ZYG11A zyg-11 family member A, cell cycle regulator [Homo sapiens (human)] - Gene

Summary

Official Symbol: ZYG11Aprovided by HGNC
Official Full Name: zyg-11 family member A, cell cycle regulatorprovided by HGNC
Primary source: HGNC:HGNC:32058
See related: Ensembl:ENSG00000203995 MIM:618675; AllianceGenome:HGNC:32058
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ZYG11
Summary: Predicted to be part of Cul2-RING ubiquitin ligase complex. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in testis (RPKM 2.3), thyroid (RPKM 1.5) and 6 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 1p32.3

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (52842760..52894998)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (52724272..52776522)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (53308432..53360670)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ZYG11A Is Expressed in Epithelial Ovarian Cancer and Correlates With Low Grade Disease.
Title: ZYG11A Is Expressed in Epithelial Ovarian Cancer and Correlates With Low Grade Disease.
Autosomal dominant diabetes associated with a novel ZYG11A mutation resulting in cell cycle arrest in beta-cells.
Title: Autosomal dominant diabetes associated with a novel ZYG11A mutation resulting in cell cycle arrest in beta-cells.
the ubiquitin ligase CRL2(ZYG-11) redundantly targets the degradation of cyclin B1 in Caenorhabditis elegans and human cells.
Title: The ubiquitin ligase CRL2ZYG11 targets cyclin B1 for degradation in a conserved pathway that facilitates mitotic slippage.
Over-expression of ZYG11A is associated with non-small cell lung cancer.
Title: ZYG11A serves as an oncogene in non-small cell lung cancer and influences CCNE1 expression.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D11S2921 (e-PCR)
- UniSTS:152074

D8S2279 (e-PCR)
- UniSTS:473907

D10S16 (e-PCR)
- UniSTS:155756

D1S1423 (e-PCR)
- UniSTS:149619

GDB:631802 (e-PCR)
- UniSTS:158429

Gene Ontology Provided by GOA

Component	Evidence Code	Pubs
part_of Cul2-RING ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: protein zyg-11 homolog A

Names: ZYG-11A early embryogenesis protein; zyg-11 homolog A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001004339.3 → NP_001004339.2 protein zyg-11 homolog A isoform 1

See identical proteins and their annotated locations for NP_001004339.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC099677, AI638616, AY271826, BC119815

Consensus CDS

CCDS44148.1

UniProtKB/Swiss-Prot

A6NCK5, Q6WRX3

Related

ENSP00000360583.1, ENST00000371528.2

Conserved Domains (3) summary

cd00020
Location:511 → 629

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

cd00116
Location:195 → 314

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00034
Location:158 → 182

LRR_AMN1; leucine-rich repeat [structural motif]
NM_001307931.2 → NP_001294860.1 protein zyg-11 homolog A isoform 2

See identical proteins and their annotated locations for NP_001294860.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an exon in the 5' coding region compared to variant 1. This variant represents translation initiation at a downstream AUG compared to variant 1; the 5'-most initiation codon, as used in variant 1, is associated with a truncated ORF that would render the transcript a candidate for nonsense-mediated decay (NMD). Leaky scanning may allow translation initiation at the downstream AUG to encode an isoform (2) that has a shorter N-terminus, compared to isoform 1.

Source sequence(s)

AC099677, AI638616, AY271826, BC119815

Consensus CDS

CCDS76166.1

UniProtKB/Swiss-Prot

Q6WRX3

Related

ENSP00000360587.1, ENST00000371532.5

Conserved Domains (2) summary

cd00020
Location:169 → 287

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

cl21453
Location:32 → 132

PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000001.11 Reference GRCh38.p14 Primary Assembly

Range

52842760..52894998

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011541482.4 → XP_011539784.1 protein zyg-11 homolog A isoform X3

Conserved Domains (4) summary

cd00020
Location:511 → 584

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

cd00116
Location:195 → 314

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00034
Location:158 → 182

LRR_AMN1; leucine-rich repeat [structural motif]

cl21453
Location:374 → 474

PKc_like; Protein Kinases, catalytic domain
XM_011541480.4 → XP_011539782.1 protein zyg-11 homolog A isoform X1

Conserved Domains (3) summary

cd00020
Location:511 → 614

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

cd00116
Location:195 → 314

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00034
Location:158 → 182

LRR_AMN1; leucine-rich repeat [structural motif]
XM_011541483.4 → XP_011539785.1 protein zyg-11 homolog A isoform X4

Conserved Domains (4) summary

cd00020
Location:511 → 660

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

cd00116
Location:195 → 314

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00034
Location:158 → 182

LRR_AMN1; leucine-rich repeat [structural motif]

cl21453
Location:374 → 474

PKc_like; Protein Kinases, catalytic domain
XM_011541481.4 → XP_011539783.1 protein zyg-11 homolog A isoform X2

Conserved Domains (3) summary

cd00020
Location:452 → 570

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

cd00116
Location:195 → 314

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00034
Location:158 → 182

LRR_AMN1; leucine-rich repeat [structural motif]
XM_011541486.2 → XP_011539788.1 protein zyg-11 homolog A isoform X5

Conserved Domains (3) summary

cd00116
Location:195 → 314

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00034
Location:158 → 182

LRR_AMN1; leucine-rich repeat [structural motif]

cl21453
Location:374 → 474

PKc_like; Protein Kinases, catalytic domain
XM_011541487.3 → XP_011539789.1 protein zyg-11 homolog A isoform X6

Conserved Domains (3) summary

cd00116
Location:195 → 314

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00034
Location:158 → 182

LRR_AMN1; leucine-rich repeat [structural motif]

cl21453
Location:374 → 474

PKc_like; Protein Kinases, catalytic domain
XM_011541488.2 → XP_011539790.1 protein zyg-11 homolog A isoform X7

Conserved Domains (2) summary

cd00116
Location:195 → 314

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00034
Location:207 → 232

LRR_AMN1; leucine-rich repeat [structural motif]