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    EIF1AD eukaryotic translation initiation factor 1A domain containing [ Homo sapiens (human) ]

    Gene ID: 84285, updated on 27-Nov-2024

    Summary

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    Official Symbol
    EIF1ADprovided by HGNC
    Official Full Name
    eukaryotic translation initiation factor 1A domain containingprovided by HGNC
    Primary source
    HGNC:HGNC:28147
    See related
    Ensembl:ENSG00000175376 MIM:618473; AllianceGenome:HGNC:28147
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    OBELIX; haponin
    Summary
    Predicted to enable RNA binding activity and translation initiation factor activity. Predicted to be involved in translational initiation. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in bone marrow (RPKM 7.6), testis (RPKM 6.0) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See EIF1AD in Genome Data Viewer
    Location:
    11q13.1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (65996545..66002157, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (65990678..65996291, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (65764016..65769628, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:65729063-65729850 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:65733572-65734072 Neighboring gene spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP Neighboring gene phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5024 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:65767725-65768224 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5025 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3569 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:65770703-65771509 Neighboring gene Sharpr-MPRA regulatory region 5067 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:65775781-65776575 Neighboring gene barrier to autointegration nuclear assembly factor 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:65780961-65781536 Neighboring gene cystatin E/M Neighboring gene cation channel sperm associated 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:65790121-65790622

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Novel protein haponin regulates cellular response to oxidative stress. Smirnova EV, et al. Dokl Biochem Biophys, 2011 Sep-Oct. PMID 22095125
    2. Comparative sequence and structure analysis of eIF1A and eIF1AD. Yu J, et al. BMC Struct Biol, 2018 Sep 4. PMID 30180896, Free PMC Article
    3. [Identification and expression of haponin, a new protein from HL-60 cells]. Vonarshenko AV, et al. Bioorg Khim, 2007 Nov-Dec. PMID 18173130
    4. Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris. Navarini AA, et al. Nat Commun, 2014 Jun 13. PMID 24927181
    5. MAP4K Interactome Reveals STRN4 as a Key STRIPAK Complex Component in Hippo Pathway Regulation. Seo G, et al. Cell Rep, 2020 Jul 7. PMID 32640226, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Novel protein haponin regulates cellular response to oxidative stress.
      Title: Novel protein haponin regulates cellular response to oxidative stress.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC11102

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables translation initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in translational initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    probable RNA-binding protein EIF1AD
    Names
    eukaryotic translation initiation factor 1A domain-containing protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001242481.2 → NP_001229410.1  probable RNA-binding protein EIF1AD

      See identical proteins and their annotated locations for NP_001229410.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript.
      Source sequence(s)
      AI831454, AP006287, BE669813, BE791453, BP328412
      Consensus CDS
      CCDS8124.1
      UniProtKB/Swiss-Prot
      B2R4N5, Q8N9N8, Q9BSC1
      Related
      ENSP00000434056.1, ENST00000533544.6
      Conserved Domains (1) summary
      cd05792
      Location:25 → 102
      S1_eIF1AD_like; eukaryotic translation initiation factor 1A domain containing protein (eIF1AD)-like, S1-like RNA-binding domain. eIF1AD is also known as MGC11102 protein. Little is known about the function of eIF1AD. S1-like RNA-binding domains are found in a wide ...

    2. NM_001242482.2 → NP_001229411.1  probable RNA-binding protein EIF1AD

      See identical proteins and their annotated locations for NP_001229411.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR, compared to variant 1, but encodes the same protein.
      Source sequence(s)
      AP006287, BE669813, BE791453, BP328412, BU790195
      Consensus CDS
      CCDS8124.1
      UniProtKB/Swiss-Prot
      B2R4N5, Q8N9N8, Q9BSC1
      Related
      ENSP00000435439.1, ENST00000527249.5
      Conserved Domains (1) summary
      cd05792
      Location:25 → 102
      S1_eIF1AD_like; eukaryotic translation initiation factor 1A domain containing protein (eIF1AD)-like, S1-like RNA-binding domain. eIF1AD is also known as MGC11102 protein. Little is known about the function of eIF1AD. S1-like RNA-binding domains are found in a wide ...

    3. NM_001242483.2 → NP_001229412.1  probable RNA-binding protein EIF1AD

      See identical proteins and their annotated locations for NP_001229412.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate splice site in the 5' UTR, compared to variant 1, but encodes the same protein.
      Source sequence(s)
      AP006287, AW872373, BE669813, BE791453, BP328412
      Consensus CDS
      CCDS8124.1
      UniProtKB/Swiss-Prot
      B2R4N5, Q8N9N8, Q9BSC1
      Conserved Domains (1) summary
      cd05792
      Location:25 → 102
      S1_eIF1AD_like; eukaryotic translation initiation factor 1A domain containing protein (eIF1AD)-like, S1-like RNA-binding domain. eIF1AD is also known as MGC11102 protein. Little is known about the function of eIF1AD. S1-like RNA-binding domains are found in a wide ...

    4. NM_001242484.2 → NP_001229413.1  probable RNA-binding protein EIF1AD

      See identical proteins and their annotated locations for NP_001229413.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) uses an alternate splice site in the 5' UTR, compared to variant 1, but encodes the same protein.
      Source sequence(s)
      AP006287, BE669813, DA024526
      Consensus CDS
      CCDS8124.1
      UniProtKB/Swiss-Prot
      B2R4N5, Q8N9N8, Q9BSC1
      Conserved Domains (1) summary
      cd05792
      Location:25 → 102
      S1_eIF1AD_like; eukaryotic translation initiation factor 1A domain containing protein (eIF1AD)-like, S1-like RNA-binding domain. eIF1AD is also known as MGC11102 protein. Little is known about the function of eIF1AD. S1-like RNA-binding domains are found in a wide ...

    5. NM_001242485.2 → NP_001229414.1  probable RNA-binding protein EIF1AD

      See identical proteins and their annotated locations for NP_001229414.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) uses multiple alternate splice sites in the 5' UTR, compared to variant 1, but encodes the same protein.
      Source sequence(s)
      AP006287, BC005131, BG149615, BP328412
      Consensus CDS
      CCDS8124.1
      UniProtKB/Swiss-Prot
      B2R4N5, Q8N9N8, Q9BSC1
      Related
      ENSP00000436644.1, ENST00000526451.5
      Conserved Domains (1) summary
      cd05792
      Location:25 → 102
      S1_eIF1AD_like; eukaryotic translation initiation factor 1A domain containing protein (eIF1AD)-like, S1-like RNA-binding domain. eIF1AD is also known as MGC11102 protein. Little is known about the function of eIF1AD. S1-like RNA-binding domains are found in a wide ...

    6. NM_001242486.2 → NP_001229415.1  probable RNA-binding protein EIF1AD

      See identical proteins and their annotated locations for NP_001229415.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) uses multiple alternate splice sites in the 5' UTR, compared to variant 1, but encodes the same protein.
      Source sequence(s)
      AP006287, BP328412
      Consensus CDS
      CCDS8124.1
      UniProtKB/Swiss-Prot
      B2R4N5, Q8N9N8, Q9BSC1
      Related
      ENSP00000435942.2, ENST00000529964.5
      Conserved Domains (1) summary
      cd05792
      Location:25 → 102
      S1_eIF1AD_like; eukaryotic translation initiation factor 1A domain containing protein (eIF1AD)-like, S1-like RNA-binding domain. eIF1AD is also known as MGC11102 protein. Little is known about the function of eIF1AD. S1-like RNA-binding domains are found in a wide ...

    7. NM_032325.4 → NP_115701.2  probable RNA-binding protein EIF1AD

      See identical proteins and their annotated locations for NP_115701.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the 5' UTR, compared to variant 1, but encodes the same protein.
      Source sequence(s)
      AK311891, AP006287, BP328412
      Consensus CDS
      CCDS8124.1
      UniProtKB/Swiss-Prot
      B2R4N5, Q8N9N8, Q9BSC1
      Related
      ENSP00000309175.2, ENST00000312234.6
      Conserved Domains (1) summary
      cd05792
      Location:25 → 102
      S1_eIF1AD_like; eukaryotic translation initiation factor 1A domain containing protein (eIF1AD)-like, S1-like RNA-binding domain. eIF1AD is also known as MGC11102 protein. Little is known about the function of eIF1AD. S1-like RNA-binding domains are found in a wide ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      65996545..66002157 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017018412.3 → XP_016873901.1  probable RNA-binding protein EIF1AD isoform X1

      UniProtKB/Swiss-Prot
      B2R4N5, Q8N9N8, Q9BSC1
      Conserved Domains (1) summary
      cd05792
      Location:25 → 102
      S1_eIF1AD_like; eukaryotic translation initiation factor 1A domain containing protein (eIF1AD)-like, S1-like RNA-binding domain. eIF1AD is also known as MGC11102 protein. Little is known about the function of eIF1AD. S1-like RNA-binding domains are found in a wide ...

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      65990678..65996291 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054370174.1 → XP_054226149.1  probable RNA-binding protein EIF1AD isoform X1

      UniProtKB/Swiss-Prot
      B2R4N5, Q8N9N8, Q9BSC1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8N9N8.1 GenPept UniProtKB/Swiss-Prot:Q8N9N8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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