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    STX10 syntaxin 10 [ Homo sapiens (human) ]

    Gene ID: 8677, updated on 2-Nov-2024

    Summary

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    Official Symbol
    STX10provided by HGNC
    Official Full Name
    syntaxin 10provided by HGNC
    Primary source
    HGNC:HGNC:11428
    See related
    Ensembl:ENSG00000104915 MIM:603765; AllianceGenome:HGNC:11428
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SYN10; hsyn10
    Summary
    This gene belongs to the syntaxin family and encodes a soluble N-ethylmaleimide sensitive factor attachment protein receptor (SNARE). The encoded protein is involved in docking and fusion events at the Golgi apparatus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012]
    Expression
    Ubiquitous expression in bone marrow (RPKM 17.6), spleen (RPKM 14.3) and 25 other tissues See more
    Orthologs
    all
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    Genomic context

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    See STX10 in Genome Data Viewer
    Location:
    19p13.13
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (13144058..13150375, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (13269272..13275588, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (13254872..13261189, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 14065 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10191 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:13220465-13220965 Neighboring gene tRNA methyltransferase 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14109 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14110 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10192 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10193 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:13230123-13230624 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:13230625-13231125 Neighboring gene nucleus accumbens associated 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10194 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14111 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:13234142-13234801 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:13247773-13248692 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10195 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10196 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14112 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14113 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10197 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14114 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:13263956-13264839 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14115 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10199 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10200 Neighboring gene immediate early response 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14116 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14117 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14118 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14119 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14120 Neighboring gene ribosomal protein L12 pseudogene 42

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Syntaxin 10: a member of the syntaxin family localized to the trans-Golgi network. Tang BL, et al. Biochem Biophys Res Commun, 1998 Jan 14. PMID 9446797
    2. The trans-Golgi SNARE syntaxin 10 is required for optimal development of Chlamydia trachomatis. Lucas AL, et al. Front Cell Infect Microbiol, 2015. PMID 26442221, Free PMC Article
    3. Structural basis for the interaction of the Golgi-Associated Retrograde Protein Complex with the t-SNARE Syntaxin 6. Abascal-Palacios G, et al. Structure, 2013 Sep 3. PMID 23932592, Free PMC Article
    4. Co-expression of several human syntaxin genes in neutrophils and differentiating HL-60 cells: variant isoforms and detection of syntaxin 1. Martín-Martín B, et al. J Leukoc Biol, 1999 Mar. PMID 10080545
    5. Trans-Golgi network syntaxin 10 functions distinctly from syntaxins 6 and 16. Wang Y, et al. Mol Membr Biol, 2005 Jul-Aug. PMID 16154903

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables SNAP receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables SNARE binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables syntaxin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    NOT involved_in early endosome to Golgi transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of protein localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in retrograde transport, endosome to Golgi IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in retrograde transport, endosome to Golgi IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in vesicle docking IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of SNARE complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in synaptic vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in trans-Golgi network IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in trans-Golgi network membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    syntaxin-10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271609.2 → NP_001258538.1  syntaxin-10 isoform 2

      See identical proteins and their annotated locations for NP_001258538.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC011446, BC095459, BM830816, BM847745, CD364936
      Consensus CDS
      CCDS62570.1
      UniProtKB/TrEMBL
      X6R2W0
      Related
      ENSP00000242770.5, ENST00000242770.9
      Conserved Domains (2) summary
      pfam09177
      Location:13 → 103
      Syntaxin-6_N; Syntaxin 6, N-terminal
      cl22856
      Location:160 → 192
      SNARE; SNARE motif

    2. NM_001271610.2 → NP_001258539.1  syntaxin-10 isoform 3

      See identical proteins and their annotated locations for NP_001258539.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC011446, AY778966, BM830816, BM847745, CD364936
      Consensus CDS
      CCDS62569.1
      UniProtKB/TrEMBL
      K7EIY4, Q5U8S2
      Related
      ENSP00000465398.1, ENST00000589083.5
      Conserved Domains (2) summary
      cd15851
      Location:160 → 225
      SNARE_Syntaxin6; SNARE motif of syntaxin 6
      pfam09177
      Location:13 → 103
      Syntaxin-6_N; Syntaxin 6, N-terminal

    3. NM_001271611.2 → NP_001258540.1  syntaxin-10 isoform 4

      See identical proteins and their annotated locations for NP_001258540.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses two alternate splice sites and lacks an internal exon, resulting in the loss of an in-frame segment in the coding region, compared to variant 1. This results in a shorter isoform (4), compared to isoform 1.
      Source sequence(s)
      AC011446, BC017237, BM830816, BM847745, CD364936
      Consensus CDS
      CCDS62571.1
      UniProtKB/Swiss-Prot
      O60499
      Related
      ENSP00000339350.4, ENST00000343587.9
      Conserved Domains (2) summary
      cd15851
      Location:111 → 176
      SNARE_Syntaxin6; SNARE motif of syntaxin 6
      pfam09177
      Location:13 → 77
      Syntaxin-6_N; Syntaxin 6, N-terminal

    4. NM_003765.3 → NP_003756.1  syntaxin-10 isoform 1

      See identical proteins and their annotated locations for NP_003756.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC011446, AF035531, BM830816, BM847745, CD364936
      Consensus CDS
      CCDS32922.1
      UniProtKB/Swiss-Prot
      A6NC41, O60499, Q6IAP4, Q96AE8
      UniProtKB/TrEMBL
      K7EIY4
      Related
      ENSP00000466298.1, ENST00000587230.6
      Conserved Domains (2) summary
      cd15851
      Location:160 → 225
      SNARE_Syntaxin6; SNARE motif of syntaxin 6
      pfam09177
      Location:13 → 103
      Syntaxin-6_N; Syntaxin 6, N-terminal

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      13144058..13150375 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011528397.3 → XP_011526699.1  syntaxin-10 isoform X1

      Conserved Domains (1) summary
      pfam09177
      Location:13 → 103
      Syntaxin-6_N; Syntaxin 6, N-terminal

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      13269272..13275588 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054322481.1 → XP_054178456.1  syntaxin-10 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O60499.1 GenPept UniProtKB/Swiss-Prot:O60499

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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