyroid gland development	IEA Inferred from Electronic Annotation more info
involved_in parathyroid hormone secretion	IEA Inferred from Electronic Annotation more info
involved_in pharyngeal system development	ISS Inferred from Sequence or Structural Similarity more info
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of T cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of T-helper 2 cell cytokine production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of endothelial cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interleukin-13 production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of interleukin-13 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interleukin-4 production	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of interleukin-5 production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of miRNA transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of thyroid hormone generation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of transcription regulatory region DNA binding	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of ureteric bud formation	ISS Inferred from Sequence or Structural Similarity more info
involved_in post-embryonic development	IEA Inferred from Electronic Annotation more info
involved_in pro-T cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in regulation of T-helper cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in regulation of cellular response to X-ray	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cytokine production	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of epithelial cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of establishment of cell polarity	IEA Inferred from Electronic Annotation more info
involved_in regulation of nephron tubule epithelial cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of neuron apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of neuron projection development	IEA Inferred from Electronic Annotation more info
involved_in response to estrogen	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to ethanol	IEA Inferred from Electronic Annotation more info
involved_in response to gamma radiation	IEA Inferred from Electronic Annotation more info
involved_in response to virus	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in sympathetic nervous system development	ISS Inferred from Sequence or Structural Similarity more info
involved_in thymic T cell selection	IEA Inferred from Electronic Annotation more info
involved_in thymus development	IEA Inferred from Electronic Annotation more info
involved_in transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in type IV hypersensitivity	IEA Inferred from Electronic Annotation more info
involved_in ureter maturation	IEA Inferred from Electronic Annotation more info
involved_in ureter morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in ureteric bud formation	ISS Inferred from Sequence or Structural Similarity more info
involved_in uterus development	ISS Inferred from Sequence or Structural Similarity more info
involved_in ventricular septum development	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in chromatin	IDA Inferred from Direct Assay more info	PubMed
located_in chromatin	ISA Inferred from Sequence Alignment more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: trans-acting T-cell-specific transcription factor GATA-3

Names: GATA-binding factor 3

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_015859.2 RefSeqGene

Range

14357..34867

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001002295.2 → NP_001002295.1 trans-acting T-cell-specific transcription factor GATA-3 isoform 1

See identical proteins and their annotated locations for NP_001002295.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AI024501, AI686327, AL390294, BC003070, BC006793, BC006839, BM152193

Consensus CDS

CCDS31143.1

UniProtKB/Swiss-Prot

P23771

Related

ENSP00000368632.3, ENST00000379328.9

Conserved Domains (2) summary

smart00401
Location:313 → 362

ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]

cd00202
Location:317 → 367

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
NM_002051.3 → NP_002042.1 trans-acting T-cell-specific transcription factor GATA-3 isoform 2

See identical proteins and their annotated locations for NP_002042.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the mid-coding region, compared to variant 1, resulting in an isoform (2) that is 1 aa shorter than isoform 1.

Source sequence(s)

AI024501, AI686327, AL390294, BC006793, BC006839, BM152193

Consensus CDS

CCDS7083.1

UniProtKB/Swiss-Prot

P23771, Q5VWG7, Q5VWG8, Q96J16

Related

ENSP00000341619.3, ENST00000346208.4

Conserved Domains (2) summary

smart00401
Location:312 → 361

ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]

cd00202
Location:316 → 366

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000010.11 Reference GRCh38.p14 Primary Assembly

Range

8045333..8075198

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005252443.6 → XP_005252500.1 trans-acting T-cell-specific transcription factor GATA-3 isoform X1

See identical proteins and their annotated locations for XP_005252500.1

UniProtKB/Swiss-Prot

P23771

Conserved Domains (2) summary

smart00401
Location:313 → 362

ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]

cd00202
Location:317 → 367

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
XM_047425045.1 → XP_047281001.1 trans-acting T-cell-specific transcription factor GATA-3 isoform X2

UniProtKB/Swiss-Prot

P23771, Q5VWG7, Q5VWG8, Q96J16
XM_005252442.3 → XP_005252499.1 trans-acting T-cell-specific transcription factor GATA-3 isoform X1

See identical proteins and their annotated locations for XP_005252499.1

UniProtKB/Swiss-Prot

P23771

Conserved Domains (2) summary

smart00401
Location:313 → 362

ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]

cd00202
Location:317 → 367

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
XM_047425044.1 → XP_047281000.1 trans-acting T-cell-specific transcription factor GATA-3 isoform X2

UniProtKB/Swiss-Prot

P23771, Q5VWG7, Q5VWG8, Q96J16

Alternate T2T-CHM13v2.0

Genomic

NC_060934.1 Alternate T2T-CHM13v2.0

Range

8046004..8076094

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054365532.1 → XP_054221507.1 trans-acting T-cell-specific transcription factor GATA-3 isoform X2

UniProtKB/Swiss-Prot

P23771, Q5VWG7, Q5VWG8, Q96J16
XM_054365530.1 → XP_054221505.1 trans-acting T-cell-specific transcription factor GATA-3 isoform X1
XM_054365528.1 → XP_054221503.1 trans-acting T-cell-specific transcription factor GATA-3 isoform X1
XM_054365529.1 → XP_054221504.1 trans-acting T-cell-specific transcription factor GATA-3 isoform X1
XM_054365531.1 → XP_054221506.1 trans-acting T-cell-specific transcription factor GATA-3 isoform X2

UniProtKB/Swiss-Prot

P23771, Q5VWG7, Q5VWG8, Q96J16