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    TMEM276 transmembrane protein 276 [ Homo sapiens (human) ]

    Gene ID: 84773, updated on 12-Sep-2024

    Summary

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    Official Symbol
    TMEM276provided by HGNC
    Official Full Name
    transmembrane protein 276provided by HGNC
    Primary source
    HGNC:HGNC:56235
    See related
    Ensembl:ENSG00000291317
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Orthologs
    mouse all
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    Genomic context

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    See TMEM276 in Genome Data Viewer
    Location:
    8q24.3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (144463825..144467015, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (145633585..145636756, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (145689208..145692398, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene tonsoku like, DNA repair protein Neighboring gene TONSL antisense RNA 1 Neighboring gene microRNA 6893 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:145668715-145669223 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19685 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19686 Neighboring gene TMEM276-ZFTRAF1 readthrough Neighboring gene zinc finger TRAF-type containing 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:145687825-145688502 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:145688503-145689180 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:145689275-145689888 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19689 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19690 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19691 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19692 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:145692087-145692923 Neighboring gene microRNA 10400 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19695 Neighboring gene kinesin family member C2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:145698787-145699682 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:145699683-145700576 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:145701473-145702366 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19696 Neighboring gene forkhead box H1 Neighboring gene protein phosphatase 1 regulatory subunit 16A Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:145709653-145710352 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:145710353-145711052 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:145715271-145715770 Neighboring gene uncharacterized LOC101928953 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:145725199-145725860 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19697

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See Variation Viewer (GRCh37.p13)

    General gene information

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    Readthrough TMEM276-ZFTRAF1

    Readthrough gene: TMEM276-ZFTRAF1, Included gene: ZFTRAF1

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 276

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001129888.2 → NP_001123360.1  transmembrane protein 276 precursor

      See identical proteins and their annotated locations for NP_001123360.1

      Status: VALIDATED

      Source sequence(s)
      AC084125
      Consensus CDS
      CCDS6426.1
      UniProtKB/Swiss-Prot
      B3KSX0, D3DWM3, P0DTL5, Q6ZMK1, Q9BSF6, Q9BSU6
      Related
      ENSP00000414647.2, ENST00000424149.6

    2. NM_001408058.1 → NP_001394987.1  transmembrane protein 276 precursor

      Status: VALIDATED

      Source sequence(s)
      AC084125
      UniProtKB/Swiss-Prot
      B3KSX0, D3DWM3, P0DTL5, Q6ZMK1, Q9BSF6, Q9BSU6
      Related
      ENSP00000385962.2, ENST00000403000.6

    3. NM_001408059.1 → NP_001394988.1  transmembrane protein 276 precursor

      Status: VALIDATED

      Source sequence(s)
      AC084125
      UniProtKB/Swiss-Prot
      B3KSX0, D3DWM3, P0DTL5, Q6ZMK1, Q9BSF6, Q9BSU6

    4. NM_001408060.1 → NP_001394989.1  transmembrane protein 276 precursor

      Status: VALIDATED

      Source sequence(s)
      AC084125
      UniProtKB/Swiss-Prot
      B3KSX0, D3DWM3, P0DTL5, Q6ZMK1, Q9BSF6, Q9BSU6

    5. NM_001408061.1 → NP_001394990.1  transmembrane protein 276 precursor

      Status: VALIDATED

      Source sequence(s)
      AC084125
      UniProtKB/Swiss-Prot
      B3KSX0, D3DWM3, P0DTL5, Q6ZMK1, Q9BSF6, Q9BSU6

    6. NM_001408062.1 → NP_001394991.1  transmembrane protein 276 precursor

      Status: VALIDATED

      Source sequence(s)
      AC084125
      UniProtKB/Swiss-Prot
      B3KSX0, D3DWM3, P0DTL5, Q6ZMK1, Q9BSF6, Q9BSU6

    7. NM_032687.4 → NP_116076.1  transmembrane protein 276 precursor

      See identical proteins and their annotated locations for NP_116076.1

      Status: VALIDATED

      Source sequence(s)
      AC084125, BC005073, BC056412, BM671891
      UniProtKB/Swiss-Prot
      B3KSX0, D3DWM3, P0DTL5, Q6ZMK1, Q9BSF6, Q9BSU6
      Related
      ENSP00000304826.5, ENST00000306145.10

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      144463825..144467015 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      145633585..145636756 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0DTL5.1 GenPept UniProtKB/Swiss-Prot:P0DTL5

    Gene LinkOut

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