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    ZNF707 zinc finger protein 707 [ Homo sapiens (human) ]

    Gene ID: 286075, updated on 10-Dec-2024

    Summary

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    Official Symbol
    ZNF707provided by HGNC
    Official Full Name
    zinc finger protein 707provided by HGNC
    Primary source
    HGNC:HGNC:27815
    See related
    Ensembl:ENSG00000181135 AllianceGenome:HGNC:27815
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis (RPKM 4.1), spleen (RPKM 3.7) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ZNF707 in Genome Data Viewer
    Location:
    8q24.3
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (143684479..143695385)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (144840870..144851771)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (144766649..144777555)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene zinc finger protein 623 Neighboring gene U7 small nuclear RNA Neighboring gene uncharacterized LOC105375799 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:144751216-144751716 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:144751717-144752217 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:144764224-144764449 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:144781964-144782464 Neighboring gene long intergenic non-protein coding RNA 2878 Neighboring gene uncharacterized LOC101928160 Neighboring gene coiled-coil domain containing 166

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Human ORFeome version 1.1: a platform for reverse proteomics. Rual JF, et al. Genome Res, 2004 Oct. PMID 15489335, Free PMC Article
    2. BRCA2 mediates centrosome cohesion via an interaction with cytoplasmic dynein. Malik S, et al. Cell Cycle, 2016 Aug 17. PMID 27433848, Free PMC Article
    3. UBE2O and USP7 co-regulate RECQL4 ubiquitinylation and homologous recombination-mediated DNA repair. Huang Q, et al. FASEB J, 2022 Jan. PMID 34921745
    4. Shifted Transversal Design smart-pooling for high coverage interactome mapping. Xin X, et al. Genome Res, 2009 Jul. PMID 19447967, Free PMC Article
    5. Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells. Chang YJ, et al. Int J Mol Sci, 2023 Jun 6. PMID 37372979, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 707

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100598.2 → NP_001094068.1  zinc finger protein 707 isoform a

      See identical proteins and their annotated locations for NP_001094068.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 4. Variants 1, 2, 3, 4, and 5 encode the same protein (isoform a).
      Source sequence(s)
      AK001126, AK055263, AW294133, BC014894, CV023324, DA007942, DB249556
      Consensus CDS
      CCDS47932.1
      UniProtKB/Swiss-Prot
      A8K317, B3KNY1, D3DWK7, Q96C28
      Related
      ENSP00000351482.4, ENST00000358656.9
      Conserved Domains (6) summary
      smart00349
      Location:8 → 68
      KRAB; krueppel associated box
      COG5048
      Location:187 → 366
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:262 → 282
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:260 → 282
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:8 → 47
      KRAB; KRAB box
      pfam13465
      Location:218 → 242
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001100599.2 → NP_001094069.1  zinc finger protein 707 isoform a

      See identical proteins and their annotated locations for NP_001094069.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 4. Variants 1, 2, 3, 4, and 5 encode the same protein (isoform a).
      Source sequence(s)
      AK001126, AK055263, AW294133, BC014894, CV023324, DA917297, DB249556
      Consensus CDS
      CCDS47932.1
      UniProtKB/Swiss-Prot
      A8K317, B3KNY1, D3DWK7, Q96C28
      Conserved Domains (6) summary
      smart00349
      Location:8 → 68
      KRAB; krueppel associated box
      COG5048
      Location:187 → 366
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:262 → 282
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:260 → 282
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:8 → 47
      KRAB; KRAB box
      pfam13465
      Location:218 → 242
      zf-H2C2_2; Zinc-finger double domain

    3. NM_001288805.2 → NP_001275734.1  zinc finger protein 707 isoform a

      See identical proteins and their annotated locations for NP_001275734.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) represents the longest transcript and encodes isoform a. Variants 1, 2, 3, 4, and 5 encode the same protein (isoform a).
      Source sequence(s)
      AC105219, AK095138, AK290432, AW294133, DB249556
      Consensus CDS
      CCDS47932.1
      UniProtKB/Swiss-Prot
      A8K317, B3KNY1, D3DWK7, Q96C28
      Related
      ENSP00000436212.1, ENST00000532205.5
      Conserved Domains (6) summary
      smart00349
      Location:8 → 68
      KRAB; krueppel associated box
      COG5048
      Location:187 → 366
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:262 → 282
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:260 → 282
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:8 → 47
      KRAB; KRAB box
      pfam13465
      Location:218 → 242
      zf-H2C2_2; Zinc-finger double domain

    4. NM_001288806.2 → NP_001275735.1  zinc finger protein 707 isoform a

      See identical proteins and their annotated locations for NP_001275735.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 4. Variants 1, 2, 3, 4, and 5 encode the same protein (isoform a).
      Source sequence(s)
      AC105219, AK290432, AW294133, DA188478, DA990503
      Consensus CDS
      CCDS47932.1
      UniProtKB/Swiss-Prot
      A8K317, B3KNY1, D3DWK7, Q96C28
      Conserved Domains (6) summary
      smart00349
      Location:8 → 68
      KRAB; krueppel associated box
      COG5048
      Location:187 → 366
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:262 → 282
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:260 → 282
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:8 → 47
      KRAB; KRAB box
      pfam13465
      Location:218 → 242
      zf-H2C2_2; Zinc-finger double domain

    5. NM_001288807.2 → NP_001275736.1  zinc finger protein 707 isoform b

      See identical proteins and their annotated locations for NP_001275736.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon in an alternate exon, compared to variant 4. This results in a shorter protein (isoform b), compared to isoform a.
      Source sequence(s)
      AC105219, AK290432, AW294133, DA957023, DB249556
      UniProtKB/Swiss-Prot
      Q96C28
      Conserved Domains (4) summary
      COG5048
      Location:95 → 262
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:189 → 209
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:187 → 209
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:145 → 169
      zf-H2C2_2; Zinc-finger double domain

    6. NM_001288808.2 → NP_001275737.1  zinc finger protein 707 isoform c

      See identical proteins and their annotated locations for NP_001275737.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 4. This results in a shorter protein (isoform c), compared to isoform a. Variants 7 and 8 encode the same protein (isoform c).
      Source sequence(s)
      AC105219, AK290432, AW294133, DA188478, DB106612
      UniProtKB/Swiss-Prot
      Q96C28
      Conserved Domains (5) summary
      smart00349
      Location:1 → 32
      KRAB; krueppel associated box
      COG5048
      Location:151 → 330
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:226 → 246
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:224 → 246
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:182 → 206
      zf-H2C2_2; Zinc-finger double domain

    7. NM_001288809.2 → NP_001275738.1  zinc finger protein 707 isoform c

      See identical proteins and their annotated locations for NP_001275738.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 4. This results in a shorter protein (isoform c), compared to isoform a. Variants 7 and 8 encode the same protein (isoform c).
      Source sequence(s)
      AC105219, AK001126, AK290432, AW294133, DA188478, DB125792
      UniProtKB/Swiss-Prot
      Q96C28
      Conserved Domains (5) summary
      smart00349
      Location:1 → 32
      KRAB; krueppel associated box
      COG5048
      Location:151 → 330
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:226 → 246
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:224 → 246
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:182 → 206
      zf-H2C2_2; Zinc-finger double domain

    8. NM_173831.4 → NP_776192.2  zinc finger protein 707 isoform a

      See identical proteins and their annotated locations for NP_776192.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR, compared to variant 4. Variants 1, 2, 3, 4, and 5 encode the same protein (isoform a).
      Source sequence(s)
      AK001126, AK055263, AW294133, BC014894, CV023324, DB249556
      Consensus CDS
      CCDS47932.1
      UniProtKB/Swiss-Prot
      A8K317, B3KNY1, D3DWK7, Q96C28
      Related
      ENSP00000436250.1, ENST00000532158.5
      Conserved Domains (6) summary
      smart00349
      Location:8 → 68
      KRAB; krueppel associated box
      COG5048
      Location:187 → 366
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:262 → 282
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:260 → 282
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:8 → 47
      KRAB; KRAB box
      pfam13465
      Location:218 → 242
      zf-H2C2_2; Zinc-finger double domain

    RNA

    1. NR_110190.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9) lacks multiple 5' exons and uses an alternate 3' splice site, compared to variant 4. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC105219, AK001126, AK290432, AW294133, DB249556
      Related
      ENST00000533031.5

    2. NR_110191.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (10) differs in its 5' exon structure and uses an alternate 3' splice site, compared to variant 4. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC105219, AK290432, AW294133, DB099015

    3. NR_110192.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (11) differs in its 5' exon structure and uses an alternate 3' splice sites, compared to variant 4. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC105219, AK001126, AK290432, AW294133, DA188478

    4. NR_110193.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (12) differs in its 5' exon structure and uses an alternate 3' splice site, compared to variant 4. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC105219, AK001126, AK290432, AW294133, DA555314

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      143684479..143695385
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_187571.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      161526..172432
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      144840870..144851771
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96C28.2 GenPept UniProtKB/Swiss-Prot:Q96C28

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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