hdac1.S histone deacetylase 1 S homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: hdac1.S
Official Full Name: histone deacetylase 1 S homeolog
Primary source: Xenbase:XB-GENE-865283
Locus tag: XELAEV_18015210mg
See related: EnsemblRapid:ENSXLAG00005004510
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: HD1; RPD3; HD1-B; hdac1; gon-10; hdac1b; rpd3l1; hdac1-a; hdac1-b
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Genomic context

Location:: chromosome: 2S

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	2S	NC_054374.1 (77884467..77901136, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	2S	NC_030727.1 (70641459..70658138, complement)

Chromosome 2S - NC_054374.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

these findings elucidate a previously uncharacterized role for HDAC activity in establishing the neural crest stem cell state.
Title: Histone deacetylase activity has an essential role in establishing and maintaining the vertebrate neural crest.
Data show that proto-oncogene transcription factor Ets1 regulates neural crest development through histone deacetylase 1 HDAC1) to down-regulate bone morphogenetic protein (BMP) signaling output and reduce id3 protein expression.
Title: The Proto-oncogene Transcription Factor Ets1 Regulates Neural Crest Development through Histone Deacetylase 1 to Mediate Output of Bone Morphogenetic Protein Signaling.
Specific knockdown of HDAC1 by a morpholino (HDAC1-MO) decreased the number of BrdU- and BLBP-labeled cells and increased the acetylation level of histone H4 at lysine 12.
Title: HDAC1 regulates the proliferation of radial glial cells in the developing Xenopus tectum.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables histone deacetylase activity	IEA Inferred from Electronic Annotation more info
enables histone deacetylase activity	ISS Inferred from Sequence or Structural Similarity more info
enables histone decrotonylase activity	ISS Inferred from Sequence or Structural Similarity more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein decrotonylase activity	IEA Inferred from Electronic Annotation more info
enables protein lysine deacetylase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within chromatin organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of NuRD complex	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: probable histone deacetylase 1-B

Names: Probable histone deacetylase 1-B; RPD3 homolog; histone deacetylase 1 b; protein deacetylase HDAC1-B; protein decrotonylase HDAC1-B

NP_001079396.1

EC 3.5.1.98

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001085927.1 → NP_001079396.1 probable histone deacetylase 1-B

See identical proteins and their annotated locations for NP_001079396.1

Status: PROVISIONAL

Source sequence(s)

BC041296

UniProtKB/Swiss-Prot

O42227

UniProtKB/TrEMBL

A0A974DJE1, Q7ZYT5

Related

ENSXLAP00005013528.1, ENSXLAT00005013710.1

Conserved Domains (1) summary

cd10010
Location:4 → 374

HDAC1; Histone deacetylase 1 (HDAC1)

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054374.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

77884467..77901136 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)