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    ART5 ADP-ribosyltransferase 5 [ Homo sapiens (human) ]

    Gene ID: 116969, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ART5provided by HGNC
    Official Full Name
    ADP-ribosyltransferase 5provided by HGNC
    Primary source
    HGNC:HGNC:24049
    See related
    Ensembl:ENSG00000167311 MIM:610625; AllianceGenome:HGNC:24049
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ARTC5
    Summary
    The protein encoded by this gene belongs to the ARG-specific ADP-ribosyltransferase family. Proteins in this family regulate the function of target proteins by attaching ADP-ribose to specific amino acid residues in their target proteins. The mouse homolog lacks a glycosylphosphatidylinositol-anchor signal sequence and is predicted to be a secretory enzyme. Several transcripts encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
    Expression
    Biased expression in testis (RPKM 6.5), ovary (RPKM 2.3) and 5 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ART5 in Genome Data Viewer
    Location:
    11p15.4
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (3638512..3642379, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (3683946..3687812, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (3659742..3663609, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene XRCC1 N-terminal domain containing 1, C-terminal like pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:3636766-3637290 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:3637291-3637815 Neighboring gene transient receptor potential cation channel subfamily C member 2 (pseudogene) Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:3662929-3663642 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3081 Neighboring gene ADP-ribosyltransferase 1 Neighboring gene cholinergic receptor nicotinic alpha 10 subunit

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Characterization of glycosylphosphatidylinositiol-anchored, secreted, and intracellular vertebrate mono-ADP-ribosyltransferases. Okazaki IJ, et al. Annu Rev Nutr, 1999. PMID 10448534
    2. LncFALEC recruits ART5/PARP1 and promotes castration-resistant prostate cancer through enhancing PARP1-meditated self PARylation. Shi F, et al. Cell Oncol (Dordr), 2023 Jun. PMID 36913068
    3. The family of toxin-related ecto-ADP-ribosyltransferases in humans and the mouse. Glowacki G, et al. Protein Sci, 2002 Jul. PMID 12070318, Free PMC Article
    4. Structure, chromosomal localization, and expression of the gene for mouse ecto-mono(ADP-ribosyl)transferase ART5. Glowacki G, et al. Gene, 2001 Sep 19. PMID 11587854
    5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. Clark HF, et al. Genome Res, 2003 Oct. PMID 12975309, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LncFALEC recruits ART5/PARP1 and promotes castration-resistant prostate cancer through enhancing PARP1-meditated self PARylation.
      Title: LncFALEC recruits ART5/PARP1 and promotes castration-resistant prostate cancer through enhancing PARP1-meditated self PARylation.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC22848

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables NAD+-protein poly-ADP-ribosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NAD+-protein-arginine ADP-ribosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ecto-ADP-ribosyltransferase 5
    Names
    ADP-ribosyltransferase C2 and C3 toxin-like 5
    NAD(P)(+)--arginine ADP-ribosyltransferase 5
    mono(ADP-ribosyl)transferase 5
    NP_001073004.1
    NP_001284597.1
    NP_443750.2
    XP_005252836.1
    XP_006718199.1
    XP_011518181.1
    XP_054223583.1
    XP_054223584.1
    XP_054223585.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001079536.2 → NP_001073004.1  ecto-ADP-ribosyltransferase 5 isoform a precursor

      See identical proteins and their annotated locations for NP_001073004.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains a different 5' UTR compared to transcript variant 1. Variants 1 and 2 both encode the same isoform (a).
      Source sequence(s)
      AC060812, AW241897, CD557970, Y16835
      Consensus CDS
      CCDS7743.1
      UniProtKB/Swiss-Prot
      C9IYG7, Q6UX84, Q86W02, Q96L15
      Related
      ENSP00000352992.4, ENST00000359918.8
      Conserved Domains (1) summary
      pfam01129
      Location:28 → 254
      ART; NAD:arginine ADP-ribosyltransferase

    2. NM_001297668.2 → NP_001284597.1  ecto-ADP-ribosyltransferase 5 isoform b precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice junction at the 3' end of an exon and an alternate splice junction at the 5' end of the last exon compared to variant 1. The resulting isoform (b) lacks an alternate internal segment and has a longer and distinct C-terminus compared to isoform a.
      Source sequence(s)
      AC060812, AY358466
      Consensus CDS
      CCDS73242.1
      UniProtKB/Swiss-Prot
      Q96L15
      Related
      ENSP00000380257.3, ENST00000397067.7
      Conserved Domains (1) summary
      cl00173
      Location:28 → 196
      VIP2; VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of ...

    3. NM_053017.5 → NP_443750.2  ecto-ADP-ribosyltransferase 5 isoform a precursor

      See identical proteins and their annotated locations for NP_443750.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode the same isoform (a).
      Source sequence(s)
      AC060812, BC014577
      Consensus CDS
      CCDS7743.1
      UniProtKB/Swiss-Prot
      C9IYG7, Q6UX84, Q86W02, Q96L15
      Related
      ENSP00000380258.3, ENST00000397068.8
      Conserved Domains (1) summary
      pfam01129
      Location:28 → 254
      ART; NAD:arginine ADP-ribosyltransferase

    RNA

    1. NR_123732.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses an alternate splice junction at the 3' end of the first exon and and alternate splice junction at the 5' end of the second exon compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
      Source sequence(s)
      AC060812, BC014577, HY018364

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      3638512..3642379 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005252779.4 → XP_005252836.1  ecto-ADP-ribosyltransferase 5 isoform X2

      UniProtKB/TrEMBL
      H7C1W0
      Related
      ENSP00000402737.2, ENST00000453353.2
      Conserved Domains (1) summary
      pfam01129
      Location:28 → 254
      ART; NAD:arginine ADP-ribosyltransferase

    2. XM_011519879.4 → XP_011518181.1  ecto-ADP-ribosyltransferase 5 isoform X1

      See identical proteins and their annotated locations for XP_011518181.1

      UniProtKB/TrEMBL
      H7C1W0
      Conserved Domains (1) summary
      pfam01129
      Location:28 → 254
      ART; NAD:arginine ADP-ribosyltransferase

    3. XM_006718136.5 → XP_006718199.1  ecto-ADP-ribosyltransferase 5 isoform X1

      See identical proteins and their annotated locations for XP_006718199.1

      UniProtKB/TrEMBL
      H7C1W0
      Conserved Domains (1) summary
      pfam01129
      Location:28 → 254
      ART; NAD:arginine ADP-ribosyltransferase

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      3683946..3687812 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054367609.1 → XP_054223584.1  ecto-ADP-ribosyltransferase 5 isoform X2

    2. XM_054367608.1 → XP_054223583.1  ecto-ADP-ribosyltransferase 5 isoform X1

    3. XM_054367610.1 → XP_054223585.1  ecto-ADP-ribosyltransferase 5 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96L15.4 GenPept UniProtKB/Swiss-Prot:Q96L15

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