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    Fyb2 FYN binding protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 242594, updated on 17-Aug-2024

    Summary

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    Official Symbol
    Fyb2provided by MGI
    Official Full Name
    FYN binding protein 2provided by MGI
    Primary source
    MGI:MGI:2685466
    See related
    Ensembl:ENSMUSG00000078612 AllianceGenome:MGI:2685466
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ARAP; Gm620; C1orf168; 1700024P16Rik
    Summary
    Predicted to be involved in cell adhesion mediated by integrin; cell surface receptor signaling pathway; and protein localization to plasma membrane. Predicted to be located in immunological synapse and membrane raft. Predicted to be active in plasma membrane. Orthologous to human FYB2 (FYN binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in genital fat pad adult (RPKM 1.2), testis adult (RPKM 1.0) and 15 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Fyb2 in Genome Data Viewer
    Location:
    4 C6; 4 48.86 cM
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (104692431..104874061)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (104835301..105016864)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene disabled 1 Neighboring gene predicted gene, 36661 Neighboring gene STARR-seq mESC enhancer starr_10944 Neighboring gene STARR-seq mESC enhancer starr_10945 Neighboring gene STARR-seq mESC enhancer starr_10949 Neighboring gene STARR-seq mESC enhancer starr_10950 Neighboring gene complement component 8, beta polypeptide Neighboring gene predicted gene, 40216 Neighboring gene complement component 8, alpha polypeptide Neighboring gene predicted gene 12721 Neighboring gene VISTA enhancer mm1176 Neighboring gene predicted gene, 52670 Neighboring gene protein kinase, AMP-activated, alpha 2 catalytic subunit Neighboring gene predicted gene, 36893

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    2. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
    3. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article
    4. Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. Carninci P, et al. Genome Res, 2000 Oct. PMID 11042159, Free PMC Article
    5. Functional annotation of a full-length mouse cDNA collection. Kawai J, et al. Nature, 2001 Feb 8. PMID 11217851

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC169347

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in T cell receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in T cell receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell adhesion mediated by integrin ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in integrin-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in immunological synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane raft ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    FYN-binding protein 2
    Names
    activation-dependent, raft-recruited ADAP-like phosphoprotein
    uncharacterized protein C1orf168 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001162980.2 → NP_001156452.2  FYN-binding protein 2 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.
      Source sequence(s)
      AL627186, AL929466
      Consensus CDS
      CCDS51250.2
      UniProtKB/Swiss-Prot
      A2A995
      UniProtKB/TrEMBL
      B2RQ28
      Related
      ENSMUSP00000102416.2, ENSMUST00000106804.2
      Conserved Domains (1) summary
      cl17036
      Location:651 → 723
      SH3; Src Homology 3 domain superfamily

    2. NM_001285952.2 → NP_001272881.2  FYN-binding protein 2 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AL627186, AL929466
      UniProtKB/TrEMBL
      B2RQ28
      Conserved Domains (1) summary
      cl17036
      Location:677 → 749
      SH3; Src Homology 3 domain superfamily

    3. NM_001285953.2 → NP_001272882.1  FYN-binding protein 2 isoform c

      See identical proteins and their annotated locations for NP_001272882.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in its 5' UTR, initiates translation at a downstream in-frame start codon, and lacks an alternate in-frame exon in the central coding region, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus, compared to isoform a.
      Source sequence(s)
      AL627186, AL929466
      UniProtKB/TrEMBL
      B2RQ28
      Conserved Domains (1) summary
      cl17036
      Location:624 → 696
      SH3; Src Homology 3 domain superfamily

    RNA

    1. NR_104376.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an alternate exon and uses an alternate splice site in the central region, and includes an additional exon in the 3' region, compared to variant 1. This variant is represented as non-coding because use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AL627186, AL929466

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      104692431..104874061
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017320219.3 → XP_017175708.1  FYN-binding protein 2 isoform X1

      UniProtKB/TrEMBL
      B2RQ28, E9PZ08
      Conserved Domains (1) summary
      cl17036
      Location:715 → 787
      SH3; Src Homology 3 domain superfamily

    2. XM_006503083.4 → XP_006503146.1  FYN-binding protein 2 isoform X2

      See identical proteins and their annotated locations for XP_006503146.1

      UniProtKB/TrEMBL
      B2RQ28
      Conserved Domains (1) summary
      cl17036
      Location:624 → 696
      SH3; Src Homology 3 domain superfamily

    3. XM_006503085.3 → XP_006503148.1  FYN-binding protein 2 isoform X3

      Conserved Domains (1) summary
      cl17036
      Location:401 → 473
      SH3; Src Homology 3 domain superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A2A995.1 GenPept UniProtKB/Swiss-Prot:A2A995

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