GPR89A G protein-coupled receptor 89A [Homo sapiens (human)] - Gene

Summary

Official Symbol: GPR89Aprovided by HGNC
Official Full Name: G protein-coupled receptor 89Aprovided by HGNC
Primary source: HGNC:HGNC:31984
See related: Ensembl:ENSG00000117262 MIM:612821; AllianceGenome:HGNC:31984
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: GPHR; GPR89; SH120; GPR89B; UNQ192
Summary: Enables voltage-gated anion channel activity. Involved in intracellular pH reduction. Located in Golgi cisterna membrane and Golgi-associated vesicle membrane. [provided by Alliance of Genome Resources, Apr 2022]
Annotation information: Note: There are multiple copies of the sequence G protein-coupled receptor 89 in the human genome. After consultation with the HUGO Gene Nomenclature committee, the symbol GPR89A was assigned to the most centromeric locus. [06 Jun 2007]
Expression: Ubiquitous expression in kidney (RPKM 15.4), testis (RPKM 12.4) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 1q21.1

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (145607988..145670650)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (144724765..144787440)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (145764409..145827075, complement)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AL009955 (e-PCR)
- UniSTS:40513

RH35978 (e-PCR)
- UniSTS:64586

WI-15443 (e-PCR)
- UniSTS:46485

SHGC-75406 (e-PCR)
- UniSTS:61379

RH104506 (e-PCR)
- UniSTS:98806

Clone Names

MGC688, FLJ10492, FLJ11696, FLJ36909, FLJ79270, MGC87324

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables voltage-gated monoatomic anion channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables voltage-gated monoatomic anion channel activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in T cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in intracellular pH reduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular pH reduction	IDA Inferred from Direct Assay more info	PubMed
involved_in monoatomic anion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of canonical NF-kappaB signal transduction	HMP more info	PubMed
involved_in protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in Golgi cisterna membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi cisterna membrane	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in Golgi-associated vesicle membrane	IDA Inferred from Direct Assay more info	PubMed
part_of monoatomic ion channel complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Golgi pH regulator A

Names: protein GPR89; putative MAPK-activating protein PM01; putative NF-kappa-B-activating protein 90

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001097612.2 → NP_001091081.1 Golgi pH regulator A isoform 1

See identical proteins and their annotated locations for NP_001091081.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the shortest transcript and encodes the longer isoform (1).

Source sequence(s)

AB097025, AC242845, BC003187, DC349534

Consensus CDS

CCDS72857.1

UniProtKB/Swiss-Prot

A6NKF9, A6NN37, B2RUV3, B3KMN3, B4DLT3, B4DXE7, B7ZAQ6, P0CG08, Q53FQ9, Q5T2V8, Q5T5P5, Q659E2, Q6NVY5, Q9P0S4, Q9Y302

UniProtKB/TrEMBL

X5D7G6, X5D920

Related

ENSP00000319673.9, ENST00000313835.14

Conserved Domains (2) summary

pfam12430
Location:276 → 446

ABA_GPCR; Abscisic acid G-protein coupled receptor

pfam12537
Location:140 → 207

GPHR_N; The Golgi pH Regulator (GPHR) Family N-terminal
NM_001097613.3 → NP_001091082.2 Golgi pH regulator A isoform 2

See identical proteins and their annotated locations for NP_001091082.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.

Source sequence(s)

AC242845, AK297145, AK316371, BC003187

Consensus CDS

CCDS72858.1

UniProtKB/TrEMBL

X5D920

Related

ENSP00000434495.1, ENST00000534502.5

Conserved Domains (2) summary

pfam12430
Location:251 → 419

ABA_GPCR; Abscisic acid G-protein coupled receptor

pfam12537
Location:115 → 182

GPHR_N; The Golgi pH Regulator (GPHR) Family N-terminal

RNA

NR_036541.2 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses an alternate splice site compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC242845, AK021758, AK297145, BC003187

Related

ENST00000460277.5