Gstk1 glutathione S-transferase kappa 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gstk1provided by MGI
Official Full Name: glutathione S-transferase kappa 1provided by MGI
Primary source: MGI:MGI:1923513
See related: Ensembl:ENSMUSG00000029864 AllianceGenome:MGI:1923513
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: DsbA-L; 0610025I19Rik
Summary: Enables glutathione peroxidase activity and glutathione transferase activity. Acts upstream of or within glutathione metabolic process. Located in mitochondrion. Orthologous to human GSTK1 (glutathione S-transferase kappa 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in liver adult (RPKM 68.9), adrenal adult (RPKM 41.8) and 19 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 B2.1; 6 20.52 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (42222869..42227375)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (42245935..42250441)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DsbA-L deletion attenuates LPS-induced acute kidney injury by modulating macrophage polarization.
Title: DsbA-L deletion attenuates LPS-induced acute kidney injury by modulating macrophage polarization.
DsbA-L interacting with catalase in peroxisome improves tubular oxidative damage in diabetic nephropathy.
Title: DsbA-L interacting with catalase in peroxisome improves tubular oxidative damage in diabetic nephropathy.
DsbA-L alleviates tubular injury in diabetic nephropathy by activating mitophagy through maintenance of MAM integrity.
Title: DsbA-L alleviates tubular injury in diabetic nephropathy by activating mitophagy through maintenance of MAM integrity.
DsbA-L deficiency in T cells promotes diet-induced thermogenesis through suppressing IFN-gamma production.
Title: DsbA-L deficiency in T cells promotes diet-induced thermogenesis through suppressing IFN-γ production.
DsbA-L mediated renal tubulointerstitial fibrosis in UUO mice.
Title: DsbA-L mediated renal tubulointerstitial fibrosis in UUO mice.
DsbA-L modifies mtROS/JNK/MFF-related mitochondrial fission, linking alterations in mitochondrial dynamics during tubular injury in the pathogenesis of diabetic kidney disease.
Title: DsbA-L deficiency exacerbates mitochondrial dysfunction of tubular cells in diabetic kidney disease.
DsbA-L plays a critical protective role in renal ectopic fat deposition and lipid-related kidney injury in mice with diabetic nephropathy (DN) and patients with DN. The mechanisms might involve the inhibition of cholesterol synthesis through the inactivation of HMGCR and the promotion of lipolysis through the activation of ATGL and the subsequent reduction of lipid droplets accumulation in the kidney.
Title: Disulfide-bond A oxidoreductase-like protein protects against ectopic fat deposition and lipid-related kidney damage in diabetic nephropathy.
DsbA-L prevents obesity-induced inflammation and insulin resistance by suppressing the mtDNA release-activated cGAS-cGAMP-STING pathway.
Title: DsbA-L prevents obesity-induced inflammation and insulin resistance by suppressing the mtDNA release-activated cGAS-cGAMP-STING pathway.
These results identify DsbA-L as a critical regulator of mitochondrial function, and its down-regulation in the liver may contribute to obesity-induced hepatosteatosis and whole body insulin resistance.
Title: Hepatic DsbA-L protects mice from diet-induced hepatosteatosis and insulin resistance.
DsbA-L is localized in both the mitochondria and the endoplasmic reticulum (ER) in adipocytes; its ER localization plays a critical role in suppressing ER stress and promoting adiponectin biosynthesis and secretion.
Title: Endoplasmic reticulum (ER) localization is critical for DsbA-L protein to suppress ER stress and adiponectin down-regulation in adipocytes.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D6Mit271 (e-PCR), detects polymorphism
- UniSTS:130818

Gstk1 (e-PCR), detects polymorphism
- UniSTS:527376

AW260476 (e-PCR)
- UniSTS:178669

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables glutathione peroxidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutathione peroxidase activity	IDA Inferred from Direct Assay more info	PubMed
enables glutathione peroxidase activity	ISO Inferred from Sequence Orthology more info
enables glutathione transferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutathione transferase activity	IDA Inferred from Direct Assay more info	PubMed
enables glutathione transferase activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular oxidant detoxification	IEA Inferred from Electronic Annotation more info
involved_in epithelial cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in glutathione metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within glutathione metabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	HDA more info	PubMed
located_in mitochondrial matrix	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
is_active_in peroxisome	IBA Inferred from Biological aspect of Ancestor more info
located_in peroxisome	IEA Inferred from Electronic Annotation more info
located_in peroxisome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: glutathione S-transferase kappa 1

Names: GST 13-13; GST class-kappa; GSTK1-1; glutathione S-transferase class kappa; glutathione S-transferase subunit 13; mGSTK1

NP_083831.1

EC 2.5.1.18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_029555.2 → NP_083831.1 glutathione S-transferase kappa 1

See identical proteins and their annotated locations for NP_083831.1

Status: PROVISIONAL

Source sequence(s)

AC155654

Consensus CDS

CCDS20063.1

UniProtKB/Swiss-Prot

Q9DCM2

Related

ENSMUSP00000031897.6, ENSMUST00000031897.8

Conserved Domains (1) summary

cd03021
Location:6 → 211

DsbA_GSTK; DsbA family, Glutathione (GSH) S-transferase Kappa (GSTK) subfamily; GSTK is a member of the GST family of enzymes which catalyzes the transfer of the thiol of GSH to electrophilic substrates. It is specifically located in the mitochondria and ...