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    PCOTH prostate and testis expressed opposite C1QTNF9B and MIPEP [ Homo sapiens (human) ]

    Gene ID: 542767, updated on 2-Nov-2024

    Summary

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    Official Symbol
    PCOTHprovided by HGNC
    Official Full Name
    prostate and testis expressed opposite C1QTNF9B and MIPEPprovided by HGNC
    Primary source
    HGNC:HGNC:39839
    See related
    Ensembl:ENSG00000205861 MIM:617122; AllianceGenome:HGNC:39839
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C1QTNF9B-AS1
    Summary
    Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in testis (RPKM 11.5), prostate (RPKM 9.5) and 14 other tissues See more
    Orthologs
    all
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    Genomic context

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    See PCOTH in Genome Data Viewer
    Location:
    13q12.12
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (23888868..23892103)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (23095303..23098541)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (24463007..24466242)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370113 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7461 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7462 Neighboring gene mitochondrial intermediate peptidase Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7463 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7464 Neighboring gene MT-CO3 pseudogene 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7465 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7466 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7467 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:24386207-24386732 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7468 Neighboring gene H3K27ac hESC enhancer GRCh37_chr13:24463319-24463819 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7469 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:24477599-24478098 Neighboring gene C1q and TNF related 9B Neighboring gene ankyrin repeat domain 20 family member A19, pseudogene Neighboring gene uncharacterized LOC105370115

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. PCOTH, a novel gene overexpressed in prostate cancers, promotes prostate cancer cell growth through phosphorylation of oncoprotein TAF-Ibeta/SET. Anazawa Y, et al. Cancer Res, 2005 Jun 1. PMID 15930275
    2. Genetic variants at 13q12.12 are associated with high myopia in the Han Chinese population. Shi Y, et al. Am J Hum Genet, 2011 Jun 10. PMID 21640322, Free PMC Article
    3. A proteome-scale map of the human interactome network. Rolland T, et al. Cell, 2014 Nov 20. PMID 25416956, Free PMC Article
    4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PCOTH is involved in growth and survival of prostate cancer cells thorough, in parts, the TAF-Ibeta pathway.
      Title: PCOTH, a novel gene overexpressed in prostate cancers, promotes prostate cancer cell growth through phosphorylation of oncoprotein TAF-Ibeta/SET.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genetic variants at 13q12.12 are associated with high myopia in the Han Chinese population.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Other Names

    • C1QTNF9B antisense RNA 1
    • C1QTNF9B antisense gene protein 1
    • Pro-X-Gly collagen triple helix like repeat containing
    • prostate collagen triple helix protein

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_172510.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL445985
      Related
      ENST00000382133.10

    2. NR_172511.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL445985
      Related
      ENST00000849009.1

    3. NR_172512.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL445985

    4. NR_172513.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL445985

    5. NR_172514.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL445985

    6. NR_172515.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL445985
      Related
      ENST00000849011.1

    7. NR_172516.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL445985

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

      Range
      23888868..23892103
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060937.1 Alternate T2T-CHM13v2.0

      Range
      23095303..23098541
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q58A44.2 GenPept UniProtKB/Swiss-Prot:Q58A44

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