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    IDUA alpha-L-iduronidase [ Canis lupus familiaris (dog) ]

    Gene ID: 100505382, updated on 17-Aug-2024

    Summary

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    Official Symbol
    IDUAprovided by VGNC
    Official Full Name
    alpha-L-iduronidaseprovided by VGNC
    Primary source
    VGNC:VGNC:41867
    See related
    Ensembl:ENSCAFG00845001029
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See IDUA in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 3 NC_051807.1 (92515340..92532617, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 3 NC_006585.4 (93988643..94001108, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 3 NC_049224.1 (92130626..92143201, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 3 NC_049263.1 (91693928..91706431, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 3 NC_049744.1 (91746826..91759387, complement)

    Chromosome 3 - NC_051807.1Genomic Context describing neighboring genes Neighboring gene ring finger protein 212 Neighboring gene fibroblast growth factor receptor like 1 Neighboring gene uncharacterized LOC119881450 Neighboring gene uncharacterized LOC119871275 Neighboring gene solute carrier family 26 member 1 Neighboring gene diacylglycerol kinase theta Neighboring gene transmembrane protein 175

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning and characterization of cDNA encoding canine alpha-L-iduronidase. mRNA deficiency in mucopolysaccharidosis I dog. Stoltzfus LJ, et al. J Biol Chem, 1992 Apr 5. PMID 1551868
    2. Architecture of the canine IDUA gene and mutation underlying canine mucopolysaccharidosis I. Menon KP, et al. Genomics, 1992 Nov. PMID 1339393
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables L-iduronidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    alpha-L-iduronidase
    Names
    iduronidase alpha-L-
    XP_038516338.1
    XP_038516339.1
    XP_038516340.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001313883.2 → NP_001300812.2  alpha-L-iduronidase precursor

      Status: PROVISIONAL

      Source sequence(s)
      JAAUVH010000011
      UniProtKB/Swiss-Prot
      Q01634
      Related
      ENSCAFP00845001447.1, ENSCAFT00845001836.1
      Conserved Domains (1) summary
      cl23725
      Location:29 → 542
      Glyco_hydro; Glycosyl hydrolases

    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051807.1 Reference ROS_Cfam_1.0

      Range
      92515340..92532617 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038660411.1 → XP_038516339.1  alpha-L-iduronidase isoform X2

      UniProtKB/Swiss-Prot
      Q01634
      Conserved Domains (1) summary
      cl23725
      Location:29 → 542
      Glyco_hydro; Glycosyl hydrolases

    2. XM_038660412.1 → XP_038516340.1  alpha-L-iduronidase isoform X1

      UniProtKB/TrEMBL
      A0A8C0LTL8
      Conserved Domains (1) summary
      cl23725
      Location:1 → 438
      Glyco_hydro; Glycosyl hydrolases

    3. XM_038660410.1 → XP_038516338.1  alpha-L-iduronidase isoform X1

      UniProtKB/TrEMBL
      A0A8C0LTL8
      Conserved Domains (1) summary
      cl23725
      Location:1 → 438
      Glyco_hydro; Glycosyl hydrolases

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049263.1 Alternate UMICH_Zoey_3.1

      Range
      91693928..91706431 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049744.1 Alternate UNSW_CanFamBas_1.0

      Range
      91746826..91759387 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049224.1 Alternate UU_Cfam_GSD_1.0

      Range
      92130626..92143201 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006585.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      93988643..94001108 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q01634.1 GenPept UniProtKB/Swiss-Prot:Q01634

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