STAU1 staufen double-stranded RNA binding protein 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: STAU1provided by HGNC
Official Full Name: staufen double-stranded RNA binding protein 1provided by HGNC
Primary source: HGNC:HGNC:11370
See related: Ensembl:ENSG00000124214 MIM:601716; AllianceGenome:HGNC:11370
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: STAU; PPP1R150
Summary: Staufen is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. The human homologue of staufen encoded by STAU, in addition contains a microtubule- binding domain similar to that of microtubule-associated protein 1B, and binds tubulin. The STAU gene product has been shown to be present in the cytoplasm in association with the rough endoplasmic reticulum (RER), implicating this protein in the transport of mRNA via the microtubule network to the RER, the site of translation. [provided by RefSeq, Apr 2020]
Expression: Ubiquitous expression in kidney (RPKM 41.4), thyroid (RPKM 35.8) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 20q13.13

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	20	NC_000020.11 (49113339..49219295, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	20	NC_060944.1 (50882825..50988811, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	20	NC_000020.10 (47729876..47835832, complement)

Chromosome 20 - NC_000020.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RNA-binding protein GIGYF2 orchestrates hepatic insulin resistance through STAU1/PTEN-mediated disruption of the PI3K/AKT signaling cascade.
Title: RNA-binding protein GIGYF2 orchestrates hepatic insulin resistance through STAU1/PTEN-mediated disruption of the PI3K/AKT signaling cascade.
STAU1-mediated CNBP mRNA degradation by LINC00665 alters stem cell characteristics in ovarian cancer.
Title: STAU1-mediated CNBP mRNA degradation by LINC00665 alters stem cell characteristics in ovarian cancer.
Excessive STAU1 condensate drives mTOR translation and autophagy dysfunction in neurodegeneration.
Title: Excessive STAU1 condensate drives mTOR translation and autophagy dysfunction in neurodegeneration.
Staufen1 Represses the FOXA1-Regulated Transcriptome by Destabilizing FOXA1 mRNA in Colorectal Cancer Cells.
Title: Staufen1 Represses the FOXA1-Regulated Transcriptome by Destabilizing FOXA1 mRNA in Colorectal Cancer Cells.
A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.
Title: A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.
Phosphomimicry on STAU1 Serine 20 Impairs STAU1 Posttranscriptional Functions and Induces Apoptosis in Human Transformed Cells.
Title: Phosphomimicry on STAU1 Serine 20 Impairs STAU1 Posttranscriptional Functions and Induces Apoptosis in Human Transformed Cells.
PART1 destabilized by NOVA2 regulates blood-brain barrier permeability in endothelial cells via STAU1-mediated mRNA degradation.
Title: PART1 destabilized by NOVA2 regulates blood-brain barrier permeability in endothelial cells via STAU1-mediated mRNA degradation.
Function of Host Protein Staufen1 in Rabies Virus Replication.
Title: Function of Host Protein Staufen1 in Rabies Virus Replication.
High Level of Staufen1 Expression Confers Longer Recurrence Free Survival to Non-Small Cell Lung Cancer Patients by Promoting THBS1 mRNA Degradation.
Title: High Level of Staufen1 Expression Confers Longer Recurrence Free Survival to Non-Small Cell Lung Cancer Patients by Promoting THBS1 mRNA Degradation.
Differential regulation of autophagy by STAU1 in alveolar rhabdomyosarcoma and non-transformed skeletal muscle cells.
Title: Differential regulation of autophagy by STAU1 in alveolar rhabdomyosarcoma and non-transformed skeletal muscle cells.

Submit: New GeneRIF Correction See all GeneRIFs (67)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study of proneness to anger. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	Tandem affinity purification and mass spectrometry analysis identify HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into Staufen1 ribonucleoprotein complexes isolated from HIV-1-expressing cells	PubMed
Gag-Pol	gag-pol	Tandem affinity purification and mass spectrometry analysis identify HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into Staufen1 ribonucleoprotein complexes isolated from HIV-1-expressing cells	PubMed
Nef	nef	Tandem affinity purification and mass spectrometry analysis identify HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into Staufen1 ribonucleoprotein complexes isolated from HIV-1-expressing cells	PubMed
Pr55(Gag)	gag	Staufen1, vRNA and Gag are found in the same ribonucleoprotein (RNP) complex. The depletion of Staufen1 results in reduced Gag levels and deregulates the assembly of newly synthesized virions	PubMed
	gag	Interaction of HIV-1 Gag with staufen is mediated by staufen's dsRBD3 domain	PubMed
	gag	Staufen is incorporated into HIV-1 virions through association with HIV-1 genomic RNA and is implicated in HIV-1 genome selection and packaging into assembling virions, a process that is mediated by the Nucleocapsid domain of HIV-1 Gag	PubMed
	gag	Tandem affinity purification and mass spectrometry analysis identify HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into Staufen1 ribonucleoprotein complexes isolated from HIV-1-expressing cells	PubMed
	gag	EAP30 interacts with HIV-1 Gag and Staufen1 in live cell tri-molecular fluorescence complementary assay	PubMed
	gag	HIV-1 Gag and Stau1 interact in both membrane-associated and cytosolic complexes. Stau1 overexpression and depletion by RNAi modulate Gag multimerization	PubMed
	gag	The NC zinc fingers mediate Stau1/Gag interaction. The N-terminal domain (residues 26-37) of Stau1 is required for its function in Gag multimerization	PubMed
nucleocapsid	gag	Staufen is incorporated into HIV-1 virions through association with HIV-1 genomic RNA and is implicated in HIV-1 genome selection and packaging into assembling virions, a process that is mediated by the Nucleocapsid domain of HIV-1 Gag	PubMed
	gag	The NC zinc fingers mediate Stau1/Gag interaction. The N-terminal domain (residues 26-37) of Stau1 is required for its function in Gag multimerization	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AL031479 (e-PCR)
- UniSTS:2337

RH12471 (e-PCR)
- UniSTS:4158

D20S1087 (e-PCR)
- UniSTS:473421

RH98959 (e-PCR)
- UniSTS:90704

WI-17676 (e-PCR)
- UniSTS:36982

G30939 (e-PCR)
- UniSTS:55934

RH11549 (e-PCR)
- UniSTS:71056

RH46281 (e-PCR)
- UniSTS:77280

Z94346 (e-PCR)
- UniSTS:32237

STS-T39112 (e-PCR)
- UniSTS:61934

RH101842 (e-PCR)
- UniSTS:96248

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables RNA binding	HDA more info	PubMed
enables double-stranded RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein phosphatase 1 binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in anterograde dendritic transport of messenger ribonucleoprotein complex	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to oxidative stress	IEA Inferred from Electronic Annotation more info
involved_in germ cell development	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular mRNA localization	IBA Inferred from Biological aspect of Ancestor more info
involved_in lncRNA-mediated post-transcriptional gene silencing	TAS Traceable Author Statement more info	PubMed
involved_in modification of postsynaptic structure	IEA Inferred from Electronic Annotation more info
involved_in positive regulation by virus of viral protein levels in host cell	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of long-term synaptic potentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of viral genome replication	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to synapse	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cell body	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic ribonucleoprotein granule	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasmic stress granule	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic stress granule	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IDA Inferred from Direct Assay more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite cytoplasm	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular exosome	HDA more info	PubMed
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
located_in membrane	HDA more info	PubMed
part_of microtubule associated complex	TAS Traceable Author Statement more info	PubMed
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
is_active_in neuronal cell body	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in rough endoplasmic reticulum	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: double-stranded RNA-binding protein Staufen homolog 1

Names: protein phosphatase 1, regulatory subunit 150; staufen, RNA binding protein, homolog 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029453.2 RefSeqGene

Range

45962..120957

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001037328.3 → NP_001032405.1 double-stranded RNA-binding protein Staufen homolog 1 isoform c

See identical proteins and their annotated locations for NP_001032405.1

Status: REVIEWED

Description

Transcript Variant: This variant (T5) differs in the 5' UTR and uses an alternate in-frame splice site in the 5' coding region compared to variant T2. The encoded isoform (c) is longer than isoform a. Both variants T5 and T6 encode the same isoform (c).

Source sequence(s)

AF061938, AK091405, BC010169, BC095397, BE439382

Consensus CDS

CCDS33481.1

UniProtKB/TrEMBL

Q5JW30

Conserved Domains (3) summary

smart00358
Location:105 → 175

DSRM; Double-stranded RNA binding motif

cd00048
Location:211 → 277

DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...

pfam16482
Location:373 → 482

Staufen_C; Staufen C-terminal domain
NM_001319134.2 → NP_001306063.1 double-stranded RNA-binding protein Staufen homolog 1 isoform c

Status: REVIEWED

Description

Transcript Variant: This variant (T6) uses an alternate in-frame splice site in the 5' coding region compared to variant T2. The encoded isoform (c) is longer than isoform a. Both variants T5 and T6 encode the same isoform (c).

Source sequence(s)

AK091405, AY546099, BE439382, BQ649508, DB100321

Consensus CDS

CCDS33481.1

UniProtKB/TrEMBL

Q5JW30

Related

ENSP00000360893.3, ENST00000371828.7

Conserved Domains (3) summary

smart00358
Location:105 → 175

DSRM; Double-stranded RNA binding motif

cd00048
Location:211 → 277

DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...

pfam16482
Location:373 → 482

Staufen_C; Staufen C-terminal domain
NM_001319135.2 → NP_001306064.1 double-stranded RNA-binding protein Staufen homolog 1 isoform b

Status: REVIEWED

Description

Transcript Variant: This variant (T7) differs in the 5' UTR and the 5' coding region, and uses an upstream translation start site compared to variant T2. The encoded isoform (b) has a longer and distinct N-terminus compared to isoform a. Both variants T3 and T7 encode the same isoform (b).

Source sequence(s)

AB209561, AK091405, BE439382, BQ649508, DB086071

Consensus CDS

CCDS13414.1

UniProtKB/Swiss-Prot

A8K9Z4, E1P5Y1, E1P608, O95793, Q5JW29, Q6GTM4, Q9H5B4, Q9H5B5, Q9Y3Q2

UniProtKB/TrEMBL

A8K622

Conserved Domains (3) summary

smart00358
Location:186 → 250

DSRM; Double-stranded RNA binding motif

cd00048
Location:286 → 352

DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...

pfam16482
Location:448 → 557

Staufen_C; Staufen C-terminal domain
NM_001322927.2 → NP_001309856.1 double-stranded RNA-binding protein Staufen homolog 1 isoform c

Status: REVIEWED

Source sequence(s)

AL133174, BE439382, DA455473, DA858410

Consensus CDS

CCDS33481.1

UniProtKB/TrEMBL

Q5JW30

Related

ENSP00000360867.1, ENST00000371802.5

Conserved Domains (3) summary

smart00358
Location:105 → 175

DSRM; Double-stranded RNA binding motif

cd00048
Location:211 → 277

DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...

pfam16482
Location:373 → 482

Staufen_C; Staufen C-terminal domain
NM_001322928.2 → NP_001309857.1 double-stranded RNA-binding protein Staufen homolog 1 isoform d

Status: REVIEWED

Source sequence(s)

AL133174, BE439382, DA455473, DA858410

UniProtKB/TrEMBL

Q5JW30

Conserved Domains (4) summary

pfam16482
Location:413 → 522

Staufen_C; Staufen C-terminal domain

cd19881
Location:41 → 105

DSRM_STAU1_rpt2; second double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 1 (Staufen 1) and similar proteins

cd19885
Location:241 → 326

DSRM_STAU1_rpt4; fourth double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 1 (Staufen 1) and similar proteins

cl00054
Location:142 → 214

DSRM_SF; double-stranded RNA binding motif (DSRM) superfamily
NM_001322929.2 → NP_001309858.1 double-stranded RNA-binding protein Staufen homolog 1 isoform b

Status: REVIEWED

Source sequence(s)

AL133174, BE439382

Consensus CDS

CCDS13414.1

UniProtKB/Swiss-Prot

A8K9Z4, E1P5Y1, E1P608, O95793, Q5JW29, Q6GTM4, Q9H5B4, Q9H5B5, Q9Y3Q2

UniProtKB/TrEMBL

A8K622

Conserved Domains (3) summary

smart00358
Location:186 → 250

DSRM; Double-stranded RNA binding motif

cd00048
Location:286 → 352

DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...

pfam16482
Location:448 → 557

Staufen_C; Staufen C-terminal domain
NM_001322930.2 → NP_001309859.1 double-stranded RNA-binding protein Staufen homolog 1 isoform b

Status: REVIEWED

Source sequence(s)

AL133174, BE439382, DA455473

Consensus CDS

CCDS13414.1

UniProtKB/Swiss-Prot

A8K9Z4, E1P5Y1, E1P608, O95793, Q5JW29, Q6GTM4, Q9H5B4, Q9H5B5, Q9Y3Q2

UniProtKB/TrEMBL

A8K622

Conserved Domains (3) summary

smart00358
Location:186 → 250

DSRM; Double-stranded RNA binding motif

cd00048
Location:286 → 352

DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...

pfam16482
Location:448 → 557

Staufen_C; Staufen C-terminal domain
NM_001322931.2 → NP_001309860.1 double-stranded RNA-binding protein Staufen homolog 1 isoform e

Status: REVIEWED

Source sequence(s)

AL133174, BE439382, DA455473, DA858410

UniProtKB/TrEMBL

Q5JW30
NM_001322932.2 → NP_001309861.1 double-stranded RNA-binding protein Staufen homolog 1 isoform f

Status: REVIEWED

Source sequence(s)

AL133174, BE439382

UniProtKB/TrEMBL

A8K622

Conserved Domains (3) summary

smart00358
Location:186 → 256

DSRM; Double-stranded RNA binding motif

cd00048
Location:292 → 358

DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...

pfam16482
Location:454 → 563

Staufen_C; Staufen C-terminal domain
NM_001322933.2 → NP_001309862.1 double-stranded RNA-binding protein Staufen homolog 1 isoform f

Status: REVIEWED

Source sequence(s)

AL133174, BE439382

UniProtKB/TrEMBL

A8K622

Conserved Domains (3) summary

smart00358
Location:186 → 256

DSRM; Double-stranded RNA binding motif

cd00048
Location:292 → 358

DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...

pfam16482
Location:454 → 563

Staufen_C; Staufen C-terminal domain
NM_004602.4 → NP_004593.2 double-stranded RNA-binding protein Staufen homolog 1 isoform a

See identical proteins and their annotated locations for NP_004593.2

Status: REVIEWED

Description

Transcript Variant: This variant (T4) has an additional exon in the 5' UTR compared to T2, the most abundantly expressed transcript variant. T4 encodes the same isoform (a) of 496 amino acids as T2.

Source sequence(s)

AF061941, AK091405, BC001893, BC050432, BC095397, BE439382

Consensus CDS

CCDS13415.1

UniProtKB/TrEMBL

Q5JW30

Related

ENSP00000345425.6, ENST00000340954.11

Conserved Domains (3) summary

smart00358
Location:105 → 169

DSRM; Double-stranded RNA binding motif

cd00048
Location:205 → 271

DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...

pfam16482
Location:367 → 476

Staufen_C; Staufen C-terminal domain
NM_017452.4 → NP_059346.2 double-stranded RNA-binding protein Staufen homolog 1 isoform a

See identical proteins and their annotated locations for NP_059346.2

Status: REVIEWED

Description

Transcript Variant: This variant (T2) is most abundantly expressed, and encodes the protein isoform (a) of 496 amino acids.

Source sequence(s)

AK091405, BC050432, BC095397, BE439382

Consensus CDS

CCDS13415.1

UniProtKB/TrEMBL

Q5JW30

Related

ENSP00000353604.4, ENST00000360426.8

Conserved Domains (3) summary

smart00358
Location:105 → 169

DSRM; Double-stranded RNA binding motif

cd00048
Location:205 → 271

DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...

pfam16482
Location:367 → 476

Staufen_C; Staufen C-terminal domain
NM_017453.4 → NP_059347.2 double-stranded RNA-binding protein Staufen homolog 1 isoform b

See identical proteins and their annotated locations for NP_059347.2

Status: REVIEWED

Description

Transcript Variant: This variant (T3) differs in the 5' UTR and the 5' coding region, and uses an upstream translation start site compared to variant T2. The encoded isoform (b) has a longer and distinct N-terminus compared to isoform a. Both variants T3 and T7 encode the same isoform (b).

Source sequence(s)

AL133174

Consensus CDS

CCDS13414.1

UniProtKB/Swiss-Prot

A8K9Z4, E1P5Y1, E1P608, O95793, Q5JW29, Q6GTM4, Q9H5B4, Q9H5B5, Q9Y3Q2

UniProtKB/TrEMBL

A8K622

Related

ENSP00000360922.2, ENST00000371856.7

Conserved Domains (3) summary

smart00358
Location:186 → 250

DSRM; Double-stranded RNA binding motif

cd00048
Location:286 → 352

DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...

pfam16482
Location:448 → 557

Staufen_C; Staufen C-terminal domain
NM_017454.4 → NP_059348.2 double-stranded RNA-binding protein Staufen homolog 1 isoform a

See identical proteins and their annotated locations for NP_059348.2

Status: REVIEWED

Description

Transcript Variant: This variant (T1) lacks an exon in the 5' UTR compared to T2, the most abundantly expressed transcript variant. T1 encodes the same isoform (a) of 496 amino acids as T2.

Source sequence(s)

AK091405, BC050432, BC095397, BE439382

Consensus CDS

CCDS13415.1

UniProtKB/TrEMBL

Q5JW30

Related

ENSP00000323443.7, ENST00000347458.9

Conserved Domains (3) summary

smart00358
Location:105 → 169

DSRM; Double-stranded RNA binding motif

cd00048
Location:205 → 271

DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...

pfam16482
Location:367 → 476

Staufen_C; Staufen C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000020.11 Reference GRCh38.p14 Primary Assembly

Range

49113339..49219295 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005260527.1 → XP_005260584.1 double-stranded RNA-binding protein Staufen homolog 1 isoform X5

See identical proteins and their annotated locations for XP_005260584.1

UniProtKB/TrEMBL

Q5JW30

Conserved Domains (3) summary

smart00358
Location:105 → 175

DSRM; Double-stranded RNA binding motif

cd00048
Location:211 → 277

DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...

pfam16482
Location:373 → 482

Staufen_C; Staufen C-terminal domain
XM_017028028.2 → XP_016883517.1 double-stranded RNA-binding protein Staufen homolog 1 isoform X4

UniProtKB/TrEMBL

Q5JW30
XM_047440423.1 → XP_047296379.1 double-stranded RNA-binding protein Staufen homolog 1 isoform X3
XM_006723865.2 → XP_006723928.1 double-stranded RNA-binding protein Staufen homolog 1 isoform X1

See identical proteins and their annotated locations for XP_006723928.1

UniProtKB/TrEMBL

A8K622

Conserved Domains (3) summary

smart00358
Location:186 → 256

DSRM; Double-stranded RNA binding motif

cd00048
Location:292 → 358

DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...

pfam16482
Location:454 → 563

Staufen_C; Staufen C-terminal domain
XM_047440420.1 → XP_047296376.1 double-stranded RNA-binding protein Staufen homolog 1 isoform X2

UniProtKB/Swiss-Prot

A8K9Z4, E1P5Y1, E1P608, O95793, Q5JW29, Q6GTM4, Q9H5B4, Q9H5B5, Q9Y3Q2
XM_047440416.1 → XP_047296372.1 double-stranded RNA-binding protein Staufen homolog 1 isoform X1
XM_047440419.1 → XP_047296375.1 double-stranded RNA-binding protein Staufen homolog 1 isoform X2

UniProtKB/Swiss-Prot

A8K9Z4, E1P5Y1, E1P608, O95793, Q5JW29, Q6GTM4, Q9H5B4, Q9H5B5, Q9Y3Q2
XM_047440414.1 → XP_047296370.1 double-stranded RNA-binding protein Staufen homolog 1 isoform X1
XM_047440418.1 → XP_047296374.1 double-stranded RNA-binding protein Staufen homolog 1 isoform X2

UniProtKB/Swiss-Prot

A8K9Z4, E1P5Y1, E1P608, O95793, Q5JW29, Q6GTM4, Q9H5B4, Q9H5B5, Q9Y3Q2
XM_047440415.1 → XP_047296371.1 double-stranded RNA-binding protein Staufen homolog 1 isoform X1
XM_047440422.1 → XP_047296378.1 double-stranded RNA-binding protein Staufen homolog 1 isoform X2

UniProtKB/Swiss-Prot

A8K9Z4, E1P5Y1, E1P608, O95793, Q5JW29, Q6GTM4, Q9H5B4, Q9H5B5, Q9Y3Q2
XM_047440421.1 → XP_047296377.1 double-stranded RNA-binding protein Staufen homolog 1 isoform X2

UniProtKB/Swiss-Prot

A8K9Z4, E1P5Y1, E1P608, O95793, Q5JW29, Q6GTM4, Q9H5B4, Q9H5B5, Q9Y3Q2
XM_047440417.1 → XP_047296373.1 double-stranded RNA-binding protein Staufen homolog 1 isoform X1
XM_047440424.1 → XP_047296380.1 double-stranded RNA-binding protein Staufen homolog 1 isoform X4

Alternate T2T-CHM13v2.0

Genomic

NC_060944.1 Alternate T2T-CHM13v2.0

Range

50882825..50988811 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054323930.1 → XP_054179905.1 double-stranded RNA-binding protein Staufen homolog 1 isoform X5
XM_054323928.1 → XP_054179903.1 double-stranded RNA-binding protein Staufen homolog 1 isoform X4
XM_054323927.1 → XP_054179902.1 double-stranded RNA-binding protein Staufen homolog 1 isoform X3
XM_054323919.1 → XP_054179894.1 double-stranded RNA-binding protein Staufen homolog 1 isoform X1
XM_054323925.1 → XP_054179900.1 double-stranded RNA-binding protein Staufen homolog 1 isoform X2

UniProtKB/Swiss-Prot

A8K9Z4, E1P5Y1, E1P608, O95793, Q5JW29, Q6GTM4, Q9H5B4, Q9H5B5, Q9Y3Q2
XM_054323924.1 → XP_054179899.1 double-stranded RNA-binding protein Staufen homolog 1 isoform X2

UniProtKB/Swiss-Prot

A8K9Z4, E1P5Y1, E1P608, O95793, Q5JW29, Q6GTM4, Q9H5B4, Q9H5B5, Q9Y3Q2
XM_054323920.1 → XP_054179895.1 double-stranded RNA-binding protein Staufen homolog 1 isoform X1
XM_054323921.1 → XP_054179896.1 double-stranded RNA-binding protein Staufen homolog 1 isoform X1
XM_054323923.1 → XP_054179898.1 double-stranded RNA-binding protein Staufen homolog 1 isoform X2

UniProtKB/Swiss-Prot

A8K9Z4, E1P5Y1, E1P608, O95793, Q5JW29, Q6GTM4, Q9H5B4, Q9H5B5, Q9Y3Q2
XM_054323926.1 → XP_054179901.1 double-stranded RNA-binding protein Staufen homolog 1 isoform X2

UniProtKB/Swiss-Prot

A8K9Z4, E1P5Y1, E1P608, O95793, Q5JW29, Q6GTM4, Q9H5B4, Q9H5B5, Q9Y3Q2
XM_054323922.1 → XP_054179897.1 double-stranded RNA-binding protein Staufen homolog 1 isoform X1
XM_054323929.1 → XP_054179904.1 double-stranded RNA-binding protein Staufen homolog 1 isoform X4