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    Pcgf6 polycomb group ring finger 6 [ Mus musculus (house mouse) ]

    Gene ID: 71041, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pcgf6provided by MGI
    Official Full Name
    polycomb group ring finger 6provided by MGI
    Primary source
    MGI:MGI:1918291
    See related
    Ensembl:ENSMUSG00000025050 AllianceGenome:MGI:1918291
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MBLR; Rnf134; 4933407A11Rik
    Summary
    Predicted to enable protein domain specific binding activity. Involved in negative regulation of transcription by RNA polymerase II. Located in nucleus. Part of PcG protein complex. Is expressed in central nervous system; eye; limb; trunk somite; and urinary system. Orthologous to human PCGF6 (polycomb group ring finger 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 18.0), whole brain E14.5 (RPKM 15.5) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pcgf6 in Genome Data Viewer
    Location:
    19 C3; 19 39.11 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (47022056..47039379, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (47033617..47050939, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene 5'-nucleotidase, cytosolic II Neighboring gene lysophosphatidic acid receptor 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_46336 Neighboring gene internexin neuronal intermediate filament protein, alpha Neighboring gene STARR-positive B cell enhancer ABC_E11037 Neighboring gene STARR-seq mESC enhancer starr_46338 Neighboring gene STARR-positive B cell enhancer ABC_E1979 Neighboring gene predicted gene, 23140 Neighboring gene TATA-box binding protein associated factor 5 Neighboring gene ATP synthase membrane subunit k

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. PCGF6 regulates stem cell pluripotency as a transcription activator via super-enhancer dependent chromatin interactions. Huang X, et al. Protein Cell, 2019 Oct. PMID 31041782, Free PMC Article
    2. PCGF6 controls murine Tuft cell differentiation via H3K9me2 modification independently of Polycomb repression. Del Vecchio A, et al. Dev Cell, 2024 Feb 5. PMID 38228142
    3. Pcgf6, a polycomb group protein, regulates mesodermal lineage differentiation in murine ESCs and functions in iPS reprogramming. Zdzieblo D, et al. Stem Cells, 2014 Dec. PMID 25187489
    4. The Transcriptional Repressor Polycomb Group Factor 6, PCGF6, Negatively Regulates Dendritic Cell Activation and Promotes Quiescence. Boukhaled GM, et al. Cell Rep, 2016 Aug 16. PMID 27498878
    5. Polycomb Group Protein Pcgf6 Acts as a Master Regulator to Maintain Embryonic Stem Cell Identity. Yang CS, et al. Sci Rep, 2016 Jun 1. PMID 27247273, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PCGF6 controls murine Tuft cell differentiation via H3K9me2 modification independently of Polycomb repression.
      Title: PCGF6 controls murine Tuft cell differentiation via H3K9me2 modification independently of Polycomb repression.
    2. Polycomb group ring finger protein 6 suppresses Myc-induced lymphomagenesis.
      Title: Polycomb group ring finger protein 6 suppresses Myc-induced lymphomagenesis.
    3. H2AK119ub1 guides maternal inheritance and zygotic deposition of H3K27me3 in mouse embryos.
      Title: H2AK119ub1 guides maternal inheritance and zygotic deposition of H3K27me3 in mouse embryos.
    4. The polycomb group protein PCGF6 mediates germline gene silencing by recruiting histone-modifying proteins to target gene promoters.
      Title: The polycomb group protein PCGF6 mediates germline gene silencing by recruiting histone-modifying proteins to target gene promoters.
    5. The authors findings highlight a novel mechanism of Pcgf6 protein in regulating stem cell pluripotency: PCGF6 is recruited to a subset of the super-enhancer (SE) regions upstream of cell cycle-associated genes by Oct4 (Octamer Transcription Factor-4) and increased their expression, also, PCGF6 activates cell cycle genes by regulating SE-promoter interactions via 3D chromatin.
      Title: PCGF6 regulates stem cell pluripotency as a transcription activator via super-enhancer dependent chromatin interactions.
    6. Pcgf6 acts as a master regulator to maintain embryonic stem cell identity.
      Title: Polycomb Group Protein Pcgf6 Acts as a Master Regulator to Maintain Embryonic Stem Cell Identity.
    7. Conditional ablation of Pcgf6 in embryonic stem cells leads to robust de-repression of germ cell-related genes, in turn affecting cell growth and viability.
      Title: PCGF6-PRC1 suppresses premature differentiation of mouse embryonic stem cells by regulating germ cell-related genes.
    8. The results identify two key regulators, PCGF6 and JARID1c that temper dendritic cells (DC) activation and implicate active transcriptional silencing via histone demethylation as a previously unappreciated mechanism for regulating DC activation and quiescence.
      Title: The Transcriptional Repressor Polycomb Group Factor 6, PCGF6, Negatively Regulates Dendritic Cell Activation and Promotes Quiescence.
    9. Pcgf6 is essential for recruitment of PRC1.6 to chromatin. Our results reveal a previously uncharacterized, H2AK119ub1-independent chromatin assembly associated with PRC1.6 complex
      Title: Essential Role for Polycomb Group Protein Pcgf6 in Embryonic Stem Cell Maintenance and a Noncanonical Polycomb Repressive Complex 1 (PRC1) Integrity.
    10. that Pcgf6 is nonredundantly involved in maintaining the pluripotent nature of embryonic stem cells and it functions in induced pluripotent stem reprogramming
      Title: Pcgf6, a polycomb group protein, regulates mesodermal lineage differentiation in murine ESCs and functions in iPS reprogramming.
    Submit: New GeneRIF Correction See all GeneRIFs (11)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC106622

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chromatin remodeling ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of PRC1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of PRC1 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of PRC1 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of PcG protein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of PcG protein complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of PcG protein complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    polycomb group RING finger protein 6
    Names
    Mel18- and Bmi1-like RING finger protein
    ring finger protein 134

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360632.1 → NP_001347561.1  polycomb group RING finger protein 6 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC108814, BC089460
      Conserved Domains (2) summary
      pfam16207
      Location:284 → 331
      RAWUL; RAWUL domain RING finger- and WD40-associated ubiquitin-like
      cd16738
      Location:133 → 177
      RING-HC_PCGF6; RING finger found in polycomb group RING finger protein 6 (PCGF6) and similar proteins

    2. NM_027654.3 → NP_081930.1  polycomb group RING finger protein 6 isoform 1

      See identical proteins and their annotated locations for NP_081930.1

      Status: VALIDATED

      Source sequence(s)
      AC108814, BC089460
      Consensus CDS
      CCDS29885.1
      UniProtKB/Swiss-Prot
      Q99NA9
      Related
      ENSMUSP00000026032.6, ENSMUST00000026032.7
      Conserved Domains (2) summary
      pfam00097
      Location:137 → 175
      zf-C3HC4; Zinc finger, C3HC4 type (RING finger)
      pfam16207
      Location:266 → 322
      RAWUL; RAWUL domain RING finger- and WD40-associated ubiquitin-like

    RNA

    1. NR_133574.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC108814, BC089460
      Related
      ENSMUST00000235633.2

    2. NR_153762.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC108814, BC089460

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      47022056..47039379 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006527338.5 → XP_006527401.1  polycomb group RING finger protein 6 isoform X1

      UniProtKB/TrEMBL
      Q3V1H7
      Conserved Domains (2) summary
      cd16738
      Location:133 → 177
      RING-HC_PCGF6; RING finger found in polycomb group RING finger protein 6 (PCGF6) and similar proteins
      cl28922
      Location:255 → 313
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    2. XM_030251075.1 → XP_030106935.1  polycomb group RING finger protein 6 isoform X2

      UniProtKB/TrEMBL
      Q3V1H7
      Conserved Domains (2) summary
      cd16738
      Location:133 → 177
      RING-HC_PCGF6; RING finger found in polycomb group RING finger protein 6 (PCGF6) and similar proteins
      cd17085
      Location:255 → 307
      RAWUL_PCGF6; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 6 (PCGF6) and similar proteins

    3. XM_036161687.1 → XP_036017580.1  polycomb group RING finger protein 6 isoform X3

      UniProtKB/TrEMBL
      A0A494B9Z3
      Conserved Domains (1) summary
      cd16738
      Location:133 → 177
      RING-HC_PCGF6; RING finger found in polycomb group RING finger protein 6 (PCGF6) and similar proteins

    RNA

    1. XR_001782614.3 RNA Sequence

    2. XR_386508.5 RNA Sequence

    3. XR_003952816.1 RNA Sequence

    4. XR_003952814.1 RNA Sequence

    5. XR_004940173.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99NA9.1 GenPept UniProtKB/Swiss-Prot:Q99NA9

    Gene LinkOut

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