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    POLY polyprotein;protein F [ Hepatitis C virus (isolate H77) ]

    Gene ID: 37619432, updated on 18-Aug-2023

    Summary

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    Gene symbol
    POLY
    Gene description
    polyprotein;protein F
    Locus tag
    D1Q49_gp1
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Hepatitis C virus (isolate H77) (strain: H77)
    Lineage
    Viruses; Riboviria; Flaviviridae; Hepacivirus
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    Genomic context

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    Location:
    clone: pCV-H77C
    Sequence:
    NC_038882.1 (342..9377)

    NC_038882.1Genomic Context describing neighboring genes

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_038882.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structure-Based Design of Hepatitis C Virus E2 Glycoprotein Improves Serum Binding and Cross-Neutralization. Pierce BG, et al. J Virol, 2020 Oct 27. PMID 32878891, Free PMC Article
    2. Transcripts from a single full-length cDNA clone of hepatitis C virus are infectious when directly transfected into the liver of a chimpanzee. Yanagi M, et al. Proc Natl Acad Sci U S A, 1997 Aug 5. PMID 9238047, Free PMC Article
    3. PACSIN2 Interacts with Nonstructural Protein 5A and Regulates Hepatitis C Virus Assembly. Nguyen LP, et al. J Virol, 2020 Feb 14. PMID 31801866, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Structure-Based Design of Hepatitis C Virus E2 Glycoprotein Improves Serum Binding and Cross-Neutralization.
      Title: Structure-Based Design of Hepatitis C Virus E2 Glycoprotein Improves Serum Binding and Cross-Neutralization.
    2. PACSIN2 Interacts with Nonstructural Protein 5A and Regulates Hepatitis C Virus Assembly.
      Title: PACSIN2 Interacts with Nonstructural Protein 5A and Regulates Hepatitis C Virus Assembly.
    Submit: New GeneRIF Correction

    General protein information

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    Preferred Names
    polyprotein;protein F
    Names
    core protein
    E1 protein
    E2 protein
    p7 protein
    NS2 protein
    NS3 protease/helicase
    NS4A protein
    NS4B protein
    NS5A protein
    NS5B RNA-dependent RNA polymerase
    YP_009590640.1
    • Potential -2/+1 frameshift protein F; position predicted based on homology to protein F in HCV1 RefSeq NC_004102.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_038882.1 Reference assembly

      Range
      342..9377
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. YP_009506357.1 polyprotein [Hepatitis C virus (isolate H77)]

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      Q9ELS8
      Conserved Domains (15) summary
      pfam01001
      Location:1728 → 1921
      HCV_NS4b; Hepatitis C virus non-structural protein NS4b
      pfam01539
      Location:193 → 382
      HCV_env; Hepatitis C virus envelope glycoprotein E1
      pfam01560
      Location:386 → 729
      HCV_NS1; Hepatitis C virus non-structural protein E2/NS1
      pfam02907
      Location:1056 → 1204
      Peptidase_S29; Hepatitis C virus NS3 protease
      pfam01543
      Location:2 → 115
      HCV_capsid; Hepatitis C virus capsid protein
      pfam08301
      Location:2068 → 2168
      HCV_NS5a_1b; Hepatitis C virus non-structural 5a domain 1b
      pfam01538
      Location:811 → 1005
      HCV_NS2; Hepatitis C virus non-structural protein NS2
      smart00487
      Location:1228 → 1355
      DEXDc; DEAD-like helicases superfamily
      cd00079
      Location:1378 → 1455
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      pfam01542
      Location:116 → 190
      HCV_core; Hepatitis C virus core protein
      pfam12941
      Location:2179 → 2420
      HCV_NS5a_C; HCV NS5a protein C-terminal region
      pfam00998
      Location:2423 → 2934
      RdRP_3; Viral RNA dependent RNA polymerase
      pfam01006
      Location:1658 → 1711
      HCV_NS4a; Hepatitis C virus non-structural protein NS4a
      pfam01506
      Location:1974 → 1996
      HCV_NS5a; Hepatitis C virus non-structural 5a protein membrane anchor
      pfam08300
      Location:2006 → 2067
      HCV_NS5a_1a; Hepatitis C virus non-structural 5a zinc finger domain

    2. YP_009709861.1 core protein

      UniProtKB/TrEMBL
      A0A075C2Z9, A0A075C392, A0A075C3A1, A0A075C3F8, A0A075C549, A0A075C551, A0A075C673, A0A077CW64, A0A077CW68, A0A077CW83, A0A077CW92, A0A077CW98, A0A077CWX7, A0A077CWY1, A0A077CWY6, A0A077CWZ4, A0A077CX03, A0A077CX08, A0A077CX16, A0A077CYR9, A0A077CYS6, A0A077CYU1, A0A077CYU8, A0A077CYW6, A0A077D120, A0A077D125, A0A077D131, A0A077D140, A0A077D156, A0A077D1H5, A0A077D1I0, A0A077D1I6, A0A077D1J1, A0A077D1J4, A0A077D1K6, A0A0A0YPR1, A0A221C814, A0A2Z4SVT1, A0A2Z4SVU0, A0A2Z4SVV0, A0A2Z4SVX4, A0A2Z4SVY6, A0A2Z4SVY8, A0A2Z4SW42, A0A2Z4SW47, A0A2Z4SW52, A0A2Z4SW53, A0A2Z4SW62, A0A2Z4SW65, A0A2Z4SW72, A0A2Z4SW76, A0A2Z4SW83, A0A2Z4SW87, A0A2Z4SW92, A0A2Z4SWA8, A0A2Z4SWB3, A0A2Z4SWD6, A0A2Z4SWE3, A0A2Z4SWE7, A0A2Z4SWF3, A0A2Z4SWG0, A0A2Z4SWG2, A0A2Z4SWG7, A0A2Z4SWG9, A0A2Z4SWH1, A0A2Z4SWH7, A0A2Z4SWI0, A0A2Z4SWI2, A0A2Z4SWI6, A0A2Z4SWI7, A0A2Z4SWI8, A0A2Z4SWJ5, A0A2Z4SWJ6, A0A2Z4SWJ7, A0A2Z4SWK2, A0A2Z4SWK4, A0A2Z4SWM2, A0A2Z4SWM6, A0A2Z4SWP3, A0A2Z4SWQ3, A0A2Z4SWR0, A0A2Z4SWS0, A0A2Z4SWS6, A0A2Z4SWT0, A0A2Z4SWT5, A0A2Z4SWU6, A0A2Z4SWV5, A0A2Z4SWX3, A0A2Z4SX06, A0A2Z4SX13, A0A2Z4SX22, A0A2Z4SX30, A0A2Z4SX88, A0A2Z4SX94, A0A2Z4SXC4, A0A2Z4SXE4, A0A2Z4SXG6, A0A2Z4SXH4, A0A2Z4SXI2, A0A2Z4SXI3, A0A2Z4SXJ3, A0A2Z4SXK8, A0A2Z4SXM1, A0A2Z4SXN0, A0A2Z4SXN5, A0A2Z4SXQ7, A0A2Z4SXR6, A0A2Z4SXS5, A0A2Z4SXT4, A0A2Z4SXU4, A0A2Z4SXV4, A0A2Z4SXW1, A0A2Z4SXW4, A0A2Z4SXW7, A0A2Z4SXY3, A0A2Z4SXZ8, A0A2Z4SY03, A0A2Z4SY17, A0A2Z4SY19, A0A2Z4SY33, A0A2Z4SY49, A0A2Z4SY52, A0A2Z4SY69, A0A2Z4SY73, A0A2Z4SY88, A0A2Z4SYB9, A0A2Z4SYD0, A0A2Z4T039, A0A2Z4T0D6, A0A2Z4T0G1, A0A2Z4T0I4, A0A2Z4T0J9, A0A2Z4T0L7, A0A2Z4T0M3, A0A2Z4T0P9, A0A2Z4T0S9, A0A2Z4T176, A0A2Z4T1E9, A0A2Z4T1F4, A0A2Z4T1H8, A0A2Z4T1K0, A0A2Z4T1L6, A0A2Z4T1M4, A0A2Z4T1N3, A0A2Z4T1R4, A0A2Z4T1S5, A0A2Z4T1T3, A0A2Z4T233, A0A2Z4T260, A0A2Z4T2B0, A0A2Z4T2B9, A0A2Z4T2H1, A0A2Z4T2K2, A0A2Z4T2N1, A0A2Z4T2N9, A0A2Z4T2Q9, A0A650G1H4, A0A650G1T5, A0A650G1W3, A0A654JSZ4, B8Y460, C8CP42, D0UVL8, D0UVL9, D0UVM0, D0UVM1, D2E5C6, D2E5D5, D2E5D6, D2E5D7, D2E5D8, D2E5D9, D2E5E0, D3HU87, D3HU88, D3HU89, D3HU90, D3HU91, D3HU92, D3HU93, D3HU94, D3HU95, D3HU98, D3HU99, D3HUA0, D3HUA1, D3HUA2, D3HUA3, D3HUA5, D3HUA6, D3HUA7, D3HUA8, D3HUA9, D3HUB0, D3HUB6, D3HUB9, D3HUC0, D3HUC1, D3HUC2, D7R6Q6, D7R6Q7, D7R6Q9, D7R6R0, D7R6R4, D7R6R5, E2ICK2, E6Z821, G3FEN7, G3FEN8, L7Z1C8, L7Z1D2, L7Z1F6, L7Z1G2, L7Z5V0, L7Z5V3, L7Z5X5, L7Z6V5, L7Z6Y6, L7Z7D6, L7Z951, Q68113, Q68123, Q68124, Q68139, Q68149, Q6QY91, Q6QY92, Q6QY99, Q6QYA1, Q6QYA2, Q6QYA6, Q6QYA7, Q6QYA8, Q6QYB1, Q6QYB2, Q6QYB4, Q6QYB6, Q6QYB7, Q6QYB8, Q6QYB9, Q6QYC1, Q6QYC2, Q6QYC3, Q6QYE5, Q6QYE6, Q6QYE7, Q6QYE8, Q6QYE9, Q6QYF0, Q6QYF1, Q6QYF2, Q6QYF6, Q6QYF7, Q6QYF9, Q6QYG0, Q6QYG5, Q6QYJ7, Q6QYJ9, Q6QYK0, Q6QYK2, Q6QYK3, Q6QYK6, Q6QYK7, Q6QYK8, Q6QYK9, Q6QYL0, Q6QYL1, Q6QYL2, Q6QYL4, Q6QYL5, Q6QYM0, Q6QYN0, Q6QYQ9, Q6QYR0, Q6QYR1, Q6QYR2, Q6QYR3, Q6QYR4, Q6QYR5, Q6QYR6, Q6QYR7, Q6QYT2, Q6QYT4, Q6QYT5, Q6QYT6, Q6QYT7, Q6QYT8, Q6QYT9, Q6QYU0, Q6QYU1, Q6QYU2, Q6QYU3, Q6QYY8, Q6QYZ1, Q6QZ00, Q6QZ04, Q6QZ15, Q6QZ18, Q6QZ19, Q6QZ20, Q6QZ21, Q6QZ22, Q6QZ25, Q6QZ26, Q6QZ27, Q6QZ28, Q6QZ29, Q6QZ31, Q6QZ32, Q6QZ56, Q6QZ58, Q6QZ60, Q6QZ61, Q6QZ62, Q6QZ63, Q6QZ64, Q6QZ67, Q6QZ80, Q6QZ81, Q6QZ82, Q6QZ83, Q6QZ84, Q6QZ85, Q6QZ87, Q6QZ88, Q6QZ91, Q6QZ99, Q6QZA0, Q6QZA1, Q6QZA2, Q6QZA3, Q6QZA4, Q6QZA5, Q6QZA6, Q6QZA7, Q6QZA9, Q6QZD2, Q6QZD3, Q6QZD8, Q6QZE2, Q6QZE3, Q6QZE5, Q6QZE6, Q6QZE7, Q6QZE8, Q6QZE9, Q6QZF1, Q6QZF2, Q6QZG0, Q6QZG4, Q6QZG5, Q6QZG6, Q6QZG7, Q6QZG8, Q6QZG9, Q6QZH0, Q6QZH1, Q6QZH2, Q6QZH3, Q6UNT8, Q8BES1
      Conserved Domains (2) summary
      pfam01543
      Location:2 → 115
      HCV_capsid; Hepatitis C virus capsid protein
      pfam01542
      Location:116 → 190
      HCV_core; Hepatitis C virus core protein

    3. YP_009709862.1 E1 protein

      UniProtKB/TrEMBL
      B6URW2, B6URW4, B6URW7, B6URW8, B6URX0, B6URX2, B6URX7, B6URX8, B6URY0, B6URY1
      Conserved Domains (1) summary
      pfam01539
      Location:2 → 191
      HCV_env; Hepatitis C virus envelope glycoprotein E1

    4. YP_009709863.1 E2 protein

      Conserved Domains (1) summary
      pfam01560
      Location:3 → 346
      HCV_NS1; Hepatitis C virus non-structural protein E2/NS1

    5. YP_009709864.1 p7 protein

      UniProtKB/TrEMBL
      Q0JXG3, Q5QRE5, Q5QRE6, Q5QRE7, Q5QRE8, Q5QRF3, Q5QRF7, Q5QRF8, Q5QRF9, Q5QRG0, Q5QRG1, Q5QRG3, Q5QRG5, Q5QRG6, Q5QRG7, Q5QRU1
      Conserved Domains (1) summary
      cd20903
      Location:1 → 49
      HCV_p7; Hepatitis C virus p7 protein

    6. YP_009709865.1 NS2 protein

      UniProtKB/TrEMBL
      C9WTV6, G8CQ45, G8CQ46, G8CQ47, G8CQ48
      Conserved Domains (1) summary
      pfam01538
      Location:2 → 196
      HCV_NS2; Hepatitis C virus non-structural protein NS2

    7. YP_009709866.1 NS3 protease/helicase

      UniProtKB/TrEMBL
      A0A0A7HBI9, A1Z092, A1Z094
      Conserved Domains (3) summary
      cl38915
      Location:336 → 457
      DEAD-like_helicase_C; C-terminal helicase domain of the DEAD-like helicases
      pfam02907
      Location:30 → 178
      Peptidase_S29; Hepatitis C virus NS3 protease
      cl28899
      Location:197 → 340
      DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily

    8. YP_009709867.1 NS4A protein

      UniProtKB/TrEMBL
      C9WTY9, C9WTZ4, C9WU13, C9WU32, C9WU38, C9WU40, C9WU43, C9WU50, C9WU54, C9WU62, C9WU67, C9WU74, C9WU75, C9WU76, C9WU93, C9WUA4, C9WUB2, C9WUB9, C9WUC7, C9WUC9, C9WUD5, C9WUD6, C9WUE1, C9WUE4
      Conserved Domains (1) summary
      pfam01006
      Location:1 → 54
      HCV_NS4a; Hepatitis C virus non-structural protein NS4a

    9. YP_009709868.1 NS4B protein

      UniProtKB/TrEMBL
      C9WUH7, C9WUM0
      Conserved Domains (1) summary
      pfam01001
      Location:17 → 210
      HCV_NS4b; Hepatitis C virus non-structural protein NS4b

    10. YP_009709869.1 NS5A protein

      UniProtKB/TrEMBL
      Q14T61, Q9E394
      Conserved Domains (4) summary
      pfam08301
      Location:96 → 196
      HCV_NS5a_1b; Hepatitis C virus non-structural 5a domain 1b
      pfam12941
      Location:207 → 448
      HCV_NS5a_C; HCV NS5a protein C-terminal region
      pfam01506
      Location:2 → 24
      HCV_NS5a; Hepatitis C virus non-structural 5a protein membrane anchor
      pfam08300
      Location:34 → 95
      HCV_NS5a_1a; Hepatitis C virus non-structural 5a zinc finger domain

    11. YP_009709870.1 NS5B RNA-dependent RNA polymerase

      UniProtKB/TrEMBL
      A0A2H4YTE1
      Conserved Domains (1) summary
      pfam00998
      Location:3 → 514
      RdRP_3; Viral RNA dependent RNA polymerase

    12. YP_009590640.1 protein F [Hepatitis C virus (isolate H77)]

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P0C045
      Conserved Domains (1) summary
      pfam01543
      Location:66 → 127
      HCV_capsid; Hepatitis C virus capsid protein
    Nucleotide Protein
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