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    Htr4 5 hydroxytryptamine (serotonin) receptor 4 [ Mus musculus (house mouse) ]

    Gene ID: 15562, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Htr4provided by MGI
    Official Full Name
    5 hydroxytryptamine (serotonin) receptor 4provided by MGI
    Primary source
    MGI:MGI:109246
    See related
    Ensembl:ENSMUSG00000026322 AllianceGenome:MGI:109246
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    5-HT4; 5HTR4; 5-HT-4; 5-HT<4L>
    Summary
    Enables G protein-coupled serotonin receptor activity. Involved in several processes, including maintenance of gastrointestinal epithelium; mucus secretion; and regulation of postsynapse assembly. Is active in glutamatergic synapse; plasma membrane; and postsynapse. Is expressed in several structures, including brain; gallbladder; genitourinary system; gut; and spinal cord. Used to study anorexia nervosa. Orthologous to human HTR4 (5-hydroxytryptamine receptor 4). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in bladder adult (RPKM 1.5), colon adult (RPKM 1.5) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Htr4 in Genome Data Viewer
    Location:
    18 E1; 18 35.1 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (62456618..62636098)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (62323546..62503027)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_44769 Neighboring gene STARR-seq mESC enhancer starr_44770 Neighboring gene predicted gene 9949 Neighboring gene adrenergic receptor, beta 2 Neighboring gene predicted gene, 36124 Neighboring gene STARR-seq mESC enhancer starr_44772 Neighboring gene predicted gene, 36316 Neighboring gene X-linked lymphocyte-regulated 5C pseudogene Neighboring gene F-box protein 38 Neighboring gene STARR-positive B cell enhancer ABC_E967 Neighboring gene serine peptidase inhibitor, Kazal type 10 Neighboring gene STARR-seq mESC enhancer starr_44774 Neighboring gene serine peptidase inhibitor, Kazal type 7 (putative)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Dual role of serotonin in the pathogenesis of indomethacin-induced small intestinal ulceration: pro-ulcerogenic action via 5-HT3 receptors and anti-ulcerogenic action via 5-HT4 receptors. Kato S, et al. Pharmacol Res, 2012 Sep. PMID 22699012
    2. How Does the Brain Implement Adaptive Decision Making to Eat? Compan V, et al. J Neurosci, 2015 Oct 14. PMID 26468187, Free PMC Article
    3. Expression and function of 5-HT4 receptors in the mouse enteric nervous system. Liu M, et al. Am J Physiol Gastrointest Liver Physiol, 2005 Dec. PMID 16037544
    4. Adaptive changes in serotonin neurons of the raphe nuclei in 5-HT(4) receptor knock-out mouse. Conductier G, et al. Eur J Neurosci, 2006 Aug. PMID 16930432
    5. Activation of 5-HT4 receptors inhibits secretion of beta-amyloid peptides and increases neuronal survival. Cho S, et al. Exp Neurol, 2007 Jan. PMID 16978609

    See all (81) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Activation of the 5-hydroxytryptamine 4 receptor ameliorates tight junction barrier dysfunction in the colon of type 1 diabetic mice.
      Title: Activation of the 5-hydroxytryptamine 4 receptor ameliorates tight junction barrier dysfunction in the colon of type 1 diabetic mice.
    2. Expression of serotonin receptor HTR4 in glucagon-like peptide-1-positive enteroendocrine cells of the murine intestine.
      Title: Expression of serotonin receptor HTR4 in glucagon-like peptide-1-positive enteroendocrine cells of the murine intestine.
    3. Serotonin 5-HT4 receptor boosts functional maturation of dendritic spines via RhoA-dependent control of F-actin.
      Title: Serotonin 5-HT(4) receptor boosts functional maturation of dendritic spines via RhoA-dependent control of F-actin.
    4. Findings of the present in vitro study enrich the understanding and provide insight roles of 5-HT4R in embryonic brain development by promoting the growth of hippocampal neurons.
      Title: Role of serotonin 4 receptor in the growth of hippocampal neurons during the embryonic development in mice.
    5. Synaptic potentiation is mediated by 5-HT4 receptors and that systemic modulation of 5-HT4 receptor function can bidirectionally impact memory formation.
      Title: Hippocampal 5-HT Input Regulates Memory Formation and Schaffer Collateral Excitation.
    6. Impeding serotonergic signaling preferentially gates spike-timing-dependent long-term depression (t-LTD) at thalamostriatal synapses. This t-LTD requires dampened activity of the 5-HT4 receptor subtype.
      Title: Serotonergic Signaling Controls Input-Specific Synaptic Plasticity at Striatal Circuits.
    7. Gut microbiota-produced Tryptamine activates epithelial 5-HT4R serotonin receptor to increase cAMP level and drive colonic fluid secretion.
      Title: Gut Microbiota-Produced Tryptamine Activates an Epithelial G-Protein-Coupled Receptor to Increase Colonic Secretion.
    8. Prefrontal cortex 5-HT4Rs mediate hypophagia following stress.
      Title: Adaptive Control of Dorsal Raphe by 5-HT4 in the Prefrontal Cortex Prevents Persistent Hypophagia following Stress.
    9. Knock down serotonin receptors 5-HTR3 and 5-HTR4 in neonatal cardiomyocytes resulted in significant increase of cell damage in response to hypoxia, and also led to alternation in heart beating.
      Title: 5-HTR3 and 5-HTR4 located on the mitochondrial membrane and functionally regulated mitochondrial functions.
    10. Study shows that in the murine gastrointestinal tract, activation of 5-HT4 receptors with prucalopride enhances cholinergic contractions, illustrating facilitation of myenteric cholinergic neurotransmission.
      Title: 5-HT(4) receptors facilitate cholinergic neurotransmission throughout the murine gastrointestinal tract.
    Submit: New GeneRIF Correction See all GeneRIFs (45)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (4)  1 citation

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled serotonin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled serotonin receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables G protein-coupled serotonin receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables G protein-coupled serotonin receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables neurotransmitter receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables serotonin receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serotonin receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in G protein-coupled serotonin receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in adenylate cyclase-activating serotonin receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chemical synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in gamma-aminobutyric acid signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in large intestinal transit IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in large intestinal transit ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in maintenance of gastrointestinal epithelium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mucus secretion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of appetite IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of postsynapse assembly EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in regulation of postsynapse assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of postsynapse assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in glutamatergic synapse EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in postsynapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    5-hydroxytryptamine receptor 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001364956.1 → NP_001351885.1  5-hydroxytryptamine receptor 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC131714, AC152454
      Consensus CDS
      CCDS89255.1
      UniProtKB/TrEMBL
      A0A494BA82
      Related
      ENSMUSP00000157982.2, ENSMUST00000237114.2
      Conserved Domains (1) summary
      cd15056
      Location:20 → 323
      7tmA_5-HT4; serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors

    2. NM_001364957.1 → NP_001351886.1  5-hydroxytryptamine receptor 4 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC131714, AC152454
      Consensus CDS
      CCDS89257.1
      Related
      ENSMUSP00000157967.2, ENSMUST00000238081.2
      Conserved Domains (1) summary
      cd15056
      Location:20 → 323
      7tmA_5-HT4; serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors

    3. NM_001364958.1 → NP_001351887.1  5-hydroxytryptamine receptor 4 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC131714, AC152454
      Conserved Domains (1) summary
      cd15056
      Location:20 → 323
      7tmA_5-HT4; serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors

    4. NM_001364959.1 → NP_001351888.1  5-hydroxytryptamine receptor 4 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC131714, AC152454
      Consensus CDS
      CCDS89256.1
      Related
      ENSMUSP00000157470.2, ENSMUST00000236691.2
      Conserved Domains (1) summary
      cd15056
      Location:20 → 323
      7tmA_5-HT4; serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors

    5. NM_008313.4 → NP_032339.2  5-hydroxytryptamine receptor 4 isoform 1

      See identical proteins and their annotated locations for NP_032339.2

      Status: VALIDATED

      Source sequence(s)
      AC131714, AC152454
      Consensus CDS
      CCDS29291.1
      UniProtKB/Swiss-Prot
      O89003, O89004, P97288, Q3URB5, Q9R2A4
      Related
      ENSMUSP00000027560.7, ENSMUST00000027560.8
      Conserved Domains (1) summary
      cd15056
      Location:20 → 323
      7tmA_5-HT4; serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      62456618..62636098
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030250347.2 → XP_030106207.1  5-hydroxytryptamine receptor 4 isoform X6

      Conserved Domains (2) summary
      cd14964
      Location:21 → 47
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:20 → 118
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    2. XM_006525682.5 → XP_006525745.1  5-hydroxytryptamine receptor 4 isoform X3

      See identical proteins and their annotated locations for XP_006525745.1

      UniProtKB/TrEMBL
      A0A494BA82
      Conserved Domains (1) summary
      cd15056
      Location:20 → 323
      7tmA_5-HT4; serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors

    3. XM_006525681.5 → XP_006525744.1  5-hydroxytryptamine receptor 4 isoform X3

      See identical proteins and their annotated locations for XP_006525744.1

      UniProtKB/TrEMBL
      A0A494BA82
      Conserved Domains (1) summary
      cd15056
      Location:20 → 323
      7tmA_5-HT4; serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors

    4. XM_006525683.5 → XP_006525746.1  5-hydroxytryptamine receptor 4 isoform X4

      See identical proteins and their annotated locations for XP_006525746.1

      UniProtKB/Swiss-Prot
      P97288
      Conserved Domains (1) summary
      cd15056
      Location:20 → 323
      7tmA_5-HT4; serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors

    5. XM_030250345.2 → XP_030106205.1  5-hydroxytryptamine receptor 4 isoform X2

      Conserved Domains (1) summary
      cd15056
      Location:20 → 323
      7tmA_5-HT4; serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors

    6. XM_011246848.4 → XP_011245150.1  5-hydroxytryptamine receptor 4 isoform X5

      Conserved Domains (1) summary
      cd15056
      Location:20 → 323
      7tmA_5-HT4; serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors

    7. XM_006525680.5 → XP_006525743.1  5-hydroxytryptamine receptor 4 isoform X2

      See identical proteins and their annotated locations for XP_006525743.1

      UniProtKB/Swiss-Prot
      P97288
      Conserved Domains (1) summary
      cd15056
      Location:20 → 323
      7tmA_5-HT4; serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors

    8. XM_030250344.2 → XP_030106204.1  5-hydroxytryptamine receptor 4 isoform X1

      UniProtKB/Swiss-Prot
      O89003, O89004, P97288, Q3URB5, Q9R2A4
      Conserved Domains (1) summary
      cd15056
      Location:20 → 323
      7tmA_5-HT4; serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors

    9. XM_030250343.2 → XP_030106203.1  5-hydroxytryptamine receptor 4 isoform X1

      UniProtKB/Swiss-Prot
      O89003, O89004, P97288, Q3URB5, Q9R2A4
      Conserved Domains (1) summary
      cd15056
      Location:20 → 323
      7tmA_5-HT4; serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors

    10. XM_006525676.5 → XP_006525739.1  5-hydroxytryptamine receptor 4 isoform X1

      See identical proteins and their annotated locations for XP_006525739.1

      UniProtKB/Swiss-Prot
      O89003, O89004, P97288, Q3URB5, Q9R2A4
      Conserved Domains (1) summary
      cd15056
      Location:20 → 323
      7tmA_5-HT4; serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors

    11. XM_006525678.5 → XP_006525741.1  5-hydroxytryptamine receptor 4 isoform X1

      See identical proteins and their annotated locations for XP_006525741.1

      UniProtKB/Swiss-Prot
      O89003, O89004, P97288, Q3URB5, Q9R2A4
      Conserved Domains (1) summary
      cd15056
      Location:20 → 323
      7tmA_5-HT4; serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P97288.3 GenPept UniProtKB/Swiss-Prot:P97288

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