Xrcc2 X-ray repair complementing defective repair in Chinese hamster cells 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Xrcc2provided by MGI
Official Full Name: X-ray repair complementing defective repair in Chinese hamster cells 2provided by MGI
Primary source: MGI:MGI:1927345
See related: Ensembl:ENSMUSG00000028933 AllianceGenome:MGI:1927345
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: RecA; RAD51; 4921524O04Rik; 8030409M04Rik
Summary: Predicted to enable ATP binding activity and ATP-dependent DNA damage sensor activity. Predicted to contribute to four-way junction DNA binding activity. Acts upstream of or within several processes, including chordate embryonic development; regulation of apoptotic process; and response to X-ray. Predicted to be located in nucleoplasm. Predicted to be part of Rad51B-Rad51C-Rad51D-XRCC2 complex. Predicted to be active in centrosome and replication fork. Is expressed in embryo. Human ortholog(s) of this gene implicated in Fanconi anemia complementation group U; pancreatic cancer; primary ovarian insufficiency 17; and spermatogenic failure 50. Orthologous to human XRCC2 (X-ray repair cross complementing 2). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Ubiquitous expression in testis adult (RPKM 4.3), CNS E11.5 (RPKM 4.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 B1; 5 12.35 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (25894812..25910795, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (25689814..25705797, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The homozygotes (knock-in mice with Xrcc2-c.T41C/p.Leu14Pro mutation) survived and exhibited meiotic arrest, azoospermia, premature ovarian failure and infertility.
Title: XRCC2 mutation causes meiotic arrest, azoospermia and infertility.
involvement of ZNF281 in the cellular response to genotoxic stress through the control exercised on the expression of genes that act in different repair mechanisms
Title: ZNF281 contributes to the DNA damage response by controlling the expression of XRCC2 and XRCC4.
Data show that XRCC2 and other homologous recombination proteins, including the key recombinase RAD51, co-localize with the centrosome, potentially to coordinate the deployment of a DNA damage response at vulnerable phases of the cell cycle.
Title: Homologous recombination proteins are associated with centrosomes and are required for mitotic stability.
These findings indicate that Xrcc2 haploinsufficiency reduces spontaneous tumor incidence on an Apc(min/+) background but increases the tumorigenic response to radiation.
Title: Xrcc2 modulates spontaneous and radiation-induced tumorigenesis in Apcmin/+ mice.
An important function of XRCC2 is to enhance the activity of RAD51, so that the loss of XRCC2 results in a severe delay in the early response of RAD51 to DNA damage.
Title: The importance of XRCC2 in RAD51-related DNA damage repair.
DNA replication licensing factor MCM2 and DNA mismatch repair (MMR) protein MSH2 were confirmed to be present in co-precipitations with MmXRCC2.
Title: The interaction profile of homologous recombination repair proteins RAD51C, RAD51D and XRCC2 as determined by proteomic analysis.
Xrcc2 is important to preserve or restore replication forks during rapid clonal expansion of developing lymphocytes.
Title: Homologous recombination is necessary for normal lymphocyte development.
ATP hydrolysis by Rad51 is more important for some homologous recombination functions than it is for other aspects of DNA repair
Title: Altered DNA repair and recombination responses in mouse cells expressing wildtype or mutant forms of RAD51.
the normal developmental programme is perturbed in Xrcc2-/- embryonic tissues, particularly during neurogenesis and somitogenesis
Title: A role for Xrcc2 in the early stages of mouse development.
Order-of-magnitude higher levels of chromosomal alterations are sustained in primary or immortal Xrcc2(-/-) embryonic fibroblasts.
Title: Homologous recombination deficiency leads to profound genetic instability in cells derived from Xrcc2-knockout mice.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Xrcc2 (e-PCR), detects polymorphism
- UniSTS:257085

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP-dependent DNA damage sensor activity	IEA Inferred from Electronic Annotation more info
contributes_to four-way junction DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables four-way junction DNA binding	IEA Inferred from Electronic Annotation more info
contributes_to four-way junction DNA binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA damage response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in DNA repair	ISO Inferred from Sequence Orthology more info
involved_in DNA strand invasion	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA strand invasion	ISO Inferred from Sequence Orthology more info
involved_in DNA strand invasion	ISS Inferred from Sequence or Structural Similarity more info
involved_in centrosome cycle	ISO Inferred from Sequence Orthology more info
involved_in centrosome cycle	ISS Inferred from Sequence or Structural Similarity more info
involved_in double-strand break repair via homologous recombination	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within double-strand break repair via homologous recombination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in double-strand break repair via homologous recombination	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within in utero embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in mitotic cell cycle	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within multicellular organism growth	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of neuron apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of neurogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neurogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of neurogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of fibroblast apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within response to X-ray	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to gamma radiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within somitogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of Rad51B-Rad51C-Rad51D-XRCC2 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Rad51B-Rad51C-Rad51D-XRCC2 complex	ISO Inferred from Sequence Orthology more info
part_of Rad51B-Rad51C-Rad51D-XRCC2 complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in centrosome	IBA Inferred from Biological aspect of Ancestor more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in centrosome	ISS Inferred from Sequence or Structural Similarity more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in replication fork	IBA Inferred from Biological aspect of Ancestor more info
located_in replication fork	ISO Inferred from Sequence Orthology more info
located_in replication fork	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: DNA repair protein XRCC2

Names: X-ray repair cross-complementing protein 2; recA/RAD51 family protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.