spast.S spastin S homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: spast.S
Official Full Name: spastin S homeolog
Primary source: Xenbase:XB-GENE-947846
Locus tag: XELAEV_18028955mg
See related: EnsemblRapid:ENSXLAG00005006922
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: spg4; spast
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Genomic context

Location:: chromosome: 5S

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	5S	NC_054380.1 (35711457..35753626, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	5S	NC_030733.1 (35580933..35623370, complement)

Chromosome 5S - NC_054380.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables alpha-tubulin binding	ISS Inferred from Sequence or Structural Similarity more info
enables beta-tubulin binding	ISS Inferred from Sequence or Structural Similarity more info
enables isomerase activity	IEA Inferred from Electronic Annotation more info
enables microtubule binding	IEA Inferred from Electronic Annotation more info
enables microtubule binding	ISS Inferred from Sequence or Structural Similarity more info
enables microtubule severing ATPase activity	IEA Inferred from Electronic Annotation more info
enables microtubule severing ATPase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within anterograde axonal transport	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within axonal transport of mitochondrion	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within axonogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cytokinetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within endoplasmic reticulum to Golgi vesicle-mediated transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within exit from mitosis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within membrane fission	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within microtubule bundle formation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within microtubule cytoskeleton organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within microtubule severing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within microtubule severing	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within mitotic cytokinesis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within mitotic spindle disassembly	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within nervous system development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within nuclear membrane reassembly	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of microtubule depolymerization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein hexamerization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein hexamerization	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within protein homooligomerization	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in axon	IEA Inferred from Electronic Annotation more info
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in microtubule cytoskeleton	IEA Inferred from Electronic Annotation more info
colocalizes_with microtubule cytoskeleton	ISS Inferred from Sequence or Structural Similarity more info
located_in midbody	ISS Inferred from Sequence or Structural Similarity more info
located_in nuclear membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in spindle	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: spastin

Names: spastic paraplegia 4 (autosomal dominant; spastin)

NP_001086725.1

EC 5.6.1.1

XP_018119942.1

EC 5.6.1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001093256.1 → NP_001086725.1 spastin

See identical proteins and their annotated locations for NP_001086725.1

Status: PROVISIONAL

Source sequence(s)

BC077358

UniProtKB/Swiss-Prot

Q6AZT2

UniProtKB/TrEMBL

A0A974CQN6

Related

ENSXLAP00005020232.1, ENSXLAT00005020694.1

Conserved Domains (5) summary

smart00382
Location:358 → 494

AAA; ATPases associated with a variety of cellular activities

cd02679
Location:107 → 185

MIT_spastin; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in the AAA protein spastin, a probable ATPase involved in the assembly or function of nuclear protein complexes; spastins might also be ...

pfam00004
Location:362 → 490

AAA; ATPase family associated with various cellular activities (AAA)

pfam09336
Location:566 → 596

Vps4_C; Vps4 C terminal oligomerization domain

cl21455
Location:325 → 381

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054380.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

35711457..35753626 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)