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    POLY polyprotein;protein F [ Hepatitis C virus genotype 7 ]

    Gene ID: 35984104, updated on 21-Jun-2023

    Summary

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    Gene symbol
    POLY
    Gene description
    polyprotein;protein F
    Locus tag
    BFX91_gp1
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Hepatitis C virus genotype 7 (subtype: 7a, isolate: QC69, nat-host: Homo sapiens)
    Lineage
    Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Flasuviricetes; Amarillovirales; Flaviviridae; Hepacivirus
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    Genomic context

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    Sequence:
    NC_030791.1 (340..9381)

    NC_030791.1Genomic Context describing neighboring genes

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_030791.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Hepatitis C virus genotype 7, a new genotype originating from central Africa. Murphy DG, et al. J Clin Microbiol, 2015 Mar. PMID 25520447, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General protein information

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    Preferred Names
    polyprotein;protein F
    Names
    core protein
    E1 protein
    E2 protein
    p7 protein
    NS2 protein
    NS3 protease/helicase
    NS4A protein
    NS4B protein
    NS5A protein
    NS5B RNA-dependent RNA polymerase
    YP_009305096.1
    • Potential -2/+1 frameshift protein F; position predicted based on homology to protein F in HCV1 RefSeq NC_004102.1; The predicted ribosomal slippage site appears to be mutated in this virus.

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_030791.1 Reference assembly

      Range
      340..9381
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. YP_009272536.1 polyprotein [Hepatitis C virus genotype 7]

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A8QPD9
      Conserved Domains (16) summary
      pfam01001
      Location:1732 → 1925
      HCV_NS4b; Hepatitis C virus non-structural protein NS4b
      pfam01539
      Location:193 → 382
      HCV_env; Hepatitis C virus envelope glycoprotein E1
      pfam01560
      Location:388 → 733
      HCV_NS1; Hepatitis C virus non-structural protein E2/NS1
      pfam02907
      Location:1060 → 1205
      Peptidase_S29; Hepatitis C virus NS3 protease
      pfam01543
      Location:2 → 115
      HCV_capsid; Hepatitis C virus capsid protein
      pfam08301
      Location:2072 → 2172
      HCV_NS5a_1b; Hepatitis C virus non-structural 5a domain 1b
      pfam01538
      Location:815 → 1009
      HCV_NS2; Hepatitis C virus non-structural protein NS2
      smart00487
      Location:1221 → 1359
      DEXDc; DEAD-like helicases superfamily
      cd00046
      Location:1228 → 1355
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd00079
      Location:1382 → 1459
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      pfam00998
      Location:2425 → 2936
      RdRP_3; Viral RNA dependent RNA polymerase
      pfam01006
      Location:1662 → 1715
      HCV_NS4a; Hepatitis C virus non-structural protein NS4a
      pfam01506
      Location:1978 → 2000
      HCV_NS5a; Hepatitis C virus non-structural 5a protein membrane anchor
      pfam01542
      Location:116 → 190
      HCV_core; Hepatitis C virus core protein
      pfam08300
      Location:2010 → 2071
      HCV_NS5a_1a; Hepatitis C virus non-structural 5a zinc finger domain
      pfam12941
      Location:2183 → 2422
      HCV_NS5a_C; HCV NS5a protein C-terminal region

    2. YP_009272680.1 core protein

    3. YP_009272681.1 E1 protein

    4. YP_009272682.1 E2 protein

    5. YP_009272683.1 p7 protein

    6. YP_009272684.1 NS2 protein

    7. YP_009272685.1 NS3 protease/helicase

    8. YP_009272686.1 NS4A protein

    9. YP_009272687.1 NS4B protein

    10. YP_009272688.1 NS5A protein

    11. YP_009272689.1 NS5B RNA-dependent RNA polymerase

    12. YP_009305096.1 protein F [Hepatitis C virus genotype 7]

      Status: PROVISIONAL

    Protein Accession Links
    GenPept Link UniProtKB Link
    ABN05226.1

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