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    POLY polyprotein;protein F [ Hepatitis C virus genotype 1 ]

    Gene ID: 951475, updated on 18-Aug-2023

    Summary

    Gene symbol
    POLY
    Gene description
    polyprotein;protein F
    Locus tag
    HCVgp1
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Hepatitis C virus genotype 1 (serotype: 1a, isolate: H77)
    Lineage
    Viruses; Riboviria; Flaviviridae; Hepacivirus
    NEW
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    Genomic context

    Sequence:
    NC_004102.1 (342..9377)

    NC_004102.1Genomic Context describing neighboring genes

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    polyprotein;protein F
    Names
    core protein
    envelope protein E1
    envelope protein E2
    protein p7
    nonstructural protein NS2
    protease/helicase protein NS3
    nonstructural protein NS4A
    nonstructural protein NS4B
    nonstructural protein NS5A
    RNA-dependent RNA polymerase NS5B
    NP_803170.1
    • -2/+1 frameshift; although the exact location of the frameshift is unknown, it was mapped to codons 9 to 11 of the core protein coding sequence.

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004102.1 Reference assembly

      Range
      342..9377
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_671491.1 polyprotein [Hepatitis C virus genotype 1]

      See identical proteins and their annotated locations for NP_671491.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9ELS8
      Conserved Domains (16) summary
      pfam01001
      Location:17281921
      HCV_NS4b; Hepatitis C virus non-structural protein NS4b
      pfam01539
      Location:193382
      HCV_env; Hepatitis C virus envelope glycoprotein E1
      pfam01560
      Location:386729
      HCV_NS1; Hepatitis C virus non-structural protein E2/NS1
      pfam02907
      Location:10561204
      Peptidase_S29; Hepatitis C virus NS3 protease
      pfam01543
      Location:2115
      HCV_capsid; Hepatitis C virus capsid protein
      pfam08301
      Location:20682168
      HCV_NS5a_1b; Hepatitis C virus non-structural 5a domain 1b
      pfam01538
      Location:8111005
      HCV_NS2; Hepatitis C virus non-structural protein NS2
      smart00487
      Location:12281355
      DEXDc; DEAD-like helicases superfamily
      cd00046
      Location:12241351
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd00079
      Location:13781455
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      pfam00998
      Location:24232934
      RdRP_3; Viral RNA dependent RNA polymerase
      pfam01006
      Location:16581711
      HCV_NS4a; Hepatitis C virus non-structural protein NS4a
      pfam01506
      Location:19741996
      HCV_NS5a; Hepatitis C virus non-structural 5a protein membrane anchor
      pfam01542
      Location:116190
      HCV_core; Hepatitis C virus core protein
      pfam08300
      Location:20062067
      HCV_NS5a_1a; Hepatitis C virus non-structural 5a zinc finger domain
      pfam12941
      Location:21792420
      HCV_NS5a_C; HCV NS5a protein C-terminal region
    2. NP_751919.1 core protein

      UniProtKB/TrEMBL
      A0A075C2Z9, A0A075C392, A0A075C3A1, A0A075C3F8, A0A075C549, A0A075C551, A0A075C673, A0A077CW64, A0A077CW68, A0A077CW83, A0A077CW92, A0A077CW98, A0A077CWX7, A0A077CWY1, A0A077CWY6, A0A077CWZ4, A0A077CX03, A0A077CX08, A0A077CX16, A0A077CYR9, A0A077CYS6, A0A077CYU1, A0A077CYU8, A0A077CYW6, A0A077D125, A0A077D131, A0A077D140, A0A077D156, A0A077D1I0, A0A077D1I6, A0A077D1J1, A0A077D1J4, A0A077D1K6, A0A0A0YPR1, A0A221C814, B8Y460, C8CP42, D2E5C6, D2E5D5, D2E5D6, D2E5D7, D2E5D8, D2E5D9, D2E5E0, E2ICK2, G3FEN7, G3FEN8, L7Z1C8, L7Z1D2, L7Z1F6, L7Z1G2, L7Z5V0, L7Z5V3, L7Z5X5, L7Z6V5, L7Z6Y6, L7Z7D6, L7Z951, Q68113, Q68123, Q68124, Q68139, Q68149, Q6QY91, Q6QY92, Q6QY99, Q6QYA1, Q6QYA2, Q6QYA6, Q6QYA7, Q6QYB1, Q6QYB2, Q6QYB4, Q6QYB6, Q6QYB7, Q6QYB8, Q6QYB9, Q6QYC1, Q6QYC2, Q6QYC3, Q6QYE5, Q6QYE6, Q6QYE7, Q6QYE8, Q6QYE9, Q6QYF0, Q6QYF1, Q6QYF2, Q6QYF6, Q6QYF7, Q6QYF9, Q6QYG0, Q6QYG5, Q6QYJ7, Q6QYJ9, Q6QYK0, Q6QYK2, Q6QYK3, Q6QYK6, Q6QYK7, Q6QYK8, Q6QYK9, Q6QYL0, Q6QYL1, Q6QYL2, Q6QYL4, Q6QYL5, Q6QYM0, Q6QYN0, Q6QYQ9, Q6QYR0, Q6QYR1, Q6QYR2, Q6QYR3, Q6QYR4, Q6QYR5, Q6QYR6, Q6QYR7, Q6QYT2, Q6QYT4, Q6QYT5, Q6QYT6, Q6QYT7, Q6QYT8, Q6QYT9, Q6QYU0, Q6QYU1, Q6QYU2, Q6QYU3, Q6QZ00, Q6QZ04, Q6QZ15, Q6QZ18, Q6QZ19, Q6QZ20, Q6QZ21, Q6QZ22, Q6QZ25, Q6QZ26, Q6QZ27, Q6QZ28, Q6QZ29, Q6QZ31, Q6QZ32, Q6QZ56, Q6QZ58, Q6QZ60, Q6QZ61, Q6QZ62, Q6QZ63, Q6QZ64, Q6QZ67, Q6QZ80, Q6QZ81, Q6QZ82, Q6QZ83, Q6QZ84, Q6QZ85, Q6QZ87, Q6QZ88, Q6QZ91, Q6QZ99, Q6QZA0, Q6QZA1, Q6QZA2, Q6QZA3, Q6QZA4, Q6QZA5, Q6QZA6, Q6QZA7, Q6QZA9, Q6QZD2, Q6QZD3, Q6QZD8, Q6QZE2, Q6QZE3, Q6QZE5, Q6QZE7, Q6QZE8, Q6QZE9, Q6QZF1, Q6QZF2, Q6QZG0, Q6QZG4, Q6QZG5, Q6QZG6, Q6QZG7, Q6QZG8, Q6QZG9, Q6QZH0, Q6QZH1, Q6QZH2, Q6QZH3, Q6UNT8, Q8BES1
      Conserved Domains (2) summary
      pfam01543
      Location:2115
      HCV_capsid; Hepatitis C virus capsid protein
      pfam01542
      Location:116190
      HCV_core; Hepatitis C virus core protein
    3. NP_751920.1 envelope protein E1

      Conserved Domains (1) summary
      pfam01539
      Location:2191
      HCV_env; Hepatitis C virus envelope glycoprotein E1
    4. NP_751921.1 envelope protein E2

      Conserved Domains (1) summary
      pfam01560
      Location:3346
      HCV_NS1; Hepatitis C virus non-structural protein E2/NS1
    5. NP_751922.1 protein p7

    6. NP_751923.1 nonstructural protein NS2

      Conserved Domains (1) summary
      pfam01538
      Location:2196
      HCV_NS2; Hepatitis C virus non-structural protein NS2
    7. NP_803144.1 protease/helicase protein NS3

      Conserved Domains (4) summary
      pfam02907
      Location:30178
      Peptidase_S29; Hepatitis C virus NS3 protease
      smart00487
      Location:202329
      DEXDc; DEAD-like helicases superfamily
      cd00046
      Location:198325
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd00079
      Location:352429
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    8. NP_751925.1 nonstructural protein NS4A

      UniProtKB/TrEMBL
      C9WU76, C9WUC9, C9WUD6, C9WUE1
      Conserved Domains (1) summary
      pfam01006
      Location:154
      HCV_NS4a; Hepatitis C virus non-structural protein NS4a
    9. NP_751926.1 nonstructural protein NS4B

    10. NP_751927.1 nonstructural protein NS5A

      Conserved Domains (4) summary
      pfam08301
      Location:96196
      HCV_NS5a_1b; Hepatitis C virus non-structural 5a domain 1b
      pfam12941
      Location:207448
      HCV_NS5a_C; HCV NS5a protein C-terminal region
      pfam01506
      Location:224
      HCV_NS5a; Hepatitis C virus non-structural 5a protein membrane anchor
      pfam08300
      Location:3495
      HCV_NS5a_1a; Hepatitis C virus non-structural 5a zinc finger domain
    11. NP_751928.1 RNA-dependent RNA polymerase NS5B

      Conserved Domains (1) summary
      pfam00998
      Location:3514
      RdRP_3; Viral RNA dependent RNA polymerase
    12. NP_803170.1 protein F [Hepatitis C virus genotype 1]

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P0C045
      Conserved Domains (1) summary
      pfam01543
      Location:66127
      HCV_capsid; Hepatitis C virus capsid protein