Serpinb12 serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 12 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Serpinb12provided by MGI
Official Full Name: serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 12provided by MGI
Primary source: MGI:MGI:1919119
See related: Ensembl:ENSMUSG00000059956 AllianceGenome:MGI:1919119
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2300003F07Rik; 4833409F13Rik
Summary: Predicted to enable serine-type endopeptidase inhibitor activity. Acts upstream of or within hematopoietic progenitor cell differentiation. Is active in cornified envelope. Is expressed in alimentary system; reproductive system; skin; and thymus. Orthologous to human SERPINB12 (serpin family B member 12). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in lung adult (RPKM 8.5), stomach adult (RPKM 4.6) and 1 other tissue See more
Orthologs: human all
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Genomic context

Location:: 1 E2.1; 1 50.34 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (106862179..106884810)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (106934449..106957080)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

data suggest that SERPINB12, like some other intracellular serpins, may play a vital role in barrier function by providing protection of epithelial cells.
Title: Human SERPINB12 Is an Abundant Intracellular Serpin Expressed in Most Surface and Glandular Epithelia.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)

General gene information

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Markers

MT1854 (e-PCR)
- UniSTS:128604

D1Mit259.2 (e-PCR), detects polymorphism
- UniSTS:128605

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables serine-type endopeptidase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables serine-type endopeptidase inhibitor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within hematopoietic progenitor cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cornified envelope	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: serpin B12

Names: serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001199213.3 → NP_001186142.1 serpin B12

See identical proteins and their annotated locations for NP_001186142.1

Status: VALIDATED

Source sequence(s)

AC163626

Consensus CDS

CCDS15212.1

UniProtKB/Swiss-Prot

Q6UKZ3, Q9D7P9

Related

ENSMUSP00000108344.3, ENSMUST00000112724.3

Conserved Domains (1) summary

cl00137
Location:4 → 423

SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...
NM_027971.4 → NP_082247.1 serpin B12

See identical proteins and their annotated locations for NP_082247.1

Status: VALIDATED

Source sequence(s)

AC163626

Consensus CDS

CCDS15212.1

UniProtKB/Swiss-Prot

Q6UKZ3, Q9D7P9

Related

ENSMUSP00000080030.3, ENSMUST00000081277.9

Conserved Domains (1) summary

cl00137
Location:4 → 423

SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...