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    OR3A4P olfactory receptor family 3 subfamily A member 4 pseudogene [ Homo sapiens (human) ]

    Gene ID: 390756, updated on 2-Nov-2024

    Summary

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    Official Symbol
    OR3A4Pprovided by HGNC
    Official Full Name
    olfactory receptor family 3 subfamily A member 4 pseudogeneprovided by HGNC
    Primary source
    HGNC:HGNC:15510
    See related
    Ensembl:ENSG00000290820 AllianceGenome:HGNC:15510
    Gene type
    pseudo
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    OR24; OR25; OR3A4; OR3A5P; OLFRA05; OLFRA06; OR17-13; OR17-16; OR17-24; OR17-25
    Summary
    Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. This olfactory receptor gene is transcribed and contains an intact ORF, but it is predicted to be a pseudogene due to a poorly conserved 7-transmembrane domain structure. [provided by RefSeq, Sep 2008]
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    Genomic context

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    See OR3A4P in Genome Data Viewer
    Location:
    17p13.3
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (3310245..3311446)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (3198677..3199878)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (3213539..3214740)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 1 subfamily D member 3 pseudogene Neighboring gene olfactory receptor family 3 subfamily A member 2 Neighboring gene olfactory receptor family 3 subfamily A member 1 Neighboring gene olfactory receptor family 3 subfamily A member 5 pseudogene Neighboring gene olfactory receptor family 1 subfamily AC member 1 pseudogene Neighboring gene olfactory receptor family 1 subfamily R member 1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. FOXM1-induced upregulation of lncRNA OR3A4 promotes the progression of diffuse large B-cell lymphoma via Wnt/β-catenin signaling pathway. Meng H, et al. Exp Mol Pathol, 2020 Aug. PMID 32417392
    2. Sequence analysis in the olfactory receptor gene cluster on human chromosome 17: recombinatorial events affecting receptor diversity. Glusman G, et al. Genomics, 1996 Oct 15. PMID 8921386
    3. Long noncoding RNA OR3A4 promotes metastasis and tumorigenicity in gastric cancer. Guo X, et al. Oncotarget, 2016 May 24. PMID 26863570, Free PMC Article
    4. Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire. Ben-Arie N, et al. Hum Mol Genet, 1994 Feb. PMID 8004088
    5. Sequence, structure, and evolution of a complete human olfactory receptor gene cluster. Glusman G, et al. Genomics, 2000 Jan 15. PMID 10673334

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FOXM1-induced upregulation of lncRNA OR3A4 promotes the progression of diffuse large B-cell lymphoma via Wnt/beta-catenin signaling pathway.
      Title: FOXM1-induced upregulation of lncRNA OR3A4 promotes the progression of diffuse large B-cell lymphoma via Wnt/β-catenin signaling pathway.
    2. Data indicate that OR3A4 upregulation contributes to metastasis and tumorigenesis in gastric cancer by regulating the activation of PDLIM2, MACC1, NTN4, and GNB2L1.
      Title: Long noncoding RNA OR3A4 promotes metastasis and tumorigenicity in gastric cancer.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See Variation Viewer (GRCh37.p13)

    Pathways from PubChem

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    General gene information

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    Other Names

    • olfactory receptor OR17-13 pseudogene
    • olfactory receptor OR17-16 pseudogene
    • olfactory receptor, family 3, subfamily A, member 4
    • olfactory receptor, family 3, subfamily A, member 5 pseudogene

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_024128.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      BC136875
      Related
      ENST00000624752.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      3310245..3311446
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      3198677..3199878
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001005334.1: Suppressed sequence

      Description
      NM_001005334.1: This RefSeq was permanently suppressed because it is now thought that this gene is a pseudogene.
    Nucleotide Protein
    Heading Accession and Version

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