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    G6pd2 glucose-6-phosphate dehydrogenase 2 [ Mus musculus (house mouse) ]

    Gene ID: 14380, updated on 9-Dec-2024

    Summary

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    Official Symbol
    G6pd2provided by MGI
    Official Full Name
    glucose-6-phosphate dehydrogenase 2provided by MGI
    Primary source
    MGI:MGI:105977
    See related
    Ensembl:ENSMUSG00000089992 AllianceGenome:MGI:105977
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gpd2; Gpd-2; G6pdx-ps1
    Summary
    Enables glucose-6-phosphate dehydrogenase activity. Predicted to be involved in several processes, including negative regulation of cell growth involved in cardiac muscle cell development; negative regulation of protein glutathionylation; and pentose-phosphate shunt, oxidative branch. Predicted to be located in several cellular components, including centriolar satellite; cytoplasmic side of plasma membrane; and intracellular membrane-bounded organelle. Predicted to be active in cytosol. Is expressed in genitourinary system; nervous system; and nose. Human ortholog(s) of this gene implicated in several diseases, including anemia (multiple); cerebrovascular disease; favism; malaria (multiple); and neonatal jaundice. Orthologous to human G6PD (glucose-6-phosphate dehydrogenase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See G6pd2 in Genome Data Viewer
    Location:
    5 C3.1; 5 31.99 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (61966186..61967820)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (61808843..61810477)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene serine/arginine-rich splicing factor 3 pseudogene Neighboring gene STARR-seq mESC enhancer starr_13166 Neighboring gene predicted gene, 40308 Neighboring gene SEC63-like pseudogene Neighboring gene predicted gene, 22273

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Autosomal control of an electrophoretic variant of glucose-6-phosphate dehydrogenase in the mouse (Mus musculus). Ruddle FH, et al. Genetics, 1968 Apr. PMID 5693479, Free PMC Article
    2. Testis-specific expression of a functional retroposon encoding glucose-6-phosphate dehydrogenase in the mouse. Hendriksen PJ, et al. Genomics, 1997 May 1. PMID 9169132
    3. The evolutionary fate of recently duplicated retrogenes in mice. Gayral P, et al. J Evol Biol, 2007 Mar. PMID 17305828
    4. Physical mapping of the Tec and Gabrb1 loci reveals that the Wsh mutation on mouse chromosome 5 is associated with an inversion. Nagle DL, et al. Hum Mol Genet, 1995 Nov. PMID 8589683
    5. Genetic mapping of three GABAA receptor-subunit genes in the mouse. Danciger M, et al. Genomics, 1993 May. PMID 8390964

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables D-glucose binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables NADP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NADP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables carbohydrate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glucose-6-phosphate dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glucose-6-phosphate dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glucose-6-phosphate dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glucose-6-phosphate dehydrogenase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in NADP metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in NADP metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in NADPH regeneration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cholesterol biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in erythrocyte maturation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glucose 6-phosphate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glucose 6-phosphate metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in glucose metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glucose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glutathione metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell growth involved in cardiac muscle cell development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of protein glutathionylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of reactive oxygen species metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in pentose biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in pentose-phosphate shunt IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pentose-phosphate shunt ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in pentose-phosphate shunt, oxidative branch IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pentose-phosphate shunt, oxidative branch ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to ethanol ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ribose phosphate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in centriolar satellite ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    glucose-6-phosphate 1-dehydrogenase 2
    Names
    G6PD
    glucose-6-phosphate dehydrogenase X-linked, pseudogene 1
    NP_062341.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019468.2 → NP_062341.2  glucose-6-phosphate 1-dehydrogenase 2

      See identical proteins and their annotated locations for NP_062341.2

      Status: VALIDATED

      Source sequence(s)
      AC114918, BC137684
      Consensus CDS
      CCDS19297.1
      UniProtKB/Swiss-Prot
      P97324, Q0VB18
      UniProtKB/TrEMBL
      G3UWD6
      Related
      ENSMUSP00000131163.2, ENSMUST00000053876.5
      Conserved Domains (3) summary
      TIGR00871
      Location:30 → 506
      zwf; glucose-6-phosphate 1-dehydrogenase
      pfam00479
      Location:35 → 209
      G6PD_N; Glucose-6-phosphate dehydrogenase, NAD binding domain
      pfam02781
      Location:212 → 503
      G6PD_C; Glucose-6-phosphate dehydrogenase, C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      61966186..61967820
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P97324.3 GenPept UniProtKB/Swiss-Prot:P97324

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