JPT2 Jupiter microtubule associated homolog 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: JPT2provided by HGNC
Official Full Name: Jupiter microtubule associated homolog 2provided by HGNC
Primary source: HGNC:HGNC:14137
See related: Ensembl:ENSG00000206053 MIM:619241; AllianceGenome:HGNC:14137
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: L11; HN1L; C16orf34
Summary: Involved in endocytosis involved in viral entry into host cell and regulation of calcium-mediated signaling. Located in cytosol; nucleus; and plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in prostate (RPKM 16.7), placenta (RPKM 16.5) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 16p13.3

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	16	NC_000016.10 (1678279..1702086)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	16	NC_060940.1 (1694127..1717934)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	16	NC_000016.9 (1728280..1752087)

Chromosome 16 - NC_000016.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

JPT2 Affects Trophoblast Functions and Macrophage Polarization and Metabolism, and Acts as a Potential Therapeutic Target for Recurrent Spontaneous Abortion.
Title: JPT2 Affects Trophoblast Functions and Macrophage Polarization and Metabolism, and Acts as a Potential Therapeutic Target for Recurrent Spontaneous Abortion.
Convergent activation of two-pore channels mediated by the NAADP-binding proteins JPT2 and LSM12.
Title: Convergent activation of two-pore channels mediated by the NAADP-binding proteins JPT2 and LSM12.
HN1L/AP-2gamma/PLK1 signaling drives tumor progression and chemotherapy resistance in esophageal squamous cell carcinoma.
Title: HN1L/AP-2γ/PLK1 signaling drives tumor progression and chemotherapy resistance in esophageal squamous cell carcinoma.
HN1L promotes stem cell-like properties by regulating TGF-beta signaling pathway through targeting FOXP2 in prostate cancer.
Title: HN1L promotes stem cell-like properties by regulating TGF-β signaling pathway through targeting FOXP2 in prostate cancer.
HN1L/JPT2: A signaling protein that connects NAADP generation to Ca(2+) microdomain formation.
Title: HN1L/JPT2: A signaling protein that connects NAADP generation to Ca(2+) microdomain formation.
HN1L promotes invasion and metastasis of the esophagogastric junction adenocarcinoma.
Title: HN1L promotes invasion and metastasis of the esophagogastric junction adenocarcinoma.
HN1L promotes migration and invasion of breast cancer by up-regulating the expression of HMGB1.
Title: HN1L promotes migration and invasion of breast cancer by up-regulating the expression of HMGB1.
Essential requirement for JPT2 in NAADP-evoked Ca(2+) signaling.
Title: Essential requirement for JPT2 in NAADP-evoked Ca(2+) signaling.
HN1L-mediated transcriptional axis AP-2gamma/METTL13/TCF3-ZEB1 drives tumor growth and metastasis in hepatocellular carcinoma.
Title: HN1L-mediated transcriptional axis AP-2γ/METTL13/TCF3-ZEB1 drives tumor growth and metastasis in hepatocellular carcinoma.
reveal that breast cancer stem cell (BCSC) in triple-negative breast cancer depend on the transcription regulator HN1L for the sustained activation of the LEPR-STAT3 pathway, which makes it a potentially important target for both prognosis and BCSC therapy.
Title: HN1L Promotes Triple-Negative Breast Cancer Stem Cells through LEPR-STAT3 Pathway.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-64081 (e-PCR)
- UniSTS:4359

RH77849 (e-PCR)
- UniSTS:57895

RH65543 (e-PCR)
- UniSTS:59956

A006J08 (e-PCR)
- UniSTS:21884

G20864 (e-PCR)
- UniSTS:21885

D16S2902 (e-PCR)
- UniSTS:153472

SHGC-60756 (e-PCR)
- UniSTS:59555

SHGC-60789 (e-PCR)
- UniSTS:20427

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in endocytosis involved in viral entry into host cell	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of calcium-mediated signaling	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info

General protein information

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Preferred Names: jupiter microtubule associated homolog 2

Names: CRAMP_1 like; HN1 like; HN1-like protein; hematological and neurological expressed 1 like; hematological and neurological expressed 1-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.