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    FCRL6 Fc receptor like 6 [ Homo sapiens (human) ]

    Gene ID: 343413, updated on 17-Jun-2024

    Summary

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    Official Symbol
    FCRL6provided by HGNC
    Official Full Name
    Fc receptor like 6provided by HGNC
    Primary source
    HGNC:HGNC:31910
    See related
    Ensembl:ENSG00000181036 MIM:613562; AllianceGenome:HGNC:31910
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FcRH6
    Summary
    Enables MHC class II protein binding activity and protein phosphatase binding activity. Predicted to be involved in cell surface receptor signaling pathway. Located in external side of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in spleen (RPKM 6.7), lung (RPKM 2.6) and 14 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See FCRL6 in Genome Data Viewer
    Location:
    1q23.2
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (159800512..159816257)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (158937524..158953270)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (159770302..159786047)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101928264 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1454 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:159751068-159751644 Neighboring gene dual specificity phosphatase 23 Neighboring gene CRISPRi-validated cis-regulatory element chr1.9322 Neighboring gene Sharpr-MPRA regulatory region 9392 Neighboring gene uncharacterized LOC105371464 Neighboring gene SLAM family member 8 Neighboring gene small nucleolar RNA host gene 28 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:159815652-159816152 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:159816153-159816653 Neighboring gene small nucleolar RNA SNORD64

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Cutting edge: FcR-like 6 is an MHC class II receptor. Schreeder DM, et al. J Immunol, 2010 Jul 1. PMID 20519654, Free PMC Article
    2. FCRL6 distinguishes mature cytotoxic lymphocytes and is upregulated in patients with B-cell chronic lymphocytic leukemia. Schreeder DM, et al. Eur J Immunol, 2008 Nov. PMID 18991291, Free PMC Article
    3. FCRL6 receptor: expression and associated proteins. Kulemzin SV, et al. Immunol Lett, 2011 Jan 30. PMID 20933011
    4. The first avian Ig-like Fc receptor family member combines features of mammalian FcR and FCRL. Taylor AI, et al. Immunogenetics, 2007 Apr. PMID 17273841
    5. Genome-wide association and population genetic analysis of C-reactive protein in African American and Hispanic American women. Reiner AP, et al. Am J Hum Genet, 2012 Sep 7. PMID 22939635, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association and population genetic analysis of C-reactive protein in African American and Hispanic American women.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat downregulates the expression of Fc receptor-like 6 (FCRL6) in human primary T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ16056

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables MHC class II protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein phosphatase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transmembrane signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell surface receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Fc receptor-like protein 6
    Names
    Fc receptor-like protein 7
    IFGP6
    IgSF type I transmembrane receptor
    fc receptor homolog 6
    fcR-like protein 6
    leukocyte receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004310.3 → NP_001004310.2  Fc receptor-like protein 6 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001004310.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript but encodes the longer protein (isoform 1).
      Source sequence(s)
      AI631310, AK131201, AL590560, AY513661, DA959587
      Consensus CDS
      CCDS30912.1
      UniProtKB/Swiss-Prot
      A1KXW6, A2A4D6, Q6DN72, Q6DN73, Q6XRC3, Q6ZNI1
      Related
      ENSP00000357086.3, ENST00000368106.4
      Conserved Domains (4) summary
      cd05753
      Location:19 → 98
      Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
      smart00410
      Location:123 → 198
      IG_like; Immunoglobulin like
      pfam13895
      Location:112 → 200
      Ig_2; Immunoglobulin domain
      pfam13927
      Location:206 → 280
      Ig_3; Immunoglobulin domain

    2. NM_001284217.2 → NP_001271146.1  Fc receptor-like protein 6 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001271146.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding region compared to variant 1. The resulting protein (isoform 2) has a shorter N-terminus.
      Source sequence(s)
      AI631310, AK131201
      Consensus CDS
      CCDS60312.1
      UniProtKB/Swiss-Prot
      Q6DN72
      Related
      ENSP00000320625.6, ENST00000321935.10
      Conserved Domains (4) summary
      cd05753
      Location:26 → 105
      Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
      smart00410
      Location:130 → 205
      IG_like; Immunoglobulin like
      pfam13895
      Location:119 → 207
      Ig_2; Immunoglobulin domain
      pfam13927
      Location:213 → 287
      Ig_3; Immunoglobulin domain

    3. NM_001426231.1 → NP_001413160.1  Fc receptor-like protein 6 isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AL590560

    4. NM_001426232.1 → NP_001413161.1  Fc receptor-like protein 6 isoform 4 precursor

      Status: VALIDATED

      Source sequence(s)
      AL590560

    5. NM_001426233.1 → NP_001413162.1  Fc receptor-like protein 6 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL590560

    6. NM_001426234.1 → NP_001413163.1  Fc receptor-like protein 6 isoform 6 precursor

      Status: VALIDATED

      Source sequence(s)
      AL590560

    7. NM_001426235.1 → NP_001413164.1  Fc receptor-like protein 6 isoform 7 precursor

      Status: VALIDATED

      Source sequence(s)
      CP068277

    8. NM_001426236.1 → NP_001413165.1  Fc receptor-like protein 6 isoform 8 precursor

      Status: VALIDATED

      Source sequence(s)
      CP068277

    9. NM_001426237.1 → NP_001413166.1  Fc receptor-like protein 6 isoform 9

      Status: VALIDATED

      Source sequence(s)
      CP068277

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      159800512..159816257
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005245128.5 → XP_005245185.1  Fc receptor-like protein 6 isoform X1

      Conserved Domains (4) summary
      cd05753
      Location:29 → 108
      Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
      smart00410
      Location:133 → 208
      IG_like; Immunoglobulin like
      pfam13895
      Location:122 → 210
      Ig_2; Immunoglobulin domain
      pfam13927
      Location:216 → 290
      Ig_3; Immunoglobulin domain

    2. XM_005245131.4 → XP_005245188.1  Fc receptor-like protein 6 isoform X4

      Related
      ENSP00000340949.5, ENST00000339348.9
      Conserved Domains (4) summary
      cd05753
      Location:29 → 108
      Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
      smart00410
      Location:133 → 208
      IG_like; Immunoglobulin like
      pfam13895
      Location:122 → 210
      Ig_2; Immunoglobulin domain
      pfam13927
      Location:216 → 290
      Ig_3; Immunoglobulin domain

    3. XM_047419607.1 → XP_047275563.1  Fc receptor-like protein 6 isoform X6

    4. XM_011509480.3 → XP_011507782.1  Fc receptor-like protein 6 isoform X2

      Conserved Domains (4) summary
      cd05753
      Location:26 → 105
      Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
      smart00410
      Location:130 → 205
      IG_like; Immunoglobulin like
      pfam13895
      Location:119 → 207
      Ig_2; Immunoglobulin domain
      pfam13927
      Location:213 → 287
      Ig_3; Immunoglobulin domain

    5. XM_047419606.1 → XP_047275562.1  Fc receptor-like protein 6 isoform X6

    6. XM_005245129.5 → XP_005245186.1  Fc receptor-like protein 6 isoform X3

      Conserved Domains (5) summary
      cd05753
      Location:14 → 93
      Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
      smart00410
      Location:118 → 193
      IG_like; Immunoglobulin like
      pfam11377
      Location:304 → 342
      DUF3180; Protein of unknown function (DUF3180)
      pfam13895
      Location:107 → 195
      Ig_2; Immunoglobulin domain
      pfam13927
      Location:201 → 275
      Ig_3; Immunoglobulin domain

    7. XM_011509481.3 → XP_011507783.1  Fc receptor-like protein 6 isoform X5

      Conserved Domains (4) summary
      cd05753
      Location:29 → 108
      Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
      smart00410
      Location:133 → 208
      IG_like; Immunoglobulin like
      pfam13895
      Location:122 → 210
      Ig_2; Immunoglobulin domain
      pfam13927
      Location:216 → 290
      Ig_3; Immunoglobulin domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      158937524..158953270
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054336355.1 → XP_054192330.1  Fc receptor-like protein 6 isoform X4

    2. XM_054336358.1 → XP_054192333.1  Fc receptor-like protein 6 isoform X10

    3. XM_054336353.1 → XP_054192328.1  Fc receptor-like protein 6 isoform X8

    4. XM_054336357.1 → XP_054192332.1  Fc receptor-like protein 6 isoform X10

    5. XM_054336354.1 → XP_054192329.1  Fc receptor-like protein 6 isoform X9

    6. XM_054336356.1 → XP_054192331.1  Fc receptor-like protein 6 isoform X5

    7. XM_054336352.1 → XP_054192327.1  Fc receptor-like protein 6 isoform X7

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6DN72.2 GenPept UniProtKB/Swiss-Prot:Q6DN72

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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