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    Glmn glomulin, FKBP associated protein [ Mus musculus (house mouse) ]

    Gene ID: 170823, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Glmnprovided by MGI
    Official Full Name
    glomulin, FKBP associated proteinprovided by MGI
    Primary source
    MGI:MGI:2141180
    See related
    Ensembl:ENSMUSG00000029276 AllianceGenome:MGI:2141180
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fap48; Fap68; 9330160J16Rik
    Summary
    Predicted to enable hepatocyte growth factor receptor binding activity; ubiquitin protein ligase binding activity; and ubiquitin-protein transferase inhibitor activity. Acts upstream of or within circulatory system development and neural tube closure. Predicted to be part of Cul2-RING ubiquitin ligase complex; Cul3-RING ubiquitin ligase complex; and Cul4A-RING E3 ubiquitin ligase complex. Predicted to be active in cytoplasm. Is expressed in several structures, including arterial system; respiratory system; skeleton; skin; and urinary system. Human ortholog(s) of this gene implicated in arteriovenous malformation; glomangioma; and glomus tumor. Orthologous to human GLMN (glomulin, FKBP associated protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 4.4), CNS E18 (RPKM 3.9) and 20 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Glmn in Genome Data Viewer
    Location:
    5 F; 5 52.23 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (107696828..107745754, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (107548962..107597888, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene BTB domain containing 8 Neighboring gene predicted gene, 33885 Neighboring gene LSM12 homolog pseudogene Neighboring gene RIKEN cDNA 1700028K03 gene Neighboring gene STARR-seq mESC enhancer starr_13890 Neighboring gene STARR-positive B cell enhancer ABC_E1683 Neighboring gene RNA polymerase II associated protein 2 Neighboring gene RIKEN cDNA A930041C12 gene Neighboring gene Gfi1 +35 kb enhancer Neighboring gene RIKEN cDNA 4930428O21 gene Neighboring gene +19.5 kb enhancer downstream of Gfi1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Shigella IpaH7.8 E3 ubiquitin ligase targets glomulin and activates inflammasomes to demolish macrophages. Suzuki S, et al. Proc Natl Acad Sci U S A, 2014 Oct 7. PMID 25246571, Free PMC Article
    2. Glomulin is predominantly expressed in vascular smooth muscle cells in the embryonic and adult mouse. McIntyre BA, et al. Gene Expr Patterns, 2004 May. PMID 15053987
    3. Shigella hijacks the glomulin-cIAPs-inflammasome axis to promote inflammation. Suzuki S, et al. EMBO Rep, 2018 Jan. PMID 29191979, Free PMC Article
    4. Targeted disruption of p185/Cul7 gene results in abnormal vascular morphogenesis. Arai T, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904573, Free PMC Article
    5. Germline Saturation Mutagenesis Induces Skeletal Phenotypes in Mice. Rios JJ, et al. J Bone Miner Res, 2021 Aug. PMID 33905568, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Shigella hijacks the glomulin-cIAP1-cIAP2-inflammasome axis to promote inflammation.
      Title: Shigella hijacks the glomulin-cIAPs-inflammasome axis to promote inflammation.
    2. Results indicate a bacterial adaptation that hijacks inflammasome activation via interactions between IpaH7.8 E3 ubiquitin ligase and glomulin (GLMN).
      Title: Shigella IpaH7.8 E3 ubiquitin ligase targets glomulin and activates inflammasomes to demolish macrophages.
    3. The glomulin expression during murine development (E9.5 days post-coitum until adulthood) by non-radioactive in situ hybridization was studied.
      Title: Glomulin is predominantly expressed in vascular smooth muscle cells in the embryonic and adult mouse.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC6885

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables hepatocyte growth factor receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables hepatocyte growth factor receptor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-protein transferase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-protein transferase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell surface receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within circulatory system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in epigenetic regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in epigenetic regulation of gene expression ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in muscle cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in muscle cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of T cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within neural tube closure IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cytokine production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cytokine production ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within positive regulation of interleukin-2 production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of interleukin-2 production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of interleukin-2 production ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in vasculogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in vasculogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul2-RING ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of Cul3-RING ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of Cul4A-RING E3 ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of cullin-RING ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    glomulin
    Names
    FAP
    FK506-binding protein-associated protein
    FKBP-associated protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001161738.1 → NP_001155210.1  glomulin isoform a

      See identical proteins and their annotated locations for NP_001155210.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (a).
      Source sequence(s)
      AC134411, AK034160
      Consensus CDS
      CCDS19505.1
      UniProtKB/Swiss-Prot
      Q3TFR5, Q8BZM1, Q99LB8
      UniProtKB/TrEMBL
      Q3TMW7
      Related
      ENSMUSP00000080766.3, ENSMUST00000082121.9
      Conserved Domains (1) summary
      pfam08568
      Location:1 → 527
      Kinetochor_Ybp2; Uncharacterized protein family, YAP/Alf4/glomulin

    2. NM_001161739.1 → NP_001155211.1  glomulin isoform b

      See identical proteins and their annotated locations for NP_001155211.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two in-frame exons in the 3' coding region compared to variant 1. This results in a shorter protein (isoform b) compared to isoform a.
      Source sequence(s)
      AC117574, AC134411, AK169045
      Consensus CDS
      CCDS51587.1
      UniProtKB/TrEMBL
      Q3T9A5, Q3TMW7
      Related
      ENSMUSP00000098509.4, ENSMUST00000100949.10
      Conserved Domains (1) summary
      pfam08568
      Location:1 → 462
      Kinetochor_Ybp2; uncharacterized protein family, YAP/Alf4/glomulin

    3. NM_133248.2 → NP_573511.2  glomulin isoform a

      See identical proteins and their annotated locations for NP_573511.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Both variants 1 and 2 encode the same isoform (a).
      Source sequence(s)
      AC134411, AK169045, BY013339
      Consensus CDS
      CCDS19505.1
      UniProtKB/Swiss-Prot
      Q3TFR5, Q8BZM1, Q99LB8
      UniProtKB/TrEMBL
      Q3TMW7
      Related
      ENSMUSP00000077168.7, ENSMUST00000078021.13
      Conserved Domains (1) summary
      pfam08568
      Location:1 → 527
      Kinetochor_Ybp2; Uncharacterized protein family, YAP/Alf4/glomulin

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      107696828..107745754 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011249410.3 → XP_011247712.1  glomulin isoform X2

      Conserved Domains (1) summary
      pfam08568
      Location:14 → 224
      Kinetochor_Ybp2; Uncharacterized protein family, YAP/Alf4/glomulin

    2. XM_030254179.1 → XP_030110039.1  glomulin isoform X2

      Conserved Domains (1) summary
      pfam08568
      Location:14 → 224
      Kinetochor_Ybp2; Uncharacterized protein family, YAP/Alf4/glomulin

    3. XM_006534800.5 → XP_006534863.1  glomulin isoform X1

      See identical proteins and their annotated locations for XP_006534863.1

      UniProtKB/Swiss-Prot
      Q3TFR5, Q8BZM1, Q99LB8
      UniProtKB/TrEMBL
      Q3TMW7
      Conserved Domains (1) summary
      pfam08568
      Location:1 → 527
      Kinetochor_Ybp2; Uncharacterized protein family, YAP/Alf4/glomulin

    4. XM_017320694.3 → XP_017176183.1  glomulin isoform X2

      Conserved Domains (1) summary
      pfam08568
      Location:14 → 224
      Kinetochor_Ybp2; Uncharacterized protein family, YAP/Alf4/glomulin

    RNA

    1. XR_001784631.2 RNA Sequence

      Related
      ENSMUST00000124546.8
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BZM1.1 GenPept UniProtKB/Swiss-Prot:Q8BZM1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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