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    STAU1 staufen double-stranded RNA binding protein 1 [ Homo sapiens (human) ]

    Gene ID: 6780, updated on 3-Nov-2024

    Summary

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    Official Symbol
    STAU1provided by HGNC
    Official Full Name
    staufen double-stranded RNA binding protein 1provided by HGNC
    Primary source
    HGNC:HGNC:11370
    See related
    Ensembl:ENSG00000124214 MIM:601716; AllianceGenome:HGNC:11370
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    STAU; PPP1R150
    Summary
    Staufen is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. The human homologue of staufen encoded by STAU, in addition contains a microtubule- binding domain similar to that of microtubule-associated protein 1B, and binds tubulin. The STAU gene product has been shown to be present in the cytoplasm in association with the rough endoplasmic reticulum (RER), implicating this protein in the transport of mRNA via the microtubule network to the RER, the site of translation. [provided by RefSeq, Apr 2020]
    Expression
    Ubiquitous expression in kidney (RPKM 41.4), thyroid (RPKM 35.8) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See STAU1 in Genome Data Viewer
    Location:
    20q13.13
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (49113339..49219295, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (50882825..50988811, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (47729876..47835832, complement)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18053 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:47663207-47663847 Neighboring gene CSE1L divergent transcript Neighboring gene chromosome segregation 1 like Neighboring gene ReSE screen-validated silencer GRCh37_chr20:47734294-47734451 Neighboring gene actin related protein 2/3 complex subunit 3 pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:47797000-47797528 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18055 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12993 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12994 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:47835541-47836266 Neighboring gene DEAD-box helicase 27 Neighboring gene zinc finger NFX1-type containing 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18056 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18057 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:47894170-47894670

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RNA-binding protein GIGYF2 orchestrates hepatic insulin resistance through STAU1/PTEN-mediated disruption of the PI3K/AKT signaling cascade.
      Title: RNA-binding protein GIGYF2 orchestrates hepatic insulin resistance through STAU1/PTEN-mediated disruption of the PI3K/AKT signaling cascade.
    2. STAU1-mediated CNBP mRNA degradation by LINC00665 alters stem cell characteristics in ovarian cancer.
      Title: STAU1-mediated CNBP mRNA degradation by LINC00665 alters stem cell characteristics in ovarian cancer.
    3. Excessive STAU1 condensate drives mTOR translation and autophagy dysfunction in neurodegeneration.
      Title: Excessive STAU1 condensate drives mTOR translation and autophagy dysfunction in neurodegeneration.
    4. Staufen1 Represses the FOXA1-Regulated Transcriptome by Destabilizing FOXA1 mRNA in Colorectal Cancer Cells.
      Title: Staufen1 Represses the FOXA1-Regulated Transcriptome by Destabilizing FOXA1 mRNA in Colorectal Cancer Cells.
    5. A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.
      Title: A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.
    6. Phosphomimicry on STAU1 Serine 20 Impairs STAU1 Posttranscriptional Functions and Induces Apoptosis in Human Transformed Cells.
      Title: Phosphomimicry on STAU1 Serine 20 Impairs STAU1 Posttranscriptional Functions and Induces Apoptosis in Human Transformed Cells.
    7. PART1 destabilized by NOVA2 regulates blood-brain barrier permeability in endothelial cells via STAU1-mediated mRNA degradation.
      Title: PART1 destabilized by NOVA2 regulates blood-brain barrier permeability in endothelial cells via STAU1-mediated mRNA degradation.
    8. Function of Host Protein Staufen1 in Rabies Virus Replication.
      Title: Function of Host Protein Staufen1 in Rabies Virus Replication.
    9. High Level of Staufen1 Expression Confers Longer Recurrence Free Survival to Non-Small Cell Lung Cancer Patients by Promoting THBS1 mRNA Degradation.
      Title: High Level of Staufen1 Expression Confers Longer Recurrence Free Survival to Non-Small Cell Lung Cancer Patients by Promoting THBS1 mRNA Degradation.
    10. Differential regulation of autophagy by STAU1 in alveolar rhabdomyosarcoma and non-transformed skeletal muscle cells.
      Title: Differential regulation of autophagy by STAU1 in alveolar rhabdomyosarcoma and non-transformed skeletal muscle cells.
    Submit: New GeneRIF Correction See all GeneRIFs (67)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study of proneness to anger.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into Staufen1 ribonucleoprotein complexes isolated from HIV-1-expressing cells PubMed
    Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into Staufen1 ribonucleoprotein complexes isolated from HIV-1-expressing cells PubMed
    Nef nef Tandem affinity purification and mass spectrometry analysis identify HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into Staufen1 ribonucleoprotein complexes isolated from HIV-1-expressing cells PubMed
    Pr55(Gag) gag Staufen1, vRNA and Gag are found in the same ribonucleoprotein (RNP) complex. The depletion of Staufen1 results in reduced Gag levels and deregulates the assembly of newly synthesized virions PubMed
    gag Interaction of HIV-1 Gag with staufen is mediated by staufen's dsRBD3 domain PubMed
    gag Staufen is incorporated into HIV-1 virions through association with HIV-1 genomic RNA and is implicated in HIV-1 genome selection and packaging into assembling virions, a process that is mediated by the Nucleocapsid domain of HIV-1 Gag PubMed
    gag Tandem affinity purification and mass spectrometry analysis identify HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into Staufen1 ribonucleoprotein complexes isolated from HIV-1-expressing cells PubMed
    gag EAP30 interacts with HIV-1 Gag and Staufen1 in live cell tri-molecular fluorescence complementary assay PubMed
    gag HIV-1 Gag and Stau1 interact in both membrane-associated and cytosolic complexes. Stau1 overexpression and depletion by RNAi modulate Gag multimerization PubMed
    gag The NC zinc fingers mediate Stau1/Gag interaction. The N-terminal domain (residues 26-37) of Stau1 is required for its function in Gag multimerization PubMed
    nucleocapsid gag Staufen is incorporated into HIV-1 virions through association with HIV-1 genomic RNA and is implicated in HIV-1 genome selection and packaging into assembling virions, a process that is mediated by the Nucleocapsid domain of HIV-1 Gag PubMed
    gag The NC zinc fingers mediate Stau1/Gag interaction. The N-terminal domain (residues 26-37) of Stau1 is required for its function in Gag multimerization PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ25010

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables double-stranded RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein phosphatase 1 binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in anterograde dendritic transport of messenger ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in germ cell development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular mRNA localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lncRNA-mediated post-transcriptional gene silencing TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in modification of postsynaptic structure IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation by virus of viral protein levels in host cell IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of long-term synaptic potentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of viral genome replication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasmic ribonucleoprotein granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasmic stress granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic stress granule ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in dendrite cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular exosome HDA PubMed 
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane HDA PubMed 
    part_of microtubule associated complex TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in neuronal cell body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in rough endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    double-stranded RNA-binding protein Staufen homolog 1
    Names
    protein phosphatase 1, regulatory subunit 150
    staufen, RNA binding protein, homolog 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029453.2 RefSeqGene

      Range
      45962..120957
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001037328.3 → NP_001032405.1  double-stranded RNA-binding protein Staufen homolog 1 isoform c

      See identical proteins and their annotated locations for NP_001032405.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (T5) differs in the 5' UTR and uses an alternate in-frame splice site in the 5' coding region compared to variant T2. The encoded isoform (c) is longer than isoform a. Both variants T5 and T6 encode the same isoform (c).
      Source sequence(s)
      AF061938, AK091405, BC010169, BC095397, BE439382
      Consensus CDS
      CCDS33481.1
      UniProtKB/TrEMBL
      Q5JW30
      Conserved Domains (3) summary
      smart00358
      Location:105 → 175
      DSRM; Double-stranded RNA binding motif
      cd00048
      Location:211 → 277
      DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
      pfam16482
      Location:373 → 482
      Staufen_C; Staufen C-terminal domain

    2. NM_001319134.2 → NP_001306063.1  double-stranded RNA-binding protein Staufen homolog 1 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (T6) uses an alternate in-frame splice site in the 5' coding region compared to variant T2. The encoded isoform (c) is longer than isoform a. Both variants T5 and T6 encode the same isoform (c).
      Source sequence(s)
      AK091405, AY546099, BE439382, BQ649508, DB100321
      Consensus CDS
      CCDS33481.1
      UniProtKB/TrEMBL
      Q5JW30
      Related
      ENSP00000360893.3, ENST00000371828.7
      Conserved Domains (3) summary
      smart00358
      Location:105 → 175
      DSRM; Double-stranded RNA binding motif
      cd00048
      Location:211 → 277
      DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
      pfam16482
      Location:373 → 482
      Staufen_C; Staufen C-terminal domain

    3. NM_001319135.2 → NP_001306064.1  double-stranded RNA-binding protein Staufen homolog 1 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (T7) differs in the 5' UTR and the 5' coding region, and uses an upstream translation start site compared to variant T2. The encoded isoform (b) has a longer and distinct N-terminus compared to isoform a. Both variants T3 and T7 encode the same isoform (b).
      Source sequence(s)
      AB209561, AK091405, BE439382, BQ649508, DB086071
      Consensus CDS
      CCDS13414.1
      UniProtKB/Swiss-Prot
      A8K9Z4, E1P5Y1, E1P608, O95793, Q5JW29, Q6GTM4, Q9H5B4, Q9H5B5, Q9Y3Q2
      UniProtKB/TrEMBL
      A8K622
      Conserved Domains (3) summary
      smart00358
      Location:186 → 250
      DSRM; Double-stranded RNA binding motif
      cd00048
      Location:286 → 352
      DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
      pfam16482
      Location:448 → 557
      Staufen_C; Staufen C-terminal domain

    4. NM_001322927.2 → NP_001309856.1  double-stranded RNA-binding protein Staufen homolog 1 isoform c

      Status: REVIEWED

      Source sequence(s)
      AL133174, BE439382, DA455473, DA858410
      Consensus CDS
      CCDS33481.1
      UniProtKB/TrEMBL
      Q5JW30
      Related
      ENSP00000360867.1, ENST00000371802.5
      Conserved Domains (3) summary
      smart00358
      Location:105 → 175
      DSRM; Double-stranded RNA binding motif
      cd00048
      Location:211 → 277
      DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
      pfam16482
      Location:373 → 482
      Staufen_C; Staufen C-terminal domain

    5. NM_001322928.2 → NP_001309857.1  double-stranded RNA-binding protein Staufen homolog 1 isoform d

      Status: REVIEWED

      Source sequence(s)
      AL133174, BE439382, DA455473, DA858410
      UniProtKB/TrEMBL
      Q5JW30
      Conserved Domains (4) summary
      pfam16482
      Location:413 → 522
      Staufen_C; Staufen C-terminal domain
      cd19881
      Location:41 → 105
      DSRM_STAU1_rpt2; second double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 1 (Staufen 1) and similar proteins
      cd19885
      Location:241 → 326
      DSRM_STAU1_rpt4; fourth double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 1 (Staufen 1) and similar proteins
      cl00054
      Location:142 → 214
      DSRM_SF; double-stranded RNA binding motif (DSRM) superfamily

    6. NM_001322929.2 → NP_001309858.1  double-stranded RNA-binding protein Staufen homolog 1 isoform b

      Status: REVIEWED

      Source sequence(s)
      AL133174, BE439382
      Consensus CDS
      CCDS13414.1
      UniProtKB/Swiss-Prot
      A8K9Z4, E1P5Y1, E1P608, O95793, Q5JW29, Q6GTM4, Q9H5B4, Q9H5B5, Q9Y3Q2
      UniProtKB/TrEMBL
      A8K622
      Conserved Domains (3) summary
      smart00358
      Location:186 → 250
      DSRM; Double-stranded RNA binding motif
      cd00048
      Location:286 → 352
      DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
      pfam16482
      Location:448 → 557
      Staufen_C; Staufen C-terminal domain

    7. NM_001322930.2 → NP_001309859.1  double-stranded RNA-binding protein Staufen homolog 1 isoform b

      Status: REVIEWED

      Source sequence(s)
      AL133174, BE439382, DA455473
      Consensus CDS
      CCDS13414.1
      UniProtKB/Swiss-Prot
      A8K9Z4, E1P5Y1, E1P608, O95793, Q5JW29, Q6GTM4, Q9H5B4, Q9H5B5, Q9Y3Q2
      UniProtKB/TrEMBL
      A8K622
      Conserved Domains (3) summary
      smart00358
      Location:186 → 250
      DSRM; Double-stranded RNA binding motif
      cd00048
      Location:286 → 352
      DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
      pfam16482
      Location:448 → 557
      Staufen_C; Staufen C-terminal domain

    8. NM_001322931.2 → NP_001309860.1  double-stranded RNA-binding protein Staufen homolog 1 isoform e

      Status: REVIEWED

      Source sequence(s)
      AL133174, BE439382, DA455473, DA858410
      UniProtKB/TrEMBL
      Q5JW30

    9. NM_001322932.2 → NP_001309861.1  double-stranded RNA-binding protein Staufen homolog 1 isoform f

      Status: REVIEWED

      Source sequence(s)
      AL133174, BE439382
      UniProtKB/TrEMBL
      A8K622
      Conserved Domains (3) summary
      smart00358
      Location:186 → 256
      DSRM; Double-stranded RNA binding motif
      cd00048
      Location:292 → 358
      DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
      pfam16482
      Location:454 → 563
      Staufen_C; Staufen C-terminal domain

    10. NM_001322933.2 → NP_001309862.1  double-stranded RNA-binding protein Staufen homolog 1 isoform f

      Status: REVIEWED

      Source sequence(s)
      AL133174, BE439382
      UniProtKB/TrEMBL
      A8K622
      Conserved Domains (3) summary
      smart00358
      Location:186 → 256
      DSRM; Double-stranded RNA binding motif
      cd00048
      Location:292 → 358
      DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
      pfam16482
      Location:454 → 563
      Staufen_C; Staufen C-terminal domain

    11. NM_004602.4 → NP_004593.2  double-stranded RNA-binding protein Staufen homolog 1 isoform a

      See identical proteins and their annotated locations for NP_004593.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (T4) has an additional exon in the 5' UTR compared to T2, the most abundantly expressed transcript variant. T4 encodes the same isoform (a) of 496 amino acids as T2.
      Source sequence(s)
      AF061941, AK091405, BC001893, BC050432, BC095397, BE439382
      Consensus CDS
      CCDS13415.1
      UniProtKB/TrEMBL
      Q5JW30
      Related
      ENSP00000345425.6, ENST00000340954.11
      Conserved Domains (3) summary
      smart00358
      Location:105 → 169
      DSRM; Double-stranded RNA binding motif
      cd00048
      Location:205 → 271
      DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
      pfam16482
      Location:367 → 476
      Staufen_C; Staufen C-terminal domain

    12. NM_017452.4 → NP_059346.2  double-stranded RNA-binding protein Staufen homolog 1 isoform a

      See identical proteins and their annotated locations for NP_059346.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (T2) is most abundantly expressed, and encodes the protein isoform (a) of 496 amino acids.
      Source sequence(s)
      AK091405, BC050432, BC095397, BE439382
      Consensus CDS
      CCDS13415.1
      UniProtKB/TrEMBL
      Q5JW30
      Related
      ENSP00000353604.4, ENST00000360426.8
      Conserved Domains (3) summary
      smart00358
      Location:105 → 169
      DSRM; Double-stranded RNA binding motif
      cd00048
      Location:205 → 271
      DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
      pfam16482
      Location:367 → 476
      Staufen_C; Staufen C-terminal domain

    13. NM_017453.4 → NP_059347.2  double-stranded RNA-binding protein Staufen homolog 1 isoform b

      See identical proteins and their annotated locations for NP_059347.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (T3) differs in the 5' UTR and the 5' coding region, and uses an upstream translation start site compared to variant T2. The encoded isoform (b) has a longer and distinct N-terminus compared to isoform a. Both variants T3 and T7 encode the same isoform (b).
      Source sequence(s)
      AL133174
      Consensus CDS
      CCDS13414.1
      UniProtKB/Swiss-Prot
      A8K9Z4, E1P5Y1, E1P608, O95793, Q5JW29, Q6GTM4, Q9H5B4, Q9H5B5, Q9Y3Q2
      UniProtKB/TrEMBL
      A8K622
      Related
      ENSP00000360922.2, ENST00000371856.7
      Conserved Domains (3) summary
      smart00358
      Location:186 → 250
      DSRM; Double-stranded RNA binding motif
      cd00048
      Location:286 → 352
      DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
      pfam16482
      Location:448 → 557
      Staufen_C; Staufen C-terminal domain

    14. NM_017454.4 → NP_059348.2  double-stranded RNA-binding protein Staufen homolog 1 isoform a

      See identical proteins and their annotated locations for NP_059348.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (T1) lacks an exon in the 5' UTR compared to T2, the most abundantly expressed transcript variant. T1 encodes the same isoform (a) of 496 amino acids as T2.
      Source sequence(s)
      AK091405, BC050432, BC095397, BE439382
      Consensus CDS
      CCDS13415.1
      UniProtKB/TrEMBL
      Q5JW30
      Related
      ENSP00000323443.7, ENST00000347458.9
      Conserved Domains (3) summary
      smart00358
      Location:105 → 169
      DSRM; Double-stranded RNA binding motif
      cd00048
      Location:205 → 271
      DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
      pfam16482
      Location:367 → 476
      Staufen_C; Staufen C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

      Range
      49113339..49219295 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005260527.1 → XP_005260584.1  double-stranded RNA-binding protein Staufen homolog 1 isoform X5

      See identical proteins and their annotated locations for XP_005260584.1

      UniProtKB/TrEMBL
      Q5JW30
      Conserved Domains (3) summary
      smart00358
      Location:105 → 175
      DSRM; Double-stranded RNA binding motif
      cd00048
      Location:211 → 277
      DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
      pfam16482
      Location:373 → 482
      Staufen_C; Staufen C-terminal domain

    2. XM_017028028.2 → XP_016883517.1  double-stranded RNA-binding protein Staufen homolog 1 isoform X4

      UniProtKB/TrEMBL
      Q5JW30

    3. XM_047440423.1 → XP_047296379.1  double-stranded RNA-binding protein Staufen homolog 1 isoform X3

    4. XM_006723865.2 → XP_006723928.1  double-stranded RNA-binding protein Staufen homolog 1 isoform X1

      See identical proteins and their annotated locations for XP_006723928.1

      UniProtKB/TrEMBL
      A8K622
      Conserved Domains (3) summary
      smart00358
      Location:186 → 256
      DSRM; Double-stranded RNA binding motif
      cd00048
      Location:292 → 358
      DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
      pfam16482
      Location:454 → 563
      Staufen_C; Staufen C-terminal domain

    5. XM_047440420.1 → XP_047296376.1  double-stranded RNA-binding protein Staufen homolog 1 isoform X2

      UniProtKB/Swiss-Prot
      A8K9Z4, E1P5Y1, E1P608, O95793, Q5JW29, Q6GTM4, Q9H5B4, Q9H5B5, Q9Y3Q2

    6. XM_047440416.1 → XP_047296372.1  double-stranded RNA-binding protein Staufen homolog 1 isoform X1

    7. XM_047440419.1 → XP_047296375.1  double-stranded RNA-binding protein Staufen homolog 1 isoform X2

      UniProtKB/Swiss-Prot
      A8K9Z4, E1P5Y1, E1P608, O95793, Q5JW29, Q6GTM4, Q9H5B4, Q9H5B5, Q9Y3Q2

    8. XM_047440414.1 → XP_047296370.1  double-stranded RNA-binding protein Staufen homolog 1 isoform X1

    9. XM_047440418.1 → XP_047296374.1  double-stranded RNA-binding protein Staufen homolog 1 isoform X2

      UniProtKB/Swiss-Prot
      A8K9Z4, E1P5Y1, E1P608, O95793, Q5JW29, Q6GTM4, Q9H5B4, Q9H5B5, Q9Y3Q2

    10. XM_047440415.1 → XP_047296371.1  double-stranded RNA-binding protein Staufen homolog 1 isoform X1

    11. XM_047440422.1 → XP_047296378.1  double-stranded RNA-binding protein Staufen homolog 1 isoform X2

      UniProtKB/Swiss-Prot
      A8K9Z4, E1P5Y1, E1P608, O95793, Q5JW29, Q6GTM4, Q9H5B4, Q9H5B5, Q9Y3Q2

    12. XM_047440421.1 → XP_047296377.1  double-stranded RNA-binding protein Staufen homolog 1 isoform X2

      UniProtKB/Swiss-Prot
      A8K9Z4, E1P5Y1, E1P608, O95793, Q5JW29, Q6GTM4, Q9H5B4, Q9H5B5, Q9Y3Q2

    13. XM_047440417.1 → XP_047296373.1  double-stranded RNA-binding protein Staufen homolog 1 isoform X1

    14. XM_047440424.1 → XP_047296380.1  double-stranded RNA-binding protein Staufen homolog 1 isoform X4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060944.1 Alternate T2T-CHM13v2.0

      Range
      50882825..50988811 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054323930.1 → XP_054179905.1  double-stranded RNA-binding protein Staufen homolog 1 isoform X5

    2. XM_054323928.1 → XP_054179903.1  double-stranded RNA-binding protein Staufen homolog 1 isoform X4

    3. XM_054323927.1 → XP_054179902.1  double-stranded RNA-binding protein Staufen homolog 1 isoform X3

    4. XM_054323919.1 → XP_054179894.1  double-stranded RNA-binding protein Staufen homolog 1 isoform X1

    5. XM_054323925.1 → XP_054179900.1  double-stranded RNA-binding protein Staufen homolog 1 isoform X2

      UniProtKB/Swiss-Prot
      A8K9Z4, E1P5Y1, E1P608, O95793, Q5JW29, Q6GTM4, Q9H5B4, Q9H5B5, Q9Y3Q2

    6. XM_054323924.1 → XP_054179899.1  double-stranded RNA-binding protein Staufen homolog 1 isoform X2

      UniProtKB/Swiss-Prot
      A8K9Z4, E1P5Y1, E1P608, O95793, Q5JW29, Q6GTM4, Q9H5B4, Q9H5B5, Q9Y3Q2

    7. XM_054323920.1 → XP_054179895.1  double-stranded RNA-binding protein Staufen homolog 1 isoform X1

    8. XM_054323921.1 → XP_054179896.1  double-stranded RNA-binding protein Staufen homolog 1 isoform X1

    9. XM_054323923.1 → XP_054179898.1  double-stranded RNA-binding protein Staufen homolog 1 isoform X2

      UniProtKB/Swiss-Prot
      A8K9Z4, E1P5Y1, E1P608, O95793, Q5JW29, Q6GTM4, Q9H5B4, Q9H5B5, Q9Y3Q2

    10. XM_054323926.1 → XP_054179901.1  double-stranded RNA-binding protein Staufen homolog 1 isoform X2

      UniProtKB/Swiss-Prot
      A8K9Z4, E1P5Y1, E1P608, O95793, Q5JW29, Q6GTM4, Q9H5B4, Q9H5B5, Q9Y3Q2

    11. XM_054323922.1 → XP_054179897.1  double-stranded RNA-binding protein Staufen homolog 1 isoform X1

    12. XM_054323929.1 → XP_054179904.1  double-stranded RNA-binding protein Staufen homolog 1 isoform X4

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O95793.2 GenPept UniProtKB/Swiss-Prot:O95793

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