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    STEAP2 STEAP2 metalloreductase [ Homo sapiens (human) ]

    Gene ID: 261729, updated on 27-Nov-2024

    Summary

    Official Symbol
    STEAP2provided by HGNC
    Official Full Name
    STEAP2 metalloreductaseprovided by HGNC
    Primary source
    HGNC:HGNC:17885
    See related
    Ensembl:ENSG00000157214 MIM:605094; AllianceGenome:HGNC:17885
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    STMP; IPCA1; PUMPCn; STAMP1; PCANAP1
    Summary
    This gene is a member of the STEAP family and encodes a multi-pass membrane protein that localizes to the Golgi complex, the plasma membrane, and the vesicular tubular structures in the cytosol. A highly similar protein in mouse has both ferrireductase and cupric reductase activity, and stimulates the cellular uptake of both iron and copper in vitro. Increased transcriptional expression of the human gene is associated with prostate cancer progression. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in prostate (RPKM 47.3), gall bladder (RPKM 4.2) and 6 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See STEAP2 in Genome Data Viewer
    Location:
    7q21.13
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (90211740..90243408)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (91460044..91491706)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (89841054..89866997)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene STEAP2 antisense RNA 1 Neighboring gene DPY19L2 pseudogene 4 Neighboring gene NANOG hESC enhancer GRCh37_chr7:89781999-89782539 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26241 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26242 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26243 Neighboring gene NANOG hESC enhancer GRCh37_chr7:89809546-89810047 Neighboring gene STEAP family member 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18357 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:89863874-89864079 Neighboring gene uncharacterized LOC107986819 Neighboring gene NANOG hESC enhancer GRCh37_chr7:89875353-89875865 Neighboring gene cilia and flagella associated protein 69 Neighboring gene uncharacterized LOC107986715 Neighboring gene uncharacterized LOC101927446 Neighboring gene family with sequence similarity 237 member B

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cupric reductase (NADH) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ferric-chelate reductase (NADPH) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in Golgi to plasma membrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in copper ion import IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in copper ion import across plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in endocytosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in iron ion import across plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulated exocytosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to hormone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in early endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endosome membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in trans-Golgi network transport vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    metalloreductase STEAP2
    Names
    STEAP family member 2, metalloreductase
    SixTransMembrane Protein of Prostate 1
    prostate cancer-associated protein 1
    protein up-regulated in metastatic prostate cancer
    protein upregulated in metastatic prostate cancer
    six transmembrane epithelial antigen of the prostate 2
    six-transmembrane epithelial antigen of prostate 2
    NP_001035755.1
    NP_001035756.1
    NP_001231873.1
    NP_001231874.1
    NP_001231875.1
    NP_694544.2
    XP_006715984.1
    XP_016867442.1
    XP_016867443.1
    XP_016867444.1
    XP_016867445.1
    XP_016867446.1
    XP_016867447.1
    XP_047276128.1
    XP_047276129.1
    XP_047276130.1
    XP_047276131.1
    XP_047276132.1
    XP_047276133.1
    XP_047276134.1
    XP_047276135.1
    XP_047276136.1
    XP_047276137.1
    XP_054213815.1
    XP_054213816.1
    XP_054213817.1
    XP_054213818.1
    XP_054213819.1
    XP_054213820.1
    XP_054213821.1
    XP_054213822.1
    XP_054213823.1
    XP_054213824.1
    XP_054213825.1
    XP_054213826.1
    XP_054213827.1
    XP_054213828.1
    XP_054213829.1
    XP_054213830.1
    XP_054213831.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001040665.2NP_001035755.1  metalloreductase STEAP2 isoform a

      See identical proteins and their annotated locations for NP_001035755.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 4 encode the same isoform.
      Source sequence(s)
      AC002064, AK092666, AY008443, AY008444
      Consensus CDS
      CCDS5615.1
      UniProtKB/Swiss-Prot
      A4D1F1, G5E9C6, Q6UXN6, Q6YPB1, Q8IUE7, Q8NFT2
      UniProtKB/TrEMBL
      B2RCC7
      Related
      ENSP00000378120.2, ENST00000394622.6
      Conserved Domains (3) summary
      COG2085
      Location:32217
      COG2085; Predicted dinucleotide-binding enzyme [General function prediction only]
      pfam01794
      Location:262405
      Ferric_reduct; Ferric reductase like transmembrane component
      pfam03807
      Location:34119
      F420_oxidored; NADP oxidoreductase coenzyme F420-dependent
    2. NM_001040666.2NP_001035756.1  metalloreductase STEAP2 isoform b

      See identical proteins and their annotated locations for NP_001035756.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, 3' UTR, and 3' coding region compared to variant 1, resulting in a protein (isoform b) that is shorter and has a unique C-terminus, compared to isoform a.
      Source sequence(s)
      AC002064, AF526382, AK092666, AY008443
      Consensus CDS
      CCDS43612.1
      UniProtKB/TrEMBL
      B3KS24, Q6YPB2
      Related
      ENSP00000378125.2, ENST00000394629.2
      Conserved Domains (3) summary
      COG2085
      Location:32217
      COG2085; Predicted dinucleotide-binding enzyme [General function prediction only]
      pfam01794
      Location:262405
      Ferric_reduct; Ferric reductase like transmembrane component
      pfam03807
      Location:34119
      F420_oxidored; NADP oxidoreductase coenzyme F420-dependent
    3. NM_001244944.2NP_001231873.1  metalloreductase STEAP2 isoform a

      See identical proteins and their annotated locations for NP_001231873.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 4 encode the same isoform.
      Source sequence(s)
      AC002064
      Consensus CDS
      CCDS5615.1
      UniProtKB/Swiss-Prot
      A4D1F1, G5E9C6, Q6UXN6, Q6YPB1, Q8IUE7, Q8NFT2
      UniProtKB/TrEMBL
      B2RCC7
      Related
      ENSP00000378119.2, ENST00000394621.7
      Conserved Domains (3) summary
      COG2085
      Location:32217
      COG2085; Predicted dinucleotide-binding enzyme [General function prediction only]
      pfam01794
      Location:262405
      Ferric_reduct; Ferric reductase like transmembrane component
      pfam03807
      Location:34119
      F420_oxidored; NADP oxidoreductase coenzyme F420-dependent
    4. NM_001244945.2NP_001231874.1  metalloreductase STEAP2 isoform b

      See identical proteins and their annotated locations for NP_001231874.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 3' UTR, and 3' coding region compared to variant 1, resulting in a protein (isoform b) that is shorter and has a unique C-terminus, compared to isoform a.
      Source sequence(s)
      AC002064
      Consensus CDS
      CCDS43612.1
      UniProtKB/TrEMBL
      B3KS24, Q6YPB2
      Related
      ENSP00000378123.1, ENST00000394626.5
      Conserved Domains (3) summary
      COG2085
      Location:32217
      COG2085; Predicted dinucleotide-binding enzyme [General function prediction only]
      pfam01794
      Location:262405
      Ferric_reduct; Ferric reductase like transmembrane component
      pfam03807
      Location:34119
      F420_oxidored; NADP oxidoreductase coenzyme F420-dependent
    5. NM_001244946.2NP_001231875.1  metalloreductase STEAP2 isoform c

      See identical proteins and their annotated locations for NP_001231875.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR, 3' UTR, and 3' coding region compared to variant 1, resulting in a protein (isoform c) that is shorter and has a unique C-terminus, compared to isoform a.
      Source sequence(s)
      AC002064
      Consensus CDS
      CCDS59064.1
      UniProtKB/TrEMBL
      B5MC02
      Related
      ENSP00000378128.1, ENST00000394632.5
      Conserved Domains (3) summary
      COG2085
      Location:32217
      COG2085; Predicted dinucleotide-binding enzyme [General function prediction only]
      pfam01794
      Location:262401
      Ferric_reduct; Ferric reductase like transmembrane component
      pfam03807
      Location:34119
      F420_oxidored; NADP oxidoreductase coenzyme F420-dependent
    6. NM_152999.4NP_694544.2  metalloreductase STEAP2 isoform a

      See identical proteins and their annotated locations for NP_694544.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Variants 1, 2 and 4 encode the same isoform.
      Source sequence(s)
      AC002064, AF455138, AK092666, AY008443, DR005432
      Consensus CDS
      CCDS5615.1
      UniProtKB/Swiss-Prot
      A4D1F1, G5E9C6, Q6UXN6, Q6YPB1, Q8IUE7, Q8NFT2
      UniProtKB/TrEMBL
      B2RCC7
      Related
      ENSP00000287908.3, ENST00000287908.7
      Conserved Domains (3) summary
      COG2085
      Location:32217
      COG2085; Predicted dinucleotide-binding enzyme [General function prediction only]
      pfam01794
      Location:262405
      Ferric_reduct; Ferric reductase like transmembrane component
      pfam03807
      Location:34119
      F420_oxidored; NADP oxidoreductase coenzyme F420-dependent

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      90211740..90243408
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047420172.1XP_047276128.1  metalloreductase STEAP2 isoform X1

      UniProtKB/Swiss-Prot
      A4D1F1, G5E9C6, Q6UXN6, Q6YPB1, Q8IUE7, Q8NFT2
    2. XM_047420175.1XP_047276131.1  metalloreductase STEAP2 isoform X1

      UniProtKB/Swiss-Prot
      A4D1F1, G5E9C6, Q6UXN6, Q6YPB1, Q8IUE7, Q8NFT2
    3. XM_047420180.1XP_047276136.1  metalloreductase STEAP2 isoform X3

      UniProtKB/TrEMBL
      Q6YPB2
    4. XM_006715921.5XP_006715984.1  metalloreductase STEAP2 isoform X1

      See identical proteins and their annotated locations for XP_006715984.1

      UniProtKB/Swiss-Prot
      A4D1F1, G5E9C6, Q6UXN6, Q6YPB1, Q8IUE7, Q8NFT2
      UniProtKB/TrEMBL
      B2RCC7
      Conserved Domains (3) summary
      COG2085
      Location:32217
      COG2085; Predicted dinucleotide-binding enzyme [General function prediction only]
      pfam01794
      Location:262405
      Ferric_reduct; Ferric reductase like transmembrane component
      pfam03807
      Location:34119
      F420_oxidored; NADP oxidoreductase coenzyme F420-dependent
    5. XM_017011956.3XP_016867445.1  metalloreductase STEAP2 isoform X3

      UniProtKB/TrEMBL
      B3KS24, Q6YPB2
      Conserved Domains (3) summary
      COG2085
      Location:32217
      COG2085; Predicted dinucleotide-binding enzyme [General function prediction only]
      pfam01794
      Location:262405
      Ferric_reduct; Ferric reductase like transmembrane component
      pfam03807
      Location:34119
      F420_oxidored; NADP oxidoreductase coenzyme F420-dependent
    6. XM_017011957.2XP_016867446.1  metalloreductase STEAP2 isoform X3

      UniProtKB/TrEMBL
      B3KS24, Q6YPB2
      Conserved Domains (3) summary
      COG2085
      Location:32217
      COG2085; Predicted dinucleotide-binding enzyme [General function prediction only]
      pfam01794
      Location:262405
      Ferric_reduct; Ferric reductase like transmembrane component
      pfam03807
      Location:34119
      F420_oxidored; NADP oxidoreductase coenzyme F420-dependent
    7. XM_047420174.1XP_047276130.1  metalloreductase STEAP2 isoform X1

      UniProtKB/Swiss-Prot
      A4D1F1, G5E9C6, Q6UXN6, Q6YPB1, Q8IUE7, Q8NFT2
    8. XM_047420173.1XP_047276129.1  metalloreductase STEAP2 isoform X1

      UniProtKB/Swiss-Prot
      A4D1F1, G5E9C6, Q6UXN6, Q6YPB1, Q8IUE7, Q8NFT2
    9. XM_017011953.3XP_016867442.1  metalloreductase STEAP2 isoform X1

      UniProtKB/Swiss-Prot
      A4D1F1, G5E9C6, Q6UXN6, Q6YPB1, Q8IUE7, Q8NFT2
      UniProtKB/TrEMBL
      B2RCC7
      Conserved Domains (3) summary
      COG2085
      Location:32217
      COG2085; Predicted dinucleotide-binding enzyme [General function prediction only]
      pfam01794
      Location:262405
      Ferric_reduct; Ferric reductase like transmembrane component
      pfam03807
      Location:34119
      F420_oxidored; NADP oxidoreductase coenzyme F420-dependent
    10. XM_017011954.3XP_016867443.1  metalloreductase STEAP2 isoform X1

      UniProtKB/Swiss-Prot
      A4D1F1, G5E9C6, Q6UXN6, Q6YPB1, Q8IUE7, Q8NFT2
      UniProtKB/TrEMBL
      B2RCC7
      Conserved Domains (3) summary
      COG2085
      Location:32217
      COG2085; Predicted dinucleotide-binding enzyme [General function prediction only]
      pfam01794
      Location:262405
      Ferric_reduct; Ferric reductase like transmembrane component
      pfam03807
      Location:34119
      F420_oxidored; NADP oxidoreductase coenzyme F420-dependent
    11. XM_047420178.1XP_047276134.1  metalloreductase STEAP2 isoform X2

    12. XM_047420177.1XP_047276133.1  metalloreductase STEAP2 isoform X2

    13. XM_017011955.2XP_016867444.1  metalloreductase STEAP2 isoform X2

      UniProtKB/TrEMBL
      B3KS24
    14. XM_047420176.1XP_047276132.1  metalloreductase STEAP2 isoform X2

    15. XM_047420179.1XP_047276135.1  metalloreductase STEAP2 isoform X2

    16. XM_047420181.1XP_047276137.1  metalloreductase STEAP2 isoform X3

      UniProtKB/TrEMBL
      Q6YPB2
    17. XM_017011958.3XP_016867447.1  metalloreductase STEAP2 isoform X4

      UniProtKB/TrEMBL
      B3KS24

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      91460044..91491706
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054357843.1XP_054213818.1  metalloreductase STEAP2 isoform X1

    2. XM_054357841.1XP_054213816.1  metalloreductase STEAP2 isoform X1

    3. XM_054357845.1XP_054213820.1  metalloreductase STEAP2 isoform X1

    4. XM_054357854.1XP_054213829.1  metalloreductase STEAP2 isoform X3

    5. XM_054357840.1XP_054213815.1  metalloreductase STEAP2 isoform X1

    6. XM_054357852.1XP_054213827.1  metalloreductase STEAP2 isoform X3

    7. XM_054357853.1XP_054213828.1  metalloreductase STEAP2 isoform X3

    8. XM_054357850.1XP_054213825.1  metalloreductase STEAP2 isoform X2

    9. XM_054357849.1XP_054213824.1  metalloreductase STEAP2 isoform X2

    10. XM_054357847.1XP_054213822.1  metalloreductase STEAP2 isoform X2

    11. XM_054357848.1XP_054213823.1  metalloreductase STEAP2 isoform X2

    12. XM_054357851.1XP_054213826.1  metalloreductase STEAP2 isoform X2

    13. XM_054357844.1XP_054213819.1  metalloreductase STEAP2 isoform X1

    14. XM_054357842.1XP_054213817.1  metalloreductase STEAP2 isoform X1

    15. XM_054357846.1XP_054213821.1  metalloreductase STEAP2 isoform X1

    16. XM_054357855.1XP_054213830.1  metalloreductase STEAP2 isoform X3

    17. XM_054357856.1XP_054213831.1  metalloreductase STEAP2 isoform X4