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    tmem126a transmembrane protein 126A [ Danio rerio (zebrafish) ]

    Gene ID: 393771, updated on 2-Nov-2024

    Summary

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    Official Symbol
    tmem126aprovided by ZNC
    Official Full Name
    transmembrane protein 126Aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1770
    See related
    Ensembl:ENSDARG00000014506 AllianceGenome:ZFIN:ZDB-GENE-040426-1770
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:73348
    Summary
    Predicted to be involved in mitochondrial respiratory chain complex I assembly. Predicted to be located in membrane. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 29 and optic atrophy 7. Orthologous to several human genes including TMEM126A (transmembrane protein 126A). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See tmem126a in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (29269998..29272757, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (29383373..29386132, complement)

    Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene synaptotagmin-like 2a Neighboring gene CREB/ATF bZIP transcription factor Neighboring gene discs, large homolog 2 (Drosophila) Neighboring gene uncharacterized LOC137496592 Neighboring gene HEPACAM family member 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC73348

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial respiratory chain complex I assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 126A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001328432.1 → NP_001315361.1  transmembrane protein 126A

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      EH441595, EH463071, EH493909, EH588251, EH594896
      UniProtKB/TrEMBL
      A0A2R8QM83, A0A8M1PFS9
      Related
      ENSDARP00000148912.1, ENSDART00000184594.1
      Conserved Domains (1) summary
      pfam07114
      Location:20 → 195
      DUF1370; Protein of unknown function (DUF1370)

    2. NM_200798.2 → NP_957092.2  transmembrane protein 126A

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      EH463071, EH493909, EH588251, EH594896
      UniProtKB/TrEMBL
      A0A2R8QM83, A0A8M1PFS9
      Related
      ENSDARP00000153689.1, ENSDART00000185371.1
      Conserved Domains (1) summary
      pfam07114
      Location:20 → 195
      DUF1370; Protein of unknown function (DUF1370)

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007121.7 Reference GRCz11 Primary Assembly

      Range
      29269998..29272757 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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