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    ROCK1 Rho associated coiled-coil containing protein kinase 1 [ Panthera tigris (tiger) ]

    Gene ID: 102963520, updated on 10-Mar-2024

    Summary

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    Gene symbol
    ROCK1
    Gene description
    Rho associated coiled-coil containing protein kinase 1
    See related
    Ensembl:ENSPTIG00000018557
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Panthera tigris
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Pantherinae; Panthera
    Orthologs
    human mouse all
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    Genomic context

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    See ROCK1 in Genome Data Viewer
    Location:
    chromosome: D3
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    102 current P.tigris_Pti1_mat1.1 (GCF_018350195.1) D3 NC_056671.1 (43661806..43837329, complement)

    Chromosome D3 - NC_056671.1Genomic Context describing neighboring genes Neighboring gene THO complex 1 Neighboring gene ubiquitin specific peptidase 14 Neighboring gene uncharacterized LOC122232745 Neighboring gene uncharacterized LOC122232744 Neighboring gene uncharacterized LOC107179028 Neighboring gene 60S ribosomal protein L21-like

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_056671.1 Chromosome D3 Reference P.tigris_Pti1_mat1.1 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Rho protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in actomyosin structure organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cortical actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in embryonic morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in mitotic cytokinesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in peptidyl-threonine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of cell junction assembly IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytoplasmic stress granule IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    rho-associated protein kinase 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Panthera tigris Annotation Release 102 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference P.tigris_Pti1_mat1.1 Primary Assembly

    Genomic

    1. NC_056671.1 Reference P.tigris_Pti1_mat1.1 Primary Assembly

      Range
      43661806..43837329 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_042961918.1 → XP_042817852.1  rho-associated protein kinase 1 isoform X2

      Conserved Domains (5) summary
      smart00109
      Location:1228 → 1282
      C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
      cd11639
      Location:488 → 553
      HR1_ROCK1; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Rho-associated coiled-coil containing protein kinase 1
      cd01242
      Location:1118 → 1224
      PH_ROCK; Rho-associated coiled-coil containing protein kinase pleckstrin homology (PH) domain
      cd05622
      Location:2 → 406
      STKc_ROCK1; Catalytic domain of the Serine/Threonine Kinase, Rho-associated coiled-coil containing protein kinase 1
      TIGR02168
      Location:420 → 1096
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    2. XM_042961917.1 → XP_042817851.1  rho-associated protein kinase 1 isoform X1

      Conserved Domains (5) summary
      smart00109
      Location:1229 → 1283
      C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
      cd11639
      Location:489 → 554
      HR1_ROCK1; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Rho-associated coiled-coil containing protein kinase 1
      cd01242
      Location:1119 → 1225
      PH_ROCK; Rho-associated coiled-coil containing protein kinase pleckstrin homology (PH) domain
      cd05622
      Location:2 → 406
      STKc_ROCK1; Catalytic domain of the Serine/Threonine Kinase, Rho-associated coiled-coil containing protein kinase 1
      TIGR02168
      Location:450 → 1097
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    3. XM_042961919.1 → XP_042817853.1  rho-associated protein kinase 1 isoform X5

      Conserved Domains (5) summary
      smart00109
      Location:1002 → 1056
      C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
      cd11639
      Location:262 → 327
      HR1_ROCK1; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Rho-associated coiled-coil containing protein kinase 1
      cd01242
      Location:892 → 998
      PH_ROCK; Rho-associated coiled-coil containing protein kinase pleckstrin homology (PH) domain
      TIGR02168
      Location:223 → 870
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cl21453
      Location:1 → 173
      PKc_like; Protein Kinases, catalytic domain

    4. XM_015534773.2 → XP_015390259.1  rho-associated protein kinase 1 isoform X4

      Conserved Domains (7) summary
      cd11639
      Location:489 → 554
      HR1_ROCK1; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Rho-associated coiled-coil containing protein kinase 1
      smart00220
      Location:76 → 338
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00029
      Location:1229 → 1283
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01242
      Location:1119 → 1225
      PH_ROCK; Rho-associated coiled-coil containing protein kinase pleckstrin homology (PH) domain
      cd05622
      Location:2 → 406
      STKc_ROCK1; Catalytic domain of the Serine/Threonine Kinase, Rho-associated coiled-coil containing protein kinase 1
      TIGR02168
      Location:450 → 1097
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam08912
      Location:949 → 1014
      Rho_Binding; Rho Binding

    5. XM_007075945.3 → XP_007076007.1  rho-associated protein kinase 1 isoform X3

      UniProtKB/TrEMBL
      A0A8C9KB13
      Related
      ENSPTIP00000021378.1
      Conserved Domains (7) summary
      cd11639
      Location:489 → 554
      HR1_ROCK1; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Rho-associated coiled-coil containing protein kinase 1
      smart00220
      Location:76 → 338
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00029
      Location:1229 → 1283
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01242
      Location:1119 → 1225
      PH_ROCK; Rho-associated coiled-coil containing protein kinase pleckstrin homology (PH) domain
      cd05622
      Location:2 → 406
      STKc_ROCK1; Catalytic domain of the Serine/Threonine Kinase, Rho-associated coiled-coil containing protein kinase 1
      TIGR02168
      Location:450 → 1097
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam08912
      Location:949 → 1014
      Rho_Binding; Rho Binding
    Nucleotide Protein
    Heading Accession and Version

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