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    Trak2 trafficking protein, kinesin binding 2 [ Mus musculus (house mouse) ]

    Gene ID: 70827, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Trak2provided by MGI
    Official Full Name
    trafficking protein, kinesin binding 2provided by MGI
    Primary source
    MGI:MGI:1918077
    See related
    Ensembl:ENSMUSG00000026028 AllianceGenome:MGI:1918077
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GRIF1; OIP98; CALS-C; GRIF-1; Als2cr3; mKIAA0549; 2900022D04Rik; 4733401O11Rik
    Summary
    Predicted to enable several functions, including GABA receptor binding activity; TPR domain binding activity; and cytoskeletal protein binding activity. Predicted to be involved in several processes, including dendrite morphogenesis; negative regulation of axonogenesis; and organelle transport along microtubule. Predicted to be located in several cellular components, including axonal growth cone; early endosome; and neuronal cell body. Predicted to be active in cytoplasmic vesicle; dendrite; and mitochondrion. Is expressed in several structures, including brain; genitourinary system; liver; retina nuclear layer; and spleen. Orthologous to human TRAK2 (trafficking kinesin protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in liver E14 (RPKM 25.9), liver E14.5 (RPKM 25.0) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Trak2 in Genome Data Viewer
    Location:
    1 C1.3; 1 29.2 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (58939608..59013509, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (58900449..58974345, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr1:58854474-58854775 Neighboring gene caspase 8 Neighboring gene predicted gene 28802 Neighboring gene STARR-seq mESC enhancer starr_01024 Neighboring gene STARR-seq mESC enhancer starr_01025 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:59013204-59013435 Neighboring gene STARR-seq mESC enhancer starr_01027 Neighboring gene STARR-positive B cell enhancer ABC_E982 Neighboring gene STE20-related kinase adaptor beta Neighboring gene C2 calcium dependent domain containing 6 Neighboring gene STARR-seq mESC enhancer starr_01029 Neighboring gene predicted gene 29018 Neighboring gene predicted gene, 25502

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. TRAK/Milton motor-adaptor proteins steer mitochondrial trafficking to axons and dendrites. van Spronsen M, et al. Neuron, 2013 Feb 6. PMID 23395375
    2. The Eutherian Armcx genes regulate mitochondrial trafficking in neurons and interact with Miro and Trak2. López-Doménech G, et al. Nat Commun, 2012 May 8. PMID 22569362
    3. Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Feb 28. PMID 12693553
    4. Genomic analysis of mouse retinal development. Blackshaw S, et al. PLoS Biol, 2004 Sep. PMID 15226823, Free PMC Article
    5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Armcx genes regulate mitochondrial trafficking in neurons and interact with Miro 1/2 and Trak2.
      Title: The Eutherian Armcx genes regulate mitochondrial trafficking in neurons and interact with Miro and Trak2.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GABA receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GABA receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables TPR domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables kinesin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables myosin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in anterograde axonal transport of mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in dendrite morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in dendritic transport of mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endosome to lysosome transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrion distribution IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of axonogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neurogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein O-linked glycosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein targeting IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein targeting ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in vesicle transport along microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in axonal growth cone ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasmic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    trafficking kinesin-binding protein 2
    Names
    amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172406.3 → NP_765994.2  trafficking kinesin-binding protein 2

      See identical proteins and their annotated locations for NP_765994.2

      Status: VALIDATED

      Source sequence(s)
      AK036650, AK053848, BC060681, CJ116609
      Consensus CDS
      CCDS14980.1
      UniProtKB/TrEMBL
      Q6P9N8, Q8BZ57
      Related
      ENSMUSP00000027186.6, ENSMUST00000027186.12
      Conserved Domains (2) summary
      pfam04849
      Location:50 → 353
      HAP1_N; HAP1 N-terminal conserved region
      pfam12448
      Location:414 → 565
      Milton; Kinesin associated protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      58939608..59013509 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036153623.1 → XP_036009516.1  trafficking kinesin-binding protein 2 isoform X1

      UniProtKB/TrEMBL
      Q8BZ57
      Conserved Domains (2) summary
      pfam04849
      Location:50 → 372
      HAP1_N; HAP1 N-terminal conserved region
      pfam12448
      Location:433 → 584
      Milton; Kinesin associated protein

    2. XM_006496280.4 → XP_006496343.1  trafficking kinesin-binding protein 2 isoform X4

      UniProtKB/TrEMBL
      Q8BZ57
      Conserved Domains (2) summary
      pfam04849
      Location:50 → 353
      HAP1_N; HAP1 N-terminal conserved region
      pfam12448
      Location:414 → 565
      Milton; Kinesin associated protein

    3. XM_036153625.1 → XP_036009518.1  trafficking kinesin-binding protein 2 isoform X1

      UniProtKB/TrEMBL
      Q8BZ57
      Conserved Domains (2) summary
      pfam04849
      Location:50 → 372
      HAP1_N; HAP1 N-terminal conserved region
      pfam12448
      Location:433 → 584
      Milton; Kinesin associated protein

    4. XM_036153639.1 → XP_036009532.1  trafficking kinesin-binding protein 2 isoform X7

      UniProtKB/TrEMBL
      Q8BZ57
      Conserved Domains (2) summary
      pfam04849
      Location:24 → 288
      HAP1_N; HAP1 N-terminal conserved region
      pfam12448
      Location:349 → 500
      Milton; Kinesin associated protein

    5. XM_006496281.5 → XP_006496344.1  trafficking kinesin-binding protein 2 isoform X6

      UniProtKB/TrEMBL
      Q8BZ57
      Conserved Domains (3) summary
      cl29994
      Location:694 → 734
      Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
      pfam04849
      Location:24 → 288
      HAP1_N; HAP1 N-terminal conserved region
      pfam12448
      Location:349 → 500
      Milton; Kinesin associated protein

    6. XM_036153638.1 → XP_036009531.1  trafficking kinesin-binding protein 2 isoform X5

      UniProtKB/TrEMBL
      Q8BZ57
      Conserved Domains (2) summary
      pfam04849
      Location:24 → 307
      HAP1_N; HAP1 N-terminal conserved region
      pfam12448
      Location:368 → 519
      Milton; Kinesin associated protein

    7. XM_036153627.1 → XP_036009520.1  trafficking kinesin-binding protein 2 isoform X2

      UniProtKB/TrEMBL
      Q8BZ57
      Conserved Domains (2) summary
      pfam04849
      Location:50 → 372
      HAP1_N; HAP1 N-terminal conserved region
      pfam12448
      Location:433 → 584
      Milton; Kinesin associated protein

    8. XM_036153640.1 → XP_036009533.1  trafficking kinesin-binding protein 2 isoform X8

      Conserved Domains (2) summary
      pfam04849
      Location:50 → 372
      HAP1_N; HAP1 N-terminal conserved region
      pfam12448
      Location:433 → 584
      Milton; Kinesin associated protein

    9. XM_030242947.2 → XP_030098807.1  trafficking kinesin-binding protein 2 isoform X3

      UniProtKB/TrEMBL
      Q6P9N8, Q8BZ57
      Conserved Domains (2) summary
      pfam04849
      Location:50 → 353
      HAP1_N; HAP1 N-terminal conserved region
      pfam12448
      Location:414 → 565
      Milton; Kinesin associated protein

    10. XM_036153630.1 → XP_036009523.1  trafficking kinesin-binding protein 2 isoform X3

      UniProtKB/TrEMBL
      Q6P9N8, Q8BZ57
      Conserved Domains (2) summary
      pfam04849
      Location:50 → 353
      HAP1_N; HAP1 N-terminal conserved region
      pfam12448
      Location:414 → 565
      Milton; Kinesin associated protein

    11. XM_036153641.1 → XP_036009534.1  trafficking kinesin-binding protein 2 isoform X9

      UniProtKB/TrEMBL
      G3UYW9
      Related
      ENSMUSP00000134253.2, ENSMUST00000174120.2
      Conserved Domains (2) summary
      pfam04849
      Location:50 → 353
      HAP1_N; HAP1 N-terminal conserved region
      pfam12448
      Location:414 → 565
      Milton; Kinesin associated protein

    12. XM_006496282.4 → XP_006496345.1  trafficking kinesin-binding protein 2 isoform X9

      UniProtKB/TrEMBL
      G3UYW9
      Conserved Domains (2) summary
      pfam04849
      Location:50 → 353
      HAP1_N; HAP1 N-terminal conserved region
      pfam12448
      Location:414 → 565
      Milton; Kinesin associated protein

    13. XM_036153642.1 → XP_036009535.1  trafficking kinesin-binding protein 2 isoform X10

      Conserved Domains (2) summary
      pfam04849
      Location:24 → 288
      HAP1_N; HAP1 N-terminal conserved region
      pfam12448
      Location:349 → 500
      Milton; Kinesin associated protein
    Nucleotide Protein Strain
    Heading Accession and Version

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