CD300LG CD300 molecule like family member g [Homo sapiens (human)] - Gene

Summary

Official Symbol: CD300LGprovided by HGNC
Official Full Name: CD300 molecule like family member gprovided by HGNC
Primary source: HGNC:HGNC:30455
See related: Ensembl:ENSG00000161649 MIM:610520; AllianceGenome:HGNC:30455
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CLM9; CLM-9; TREM4; TREM-4; NEPMUCIN
Summary: Members of the CD300 (see MIM 606786)-like (CD300L) family, such as CD300LG, are widely expressed on hematopoietic cells. All CD300L proteins are type I cell surface glycoproteins that contain a single immunoglobulin (Ig) V-like domain (Takatsu et al., 2006 [PubMed 16876123]).[supplied by OMIM, Mar 2008]
Expression: Biased expression in fat (RPKM 45.4), placenta (RPKM 12.3) and 3 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 17q21.31

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	17	NC_000017.11 (43847176..43863639)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	17	NC_060941.1 (44699730..44716193)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	17	NC_000017.10 (41924544..41941007)

Chromosome 17 - NC_000017.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Both mRNA and protein levels of CD300LG-g in pulmonary carcinoma tissues were significantly lower than that in tumor-adjacent tissues, which might lead to inhibition of killing function of immunocytes, resulting in immune escape of lung cancer cells.
Title: Expression Depression of CD300LG-γ in Human Pulmonary Carcinoma.
Blood pressure, measured with a sensitive method, in a small sample of CD300LG rs72836561 CT-carriers was higher than in CC-carriers.
Title: Blood pressure levels in male carriers of Arg82Cys in CD300LG.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH123945 (e-PCR)
- UniSTS:136320

D17S1504E (e-PCR)
- UniSTS:151709

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in immune system process	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in multivesicular body membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: CMRF35-like molecule 9

Names: CD300 antigen-like family member G; triggering receptor expressed on myeloid cells 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001168322.2 → NP_001161794.1 CMRF35-like molecule 9 isoform 4 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 3' UTR and coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 4, which is shorter than isoform 1.

Source sequence(s)

AK309938

Consensus CDS

CCDS54131.1

UniProtKB/Swiss-Prot

Q6UXG3

Related

ENSP00000442368.1, ENST00000539718.5

Conserved Domains (2) summary

cd05716
Location:24 → 113

Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)

smart00410
Location:22 → 124

IG_like; Immunoglobulin like
NM_001168323.2 → NP_001161795.1 CMRF35-like molecule 9 isoform 3 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (3) has multiple differences in the coding region, compared to variant 1, one of which results in a translational frameshift. The resulting protein (isoform 3) has a distinct C-terminus and is shorter than isoform 1.

Source sequence(s)

AC015937, AK298112, AK309938

Consensus CDS

CCDS54132.1

UniProtKB/Swiss-Prot

Q6UXG3

Related

ENSP00000366408.3, ENST00000377203.8

Conserved Domains (2) summary

cd05716
Location:24 → 113

Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)

smart00410
Location:22 → 124

IG_like; Immunoglobulin like
NM_001168324.2 → NP_001161796.1 CMRF35-like molecule 9 isoform 2 precursor

See identical proteins and their annotated locations for NP_001161796.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) has multiple differences in the coding region, compared to variant 1, one of which results in a translational frameshift. The resulting protein (isoform 2) has a distinct C-terminus and is shorter than isoform 1.

Source sequence(s)

AC015937, AF427619

Consensus CDS

CCDS54133.1

UniProtKB/Swiss-Prot

Q6UXG3

Related

ENSP00000293396.7, ENST00000293396.12

Conserved Domains (2) summary

cd05716
Location:24 → 113

Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)

smart00410
Location:22 → 124

IG_like; Immunoglobulin like
NM_001411122.1 → NP_001398051.1 CMRF35-like molecule 9 isoform 5 precursor

Status: VALIDATED

Source sequence(s)

AC007993, AC015937

Consensus CDS

CCDS92332.1

UniProtKB/TrEMBL

A0A8V8TQK5

Related

ENSP00000515157.1, ENST00000700726.1
NM_145273.4 → NP_660316.2 CMRF35-like molecule 9 isoform 1 precursor

See identical proteins and their annotated locations for NP_660316.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AC007993, AC015937, AK298112, AY358364, BC025395

Consensus CDS

CCDS11470.1

UniProtKB/Swiss-Prot

B4DNY5, F5H7P9, F8W9M3, Q6UXG3, Q8IX38, Q8IX39, Q8TA95

Related

ENSP00000321005.3, ENST00000317310.5

Conserved Domains (2) summary

cd05716
Location:24 → 113

Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)

smart00410
Location:22 → 124

IG_like; Immunoglobulin like

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000017.11 Reference GRCh38.p14 Primary Assembly

Range

43847176..43863639

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006721721.4 → XP_006721784.1 CMRF35-like molecule 9 isoform X1

Conserved Domains (2) summary

cd05716
Location:24 → 113

Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)

smart00410
Location:22 → 124

IG_like; Immunoglobulin like
XM_005257075.4 → XP_005257132.1 CMRF35-like molecule 9 isoform X3

Conserved Domains (2) summary

cd05716
Location:24 → 113

Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)

smart00410
Location:22 → 124

IG_like; Immunoglobulin like
XM_006721722.4 → XP_006721785.1 CMRF35-like molecule 9 isoform X2

Conserved Domains (2) summary

cd05716
Location:24 → 113

Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)

smart00410
Location:22 → 124

IG_like; Immunoglobulin like
XM_005257076.4 → XP_005257133.1 CMRF35-like molecule 9 isoform X5

Conserved Domains (2) summary

cd05716
Location:24 → 113

Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)

smart00410
Location:22 → 124

IG_like; Immunoglobulin like
XM_011524384.4 → XP_011522686.1 CMRF35-like molecule 9 isoform X4

Conserved Domains (2) summary

cd05716
Location:24 → 113

Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)

smart00410
Location:22 → 124

IG_like; Immunoglobulin like