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    Trpm6 transient receptor potential cation channel, subfamily M, member 6 [ Mus musculus (house mouse) ]

    Gene ID: 225997, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Trpm6provided by MGI
    Official Full Name
    transient receptor potential cation channel, subfamily M, member 6provided by MGI
    Primary source
    MGI:MGI:2675603
    See related
    Ensembl:ENSMUSG00000024727 AllianceGenome:MGI:2675603
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CHAK2; TRPM6/CHAK2
    Summary
    Enables monoatomic cation channel activity. Acts upstream of or within metal ion transport. Located in apical plasma membrane and brush border membrane. Is expressed in several structures, including cochlea; colon; extraembryonic component; ganglia; and genitourinary system. Human ortholog(s) of this gene implicated in intestinal hypomagnesemia 1 and metal metabolism disorder. Orthologous to human TRPM6 (transient receptor potential cation channel subfamily M member 6). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in colon adult (RPKM 3.2), lung adult (RPKM 1.8) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Trpm6 in Genome Data Viewer
    Location:
    19 B; 19 13.21 cM
    Exon count:
    44
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (18707566..18869885)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (18730177..18892521)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E9992 Neighboring gene RIKEN cDNA D030056L22 gene Neighboring gene STARR-seq mESC enhancer starr_45692 Neighboring gene carnosine N-methyltransferase 1 Neighboring gene STARR-positive B cell enhancer ABC_E3247 Neighboring gene predicted gene, 23238 Neighboring gene predicted gene, 41814 Neighboring gene STARR-seq mESC enhancer starr_45694 Neighboring gene RAR-related orphan receptor beta Neighboring gene STARR-seq mESC enhancer starr_45696 Neighboring gene STARR-seq mESC enhancer starr_45697 Neighboring gene predicted gene, 50212 Neighboring gene predicted gene, 25437

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Relationship between low magnesium status and TRPM6 expression in the kidney and large intestine. Rondón LJ, et al. Am J Physiol Regul Integr Comp Physiol, 2008 Jun. PMID 18385471
    2. Mice defective in Trpm6 show embryonic mortality and neural tube defects. Walder RY, et al. Hum Mol Genet, 2009 Nov 15. PMID 19692351, Free PMC Article
    3. Modulation of TRPM6 and Na(+)/Mg(2+) exchange in mammary epithelial cells in response to variations of magnesium availability. Wolf FI, et al. J Cell Physiol, 2010 Feb. PMID 19890837
    4. Transient receptor potential melastatin 6 knockout mice are lethal whereas heterozygous deletion results in mild hypomagnesemia. Woudenberg-Vrenken TE, et al. Nephron Physiol, 2011. PMID 20814221
    5. Decreased renal mRNA expression of TRPM6 is associated with hypomagnesemia in C57BL/6 asthmatic mice. Jiang SP, et al. Eur Rev Med Pharmacol Sci, 2010 Nov. PMID 21284342

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Importance of the renal ion channel TRPM6 in the circadian secretion of renin to raise blood pressure.
      Title: Importance of the renal ion channel TRPM6 in the circadian secretion of renin to raise blood pressure.
    2. increased urinary UMOD secretion in low-magnesium states reduces TRPM6 endocytosis and thereby up-regulates TRPM6 cell-surface abundance to defend against further urinary magn
      Title: Uromodulin regulates renal magnesium homeostasis through the ion channel transient receptor potential melastatin 6 (TRPM6).
    3. mTRPM6 and mTRPM7 contribute differentially to key functional characteristics of mTRPM6/7 complexes thereby functionally defining a new type of channel that remains active in the presence of physiological concentrations of [Mg2+]i and [Mg.ATP]i.
      Title: TRPM6 and TRPM7 differentially contribute to the relief of heteromeric TRPM6/7 channels from inhibition by cytosolic Mg(2+) and Mg·ATP.
    4. Hence, maintenance of organismal Mg(2+) balance by TRPM6 is crucial for prenatal development and survival to adulthood.
      Title: Epithelial magnesium transport by TRPM6 is essential for prenatal development and adult survival.
    5. TRPM6 mRNA increased during the last 4 days of pregnancy, coinciding with fetal bone mineralization in mice. TRPM6 mRNA and protein was localized in the trophoblasts in labyrinth where the maternal-fetal Ca(2+) transport occurs. In patch-clamp recordings, we observed TRPM6/TRPM7-like currents in mouse trophoblasts after starting fetal bone mineralization but not before mineralization.
      Title: Expression of the TRPM6 in mouse placental trophoblasts; potential role in maternal-fetal calcium transport.
    6. in a model of inherited hypomagnesemia, TRPM6 and TRPM7, but not paracellin-1, are downregulated
      Title: Dysregulation of renal transient receptor potential melastatin 6/7 but not paracellin-1 in aldosterone-induced hypertension and kidney damage in a model of hereditary hypomagnesemia.
    7. TRPM6 deletion is embryonic lethal in mice; Heterozygous deletion of TRPM6 results in a mild hypomagnesemia
      Title: Transient receptor potential melastatin 6 knockout mice are lethal whereas heterozygous deletion results in mild hypomagnesemia.
    8. consistently reduced expression of TRPM6 mRNA may play a role in the pathogenesis of hypomagnesemia in C57BL/6 asthmatic mice.
      Title: Decreased renal mRNA expression of TRPM6 is associated with hypomagnesemia in C57BL/6 asthmatic mice.
    9. MsrB1 recovers TRPM6 channel activity by reducing the oxidation of Met(1755) and could, thereby, function as a modulator of TRPM6 during oxidative stress.
      Title: Methionine sulfoxide reductase B1 (MsrB1) recovers TRPM6 channel activity during oxidative stress.
    10. Trpm6(-/-) mice almost never survived to weaning and show neural tube defects.
      Title: Mice defective in Trpm6 show embryonic mortality and neural tube defects.
    Submit: New GeneRIF Correction See all GeneRIFs (13)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monoatomic cation channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables monoatomic cation channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in calcium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in magnesium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in metal ion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within metal ion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in monoatomic cation transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein tetramerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to toxic substance IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to toxic substance ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in apical plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in brush border membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    transient receptor potential cation channel subfamily M member 6
    Names
    melastatin-related TRP cation channel 6
    putative cation channel subfamily M member 6
    transient receptor potential cation channel 6/channel-kinase 2
    NP_700466.1
    XP_006527014.1
    XP_006527015.1
    XP_011245528.1
    XP_017173641.1
    XP_017173642.1
    XP_030106746.1
    XP_036017442.1
    XP_036017443.1
    XP_036017444.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_153417.2 → NP_700466.1  transient receptor potential cation channel subfamily M member 6

      See identical proteins and their annotated locations for NP_700466.1

      Status: VALIDATED

      Source sequence(s)
      AC134906, AC140458
      Consensus CDS
      CCDS29691.1
      UniProtKB/Swiss-Prot
      Q8CIR4
      UniProtKB/TrEMBL
      A0A1W5LU38
      Related
      ENSMUSP00000037443.8, ENSMUST00000040489.9
      Conserved Domains (3) summary
      smart00811
      Location:1760 → 1978
      Alpha_kinase; Alpha-kinase family
      pfam16519
      Location:1180 → 1231
      TRPM_tetra; Tetramerisation domain of TRPM
      cl26777
      Location:661 → 1111
      TRP_2; Transient receptor ion channel II

    RNA

    1. NR_157571.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC134906, AC140458
      Related
      ENSMUST00000236199.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      18707566..18869885
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006526951.4 → XP_006527014.1  transient receptor potential cation channel subfamily M member 6 isoform X1

      Conserved Domains (4) summary
      TIGR00870
      Location:660 → 1110
      trp; transient-receptor-potential calcium channel protein
      cd16972
      Location:1741 → 1979
      Alpha_kinase_ChaK2_TRPM6; Alpha-kinase domain of channel kinase 2, also called transient receptor potential cation channel subfamily M member 6
      pfam16519
      Location:1175 → 1230
      TRPM_tetra; Tetramerisation domain of TRPM
      pfam18139
      Location:99 → 362
      LSDAT_euk; SLOG in TRPM

    2. XM_017318152.2 → XP_017173641.1  transient receptor potential cation channel subfamily M member 6 isoform X1

      Conserved Domains (4) summary
      TIGR00870
      Location:660 → 1110
      trp; transient-receptor-potential calcium channel protein
      cd16972
      Location:1741 → 1979
      Alpha_kinase_ChaK2_TRPM6; Alpha-kinase domain of channel kinase 2, also called transient receptor potential cation channel subfamily M member 6
      pfam16519
      Location:1175 → 1230
      TRPM_tetra; Tetramerisation domain of TRPM
      pfam18139
      Location:99 → 362
      LSDAT_euk; SLOG in TRPM

    3. XM_030250886.2 → XP_030106746.1  transient receptor potential cation channel subfamily M member 6 isoform X6

      Conserved Domains (4) summary
      TIGR00870
      Location:544 → 994
      trp; transient-receptor-potential calcium channel protein
      cd16972
      Location:1625 → 1863
      Alpha_kinase_ChaK2_TRPM6; Alpha-kinase domain of channel kinase 2, also called transient receptor potential cation channel subfamily M member 6
      pfam16519
      Location:1059 → 1114
      TRPM_tetra; Tetramerisation domain of TRPM
      pfam18139
      Location:1 → 246
      LSDAT_euk; SLOG in TRPM

    4. XM_017318153.3 → XP_017173642.1  transient receptor potential cation channel subfamily M member 6 isoform X2

      Conserved Domains (4) summary
      TIGR00870
      Location:661 → 1111
      trp; transient-receptor-potential calcium channel protein
      cd16972
      Location:1741 → 1979
      Alpha_kinase_ChaK2_TRPM6; Alpha-kinase domain of channel kinase 2, also called transient receptor potential cation channel subfamily M member 6
      pfam16519
      Location:1176 → 1231
      TRPM_tetra; Tetramerisation domain of TRPM
      pfam18139
      Location:100 → 363
      LSDAT_euk; SLOG in TRPM

    5. XM_036161550.1 → XP_036017443.1  transient receptor potential cation channel subfamily M member 6 isoform X5

      Conserved Domains (4) summary
      TIGR00870
      Location:905 → 1068
      trp; transient-receptor-potential calcium channel protein
      cd16972
      Location:1699 → 1937
      Alpha_kinase_ChaK2_TRPM6; Alpha-kinase domain of channel kinase 2, also called transient receptor potential cation channel subfamily M member 6
      pfam16519
      Location:1133 → 1187
      TRPM_tetra; Tetramerisation domain of TRPM
      pfam18139
      Location:101 → 363
      LSDAT_euk; SLOG in TRPM

    6. XM_036161549.1 → XP_036017442.1  transient receptor potential cation channel subfamily M member 6 isoform X3

      Conserved Domains (4) summary
      TIGR00870
      Location:648 → 1098
      trp; transient-receptor-potential calcium channel protein
      cd16972
      Location:1729 → 1967
      Alpha_kinase_ChaK2_TRPM6; Alpha-kinase domain of channel kinase 2, also called transient receptor potential cation channel subfamily M member 6
      pfam16519
      Location:1163 → 1217
      TRPM_tetra; Tetramerisation domain of TRPM
      pfam18139
      Location:88 → 350
      LSDAT_euk; SLOG in TRPM

    7. XM_036161551.1 → XP_036017444.1  transient receptor potential cation channel subfamily M member 6 isoform X7

      Conserved Domains (1) summary
      pfam18139
      Location:101 → 339
      LSDAT_euk; SLOG in TRPM

    8. XM_006526952.4 → XP_006527015.1  transient receptor potential cation channel subfamily M member 6 isoform X8

      Conserved Domains (1) summary
      pfam18139
      Location:100 → 328
      LSDAT_euk; SLOG in TRPM

    9. XM_011247226.3 → XP_011245528.1  transient receptor potential cation channel subfamily M member 6 isoform X4

      Conserved Domains (4) summary
      TIGR00870
      Location:645 → 1095
      trp; transient-receptor-potential calcium channel protein
      cd16972
      Location:1726 → 1964
      Alpha_kinase_ChaK2_TRPM6; Alpha-kinase domain of channel kinase 2, also called transient receptor potential cation channel subfamily M member 6
      pfam16519
      Location:1160 → 1215
      TRPM_tetra; Tetramerisation domain of TRPM
      pfam18139
      Location:84 → 347
      LSDAT_euk; SLOG in TRPM
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CIR4.1 GenPept UniProtKB/Swiss-Prot:Q8CIR4

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