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    Tnfrsf18 tumor necrosis factor receptor superfamily, member 18 [ Mus musculus (house mouse) ]

    Gene ID: 21936, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tnfrsf18provided by MGI
    Official Full Name
    tumor necrosis factor receptor superfamily, member 18provided by MGI
    Primary source
    MGI:MGI:894675
    See related
    Ensembl:ENSMUSG00000041954 AllianceGenome:MGI:894675
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AITR; Gitr
    Summary
    Predicted to enable tumor necrosis factor receptor activity. Involved in positive regulation of cell adhesion. Located in external side of plasma membrane. Is expressed in genitourinary system; gut; heart ventricle; lung; and skin. Orthologous to human TNFRSF18 (TNF receptor superfamily member 18). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 23.3), mammary gland adult (RPKM 14.4) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tnfrsf18 in Genome Data Viewer
    Location:
    4 E2; 4 87.76 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (156110779..156113351)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (156026322..156028894)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene stromal cell derived factor 4 Neighboring gene tumor necrosis factor receptor superfamily, member 4 Neighboring gene predicted gene 16008 Neighboring gene predicted gene, 25982 Neighboring gene tubulin tyrosine ligase-like family, member 10 Neighboring gene predicted gene 13648 Neighboring gene microRNA 429

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Conversion of alloantigen-specific CD8+ T cell anergy to CD8+ T cell priming through in vivo ligation of glucocorticoid-induced TNF receptor. Kim J, et al. J Immunol, 2006 May 1. PMID 16621987
    2. Constitutive GITR Activation Reduces Atherosclerosis by Promoting Regulatory CD4+ T-Cell Responses-Brief Report. Meiler S, et al. Arterioscler Thromb Vasc Biol, 2016 Sep. PMID 27444204
    3. Blockade of Glucocorticoid-Induced Tumor Necrosis Factor-Receptor-Related Protein Signaling Ameliorates Murine Collagen-Induced Arthritis by Modulating Follicular Helper T Cells. Ma J, et al. Am J Pathol, 2016 Jun. PMID 27106763
    4. GITR Activation Positively Regulates Immune Responses against Toxoplasma gondii. Costa FR, et al. PLoS One, 2016. PMID 27027302, Free PMC Article
    5. Costimulation via glucocorticoid-induced TNF receptor in both conventional and CD25+ regulatory CD4+ T cells. Kanamaru F, et al. J Immunol, 2004 Jun 15. PMID 15187106

    See all (135) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GITR agonistic stimulation enhances the anti-tumor immune response in a mouse model of ESCC.
      Title: GITR agonistic stimulation enhances the anti-tumor immune response in a mouse model of ESCC.
    2. Glucocorticoid induced TNF receptor family-related protein (GITR) - A novel driver of atherosclerosis.
      Title: Glucocorticoid induced TNF receptor family-related protein (GITR) - A novel driver of atherosclerosis.
    3. Multiple mechanisms for TRAF3-mediated regulation of the T cell costimulatory receptor GITR.
      Title: Multiple mechanisms for TRAF3-mediated regulation of the T cell costimulatory receptor GITR.
    4. T Cell-Intrinsic CX3CR1 Marks the Most Differentiated Effector CD4(+) T Cells, but Is Largely Dispensable for CD4(+) T Cell Responses during Chronic Viral Infection.
      Title: T Cell-Intrinsic CX3CR1 Marks the Most Differentiated Effector CD4(+) T Cells, but Is Largely Dispensable for CD4(+) T Cell Responses during Chronic Viral Infection.
    5. Blockade of GITRL/GITR signaling pathway attenuates house dust mite-induced allergic asthma in mice through inhibition of MAPKs and NF-kappaB signaling.
      Title: Blockade of GITRL/GITR signaling pathway attenuates house dust mite-induced allergic asthma in mice through inhibition of MAPKs and NF-κB signaling.
    6. Evaluation of glucocorticoid-induced TNF receptor (GITR) expression in breast cancer and across multiple tumor types.
      Title: Evaluation of glucocorticoid-induced TNF receptor (GITR) expression in breast cancer and across multiple tumor types.
    7. Glucocorticoid-induced tumour necrosis factor receptor family-related protein (GITR) drives atherosclerosis in mice and is associated with an unstable plaque phenotype and cerebrovascular events in humans.
      Title: Glucocorticoid-induced tumour necrosis factor receptor family-related protein (GITR) drives atherosclerosis in mice and is associated with an unstable plaque phenotype and cerebrovascular events in humans.
    8. GITR controls intestinal inflammation by suppressing IL-15-dependent NK cell activity.
      Title: GITR controls intestinal inflammation by suppressing IL-15-dependent NK cell activity.
    9. Structures of mouse and human GITR-GITRL complexes reveal unique TNF superfamily interactions.
      Title: Structures of mouse and human GITR-GITRL complexes reveal unique TNF superfamily interactions.
    10. GITR Agonism Triggers Antitumor Immune Responses through IL21-Expressing Follicular Helper T Cells.
      Title: GITR Agonism Triggers Antitumor Immune Responses through IL21-Expressing Follicular Helper T Cells.
    Submit: New GeneRIF Correction See all GeneRIFs (86)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (6) 
    • Targeted (7)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables tumor necrosis factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of leukocyte migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of tyrosine phosphorylation of STAT protein ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tumor necrosis factor-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    tumor necrosis factor receptor superfamily member 18
    Names
    glucocorticoid-induced TNFR-related protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009400.3 → NP_033426.1  tumor necrosis factor receptor superfamily member 18 isoform 1 precursor

      See identical proteins and their annotated locations for NP_033426.1

      Status: VALIDATED

      Source sequence(s)
      AK020762, AK081878, AY157833
      Consensus CDS
      CCDS19056.1
      UniProtKB/Swiss-Prot
      O35714, Q9JKR1, Q9JKR2, Q9JKR3
      UniProtKB/TrEMBL
      Q540M6, Q8C4K3
      Related
      ENSMUSP00000099462.4, ENSMUST00000103173.10
      Conserved Domains (1) summary
      cd13417
      Location:43 → 168
      TNFRSF18; Tumor necrosis factor receptor superfamily member 18 (TNFRSF18), also known as glucocorticoid-induced tumor necrosis factor receptor family-related protein (GITR)

    2. NM_021985.3 → NP_068820.1  tumor necrosis factor receptor superfamily member 18 isoform 2 precursor

      See identical proteins and their annotated locations for NP_068820.1

      Status: VALIDATED

      Source sequence(s)
      AK020762, AK081878, AY157833
      Consensus CDS
      CCDS19057.1
      UniProtKB/Swiss-Prot
      O35714
      Related
      ENSMUSP00000040035.8, ENSMUST00000040274.13
      Conserved Domains (2) summary
      cd00185
      Location:77 → 121
      TNFRSF; CRD2 [structural motif]
      cl22855
      Location:43 → 121
      TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      156110779..156113351
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O35714.1 GenPept UniProtKB/Swiss-Prot:O35714

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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