U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from Nucleotide

    • Showing Current items.

    TMEM8B transmembrane protein 8B [ Homo sapiens (human) ]

    Gene ID: 51754, updated on 10-Dec-2024

    Summary

    Official Symbol
    TMEM8Bprovided by HGNC
    Official Full Name
    transmembrane protein 8Bprovided by HGNC
    Primary source
    HGNC:HGNC:21427
    See related
    Ensembl:ENSG00000137103 MIM:616888; AllianceGenome:HGNC:21427
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NAG5; NGX6; FP588; NAG-5; NGX6a; C9orf127; LINC00950
    Summary
    Involved in cell-matrix adhesion. Located in cell surface and plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in brain (RPKM 4.5), ovary (RPKM 3.3) and 23 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See TMEM8B in Genome Data Viewer
    Location:
    9p13.3
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (35829228..35865515)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (35849899..35886190)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (35829225..35865512)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19881 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28338 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19882 Neighboring gene histidine triad nucleotide binding protein 2 Neighboring gene family with sequence similarity 221 member B Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28339 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19883 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:35829817-35830317 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:35835675-35836588 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28340 Neighboring gene Sharpr-MPRA regulatory region 825 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:35846373-35847248 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28341 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28342 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28343 Neighboring gene olfactory receptor family 13 subfamily E member 1 pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:35865013-35865512 Neighboring gene olfactory receptor family 13 subfamily J member 1 Neighboring gene NADH:ubiquinone oxidoreductase subunit A5 pseudogene 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ30363, FLJ30741, MGC120460, DKFZp547N0218

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cell-matrix adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of mitotic cell cycle TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    transmembrane protein 8B
    Names
    nasopharyngeal carcinoma expressed 6
    nasopharyngeal carcinoma related protein
    nasopharyngeal carcinoma-associated gene 6 protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001042589.3NP_001036054.1  transmembrane protein 8B isoform a

      See identical proteins and their annotated locations for NP_001036054.1

      Status: VALIDATED

      Source sequence(s)
      AL133410, BC043384
      Consensus CDS
      CCDS43800.1
      UniProtKB/Swiss-Prot
      A6NDV4, B3KQF3, O75539, Q49AB1, Q4KMX5, Q5TCW5, Q9HBY2, Q9P0U7
      Related
      ENSP00000367230.4, ENST00000377991.9
      Conserved Domains (1) summary
      pfam12036
      Location:245415
      DUF3522; Protein of unknown function (DUF3522)
    2. NM_001042590.4NP_001036055.2  transmembrane protein 8B isoform c

      Status: VALIDATED

      Source sequence(s)
      AL133410
      Consensus CDS
      CCDS94406.1
      UniProtKB/TrEMBL
      A0A2R8Y2M5
      Related
      ENSP00000493496.1, ENST00000643932.2
      Conserved Domains (2) summary
      pfam12036
      Location:697867
      DUF3522; Protein of unknown function (DUF3522)
      cl26464
      Location:34144
      Atrophin-1; Atrophin-1 family
    3. NM_001363620.1NP_001350549.1  transmembrane protein 8B isoform d

      Status: VALIDATED

      Source sequence(s)
      AL133410
      Conserved Domains (2) summary
      pfam12036
      Location:697751
      DUF3522; Protein of unknown function (DUF3522)
      cl26464
      Location:34144
      Atrophin-1; Atrophin-1 family
    4. NM_001363621.1NP_001350550.1  transmembrane protein 8B isoform b

      Status: VALIDATED

      Source sequence(s)
      AL133410
      Consensus CDS
      CCDS6595.1
      Related
      ENSP00000367235.1, ENST00000377996.5
      Conserved Domains (1) summary
      pfam12036
      Location:245299
      DUF3522; Protein of unknown function (DUF3522)
    5. NM_001363622.1NP_001350551.1  transmembrane protein 8B isoform e

      Status: VALIDATED

      Source sequence(s)
      AL133410
      Conserved Domains (1) summary
      pfam12036
      Location:245361
      DUF3522; Protein of unknown function (DUF3522)
    6. NM_001363625.1NP_001350554.1  transmembrane protein 8B isoform f

      Status: VALIDATED

      Source sequence(s)
      AL133410, BC064951
      Conserved Domains (1) summary
      cl26464
      Location:34144
      Atrophin-1; Atrophin-1 family
    7. NM_016446.4NP_057530.2  transmembrane protein 8B isoform b

      See identical proteins and their annotated locations for NP_057530.2

      Status: VALIDATED

      Source sequence(s)
      AF188239, AL133410
      Consensus CDS
      CCDS6595.1
      UniProtKB/Swiss-Prot
      A6NDV4
      Related
      ENSP00000395810.2, ENST00000439587.6
      Conserved Domains (1) summary
      pfam12036
      Location:245299
      DUF3522; Protein of unknown function (DUF3522)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      35829228..35865515
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011517902.3XP_011516204.2  transmembrane protein 8B isoform X2

    2. XM_047423472.1XP_047279428.1  transmembrane protein 8B isoform X15

      UniProtKB/Swiss-Prot
      A6NDV4, B3KQF3, O75539, Q49AB1, Q4KMX5, Q5TCW5, Q9HBY2, Q9P0U7
    3. XM_011517901.3XP_011516203.2  transmembrane protein 8B isoform X1

    4. XM_011517903.3XP_011516205.2  transmembrane protein 8B isoform X4

    5. XM_005251483.5XP_005251540.4  transmembrane protein 8B isoform X3

    6. XM_024447570.2XP_024303338.2  transmembrane protein 8B isoform X5

    7. XM_047423467.1XP_047279423.1  transmembrane protein 8B isoform X8

    8. XM_047423468.1XP_047279424.1  transmembrane protein 8B isoform X11

    9. XM_011517912.3XP_011516214.1  transmembrane protein 8B isoform X10

      See identical proteins and their annotated locations for XP_011516214.1

      Conserved Domains (1) summary
      pfam12036
      Location:271383
      DUF3522; Protein of unknown function (DUF3522)
    10. XM_011517910.4XP_011516212.1  transmembrane protein 8B isoform X10

      See identical proteins and their annotated locations for XP_011516212.1

      Conserved Domains (1) summary
      pfam12036
      Location:271383
      DUF3522; Protein of unknown function (DUF3522)
    11. XM_047423466.1XP_047279422.1  transmembrane protein 8B isoform X7

    12. XM_011517905.2XP_011516207.2  transmembrane protein 8B isoform X6

    13. XM_047423470.1XP_047279426.1  transmembrane protein 8B isoform X13

    14. XM_047423469.1XP_047279425.1  transmembrane protein 8B isoform X12

    15. XM_011517913.3XP_011516215.1  transmembrane protein 8B isoform X10

      See identical proteins and their annotated locations for XP_011516215.1

      Conserved Domains (1) summary
      pfam12036
      Location:271383
      DUF3522; Protein of unknown function (DUF3522)
    16. XM_011517914.3XP_011516216.1  transmembrane protein 8B isoform X10

      See identical proteins and their annotated locations for XP_011516216.1

      Conserved Domains (1) summary
      pfam12036
      Location:271383
      DUF3522; Protein of unknown function (DUF3522)
    17. XM_047423471.1XP_047279427.1  transmembrane protein 8B isoform X14

    18. XM_017014805.2XP_016870294.1  transmembrane protein 8B isoform X9

      Conserved Domains (1) summary
      pfam12036
      Location:438550
      DUF3522; Protein of unknown function (DUF3522)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      35849899..35886190
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054363088.1XP_054219063.1  transmembrane protein 8B isoform X2

    2. XM_054363105.1XP_054219080.1  transmembrane protein 8B isoform X15

      UniProtKB/Swiss-Prot
      A6NDV4, B3KQF3, O75539, Q49AB1, Q4KMX5, Q5TCW5, Q9HBY2, Q9P0U7
    3. XM_054363107.1XP_054219082.1  transmembrane protein 8B isoform X15

      UniProtKB/Swiss-Prot
      A6NDV4, B3KQF3, O75539, Q49AB1, Q4KMX5, Q5TCW5, Q9HBY2, Q9P0U7
    4. XM_054363090.1XP_054219065.1  transmembrane protein 8B isoform X4

    5. XM_054363091.1XP_054219066.1  transmembrane protein 8B isoform X5

    6. XM_054363098.1XP_054219073.1  transmembrane protein 8B isoform X11

    7. XM_054363087.1XP_054219062.1  transmembrane protein 8B isoform X1

    8. XM_054363089.1XP_054219064.1  transmembrane protein 8B isoform X3

    9. XM_054363094.1XP_054219069.1  transmembrane protein 8B isoform X8

    10. XM_054363097.1XP_054219072.1  transmembrane protein 8B isoform X10

    11. XM_054363096.1XP_054219071.1  transmembrane protein 8B isoform X10

    12. XM_054363101.1XP_054219076.1  transmembrane protein 8B isoform X10

    13. XM_054363102.1XP_054219077.1  transmembrane protein 8B isoform X10

    14. XM_054363093.1XP_054219068.1  transmembrane protein 8B isoform X7

    15. XM_054363092.1XP_054219067.1  transmembrane protein 8B isoform X6

    16. XM_054363100.1XP_054219075.1  transmembrane protein 8B isoform X13

    17. XM_054363099.1XP_054219074.1  transmembrane protein 8B isoform X12

    18. XM_054363103.1XP_054219078.1  transmembrane protein 8B isoform X10

    19. XM_054363106.1XP_054219081.1  transmembrane protein 8B isoform X10

    20. XM_054363104.1XP_054219079.1  transmembrane protein 8B isoform X14

    21. XM_054363095.1XP_054219070.1  transmembrane protein 8B isoform X9

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NR_024006.1: Suppressed sequence

      Description
      NR_024006.1: This RefSeq was removed because the gene was discontinued.