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    C1orf159 chromosome 1 open reading frame 159 [ Homo sapiens (human) ]

    Gene ID: 54991, updated on 3-Nov-2024

    Summary

    Official Symbol
    C1orf159provided by HGNC
    Official Full Name
    chromosome 1 open reading frame 159provided by HGNC
    Primary source
    HGNC:HGNC:26062
    See related
    Ensembl:ENSG00000131591 AllianceGenome:HGNC:26062
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to be located in membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in testis (RPKM 2.6), skin (RPKM 1.2) and 24 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See C1orf159 in Genome Data Viewer
    Location:
    1p36.33
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (1081823..1116089, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (510436..544704, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (1017203..1051469, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100288175 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:1000857-1001357 Neighboring gene uncharacterized LOC105378948 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 27 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 28 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:1004678-1005443 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:1009379-1009878 Neighboring gene ring finger protein 223 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 30 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 31 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:1015879-1016581 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:1016582-1017283 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:1017301-1017480 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:1047169-1047670 Neighboring gene Sharpr-MPRA regulatory region 13538 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 32 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 33 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 34 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 35 Neighboring gene uncharacterized LOC124903819 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:1058337-1059155 Neighboring gene uncharacterized LOC124903820 Neighboring gene CRISPRi-validated cis-regulatory element chr1.97 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 36 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 37 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 38 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 39 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 40 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:1073727-1074228 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:1074229-1074728 Neighboring gene long intergenic non-protein coding RNA 1342 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:1076651-1077172

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ20584, FLJ21143, FLJ36119

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    uncharacterized protein C1orf159

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001330306.2NP_001317235.1  uncharacterized protein C1orf159 isoform 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AL390719
      Consensus CDS
      CCDS81250.1
      UniProtKB/Swiss-Prot
      B3KQ46, Q5T2W6, Q6UX67, Q6ZR77, Q96HA4, Q9NWV0
      Related
      ENSP00000368644.1, ENST00000379339.5
    2. NM_001363525.2NP_001350454.1  uncharacterized protein C1orf159 isoform 3 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AL390719
      Consensus CDS
      CCDS85917.1
      UniProtKB/TrEMBL
      Q5T2W9
      Related
      ENSP00000368624.1, ENST00000379320.5
      Conserved Domains (1) summary
      pfam14946
      Location:23167
      DUF4501; Domain of unknown function (DUF4501)
    3. NM_017891.5NP_060361.4  uncharacterized protein C1orf159 isoform 2 precursor

      See identical proteins and their annotated locations for NP_060361.4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks an alternate in-frame exon, and uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AK000591, BE280321, BM974309
      Consensus CDS
      CCDS7.2
      Related
      ENSP00000400736.2, ENST00000421241.7
      Conserved Domains (1) summary
      pfam14946
      Location:23198
      DUF4501; Domain of unknown function (DUF4501)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      1081823..1116089 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      510436..544704 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)