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    MERTK MER proto-oncogene, tyrosine kinase [ Pongo abelii (Sumatran orangutan) ]

    Gene ID: 100171862, updated on 6-Jun-2024

    Summary

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    Gene symbol
    MERTK
    Gene description
    MER proto-oncogene, tyrosine kinase
    Locus tag
    CR201_G0043094
    See related
    Ensembl:ENSPPYG00000012162
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Pongo abelii
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pongo
    Orthologs
    human mouse all
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    Genomic context

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    See MERTK in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current NHGRI_mPonAbe1-v2.0_pri (GCF_028885655.2) 12 NC_071997.2 (41860917..41996236)
    RS_2023_04 previous assembly NHGRI_mPonAbe1-v1.1-hic.freeze_pri (GCF_028885655.1) 2A NC_071986.1 (38446368..38581687)

    Chromosome 12 - NC_071997.2Genomic Context describing neighboring genes Neighboring gene anaphase promoting complex subunit 1 Neighboring gene eukaryotic translation elongation factor 1 epsilon-1-like Neighboring gene RNA transcription, translation and transport factor protein-like Neighboring gene U2 spliceosomal RNA Neighboring gene uncharacterized LOC112132096

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • DKFZp469D2215

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables transmembrane receptor protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell migration IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of receptor complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tyrosine-protein kinase Mer
    Names
    c-mer proto-oncogene tyrosine kinase
    NP_001124988.1
    XP_024097646.2
    XP_054401337.1
    XP_054401342.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001131516.1 → NP_001124988.1  tyrosine-protein kinase Mer

      See identical proteins and their annotated locations for NP_001124988.1

      Status: PROVISIONAL

      Source sequence(s)
      CR857807
      UniProtKB/TrEMBL
      A0A2J8SGX8, A0A8I5T9K9, Q5RDU1
      Related
      ENSPPYP00000034098.1, ENSPPYT00000040898.1
      Conserved Domains (5) summary
      cd05749
      Location:23 → 103
      Ig2_Tyro3_like; Second immunoglobulin (Ig)-like domain of Axl/Tyro3 receptor tyrosine kinases (RTKs)
      smart00410
      Location:27 → 104
      IG_like; Immunoglobulin like
      cd00063
      Location:108 → 202
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd14204
      Location:403 → 686
      PTKc_Mer; Catalytic Domain of the Protein Tyrosine Kinase, Mer
      pfam07714
      Location:411 → 678
      Pkinase_Tyr; Protein tyrosine kinase

    RefSeqs of Annotated Genomes: GCF_028885655.2-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference NHGRI_mPonAbe1-v2.0_pri Primary Assembly

    Genomic

    1. NC_071997.2 Reference NHGRI_mPonAbe1-v2.0_pri Primary Assembly

      Range
      41860917..41996236
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024241878.2 → XP_024097646.2  tyrosine-protein kinase Mer isoform X2

      UniProtKB/TrEMBL
      A0A2J8SGX3, H2P5E7

    2. XM_054545362.2 → XP_054401337.1  tyrosine-protein kinase Mer isoform X1

      UniProtKB/TrEMBL
      A0A2J8SGX3, H2P5E7

    3. XM_054545367.2 → XP_054401342.1  tyrosine-protein kinase Mer isoform X3

      UniProtKB/TrEMBL
      A0A8I5TFG4
    Nucleotide Protein
    Heading Accession and Version

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