NR1H3 nuclear receptor subfamily 1 group H member 3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: NR1H3provided by HGNC
Official Full Name: nuclear receptor subfamily 1 group H member 3provided by HGNC
Primary source: HGNC:HGNC:7966
See related: Ensembl:ENSG00000025434 MIM:602423; AllianceGenome:HGNC:7966
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: LXRA; LXR-a; RLD-1
Summary: The protein encoded by this gene belongs to the NR1 subfamily of the nuclear receptor superfamily. The NR1 family members are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. This protein is highly expressed in visceral organs, including liver, kidney and intestine. It forms a heterodimer with retinoid X receptor (RXR), and regulates expression of target genes containing retinoid response elements. Studies in mice lacking this gene suggest that it may play an important role in the regulation of cholesterol homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Expression: Ubiquitous expression in fat (RPKM 25.1), spleen (RPKM 16.7) and 23 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 11p11.2

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	11	NC_000011.10 (47248300..47269033)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	11	NC_060935.1 (47405058..47425803)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	11	NC_000011.9 (47269851..47290584)

Chromosome 11 - NC_000011.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Decreased mRNA expression of NR1H3 and ABCA1 in pulmonary tuberculosis patients from population of Punjab, India.
Title: Decreased mRNA expression of NR1H3 and ABCA1 in pulmonary tuberculosis patients from population of Punjab, India.
Liver X receptor alpha ensures blood-brain barrier function by suppressing SNAI2.
Title: Liver X receptor alpha ensures blood-brain barrier function by suppressing SNAI2.
Inhibition of LXR controls the polarization of human inflammatory macrophages through upregulation of MAFB.
Title: Inhibition of LXR controls the polarization of human inflammatory macrophages through upregulation of MAFB.
Contributions of NR1H3 genetic polymorphisms to susceptibility and effects of narrowband UVB phototherapy to nonsegmental vitiligo.
Title: Contributions of NR1H3 genetic polymorphisms to susceptibility and effects of narrowband UVB phototherapy to nonsegmental vitiligo.
Sterol-regulated transmembrane protein TMEM86a couples LXR signaling to regulation of lysoplasmalogens in macrophages.
Title: Sterol-regulated transmembrane protein TMEM86a couples LXR signaling to regulation of lysoplasmalogens in macrophages.
Insulin Downregulates the Expression of ATP-binding Cassette Transporter A-I in Human Hepatoma Cell Line HepG2 in a FOXO1 and LXR Dependent Manner.
Title: Insulin Downregulates the Expression of ATP-binding Cassette Transporter A-I in Human Hepatoma Cell Line HepG2 in a FOXO1 and LXR Dependent Manner.
CYP27A1 inhibits proliferation and migration of clear cell renal cell carcinoma via activation of LXRs/ABCA1.
Title: CYP27A1 inhibits proliferation and migration of clear cell renal cell carcinoma via activation of LXRs/ABCA1.
Association between the rs2279238 of the Liver X receptor alpha gene polymorphism and advanced carotid atherosclerosis in the Slovenian cohort.
Title: Association between the rs2279238 of the Liver X receptor alpha gene polymorphism and advanced carotid atherosclerosis in the Slovenian cohort.
Transcriptional Regulation of Carboxylesterase 1 in Human Liver: Role of the Nuclear Receptor Subfamily 1 Group H Member 3 and Its Splice Isoforms.
Title: Transcriptional Regulation of Carboxylesterase 1 in Human Liver: Role of the Nuclear Receptor Subfamily 1 Group H Member 3 and Its Splice Isoforms.
RNA binding Motif protein-38 regulates myocardial hypertrophy in LXR-alpha-dependent lipogenesis pathway.
Title: RNA binding Motif protein-38 regulates myocardial hypertrophy in LXR-α-dependent lipogenesis pathway.

Submit: New GeneRIF Correction See all GeneRIFs (267)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Biological, clinical and population relevance of 95 loci for blood lipids. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association analysis of metabolic traits in a birth cohort from a founder population. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
matrix	gag	HIV-1 MA activates NR1H3 signaling in primary hepatocytes	PubMed
	gag	HIV-1 MA upregulates NR1H3 mRNA expression in HepG2 cells and primary hepatocytes	PubMed
	gag	HIV-1 MA upregulates NR1H3 (LXR-alpha) gene expresssion in HepG2 cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC33205P3 (e-PCR)
- UniSTS:273158

PMC99927P1 (e-PCR)
- UniSTS:273704

RH79033 (e-PCR)
- UniSTS:43048

ksks34 (e-PCR)
- UniSTS:514386

STS-U22662 (e-PCR)
- UniSTS:66401

STS-U22662 (e-PCR)
- UniSTS:24773

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA binding	TAS Traceable Author Statement more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISA Inferred from Sequence Alignment more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables cholesterol binding	TAS Traceable Author Statement more info	PubMed
enables chromatin DNA binding	IEA Inferred from Electronic Annotation more info
enables nuclear receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables nuclear receptor activity	TAS Traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sterol response element binding	IDA Inferred from Direct Assay more info	PubMed
contributes_to transcription cis-regulatory region binding	IDA Inferred from Direct Assay more info	PubMed
enables transcription cis-regulatory region binding	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in apoptotic cell clearance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to lipopolysaccharide	IDA Inferred from Direct Assay more info	PubMed
involved_in cholesterol homeostasis	IDA Inferred from Direct Assay more info	PubMed
involved_in cholesterol homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in hormone-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in hormone-mediated signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in intracellular receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in lipid homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in mRNA transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in mRNA transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cholesterol storage	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cold-induced thermogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in negative regulation of inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of inflammatory response	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of lipid transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of macrophage activation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of macrophage derived foam cell differentiation	IC Inferred by Curator more info	PubMed
involved_in negative regulation of pancreatic juice secretion	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of pinocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of proteolysis	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of response to endoplasmic reticulum stress	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of secretion of lysosomal enzymes	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of type II interferon-mediated signaling pathway	NAS Non-traceable Author Statement more info	PubMed
involved_in phosphatidylcholine acyl-chain remodeling	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cholesterol efflux	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cholesterol efflux	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cholesterol efflux	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of cholesterol transport	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of fatty acid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of lipid biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of lipoprotein lipase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of toll-like receptor 4 signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of transcription by RNA polymerase II	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of transporter activity	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of triglyceride biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of circadian rhythm	TAS Traceable Author Statement more info	PubMed
involved_in response to progesterone	IDA Inferred from Direct Assay more info	PubMed
involved_in sterol homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in triglyceride homeostasis	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of RNA polymerase II transcription regulator complex	EXP Inferred from Experiment more info	PubMed
part_of RNA polymerase II transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info
part_of RNA polymerase II transcription regulator complex	IDA Inferred from Direct Assay more info	PubMed
part_of RNA polymerase II transcription regulator complex	IPI Inferred from Physical Interaction more info	PubMed
located_in chromatin	IDA Inferred from Direct Assay more info	PubMed
located_in chromatin	ISA Inferred from Sequence Alignment more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IDA Inferred from Direct Assay more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of receptor complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: oxysterols receptor LXR-alpha

NP_001123573.1

EC 3.4.13.9

NP_001123574.1

EC 3.4.13.9

NP_001238863.1

EC 3.4.13.9

NP_001238864.1

EC 3.4.13.9

NP_001350524.1

EC 3.4.13.9

NP_005684.2

EC 3.4.13.9

XP_005252763.1

EC 3.4.13.9

XP_011518107.1

EC 3.4.13.9

XP_011518108.1

EC 3.4.13.9

XP_011518109.1

EC 3.4.13.9

XP_011518110.1

EC 3.4.13.9

XP_016872545.1

EC 3.4.13.9

XP_024304066.1

EC 3.4.13.9

XP_047282149.1

EC 3.4.13.9

XP_047282150.1

EC 3.4.13.9

XP_047282151.1

EC 3.4.13.9

XP_047282153.1

EC 3.4.13.9

XP_047282154.1

EC 3.4.13.9

XP_047282155.1

EC 3.4.13.9

XP_047282156.1

EC 3.4.13.9

XP_047282157.1

EC 3.4.13.9

XP_047282158.1

EC 3.4.13.9

XP_054223344.1

EC 3.4.13.9

XP_054223345.1

EC 3.4.13.9

XP_054223346.1

EC 3.4.13.9

XP_054223347.1

EC 3.4.13.9

XP_054223348.1

EC 3.4.13.9

XP_054223349.1

EC 3.4.13.9

XP_054223350.1

EC 3.4.13.9

XP_054223351.1

EC 3.4.13.9

XP_054223352.1

EC 3.4.13.9

XP_054223353.1

EC 3.4.13.9

XP_054223354.1

EC 3.4.13.9

XP_054223355.1

EC 3.4.13.9

XP_054223356.1

EC 3.4.13.9

XP_054223357.1

EC 3.4.13.9

XP_054223358.1

EC 3.4.13.9

XP_054223359.1

EC 3.4.13.9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_030392.1 RefSeqGene

Range

14697..25734

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001130101.3 → NP_001123573.1 oxysterols receptor LXR-alpha isoform 2

See identical proteins and their annotated locations for NP_001123573.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an internal in-frame coding exon compared to variant 1. This results in a shorter isoform (2) missing an internal protein segment compared to isoform 1.

Source sequence(s)

AA644385, AI097478, AU133574, BC008819

Consensus CDS

CCDS44584.1

UniProtKB/TrEMBL

B2R8B9, B3KV37

Related

ENSP00000384745.3, ENST00000405853.7

Conserved Domains (2) summary

cd07160
Location:78 → 178

NR_DBD_LXR; DNA-binding domain of Liver X receptors (LXRs) family is composed of two C4-type zinc fingers

cl11397
Location:210 → 385

NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
NM_001130102.3 → NP_001123574.1 oxysterols receptor LXR-alpha isoform 3

See identical proteins and their annotated locations for NP_001123574.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) contains an alternate 5' terminal exon and lacks another exon compared to variant 1. This results in translation initiation from an in-frame downstream AUG, and an isoform (3) with a shorter N-terminus compared to isoform 1.

Source sequence(s)

AA644385, AC018410, AI097478, AU135617, BC041172

Consensus CDS

CCDS44585.1

UniProtKB/TrEMBL

B2R8B9, B3KV37

Related

ENSP00000378793.3, ENST00000395397.7

Conserved Domains (2) summary

cd06954
Location:165 → 400

NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors

cd07160
Location:33 → 133

NR_DBD_LXR; DNA-binding domain of Liver X receptors (LXRs) family is composed of two C4-type zinc fingers
NM_001251934.2 → NP_001238863.1 oxysterols receptor LXR-alpha isoform 4

See identical proteins and their annotated locations for NP_001238863.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) contains 2 alternate exons at the 5' end compared to variant 1. This results in translation initiation from an in-frame upstream AUG, and an isoform (4) with a longer and distinct N-terminus compared to isoform 1. Variants 4 and 5 (which differ in the 5'UTR) encode the same isoform.

Source sequence(s)

AA644385, AI097478, AK302132, AK311590

Consensus CDS

CCDS73285.1

UniProtKB/TrEMBL

B2R8B9, B3KV37, B4DXU5

Related

ENST00000529540.5

Conserved Domains (2) summary

cd06954
Location:216 → 451

NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors

cd07160
Location:84 → 184

NR_DBD_LXR; DNA-binding domain of Liver X receptors (LXRs) family is composed of two C4-type zinc fingers
NM_001251935.2 → NP_001238864.1 oxysterols receptor LXR-alpha isoform 4

See identical proteins and their annotated locations for NP_001238864.1

Status: REVIEWED

Description

Transcript Variant: This variant (5) contains 2 alternate exons at the 5' end compared to variant 1. This results in translation initiation from an in-frame upstream AUG, and an isoform (4) with a longer and distinct N-terminus compared to isoform 1. Variants 4 and 5 (which differ in the 5'UTR) encode the same isoform (4).

Source sequence(s)

AA644385, AI097478, AK302132, AK311590

Consensus CDS

CCDS73285.1

UniProtKB/TrEMBL

B2R8B9, B3KV37, B4DXU5

Related

ENSP00000477707.1, ENST00000616973.4

Conserved Domains (2) summary

cd06954
Location:216 → 451

NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors

cd07160
Location:84 → 184

NR_DBD_LXR; DNA-binding domain of Liver X receptors (LXRs) family is composed of two C4-type zinc fingers
NM_001363595.2 → NP_001350524.1 oxysterols receptor LXR-alpha isoform 5

Status: REVIEWED

Source sequence(s)

AC018410

Consensus CDS

CCDS86200.1

UniProtKB/TrEMBL

B5MBY7, E9PID2

Related

ENSP00000385073.1, ENST00000405576.5

Conserved Domains (2) summary

cd07160
Location:33 → 133

NR_DBD_LXR; DNA-binding domain of Liver X receptors (LXRs) family is composed of two C4-type zinc fingers

cl11397
Location:165 → 340

NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
NM_005693.4 → NP_005684.2 oxysterols receptor LXR-alpha isoform 1

See identical proteins and their annotated locations for NP_005684.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the predominant transcript, and encodes isoform 1.

Source sequence(s)

AA644385, AI097478, AK290614, AK302132

Consensus CDS

CCDS7929.1

UniProtKB/Swiss-Prot

A8K3J9, D3DQR1, Q13133, Q8IW13, Q96H87

UniProtKB/TrEMBL

B2R8B9, B3KV37, F1D8N1

Related

ENSP00000387946.2, ENST00000441012.7

Conserved Domains (2) summary

cd06954
Location:210 → 445

NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors

cd07160
Location:78 → 178

NR_DBD_LXR; DNA-binding domain of Liver X receptors (LXRs) family is composed of two C4-type zinc fingers

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000011.10 Reference GRCh38.p14 Primary Assembly

Range

47248300..47269033

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047426201.1 → XP_047282157.1 oxysterols receptor LXR-alpha isoform X1
XM_011519805.3 → XP_011518107.1 oxysterols receptor LXR-alpha isoform X2

See identical proteins and their annotated locations for XP_011518107.1

UniProtKB/Swiss-Prot

A8K3J9, D3DQR1, Q13133, Q8IW13, Q96H87

UniProtKB/TrEMBL

B2R8B9, B3KV37, F1D8N1

Conserved Domains (2) summary

cd06954
Location:210 → 445

NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors

cd07160
Location:78 → 178

NR_DBD_LXR; DNA-binding domain of Liver X receptors (LXRs) family is composed of two C4-type zinc fingers
XM_047426198.1 → XP_047282154.1 oxysterols receptor LXR-alpha isoform X1
XM_011519808.3 → XP_011518110.1 oxysterols receptor LXR-alpha isoform X8

Conserved Domains (1) summary

cd06954
Location:1 → 233

NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
XM_024448298.2 → XP_024304066.1 oxysterols receptor LXR-alpha isoform X1

UniProtKB/TrEMBL

B2R8B9, B3KV37

Conserved Domains (2) summary

cd06954
Location:165 → 400

NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors

cd07160
Location:33 → 133

NR_DBD_LXR; DNA-binding domain of Liver X receptors (LXRs) family is composed of two C4-type zinc fingers
XM_047426197.1 → XP_047282153.1 oxysterols receptor LXR-alpha isoform X1
XM_047426193.1 → XP_047282149.1 oxysterols receptor LXR-alpha isoform X1
XM_047426202.1 → XP_047282158.1 oxysterols receptor LXR-alpha isoform X7
XM_047426194.1 → XP_047282150.1 oxysterols receptor LXR-alpha isoform X2

UniProtKB/Swiss-Prot

A8K3J9, D3DQR1, Q13133, Q8IW13, Q96H87

UniProtKB/TrEMBL

F1D8N1

Related

ENSP00000420656.1, ENST00000467728.5
XM_047426200.1 → XP_047282156.1 oxysterols receptor LXR-alpha isoform X6
XM_005252706.2 → XP_005252763.1 oxysterols receptor LXR-alpha isoform X2

See identical proteins and their annotated locations for XP_005252763.1

UniProtKB/Swiss-Prot

A8K3J9, D3DQR1, Q13133, Q8IW13, Q96H87

UniProtKB/TrEMBL

B2R8B9, B3KV37, F1D8N1

Conserved Domains (2) summary

cd06954
Location:210 → 445

NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors

cd07160
Location:78 → 178

NR_DBD_LXR; DNA-binding domain of Liver X receptors (LXRs) family is composed of two C4-type zinc fingers
XM_047426195.1 → XP_047282151.1 oxysterols receptor LXR-alpha isoform X2

UniProtKB/Swiss-Prot

A8K3J9, D3DQR1, Q13133, Q8IW13, Q96H87

UniProtKB/TrEMBL

F1D8N1
XM_011519806.2 → XP_011518108.1 oxysterols receptor LXR-alpha isoform X3

UniProtKB/TrEMBL

B5MBY7, E9PID2

Conserved Domains (2) summary

cd07160
Location:33 → 133

NR_DBD_LXR; DNA-binding domain of Liver X receptors (LXRs) family is composed of two C4-type zinc fingers

cl11397
Location:165 → 340

NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
XM_011519807.2 → XP_011518109.1 oxysterols receptor LXR-alpha isoform X5

See identical proteins and their annotated locations for XP_011518109.1

Conserved Domains (1) summary

cd06954
Location:76 → 311

NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
XM_017017056.2 → XP_016872545.1 oxysterols receptor LXR-alpha isoform X4
XM_047426199.1 → XP_047282155.1 oxysterols receptor LXR-alpha isoform X1

Alternate T2T-CHM13v2.0

Genomic

NC_060935.1 Alternate T2T-CHM13v2.0

Range

47405058..47425803

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054367381.1 → XP_054223356.1 oxysterols receptor LXR-alpha isoform X1
XM_054367372.1 → XP_054223347.1 oxysterols receptor LXR-alpha isoform X2

UniProtKB/Swiss-Prot

A8K3J9, D3DQR1, Q13133, Q8IW13, Q96H87

UniProtKB/TrEMBL

F1D8N1
XM_054367376.1 → XP_054223351.1 oxysterols receptor LXR-alpha isoform X1
XM_054367384.1 → XP_054223359.1 oxysterols receptor LXR-alpha isoform X8
XM_054367382.1 → XP_054223357.1 oxysterols receptor LXR-alpha isoform X1
XM_054367378.1 → XP_054223353.1 oxysterols receptor LXR-alpha isoform X1
XM_054367375.1 → XP_054223350.1 oxysterols receptor LXR-alpha isoform X1
XM_054367369.1 → XP_054223344.1 oxysterols receptor LXR-alpha isoform X1
XM_054367383.1 → XP_054223358.1 oxysterols receptor LXR-alpha isoform X7
XM_054367370.1 → XP_054223345.1 oxysterols receptor LXR-alpha isoform X2

UniProtKB/Swiss-Prot

A8K3J9, D3DQR1, Q13133, Q8IW13, Q96H87

UniProtKB/TrEMBL

F1D8N1
XM_054367380.1 → XP_054223355.1 oxysterols receptor LXR-alpha isoform X6
XM_054367371.1 → XP_054223346.1 oxysterols receptor LXR-alpha isoform X2

UniProtKB/Swiss-Prot

A8K3J9, D3DQR1, Q13133, Q8IW13, Q96H87

UniProtKB/TrEMBL

F1D8N1
XM_054367373.1 → XP_054223348.1 oxysterols receptor LXR-alpha isoform X3

UniProtKB/TrEMBL

B5MBY7
XM_054367379.1 → XP_054223354.1 oxysterols receptor LXR-alpha isoform X5
XM_054367374.1 → XP_054223349.1 oxysterols receptor LXR-alpha isoform X4
XM_054367377.1 → XP_054223352.1 oxysterols receptor LXR-alpha isoform X1