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    Bicdl1 BICD family like cargo adaptor 1 [ Mus musculus (house mouse) ]

    Gene ID: 75665, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Bicdl1provided by MGI
    Official Full Name
    BICD family like cargo adaptor 1provided by MGI
    Primary source
    MGI:MGI:1922915
    See related
    Ensembl:ENSMUSG00000041609 AllianceGenome:MGI:1922915
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ccdc64; BICDR-1; 2210403N09Rik
    Summary
    Enables dynactin binding activity and small GTPase binding activity. Involved in Golgi to secretory granule transport and neuron projection development. Located in centrosome. Is expressed in several structures, including adrenal gland; genitourinary system; gut; nervous system; and sensory organ. Orthologous to human BICDL1 (BICD family like cargo adaptor 1). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 26.8), CNS E18 (RPKM 20.2) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Bicdl1 in Genome Data Viewer
    Location:
    5 F; 5 56.1 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (115786233..115869824, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (115648174..115731844, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1110006O24 gene Neighboring gene STARR-positive B cell enhancer ABC_E154 Neighboring gene RAB35, member RAS oncogene family Neighboring gene microRNA 7030 Neighboring gene STARR-seq mESC enhancer starr_14136 Neighboring gene ribosomal protein L29 Neighboring gene STARR-positive B cell enhancer ABC_E430 Neighboring gene citron Neighboring gene predicted gene, 42008

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Pericentrosomal targeting of Rab6 secretory vesicles by Bicaudal-D-related protein 1 (BICDR-1) regulates neuritogenesis. Schlager MA, et al. EMBO J, 2010 May 19. PMID 20360680, Free PMC Article
    2. A mutation in the Srrm4 gene causes alternative splicing defects and deafness in the Bronx waltzer mouse. Nakano Y, et al. PLoS Genet, 2012. PMID 23055939, Free PMC Article
    3. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
    4. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. BICDR-1 has an important role as temporal regulator of secretory trafficking during the early phase of neuronal differentiation
      Title: Pericentrosomal targeting of Rab6 secretory vesicles by Bicaudal-D-related protein 1 (BICDR-1) regulates neuritogenesis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC143541

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables dynactin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables small GTPase binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Golgi to secretory granule transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Golgi to secretory granule transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vesicle transport along microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    BICD family-like cargo adapter 1
    Names
    BICD-related protein 1
    bicaudal D-related protein 1
    coiled-coil domain containing 64
    coiled-coil domain-containing protein 64A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001080808.2 → NP_001074277.1  BICD family-like cargo adapter 1

      See identical proteins and their annotated locations for NP_001074277.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the protein-coding transcript.
      Source sequence(s)
      AC139562, GU973876
      Consensus CDS
      CCDS39230.1
      UniProtKB/Swiss-Prot
      A0JNT9, Q8C9J5, Q8CB56, Q8R1D2
      UniProtKB/TrEMBL
      D4PEG0
      Related
      ENSMUSP00000053547.7, ENSMUST00000055408.13
      Conserved Domains (1) summary
      TIGR02168
      Location:101 → 331
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    RNA

    1. NR_151598.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains three alternate exons compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC139562, AC159539

    2. NR_151599.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains three alternate exons compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC139562, AC159539

    3. NR_151600.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' end and contains and alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC159539

    4. NR_151601.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' end and contains and alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC159539

    5. NR_151602.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' end compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC159539

    6. NR_151603.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) differs in the 5' end compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC159539

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      115786233..115869824 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006530487.4 → XP_006530550.1  BICD family-like cargo adapter 1 isoform X2

      UniProtKB/TrEMBL
      D4PEG0
      Conserved Domains (1) summary
      TIGR02168
      Location:101 → 331
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    2. XM_006530489.4 → XP_006530552.1  BICD family-like cargo adapter 1 isoform X3

      UniProtKB/TrEMBL
      D4PEG0
      Conserved Domains (1) summary
      TIGR02168
      Location:101 → 335
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    3. XM_006530490.5 → XP_006530553.1  BICD family-like cargo adapter 1 isoform X1

      UniProtKB/TrEMBL
      D4PEG0
      Conserved Domains (1) summary
      TIGR02168
      Location:101 → 335
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    RNA

    1. XR_003955719.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0JNT9.1 GenPept UniProtKB/Swiss-Prot:A0JNT9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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