H2-T27 histocompatibility 2, T region locus 27 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: H2-T27provided by MGI
Official Full Name: histocompatibility 2, T region locus 27provided by MGI
Primary source: MGI:MGI:3779381
See related: Ensembl:ENSMUSG00000079492 AllianceGenome:MGI:3779381
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: H-2T15; H2-T15; Gm11127; H2-gs14-2
Summary: Predicted to enable peptide antigen binding activity and signaling receptor binding activity. Predicted to be involved in several processes, including antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent; antigen processing and presentation of endogenous peptide antigen via MHC class Ib; and positive regulation of T cell mediated cytotoxicity. Predicted to be active in external side of plasma membrane and extracellular space. Human ortholog(s) of this gene implicated in asthma; hepatitis C; and occupational asthma. Orthologous to human HLA-E (major histocompatibility complex, class I, E); HLA-F (major histocompatibility complex, class I, F); and HLA-G (major histocompatibility complex, class I, G). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in duodenum adult (RPKM 140.0), small intestine adult (RPKM 139.5) and 15 other tissues See more
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Genomic context

Location:: 17 18.88 cM; 17 B1

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (36366708..36369346, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (36055816..36058371, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

px-50g7 (e-PCR)
- UniSTS:257891

33.MMHAP25FLC6.seq (e-PCR)
- UniSTS:124030

BE199223 (e-PCR)
- UniSTS:209307

H2-T15 (e-PCR), detects polymorphism
- UniSTS:525240

H2-T9 (e-PCR), detects polymorphism
- UniSTS:525247

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables peptide antigen binding	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent	IBA Inferred from Biological aspect of Ancestor more info
involved_in antigen processing and presentation of endogenous peptide antigen via MHC class Ib	IBA Inferred from Biological aspect of Ancestor more info
involved_in immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of T cell mediated cytotoxicity	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: predicted gene 11127

Names: H2-GS14-2 antigen; MHC class I like protein GS14-2; histocompatibility 2, T region locus 15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001199967.2 → NP_001186896.1 predicted gene 11127 precursor

See identical proteins and their annotated locations for NP_001186896.1

Status: VALIDATED

Source sequence(s)

CT030728

Consensus CDS

CCDS57078.1

UniProtKB/TrEMBL

A7VMS2

Related

ENSMUSP00000109371.3, ENSMUST00000113742.3

Conserved Domains (2) summary

pfam00129
Location:27 → 198

MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

cd21016
Location:204 → 298

IgC1_MHC_Ib_T10_T22_like; Class Ib major histocompatibility complex (MHC) immunoglobulin domain of T10, T22, and similar proteins; member of the C1-set of Ig superfamily (IgSF) domains