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    LRG1 leucine rich alpha-2-glycoprotein 1 [ Homo sapiens (human) ]

    Gene ID: 116844, updated on 10-Dec-2024

    Summary

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    Official Symbol
    LRG1provided by HGNC
    Official Full Name
    leucine rich alpha-2-glycoprotein 1provided by HGNC
    Primary source
    HGNC:HGNC:29480
    See related
    Ensembl:ENSG00000171236 MIM:611289; AllianceGenome:HGNC:29480
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LRG; HMFT1766
    Summary
    The leucine-rich repeat (LRR) family of proteins, including LRG1, have been shown to be involved in protein-protein interaction, signal transduction, and cell adhesion and development. LRG1 is expressed during granulocyte differentiation (O'Donnell et al., 2002 [PubMed 12223515]).[supplied by OMIM, Mar 2008]
    Expression
    Biased expression in liver (RPKM 150.7), esophagus (RPKM 16.6) and 4 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See LRG1 in Genome Data Viewer
    Location:
    19p13.3
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (4536402..4540036, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (4520069..4523703, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (4536414..4540048, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene HDGF like 2 Neighboring gene perilipin 4 Neighboring gene perilipin 5 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:4534387-4534942 Neighboring gene semaphorin 6B Neighboring gene Sharpr-MPRA regulatory region 7851 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:4567569-4568069 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:4575301-4575893 Neighboring gene uncharacterized LOC105372249 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9894

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Serum Leucine-Rich α2-Glycoprotein as a Biomarker for Monitoring Disease Activity in Patients with Systemic Juvenile Idiopathic Arthritis. Shimizu M, et al. J Immunol Res, 2019. PMID 30863782, Free PMC Article
    2. Electrochemical peptide sensor for diagnosing adenoma-carcinoma transition in colon cancer. Lim JM, et al. Biosens Bioelectron, 2017 Dec 15. PMID 28697446
    3. Overexpression of leucine-rich α2-glycoprotein-1 is a prognostic marker and enhances tumor migration in gastric cancer. Yamamoto M, et al. Cancer Sci, 2017 Oct. PMID 28746773, Free PMC Article
    4. Value of Leucine-rich alpha-2-glycoprotein-1 (LRG-1) on diagnosis of acute appendicitis in female patients with right lower-quadrant abdominal pain. Demirci OL, et al. J Pak Med Assoc, 2017 Sep. PMID 28924279
    5. Plasma Leucine-Rich α-2-Glycoprotein 1 Predicts Rapid eGFR Decline and Albuminuria Progression in Type 2 Diabetes Mellitus. Liu JJ, et al. J Clin Endocrinol Metab, 2017 Oct 1. PMID 28973352

    See all (121) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Leucine rich alpha2 glycoprotein 1 derived from malignant pleural mesothelioma cells facilitates macrophage M2 phenotypes.
      Title: Leucine rich α2 glycoprotein 1 derived from malignant pleural mesothelioma cells facilitates macrophage M2 phenotypes.
    2. LRG1 and SDR16C5 protein expressions differ according to HPV status in oropharyngeal squamous cell carcinoma.
      Title: LRG1 and SDR16C5 protein expressions differ according to HPV status in oropharyngeal squamous cell carcinoma.
    3. High serum levels of leucine-rich alpha-2 glycoprotein 1 (LRG-1) are associated with poor survival in patients with early breast cancer.
      Title: High serum levels of leucine-rich α-2 glycoprotein 1 (LRG-1) are associated with poor survival in patients with early breast cancer.
    4. Relation between LRG1 and CD4[+] T cells, cognitive impairment and neurological function in patients with acute ischemic stroke.
      Title: Relation between LRG1 and CD4(+) T cells, cognitive impairment and neurological function in patients with acute ischemic stroke.
    5. Lrg1 silencing attenuates ischemia-reperfusion renal injury by regulating autophagy and apoptosis through the TGFbeta1- Smad1/5 signaling pathway.
      Title: Lrg1 silencing attenuates ischemia-reperfusion renal injury by regulating autophagy and apoptosis through the TGFβ1- Smad1/5 signaling pathway.
    6. Leucine-Rich Alpha-2 Glycoprotein 1 Accumulates in Complicated Atherosclerosis and Promotes Calcification.
      Title: Leucine-Rich Alpha-2 Glycoprotein 1 Accumulates in Complicated Atherosclerosis and Promotes Calcification.
    7. Relationship between plasma leucine-rich alpha-2-glycoprotein 1 and urinary albumin excretion in patients with type 2 diabetes.
      Title: Relationship between plasma leucine-rich α-2-glycoprotein 1 and urinary albumin excretion in patients with type 2 diabetes.
    8. Leucine-Rich Alpha-2 Glycoprotein Is a Reliable Serum Biomarker for Evaluating Clinical and Endoscopic Disease Activity in Inflammatory Bowel Disease.
      Title: Leucine-Rich Alpha-2 Glycoprotein Is a Reliable Serum Biomarker for Evaluating Clinical and Endoscopic Disease Activity in Inflammatory Bowel Disease.
    9. LRG1 Promotes ECM Integrity by Activating the TGF-beta Signaling Pathway in Fibroblasts.
      Title: LRG1 Promotes ECM Integrity by Activating the TGF-β Signaling Pathway in Fibroblasts.
    10. Systemic LRG1 Expression in Melanoma is Associated with Disease Progression and Recurrence.
      Title: Systemic LRG1 Expression in Melanoma is Associated with Disease Progression and Recurrence.
    Submit: New GeneRIF Correction See all GeneRIFs (99)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Potential readthrough

    Included gene: PLIN5

    Homology

    Clone Names

    • FLJ45787

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transforming growth factor beta binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables type I transforming growth factor beta receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables type II transforming growth factor beta receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in brown fat cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of keratinocyte migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of leukocyte adhesion to vascular endothelial cell IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of positive regulation of angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of positive regulation of endothelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of positive regulation of epithelial cell proliferation involved in wound healing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of epithelial to mesenchymal transition IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of positive regulation of keratinocyte proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transforming growth factor beta receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to bacterium IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transforming growth factor beta receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within wound healing, spreading of epidermal cells IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular exosome HDA PubMed 
    located_in extracellular region HDA PubMed 
    located_in extracellular region NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
    		  
    located_in extracellular space HDA PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in ficolin-1-rich granule lumen TAS
    Traceable Author Statement
    more info
    		  
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    		  
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in specific granule lumen TAS
    Traceable Author Statement
    more info
    		  
    located_in tertiary granule lumen TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    leucine-rich alpha-2-glycoprotein
    Names
    1300008B03Rik
    2310031E04Rik
    leucine rich alpha 2 glycoprotein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_052972.3 → NP_443204.1  leucine-rich alpha-2-glycoprotein precursor

      See identical proteins and their annotated locations for NP_443204.1

      Status: VALIDATED

      Source sequence(s)
      AC011498, AF403428, AK027382
      Consensus CDS
      CCDS12130.1
      UniProtKB/Swiss-Prot
      P02750, Q8N4F5, Q96QZ4
      UniProtKB/TrEMBL
      Q68CK4
      Related
      ENSP00000302621.4, ENST00000306390.7
      Conserved Domains (4) summary
      smart00082
      Location:299 → 346
      LRRCT; Leucine rich repeat C-terminal domain
      cd00116
      Location:82 → 248
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:94 → 117
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:116 → 176
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      4536402..4540036 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      4520069..4523703 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P02750.2 GenPept UniProtKB/Swiss-Prot:P02750

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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