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    RNH1 ribonuclease/angiogenin inhibitor 1 [ Homo sapiens (human) ]

    Gene ID: 6050, updated on 14-Nov-2024

    Summary

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    Official Symbol
    RNH1provided by HGNC
    Official Full Name
    ribonuclease/angiogenin inhibitor 1provided by HGNC
    Primary source
    HGNC:HGNC:10074
    See related
    Ensembl:ENSG00000023191 MIM:173320; AllianceGenome:HGNC:10074
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RAI; RNH; IIAE12
    Summary
    Placental ribonuclease inhibitor (PRI) is a member of a family of proteinaceous cytoplasmic RNase inhibitors that occur in many tissues and bind to both intracellular and extracellular RNases (summarized by Lee et al., 1988 [PubMed 3219362]). In addition to control of intracellular RNases, the inhibitor may have a role in the regulation of angiogenin (MIM 105850). Ribonuclease inhibitor, of 50,000 Da, binds to ribonucleases and holds them in a latent form. Since neutral and alkaline ribonucleases probably play a critical role in the turnover of RNA in eukaryotic cells, RNH may be essential for control of mRNA turnover; the interaction of eukaryotic cells with ribonuclease may be reversible in vivo.[supplied by OMIM, Jul 2010]
    Expression
    Ubiquitous expression in skin (RPKM 36.6), lung (RPKM 36.0) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See RNH1 in Genome Data Viewer
    Location:
    11p15.5
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (494515..507242, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (540227..553016, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (494515..507242, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376506 Neighboring gene anoctamin 9 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3005 Neighboring gene Sharpr-MPRA regulatory region 223 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:442612-443409 Neighboring gene RNA, 7SL, cytoplasmic 838, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4275 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3006 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3007 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:449779-450465 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3009 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3010 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:454927-455648 Neighboring gene phosphatidylserine synthase 2 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:460662-460845 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:467161-467660 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:471334-471857 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:471858-472380 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:476893-477888 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:484337-484858 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:487868-488008 Neighboring gene MPRA-validated peak1145 silencer Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_21531 Neighboring gene leucine rich repeat containing 56 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:528505-529042 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:533792-534649 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:534650-535506 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:535528-536235 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:540668-541490 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:543860-544362 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:544865-545366 Neighboring gene HRas proto-oncogene, GTPase Neighboring gene H3K4me1 hESC enhancers GRCh37_chr11:548147-548965 and GRCh37_chr11:548966-549783 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:556675-557511 Neighboring gene LMNTD2 antisense RNA 1 Neighboring gene lamin tail domain containing 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Mapping of the human ribonuclease inhibitor gene (RNH) to chromosome 11p15 by in situ hybridization. Zneimer SM, et al. Genomics, 1990 Sep. PMID 2081593
    2. Down-regulating ribonuclease inhibitor enhances metastasis of bladder cancer cells through regulating epithelial-mesenchymal transition and ILK signaling pathway. Xiong D, et al. Exp Mol Pathol, 2014 Jun. PMID 24768914
    3. RNH1 regulation of reactive oxygen species contributes to histone deacetylase inhibitor resistance in gastric cancer cells. Zhu Y, et al. Oncogene, 2014 Mar 20. PMID 23584480
    4. The ribonuclease/angiogenin inhibitor is also present in mitochondria and nuclei. Furia A, et al. FEBS Lett, 2011 Feb 18. PMID 21276451
    5. Knockdown of ribonuclease inhibitor expression with siRNA in non-invasive bladder cancer cell line BIU-87 promotes growth and metastasis potentials. Chen J, et al. Mol Cell Biochem, 2011 Mar. PMID 21125316

    See all (170) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. New link between RNH1 and E2F1: regulates the development of lung adenocarcinoma.
      Title: New link between RNH1 and E2F1: regulates the development of lung adenocarcinoma.
    2. Biallelic variants in ribonuclease inhibitor (RNH1), an inflammasome modulator, are associated with a distinctive subtype of acute, necrotizing encephalopathy.
      Title: Biallelic variants in ribonuclease inhibitor (RNH1), an inflammasome modulator, are associated with a distinctive subtype of acute, necrotizing encephalopathy.
    3. Ribonuclease inhibitor 1 (RNH1) deficiency cause congenital cataracts and global developmental delay with infection-induced psychomotor regression and anemia.
      Title: Ribonuclease inhibitor 1 (RNH1) deficiency cause congenital cataracts and global developmental delay with infection-induced psychomotor regression and anemia.
    4. Functional status analysis of RNH1 in bladder cancer for predicting immunotherapy response.
      Title: Functional status analysis of RNH1 in bladder cancer for predicting immunotherapy response.
    5. LRR-protein RNH1 dampens the inflammasome activation and is associated with COVID-19 severity.
      Title: LRR-protein RNH1 dampens the inflammasome activation and is associated with COVID-19 severity.
    6. Angiogenin (ANG)-Ribonuclease Inhibitor (RNH1) System in Protein Synthesis and Disease.
      Title: Angiogenin (ANG)-Ribonuclease Inhibitor (RNH1) System in Protein Synthesis and Disease.
    7. This study first time revealed in vivo role of RNH1. This study report that RNH1 is important for embryonic development and erythropoiesis. RNH1 binds to ribosomes and regulates erythropoiesis by controlling translation of the erythroid transcription factor GATA1.
      Title: Ribonuclease inhibitor 1 regulates erythropoiesis by controlling GATA1 translation.
    8. RNH1 might represent the first direct regulator of IRE1 RNase activity
      Title: Regulation of IRE1 RNase activity by the Ribonuclease inhibitor 1 (RNH1).
    9. Results show that a low expression of RNH1 in metastasis of bladder cancer and suggest that it might regulate the function of ILK through mutual binding.
      Title: Interplay between intergrin-linked kinase and ribonuclease inhibitor affects growth and metastasis of bladder cancer through signaling ILK pathways.
    10. Data suggest that ribonuclease inhibitor (RNH1) protects HeLa cells from ribonuclease 1 (RNase 1).
      Title: Knockout of the Ribonuclease Inhibitor Gene Leaves Human Cells Vulnerable to Secretory Ribonucleases.
    Submit: New GeneRIF Correction See all GeneRIFs (27)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Encephalitis, acute, infection-induced, susceptibility to, 12
    MedGen: C5882673 OMIM: 620461 GeneReviews: Not available
    		not available

    Variation

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    See Variation Viewer (GRCh37.p13)

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of ribonuclease/angiogenin inhibitor 1 (RNH1) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 interacts with RNH1 PubMed
    nucleocapsid gag HIV-1 NC is identified to have a physical interaction with ribonuclease/angiogenin inhibitor 1 (RNH1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
    retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human ribonuclease/angiogenin inhibitor 1 (RNH1) at amino acid residues 445-446 by the HIV-1 protease PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC4569, MGC18200, MGC54054

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ribonuclease inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ribonuclease inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA catabolic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of Arp2/3 complex-mediated actin nucleation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of angiogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of angiogenesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in tRNA stabilization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of angiogenin-PRI complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of angiogenin-PRI complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    is_active_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in extracellular exosome HDA PubMed 
    is_active_in lamellipodium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ribonuclease inhibitor
    Names
    placental RNase inhibitor
    placental ribonuclease inhibitor
    testicular tissue protein Li 164

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_002939.4 → NP_002930.2  ribonuclease inhibitor

      See identical proteins and their annotated locations for NP_002930.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. All eight variants of this gene encode the same protein.
      Source sequence(s)
      BC047730
      Consensus CDS
      CCDS7697.1
      UniProtKB/Swiss-Prot
      P13489, Q8IZK8, Q96FD7, Q9BQ80, Q9UDK6
      UniProtKB/TrEMBL
      A0A140VJT8
      Related
      ENSP00000380739.2, ENST00000397615.6
      Conserved Domains (3) summary
      smart00368
      Location:397 → 424
      LRR_RI; Leucine rich repeat, ribonuclease inhibitor type
      cd00116
      Location:6 → 325
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:6 → 29
      LRR_RI; leucine-rich repeat [structural motif]

    2. NM_203383.2 → NP_976317.1  ribonuclease inhibitor

      See identical proteins and their annotated locations for NP_976317.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses a different splice site in the 5' UTR, compared to variant 1. All eight variants of this gene encode the same protein.
      Source sequence(s)
      BC011186, BG752774
      Consensus CDS
      CCDS7697.1
      UniProtKB/Swiss-Prot
      P13489, Q8IZK8, Q96FD7, Q9BQ80, Q9UDK6
      UniProtKB/TrEMBL
      A0A140VJT8
      Conserved Domains (3) summary
      smart00368
      Location:397 → 424
      LRR_RI; Leucine rich repeat, ribonuclease inhibitor type
      cd00116
      Location:6 → 325
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:6 → 29
      LRR_RI; leucine-rich repeat [structural motif]

    3. NM_203384.2 → NP_976318.1  ribonuclease inhibitor

      See identical proteins and their annotated locations for NP_976318.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate exon and uses a different splice site in the 5' UTR, compared to variant 1. All eight variants of this gene encode the same protein.
      Source sequence(s)
      BC003506, BC011186, BM019570
      Consensus CDS
      CCDS7697.1
      UniProtKB/Swiss-Prot
      P13489, Q8IZK8, Q96FD7, Q9BQ80, Q9UDK6
      UniProtKB/TrEMBL
      A0A140VJT8
      Related
      ENSP00000416589.2, ENST00000438658.6
      Conserved Domains (3) summary
      smart00368
      Location:397 → 424
      LRR_RI; Leucine rich repeat, ribonuclease inhibitor type
      cd00116
      Location:6 → 325
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:6 → 29
      LRR_RI; leucine-rich repeat [structural motif]

    4. NM_203385.2 → NP_976319.1  ribonuclease inhibitor

      See identical proteins and their annotated locations for NP_976319.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an alternate exon in the 5' UTR, compared to variant 1. All eight variants of this gene encode the same protein.
      Source sequence(s)
      BC011186, BM019570, BQ954409
      Consensus CDS
      CCDS7697.1
      UniProtKB/Swiss-Prot
      P13489, Q8IZK8, Q96FD7, Q9BQ80, Q9UDK6
      UniProtKB/TrEMBL
      A0A140VJT8
      Related
      ENSP00000380738.1, ENST00000397614.5
      Conserved Domains (3) summary
      smart00368
      Location:397 → 424
      LRR_RI; Leucine rich repeat, ribonuclease inhibitor type
      cd00116
      Location:6 → 325
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:6 → 29
      LRR_RI; leucine-rich repeat [structural motif]

    5. NM_203386.3 → NP_976320.1  ribonuclease inhibitor

      See identical proteins and their annotated locations for NP_976320.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) contains a different exon and uses a different splice site in its 5' UTR, compared to variant 1. All eight variants of this gene encode the same protein.
      Source sequence(s)
      AC137894, BC011186, BM465975
      Consensus CDS
      CCDS7697.1
      UniProtKB/Swiss-Prot
      P13489, Q8IZK8, Q96FD7, Q9BQ80, Q9UDK6
      UniProtKB/TrEMBL
      A0A140VJT8
      Related
      ENSP00000435594.1, ENST00000533410.5
      Conserved Domains (3) summary
      smart00368
      Location:397 → 424
      LRR_RI; Leucine rich repeat, ribonuclease inhibitor type
      cd00116
      Location:6 → 325
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:6 → 29
      LRR_RI; leucine-rich repeat [structural motif]

    6. NM_203387.3 → NP_976321.1  ribonuclease inhibitor

      See identical proteins and their annotated locations for NP_976321.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) contains a different exon in its 5' UTR, compared to variant 1. All eight variants of this gene encode the same protein.
      Source sequence(s)
      AC137894, BC011186, DC296330
      Consensus CDS
      CCDS7697.1
      UniProtKB/Swiss-Prot
      P13489, Q8IZK8, Q96FD7, Q9BQ80, Q9UDK6
      UniProtKB/TrEMBL
      A0A140VJT8
      Related
      ENSP00000346402.2, ENST00000354420.7
      Conserved Domains (3) summary
      smart00368
      Location:397 → 424
      LRR_RI; Leucine rich repeat, ribonuclease inhibitor type
      cd00116
      Location:6 → 325
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:6 → 29
      LRR_RI; leucine-rich repeat [structural motif]

    7. NM_203388.3 → NP_976322.1  ribonuclease inhibitor

      See identical proteins and their annotated locations for NP_976322.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) has multiple differences in its 5' UTR, compared to variant 1. All eight variants of this gene encode the same protein.
      Source sequence(s)
      AC137894, BC011500
      Consensus CDS
      CCDS7697.1
      UniProtKB/Swiss-Prot
      P13489, Q8IZK8, Q96FD7, Q9BQ80, Q9UDK6
      UniProtKB/TrEMBL
      A0A140VJT8
      Related
      ENSP00000380729.3, ENST00000397604.7
      Conserved Domains (3) summary
      smart00368
      Location:397 → 424
      LRR_RI; Leucine rich repeat, ribonuclease inhibitor type
      cd00116
      Location:6 → 325
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:6 → 29
      LRR_RI; leucine-rich repeat [structural motif]

    8. NM_203389.3 → NP_976323.1  ribonuclease inhibitor

      See identical proteins and their annotated locations for NP_976323.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) has multiple differences in its 5' UTR, compared to variant 1. All eight variants of this gene encode the same protein.
      Source sequence(s)
      AC137894, BC014629
      Consensus CDS
      CCDS7697.1
      UniProtKB/Swiss-Prot
      P13489, Q8IZK8, Q96FD7, Q9BQ80, Q9UDK6
      UniProtKB/TrEMBL
      A0A140VJT8
      Related
      ENSP00000348515.5, ENST00000356187.9
      Conserved Domains (3) summary
      smart00368
      Location:397 → 424
      LRR_RI; Leucine rich repeat, ribonuclease inhibitor type
      cd00116
      Location:6 → 325
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:6 → 29
      LRR_RI; leucine-rich repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      494515..507242 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011520260.3 → XP_011518562.1  ribonuclease inhibitor isoform X1

      See identical proteins and their annotated locations for XP_011518562.1

      UniProtKB/Swiss-Prot
      P13489, Q8IZK8, Q96FD7, Q9BQ80, Q9UDK6
      UniProtKB/TrEMBL
      A0A140VJT8
      Conserved Domains (3) summary
      smart00368
      Location:397 → 424
      LRR_RI; Leucine rich repeat, ribonuclease inhibitor type
      cd00116
      Location:6 → 325
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:6 → 29
      LRR_RI; leucine-rich repeat [structural motif]

    2. XM_011520255.2 → XP_011518557.1  ribonuclease inhibitor isoform X1

      See identical proteins and their annotated locations for XP_011518557.1

      UniProtKB/Swiss-Prot
      P13489, Q8IZK8, Q96FD7, Q9BQ80, Q9UDK6
      UniProtKB/TrEMBL
      A0A140VJT8
      Conserved Domains (3) summary
      smart00368
      Location:397 → 424
      LRR_RI; Leucine rich repeat, ribonuclease inhibitor type
      cd00116
      Location:6 → 325
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:6 → 29
      LRR_RI; leucine-rich repeat [structural motif]

    3. XM_011520261.3 → XP_011518563.1  ribonuclease inhibitor isoform X1

      See identical proteins and their annotated locations for XP_011518563.1

      UniProtKB/Swiss-Prot
      P13489, Q8IZK8, Q96FD7, Q9BQ80, Q9UDK6
      UniProtKB/TrEMBL
      A0A140VJT8
      Conserved Domains (3) summary
      smart00368
      Location:397 → 424
      LRR_RI; Leucine rich repeat, ribonuclease inhibitor type
      cd00116
      Location:6 → 325
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:6 → 29
      LRR_RI; leucine-rich repeat [structural motif]

    4. XM_017018106.2 → XP_016873595.1  ribonuclease inhibitor isoform X1

      UniProtKB/Swiss-Prot
      P13489, Q8IZK8, Q96FD7, Q9BQ80, Q9UDK6
      UniProtKB/TrEMBL
      A0A140VJT8
      Conserved Domains (3) summary
      smart00368
      Location:397 → 424
      LRR_RI; Leucine rich repeat, ribonuclease inhibitor type
      cd00116
      Location:6 → 325
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:6 → 29
      LRR_RI; leucine-rich repeat [structural motif]

    5. XM_011520263.2 → XP_011518565.1  ribonuclease inhibitor isoform X1

      See identical proteins and their annotated locations for XP_011518565.1

      UniProtKB/Swiss-Prot
      P13489, Q8IZK8, Q96FD7, Q9BQ80, Q9UDK6
      UniProtKB/TrEMBL
      A0A140VJT8
      Conserved Domains (3) summary
      smart00368
      Location:397 → 424
      LRR_RI; Leucine rich repeat, ribonuclease inhibitor type
      cd00116
      Location:6 → 325
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:6 → 29
      LRR_RI; leucine-rich repeat [structural motif]

    6. XM_011520259.4 → XP_011518561.1  ribonuclease inhibitor isoform X1

      See identical proteins and their annotated locations for XP_011518561.1

      UniProtKB/Swiss-Prot
      P13489, Q8IZK8, Q96FD7, Q9BQ80, Q9UDK6
      UniProtKB/TrEMBL
      A0A140VJT8
      Related
      ENSP00000433999.1, ENST00000534797.5
      Conserved Domains (3) summary
      smart00368
      Location:397 → 424
      LRR_RI; Leucine rich repeat, ribonuclease inhibitor type
      cd00116
      Location:6 → 325
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:6 → 29
      LRR_RI; leucine-rich repeat [structural motif]

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_187586.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      24156..36883 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054328929.1 → XP_054184904.1  ribonuclease inhibitor isoform X1

      UniProtKB/Swiss-Prot
      P13489, Q8IZK8, Q96FD7, Q9BQ80, Q9UDK6
      UniProtKB/TrEMBL
      A0A140VJT8

    2. XM_054328928.1 → XP_054184903.1  ribonuclease inhibitor isoform X1

      UniProtKB/Swiss-Prot
      P13489, Q8IZK8, Q96FD7, Q9BQ80, Q9UDK6
      UniProtKB/TrEMBL
      A0A140VJT8

    3. XM_054328924.1 → XP_054184899.1  ribonuclease inhibitor isoform X1

      UniProtKB/Swiss-Prot
      P13489, Q8IZK8, Q96FD7, Q9BQ80, Q9UDK6
      UniProtKB/TrEMBL
      A0A140VJT8

    4. XM_054328923.1 → XP_054184898.1  ribonuclease inhibitor isoform X1

      UniProtKB/Swiss-Prot
      P13489, Q8IZK8, Q96FD7, Q9BQ80, Q9UDK6
      UniProtKB/TrEMBL
      A0A140VJT8

    5. XM_054328926.1 → XP_054184901.1  ribonuclease inhibitor isoform X1

      UniProtKB/Swiss-Prot
      P13489, Q8IZK8, Q96FD7, Q9BQ80, Q9UDK6
      UniProtKB/TrEMBL
      A0A140VJT8

    6. XM_054328925.1 → XP_054184900.1  ribonuclease inhibitor isoform X1

      UniProtKB/Swiss-Prot
      P13489, Q8IZK8, Q96FD7, Q9BQ80, Q9UDK6
      UniProtKB/TrEMBL
      A0A140VJT8

    7. XM_054328927.1 → XP_054184902.1  ribonuclease inhibitor isoform X1

      UniProtKB/Swiss-Prot
      P13489, Q8IZK8, Q96FD7, Q9BQ80, Q9UDK6
      UniProtKB/TrEMBL
      A0A140VJT8

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      540227..553016 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054369610.1 → XP_054225585.1  ribonuclease inhibitor isoform X1

    2. XM_054369606.1 → XP_054225581.1  ribonuclease inhibitor isoform X1

    3. XM_054369604.1 → XP_054225579.1  ribonuclease inhibitor isoform X1

    4. XM_054369607.1 → XP_054225582.1  ribonuclease inhibitor isoform X1

    5. XM_054369605.1 → XP_054225580.1  ribonuclease inhibitor isoform X1

    6. XM_054369609.1 → XP_054225584.1  ribonuclease inhibitor isoform X1

    7. XM_054369608.1 → XP_054225583.1  ribonuclease inhibitor isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P13489.2 GenPept UniProtKB/Swiss-Prot:P13489

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