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    mogs.L mannosyl-oligosaccharide glucosidase L homeolog [ Xenopus laevis (African clawed frog) ]

    Gene ID: 100158418, updated on 4-Nov-2024

    Summary

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    Official Symbol
    mogs.L
    Official Full Name
    mannosyl-oligosaccharide glucosidase L homeolog
    Primary source
    Xenbase:XB-GENE-5911821
    Locus tag
    XELAEV_18003710mg
    See related
    EnsemblRapid:ENSXLAG00005005983 AllianceGenome:Xenbase:XB-GENE-5911821
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Xenopus laevis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
    Also known as
    mogA; mogs
    Summary
    Predicted to enable Glc3Man9GlcNAc2 oligosaccharide glucosidase activity. Predicted to act upstream of or within oligosaccharide metabolic process and protein N-linked glycosylation. Predicted to be located in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type IIb. Orthologous to human MOGS (mannosyl-oligosaccharide glucosidase). [provided by Alliance of Genome Resources, Nov 2024]
    Annotation information
    Annotation category: partial on reference assembly
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    Genomic context

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    See mogs.L in Genome Data Viewer
    Location:
    chromosome: 1L
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 1L NC_054371.1 (530976..538929)
    100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) Unplaced Scaffold NW_016694845.1 (1081588..1089353, complement)

    Chromosome 1L - NC_054371.1Genomic Context describing neighboring genes Neighboring gene tetratricopeptide repeat protein 31 Neighboring gene uncharacterized LOC121401503 Neighboring gene programmed cell death protein 4 Neighboring gene LWamide neuropeptides-like Neighboring gene WW domain-binding protein 1-like Neighboring gene uncharacterized LOC108704864 Neighboring gene E3 ubiquitin-protein ligase TRIM39

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Protein interactomes of protein phosphatase 2A B55 regulatory subunits reveal B55-mediated regulation of replication protein A under replication stress. Wang F, et al. Sci Rep, 2018 Feb 8. PMID 29422626, Free PMC Article
    2. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables Glc3Man9GlcNAc2 oligosaccharide glucosidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, acting on glycosyl bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within oligosaccharide metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein N-linked glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    mannosyl-oligosaccharide glucosidase
    NP_001121329.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001127857.1 → NP_001121329.1  mannosyl-oligosaccharide glucosidase

      See identical proteins and their annotated locations for NP_001121329.1

      Status: PROVISIONAL

      Source sequence(s)
      BC161695
      UniProtKB/TrEMBL
      B1WBB6
      Related
      ENSXLAP00005017887.1, ENSXLAT00005018183.1
      Conserved Domains (2) summary
      pfam03200
      Location:336 → 824
      Glyco_hydro_63; Glycosyl hydrolase family 63 C-terminal domain
      pfam16923
      Location:84 → 247
      Glyco_hydro_63N; Glycosyl hydrolase family 63 N-terminal domain

    RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Xenopus_laevis_v10.1 Primary Assembly

    Genomic

    1. NC_054371.1 Reference Xenopus_laevis_v10.1 Primary Assembly

      Range
      530976..538929
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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