RGS3 regulator of G protein signaling 3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: RGS3provided by HGNC
Official Full Name: regulator of G protein signaling 3provided by HGNC
Primary source: HGNC:HGNC:9999
See related: Ensembl:ENSG00000138835 MIM:602189; AllianceGenome:HGNC:9999
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: C2PA; RGP3
Summary: This gene encodes a member of the regulator of G-protein signaling (RGS) family. This protein is a GTPase-activating protein that inhibits G-protein-mediated signal transduction. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms. Long isoforms are largely cytosolic and plasma membrane-associated with a function in Wnt signaling and in the epithelial mesenchymal transition, while shorter N-terminally-truncated isoforms can be nuclear. [provided by RefSeq, Jan 2013]
Expression: Ubiquitous expression in heart (RPKM 8.0), fat (RPKM 4.2) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 9q32

Exon count:: 34

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	9	NC_000009.12 (113444730..113597738)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	9	NC_060933.1 (125643547..125796339)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	9	NC_000009.11 (116207010..116360018)

Chromosome 9 - NC_000009.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RGS3 and IL1RAPL1 missense variants implicate defective neurotransmission in early-onset inherited schizophrenias.
Title: RGS3 and IL1RAPL1 missense variants implicate defective neurotransmission in early-onset inherited schizophrenias.
Pseudogene UBE2MP1 derived transcript enhances in vitro cell proliferation and apoptosis resistance of hepatocellular carcinoma cells through miR-145-5p/RGS3 axis.
Title: Pseudogene UBE2MP1 derived transcript enhances in vitro cell proliferation and apoptosis resistance of hepatocellular carcinoma cells through miR-145-5p/RGS3 axis.
The G protein signaling regulator RGS3 enhances the GTPase activity of KRAS.
Title: The G protein signaling regulator RGS3 enhances the GTPase activity of KRAS.
Regulator of G-protein signalling 3 and its regulator microRNA-133a mediate cell proliferation in gastric cancer.
Title: Regulator of G-protein signalling 3 and its regulator microRNA-133a mediate cell proliferation in gastric cancer.
A Multi-Trait Approach Identified Genetic Variants Including a Rare Mutation in RGS3 with Impact on Abnormalities of Cardiac Structure/Function.
Title: A Multi-Trait Approach Identified Genetic Variants Including a Rare Mutation in RGS3 with Impact on Abnormalities of Cardiac Structure/Function.
The present study revealed that miR1263p plays a role as a tumor suppressor in regulating TNBC cell activities by targeting RGS3.
Title: MicroRNA‑126‑3p inhibits the proliferation, migration, invasion, and angiogenesis of triple‑negative breast cancer cells by targeting RGS3.
It has been reported that mitotic kinesin KIF20A interacts with RGS3 and plays a crucial role in controlling the division modes of neural progenitor cells during cortical neurogenesis.
Title: KIF20A/MKLP2 regulates the division modes of neural progenitor cells during cortical development.
Findings suggest that overexpressed RGS3 regulated by microRNA-126 through the post-transcriptional modulation is associated significantly with a poor prognosis of GC patients.
Title: Regulator of G-protein signaling 3 targeted by miR-126 correlates with poor prognosis in gastric cancer patients.
Our data provide a novel miR-25/RGS3 signal in the development of lung cancer.
Title: Elevated microRNA-25 inhibits cell apoptosis in lung cancer by targeting RGS3.
cardiac overexpression of RGS3 inhibits maladaptive hypertrophy and fibrosis and improves cardiac function by blocking MEK-ERK1/2 signaling
Title: Regulator of G protein signaling 3 protects against cardiac hypertrophy in mice.

Submit: New GeneRIF Correction See all GeneRIFs (25)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH45468 (e-PCR)
- UniSTS:46597

WI-14933 (e-PCR)
- UniSTS:72722

D9S106 (e-PCR), detects polymorphism
- UniSTS:21315

RH36572 (e-PCR)
- UniSTS:30024

RH80823 (e-PCR)
- UniSTS:84824

D9S1152 (e-PCR)
- UniSTS:58721

SHGC-149841 (e-PCR)
- UniSTS:177253

STS-W94230 (e-PCR)
- UniSTS:24169

D9S279 (e-PCR)
- UniSTS:36718

MARC_8225-8226:996688427:1 (e-PCR)
- UniSTS:269935

D9S279 (e-PCR)
- UniSTS:79472

SHGC-154031 (e-PCR)
- UniSTS:184948

A002B06 (e-PCR)
- UniSTS:35200

STS-M78362 (e-PCR)
- UniSTS:80005

G42195 (e-PCR)
- UniSTS:105113

SHGC-81067 (e-PCR)
- UniSTS:103579

RGS3_1429 (e-PCR)
- UniSTS:277669

RGS3_v471 (e-PCR)
- UniSTS:277669

SHGC-149632 (e-PCR)
- UniSTS:177127

SHGC-24301 (e-PCR)
- UniSTS:43002

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables GTPase activator activity	TAS Traceable Author Statement more info	PubMed
enables GTPase activity	TAS Traceable Author Statement more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	TAS Traceable Author Statement more info
involved_in negative regulation of signal transduction	IEA Inferred from Electronic Annotation more info
involved_in regulation of G protein-coupled receptor signaling pathway	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	TAS Traceable Author Statement more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: regulator of G-protein signaling 3

Names: regulator of G-protein signalling 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029512.1 RefSeqGene

Range

23997..158008

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001276260.2 → NP_001263189.1 regulator of G-protein signaling 3 isoform 2

See identical proteins and their annotated locations for NP_001263189.1

Status: REVIEWED

Description

Transcript Variant: This variant (7) lacks several 5' exons but includes an alternate 5' exon, and it thus differs in the 5' UTR, lacks a large portion of the 5' coding region, and uses a downstream in-frame start codon, compared to variant 6. The encoded isoform (2) is significantly shorter at the N-terminus, compared to isoform 6. Variants 2, 7 and 13 encode the same isoform (2).

Source sequence(s)

AK123387, AK226153, BM690084, U27655

Consensus CDS

CCDS6798.1

UniProtKB/TrEMBL

B3KVT7

Related

ENSP00000420356.1, ENST00000462143.5

Conserved Domains (2) summary

cd08713
Location:395 → 508

RGS_RGS3; Regulator of G protein signaling (RGS) domain found in the RGS3 protein

cl26464
Location:20 → 180

Atrophin-1; Atrophin-1 family
NM_001276261.2 → NP_001263190.1 regulator of G-protein signaling 3 isoform 7

See identical proteins and their annotated locations for NP_001263190.1

Status: REVIEWED

Description

Transcript Variant: This variant (8) lacks several 5' exons but includes an alternate 5' exon, and it thus differs in the 5' UTR and 5' coding region, and it lacks an alternate in-frame exon in the 3' coding region, compared to variant 6. The encoded isoform (7) is shorter and has a distinct N-terminus, compared to isoform 6.

Source sequence(s)

AK096840, AK226153, BM690084

Consensus CDS

CCDS65111.1

UniProtKB/Swiss-Prot

P49796

Related

ENSP00000378141.3, ENST00000394646.7

Conserved Domains (2) summary

cd08713
Location:467 → 580

RGS_RGS3; Regulator of G protein signaling (RGS) domain found in the RGS3 protein

cd00992
Location:17 → 91

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
NM_001276262.2 → NP_001263191.1 regulator of G-protein signaling 3 isoform 4

See identical proteins and their annotated locations for NP_001263191.1

Status: REVIEWED

Description

Transcript Variant: This variant (9) lacks several 5' exons but includes an alternate 5' exon, and it thus differs in the 5' UTR, lacks a large portion of the 5' coding region, and uses a downstream in-frame start codon, compared to variant 6. The encoded isoform (4, also known as RGS3S in PubMedID:11330340) is significantly shorter at the N-terminus, compared to isoform 6. Both variants 4 and 9 encode isoform 4.

Source sequence(s)

AL162727, BC019039, BE256545

UniProtKB/TrEMBL

H7BXY1

Conserved Domains (1) summary

cd08713
Location:44 → 157

RGS_RGS3; Regulator of G protein signaling (RGS) domain found in the RGS3 protein
NM_001282922.2 → NP_001269851.1 regulator of G-protein signaling 3 isoform 2

See identical proteins and their annotated locations for NP_001269851.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks several 5' exons but includes an alternate 5' exon, and it thus differs in the 5' UTR, lacks a large portion of the 5' coding region, and uses a downstream in-frame start codon, compared to variant 6. The encoded isoform (2) is significantly shorter at the N-terminus, compared to isoform 6. Variants 2, 7 and 13 encode the same isoform (2).

Source sequence(s)

BC019039, DA875652, U27655

Consensus CDS

CCDS6798.1

UniProtKB/TrEMBL

B3KVT7

Related

ENSP00000363249.3, ENST00000374134.7

Conserved Domains (2) summary

cd08713
Location:395 → 508

RGS_RGS3; Regulator of G protein signaling (RGS) domain found in the RGS3 protein

cl26464
Location:20 → 180

Atrophin-1; Atrophin-1 family
NM_001282923.2 → NP_001269852.1 regulator of G-protein signaling 3 isoform 8

See identical proteins and their annotated locations for NP_001269852.1

Status: REVIEWED

Description

Transcript Variant: This variant (10) uses an alternate 5' structure and thus differs in the 5' UTR and 5' coding region compared to variant 6. These differences cause translation initiation at an alternate AUG and result in an isoform (8) with a shorter and distinct N-terminus, compared to isoform 6.

Source sequence(s)

AF463495, AK074977, AK125059, AK226153, BM690084, DA680346

UniProtKB/TrEMBL

B3KWG8

Related

ENST00000478599.5

Conserved Domains (6) summary

cd08685
Location:44 → 148

C2_RGS-like; C2 domain of the Regulator Of G-Protein Signaling (RGS) family

cd08713
Location:964 → 1077

RGS_RGS3; Regulator of G protein signaling (RGS) domain found in the RGS3 protein

COG0265
Location:209 → 264

DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]

cd00992
Location:190 → 262

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam16228
Location:533 → 699

DUF4887; Domain of unknown function (DUF4887)

cl23807
Location:588 → 661

WWbp; WW-domain ligand protein
NM_001322214.3 → NP_001309143.1 regulator of G-protein signaling 3 isoform 9

Status: REVIEWED

Source sequence(s)

AL162727, AL359455

UniProtKB/TrEMBL

Q53GP3

Conserved Domains (1) summary

cd00992
Location:17 → 91

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
NM_001322215.2 → NP_001309144.1 regulator of G-protein signaling 3 isoform 10

Status: REVIEWED

Source sequence(s)

AL162727

UniProtKB/TrEMBL

B3KVT7

Conserved Domains (1) summary

cd08713
Location:413 → 526

RGS_RGS3; Regulator of G protein signaling (RGS) domain found in the RGS3 protein
NM_001351526.2 → NP_001338455.1 regulator of G-protein signaling 3 isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (13) lacks several 5' exons but includes several alternate exons in the 5' region, and it thus differs in the 5' UTR, lacks a large portion of the 5' coding region, and uses a downstream in-frame start codon, compared to variant 6. The encoded isoform (2) is significantly shorter at the N-terminus, compared to isoform 6. Variants 2, 7 and 13 encode the same isoform (2).

Source sequence(s)

AF463495, AL162727, AY585192, BE385269, BP257809, BQ953216, DA575364

Consensus CDS

CCDS6798.1

UniProtKB/TrEMBL

B3KVT7

Conserved Domains (2) summary

cd08713
Location:395 → 508

RGS_RGS3; Regulator of G protein signaling (RGS) domain found in the RGS3 protein

cl26464
Location:20 → 180

Atrophin-1; Atrophin-1 family
NM_001394167.1 → NP_001381096.1 regulator of G-protein signaling 3 isoform 11

Status: REVIEWED

Source sequence(s)

AL137066, AL162727, AL359455

Consensus CDS

CCDS94464.1

UniProtKB/TrEMBL

A0A8Q3WKG2, B3KWG8

Related

ENSP00000511882.1, ENST00000695401.1

Conserved Domains (4) summary

cd08685
Location:27 → 146

C2_RGS-like; C2 domain of the Regulator Of G-Protein Signaling (RGS) family

cd08713
Location:962 → 1075

RGS_RGS3; Regulator of G protein signaling (RGS) domain found in the RGS3 protein

PHA03247
Location:578 → 740

PHA03247; large tegument protein UL36; Provisional

cd00992
Location:188 → 260

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
NM_017790.6 → NP_060260.3 regulator of G-protein signaling 3 isoform 3

See identical proteins and their annotated locations for NP_060260.3

Status: REVIEWED

Source sequence(s)

AL137066, AL162727, AL359455

Consensus CDS

CCDS35113.1

UniProtKB/Swiss-Prot

P49796

UniProtKB/TrEMBL

B3KWG8, Q53GP3

Related

ENSP00000312844.6, ENST00000317613.10

Conserved Domains (3) summary

cd08685
Location:27 → 146

C2_RGS-like; C2 domain of the Regulator Of G-Protein Signaling (RGS) family

COG0265
Location:207 → 262

DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]

cd00992
Location:188 → 260

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
NM_130795.4 → NP_570613.2 regulator of G-protein signaling 3 isoform 1

See identical proteins and their annotated locations for NP_570613.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) lacks several 5' exons but includes an alternate 5' exon, and it thus differs in the 5' UTR and 5' coding region, compared to variant 6. The encoded isoform (1, also known as PDZ-RGS3) has a shorter and distinct N-terminus, compared to isoform 6.

Source sequence(s)

AF463495, AK226153, BC042555, BM690084

Consensus CDS

CCDS6797.1

UniProtKB/TrEMBL

B3KWG8

Related

ENSP00000340284.5, ENST00000343817.9

Conserved Domains (4) summary

cd08713
Location:793 → 906

RGS_RGS3; Regulator of G protein signaling (RGS) domain found in the RGS3 protein

COG0265
Location:38 → 93

DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]

cd00992
Location:17 → 91

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam16228
Location:362 → 528

DUF4887; Domain of unknown function (DUF4887)
NM_134427.3 → NP_602299.1 regulator of G-protein signaling 3 isoform 4

See identical proteins and their annotated locations for NP_602299.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) lacks several 5' exons but includes an alternate 5' exon, and it thus differs in the 5' UTR, lacks a large portion of the 5' coding region, and uses a downstream in-frame start codon, compared to variant 6. The encoded isoform (4, also known as RGS3S in PubMed ID:11330340) is significantly shorter at the N-terminus, compared to isoform 6. Both variants 4 and 9 encode isoform 4.

Source sequence(s)

BC019039, BE298009, BP257809

UniProtKB/TrEMBL

H7BXY1

Related

ENSP00000343359.5, ENST00000342620.9

Conserved Domains (1) summary

cd08713
Location:44 → 157

RGS_RGS3; Regulator of G protein signaling (RGS) domain found in the RGS3 protein
NM_144488.8 → NP_652759.4 regulator of G-protein signaling 3 isoform 12

Status: REVIEWED

Source sequence(s)

AL137066, AL162727, AL359455

Consensus CDS

CCDS43869.1

UniProtKB/TrEMBL

B3KWG8

Related

ENSP00000363255.2, ENST00000374140.6

Conserved Domains (4) summary

cd08685
Location:35 → 154

C2_RGS-like; C2 domain of the Regulator Of G-Protein Signaling (RGS) family

cd08713
Location:970 → 1083

RGS_RGS3; Regulator of G protein signaling (RGS) domain found in the RGS3 protein

PHA03247
Location:586 → 748

PHA03247; large tegument protein UL36; Provisional

cd00992
Location:196 → 268

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
NM_144489.4 → NP_652760.3 regulator of G-protein signaling 3 isoform 5

Status: REVIEWED

Source sequence(s)

AL162727

Consensus CDS

CCDS35114.2

UniProtKB/TrEMBL

A0A087WUY2

Related

ENSP00000479017.1, ENST00000620489.1

Conserved Domains (1) summary

cd08713
Location:68 → 181

RGS_RGS3; Regulator of G protein signaling (RGS) domain found in the RGS3 protein