E2F2 E2F transcription factor 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: E2F2provided by HGNC
Official Full Name: E2F transcription factor 2provided by HGNC
Primary source: HGNC:HGNC:3114
See related: Ensembl:ENSG00000007968 MIM:600426; AllianceGenome:HGNC:3114
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: E2F-2
Summary: The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F3, have an additional cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner, and it exhibits overall 46% amino acid identity to E2F1. [provided by RefSeq, Jul 2008]
Expression: Biased expression in bone marrow (RPKM 17.6), lymph node (RPKM 3.1) and 8 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 1p36.12

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (23505212..23531233, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (23339773..23365799, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (23832930..23857725, complement)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

B-Myb accelerates colorectal cancer progression through reciprocal feed-forward transactivation of E2F2.
Title: B-Myb accelerates colorectal cancer progression through reciprocal feed-forward transactivation of E2F2.
The association of E2F1 and E2F2 single nucleotide polymorphisms with laryngeal squamous cell carcinoma pathomorphological features.
Title: The association of E2F1 and E2F2 single nucleotide polymorphisms with laryngeal squamous cell carcinoma pathomorphological features.
DNM3OS Enhances the Apoptosis and Senescence of Spermatogonia Associated with Nonobstructive Azoospermia by Providing miR-214-5p and Decreasing E2F2 Expression.
Title: DNM3OS Enhances the Apoptosis and Senescence of Spermatogonia Associated with Nonobstructive Azoospermia by Providing miR-214-5p and Decreasing E2F2 Expression.
C/EBPbeta Coupled with E2F2 Promoted the Proliferation of hESC-Derived Hepatocytes through Direct Binding to the Promoter Regions of Cell-Cycle-Related Genes.
Title: C/EBPβ Coupled with E2F2 Promoted the Proliferation of hESC-Derived Hepatocytes through Direct Binding to the Promoter Regions of Cell-Cycle-Related Genes.
Atypical E3 ligase ZFP91 promotes small-molecule-induced E2F2 transcription factor degradation for cancer therapy.
Title: Atypical E3 ligase ZFP91 promotes small-molecule-induced E2F2 transcription factor degradation for cancer therapy.
Molecular Regulation of Heme Oxygenase-1 Expression by E2F Transcription Factor 2 in Lung Fibroblast Cells: Relevance to Idiopathic Pulmonary Fibrosis.
Title: Molecular Regulation of Heme Oxygenase-1 Expression by E2F Transcription Factor 2 in Lung Fibroblast Cells: Relevance to Idiopathic Pulmonary Fibrosis.
Alteration of E2F2 Expression in Governing Endothelial Cell Senescence.
Title: Alteration of E2F2 Expression in Governing Endothelial Cell Senescence.
E2F2 promotes lung adenocarcinoma progression through B-Myb- and FOXM1-facilitated core transcription regulatory circuitry.
Title: E2F2 promotes lung adenocarcinoma progression through B-Myb- and FOXM1-facilitated core transcription regulatory circuitry.
E2F2 enhances the chemoresistance of pancreatic cancer to gemcitabine by regulating the cell cycle and upregulating the expression of RRM2.
Title: E2F2 enhances the chemoresistance of pancreatic cancer to gemcitabine by regulating the cell cycle and upregulating the expression of RRM2.
Circular RNA circE2F2 promotes malignant progression of ovarian cancer cells by upregulating the expression of E2F2 protein via binding to HuR protein.
Title: Circular RNA circE2F2 promotes malignant progression of ovarian cancer cells by upregulating the expression of E2F2 protein via binding to HuR protein.

Submit: New GeneRIF Correction See all GeneRIFs (70)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

GDB:636071 (e-PCR)
- UniSTS:158520

RH78295 (e-PCR)
- UniSTS:56918

SHGC-74380 (e-PCR)
- UniSTS:76656

D1S1425 (e-PCR)
- UniSTS:149621

D1S482 (e-PCR), detects polymorphism
- UniSTS:31377

SHGC-74381 (e-PCR)
- UniSTS:34021

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA binding	TAS Traceable Author Statement more info	PubMed
contributes_to DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	NAS Non-traceable Author Statement more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISA Inferred from Sequence Alignment more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
contributes_to RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific double-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in intrinsic apoptotic signaling pathway by p53 class mediator	IEA Inferred from Electronic Annotation more info
involved_in lens fiber cell apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of sprouting angiogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cell cycle	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in transcription initiation at RNA polymerase II promoter	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of RNA polymerase II transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info
part_of RNA polymerase II transcription regulator complex	IDA Inferred from Direct Assay more info	PubMed
part_of RNA polymerase II transcription regulator complex	ISS Inferred from Sequence or Structural Similarity more info
part_of Rb-E2F complex	ISS Inferred from Sequence or Structural Similarity more info
located_in chromatin	ISA Inferred from Sequence Alignment more info
located_in nucleoplasm	TAS Traceable Author Statement more info

General protein information

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Preferred Names: transcription factor E2F2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_004091.4 → NP_004082.1 transcription factor E2F2

See identical proteins and their annotated locations for NP_004082.1

Status: REVIEWED

Source sequence(s)

AF086395, AL021154, L22846

Consensus CDS

CCDS236.1

UniProtKB/Swiss-Prot

B2R9W1, Q14209, Q7Z6H1

UniProtKB/TrEMBL

Q5U0J0

Related

ENSP00000355249.2, ENST00000361729.3

Conserved Domains (2) summary

cd14660
Location:206 → 306

E2F_DD; Dimerization domain of E2F transcription factors

pfam02319
Location:131 → 194

E2F_TDP; E2F/DP family winged-helix DNA-binding domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000001.11 Reference GRCh38.p14 Primary Assembly

Range

23505212..23531233 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047448092.1 → XP_047304048.1 transcription factor E2F2 isoform X4
XM_011540870.4 → XP_011539172.1 transcription factor E2F2 isoform X3

Conserved Domains (1) summary

cd14660
Location:206 → 306

E2F_DD; Dimerization domain of E2F transcription factors
XM_047448091.1 → XP_047304047.1 transcription factor E2F2 isoform X2

UniProtKB/TrEMBL

Q5U0J0
XM_011540871.3 → XP_011539173.1 transcription factor E2F2 isoform X6

See identical proteins and their annotated locations for XP_011539173.1

Conserved Domains (1) summary

cd14660
Location:10 → 110

E2F_DD; Dimerization domain of E2F transcription factors
XM_011540868.4 → XP_011539170.1 transcription factor E2F2 isoform X1

UniProtKB/TrEMBL

Q5U0J0

Conserved Domains (2) summary

cd14660
Location:204 → 304

E2F_DD; Dimerization domain of E2F transcription factors

pfam02319
Location:131 → 194

E2F_TDP; E2F/DP family winged-helix DNA-binding domain
XM_047448093.1 → XP_047304049.1 transcription factor E2F2 isoform X6
XM_047448094.1 → XP_047304050.1 transcription factor E2F2 isoform X6
XM_005245749.4 → XP_005245806.1 transcription factor E2F2 isoform X6

See identical proteins and their annotated locations for XP_005245806.1

Conserved Domains (1) summary

cd14660
Location:10 → 110

E2F_DD; Dimerization domain of E2F transcription factors
XM_005245748.4 → XP_005245805.1 transcription factor E2F2 isoform X5

Conserved Domains (1) summary

cd14660
Location:18 → 118

E2F_DD; Dimerization domain of E2F transcription factors

Reference GRCh38.p14 PATCHES

Genomic

NW_014040926.1 Reference GRCh38.p14 PATCHES

Range

275191..301212 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054331916.1 → XP_054187891.1 transcription factor E2F2 isoform X4
XM_054331915.1 → XP_054187890.1 transcription factor E2F2 isoform X3
XM_054331914.1 → XP_054187889.1 transcription factor E2F2 isoform X2

UniProtKB/TrEMBL

Q5U0J0
XM_054331913.1 → XP_054187888.1 transcription factor E2F2 isoform X1

UniProtKB/TrEMBL

Q5U0J0
XM_054331918.1 → XP_054187893.1 transcription factor E2F2 isoform X6
XM_054331917.1 → XP_054187892.1 transcription factor E2F2 isoform X5

Alternate T2T-CHM13v2.0

Genomic

NC_060925.1 Alternate T2T-CHM13v2.0

Range

23339773..23365799 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054334810.1 → XP_054190785.1 transcription factor E2F2 isoform X4
XM_054334809.1 → XP_054190784.1 transcription factor E2F2 isoform X3
XM_054334808.1 → XP_054190783.1 transcription factor E2F2 isoform X2

UniProtKB/TrEMBL

Q5U0J0
XM_054334807.1 → XP_054190782.1 transcription factor E2F2 isoform X1

UniProtKB/TrEMBL

Q5U0J0
XM_054334812.1 → XP_054190787.1 transcription factor E2F2 isoform X6
XM_054334811.1 → XP_054190786.1 transcription factor E2F2 isoform X5