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    VIPR1 vasoactive intestinal peptide receptor 1 [ Homo sapiens (human) ]

    Gene ID: 7433, updated on 14-Nov-2024

    Summary

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    Official Symbol
    VIPR1provided by HGNC
    Official Full Name
    vasoactive intestinal peptide receptor 1provided by HGNC
    Primary source
    HGNC:HGNC:12694
    See related
    Ensembl:ENSG00000114812 MIM:192321; AllianceGenome:HGNC:12694
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    II; HVR1; RDC1; V1RG; VIPR; VIRG; VAPC1; VPAC1; VPAC1R; VIP-R-1; VPCAP1R; PACAP-R2; PACAP-R-2
    Summary
    This gene encodes a receptor for vasoactive intestinal peptide, a small neuropeptide. Vasoactive intestinal peptide is involved in smooth muscle relaxation, exocrine and endocrine secretion, and water and ion flux in lung and intestinal epithelia. Its actions are effected through integral membrane receptors associated with a guanine nucleotide binding protein which activates adenylate cyclase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
    Expression
    Broad expression in lung (RPKM 17.1), duodenum (RPKM 12.7) and 17 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See VIPR1 in Genome Data Viewer
    Location:
    3p22.1
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (42489299..42537568)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (42507314..42555561)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (42530791..42579060)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:42411131-42411759 Neighboring gene NANOG hESC enhancer GRCh37_chr3:42426849-42427356 Neighboring gene lysozyme like 4 Neighboring gene uncharacterized LOC124909371 Neighboring gene ribosomal protein L35a pseudogene 8 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19745 Neighboring gene uncharacterized LOC124909372 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:42542633-42543206 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14243 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14244 Neighboring gene Sharpr-MPRA regulatory region 5178 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:42566136-42566306 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:42574871-42575372 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:42581415-42581916 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:42581917-42582416 Neighboring gene VIPR1 antisense RNA 1 Neighboring gene SEC22 homolog C, vesicle trafficking protein Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:42622926-42623752 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19746 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14246 Neighboring gene SS18 like 2 Neighboring gene ZBTB47 and NKTR antisense RNA 1 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:42672544-42673392 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:42673393-42674241 Neighboring gene natural killer cell triggering receptor Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19747 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19748

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Vasoactive intestinal peptide (VIP) stimulates cortisol secretion from the H295 human adrenocortical tumour cell line via VPAC1 receptors. Nicol MR, et al. J Mol Endocrinol, 2004 Jun. PMID 15171718
    2. VPAC1 receptor expression in peripheral blood mononuclear cells in a human endotoxemia model. Storka A, et al. J Transl Med, 2013 May 7. PMID 23651810, Free PMC Article
    3. Characterization of a G protein coupling "YL" motif of the human VPAC1 receptor, equivalent to the first two amino acids in the "DRY" motif of the rhodopsin family. Tams JW, et al. J Mol Neurosci, 2001 Dec. PMID 11859928
    4. Expression and function of vasoactive intestinal peptide, pituitary adenylate cyclase-activating polypeptide, and their receptors in the human adrenal gland. Mazzocchi G, et al. J Clin Endocrinol Metab, 2002 Jun. PMID 12050216
    5. Spatial proximity between the VPAC1 receptor and the amino terminus of agonist and antagonist peptides reveals distinct sites of interaction. Ceraudo E, et al. FASEB J, 2012 May. PMID 22291440

    See all (111) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PAC1, VPAC1, and VPAC2 Receptor Expression in Rat and Human Trigeminal Ganglia: Characterization of PACAP-Responsive Receptor Antibodies.
      Title: PAC(1), VPAC(1), and VPAC(2) Receptor Expression in Rat and Human Trigeminal Ganglia: Characterization of PACAP-Responsive Receptor Antibodies.
    2. [VIPR1 promoter methylation promotes transcription factor AP-2alpha binding to inhibit VIPR1 expression and promote hepatocellular carcinoma cell growth in vitro].
      Title: [VIPR1 promoter methylation promotes transcription factor AP-2α binding to inhibit VIPR1 expression and promote hepatocellular carcinoma cell growth in vitro].
    3. Activation of VIPR1 suppresses hepatocellular carcinoma progression by regulating arginine and pyrimidine metabolism.
      Title: Activation of VIPR1 suppresses hepatocellular carcinoma progression by regulating arginine and pyrimidine metabolism.
    4. Activation of Th lymphocytes alters pattern expression and cellular location of VIP receptors in healthy donors and early arthritis patients.
      Title: Activation of Th lymphocytes alters pattern expression and cellular location of VIP receptors in healthy donors and early arthritis patients.
    5. Cryo-EM structure of an activated VIP1 receptor-G protein complex revealed by a NanoBiT tethering strategy.
      Title: Cryo-EM structure of an activated VIP1 receptor-G protein complex revealed by a NanoBiT tethering strategy.
    6. 3D structure prediction of VAPC1 and identification of dual natural inhibitors for VPAC1 and EGFR.
      Title: 3D structure prediction of VAPC1 and identification of dual natural inhibitors for VPAC1 and EGFR.
    7. follicle-associated epithelium-adjacent villus epithelium in ileum of Crohn's disease possessed more mucosal mast cells and mucosal mast cells expressing VPAC1 but not VPAC2.
      Title: Upregulation of intestinal mucosal mast cells expressing VPAC1 in close proximity to vasoactive intestinal polypeptide in inflammatory bowel disease and murine colitis.
    8. S. Typhimurium infection exploits host VPAC1/VIP to gain survival advantage in human monocytes.
      Title: Immune evasion by Salmonella: exploiting the VPAC1/VIP axis in human monocytes.
    9. Enhanced expression of VPAC1 in primary gastric cancer correlates with metastasis and poor prognosis.VPAC1 activation induces Ca2+ signaling to promote migration and invasion of gastric cancer cells.
      Title: VPAC1 couples with TRPV4 channel to promote calcium-dependent gastric cancer progression via a novel autocrine mechanism.
    10. Findings point out the tumor suppressor roles of VIPR1 in human LUAD pathogenesis.
      Title: Mechanism of VIPR1 gene regulating human lung adenocarcinoma H1299 cells.
    Submit: New GeneRIF Correction See all GeneRIFs (65)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See Variation Viewer (GRCh37.p13)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 has sequence similarity to the natural ligand for VPAC1 and it can activate this receptor directly PubMed
    Tat tat HIV-1 Tat downregulates the expression of vasoactive intestinal peptide receptor 1 (VIPR1) in human primary T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ41949

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled peptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptide hormone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptide hormone binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables pituitary adenylate cyclase-activating polypeptide receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables vasoactive intestinal polypeptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables vasoactive intestinal polypeptide receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cell population proliferation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    part_of receptor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    vasoactive intestinal polypeptide receptor 1
    Names
    PACAP type II receptor
    VIP and PACAP receptor 1
    VIP receptor, type I
    VPAC1 receptor
    pituitary adenylate cyclase activating polypeptide receptor, type II
    type 1 vasoactive intestinal peptide receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_030371.1 RefSeqGene

      Range
      18345..53270
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001251882.2 → NP_001238811.1  vasoactive intestinal polypeptide receptor 1 isoform 2

      See identical proteins and their annotated locations for NP_001238811.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AC092047, AK056819, AK298115, BU681817
      Consensus CDS
      CCDS58828.1
      Related
      ENSP00000394950.1, ENST00000433647.5
      Conserved Domains (2) summary
      smart00008
      Location:18 → 87
      HormR; Domain present in hormone receptors
      pfam00002
      Location:98 → 343
      7tm_2; 7 transmembrane receptor (Secretin family)

    2. NM_001251883.2 → NP_001238812.1  vasoactive intestinal polypeptide receptor 1 isoform 3

      See identical proteins and their annotated locations for NP_001238812.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate exon in the 5' coding region, uses a downstream start codon, and has multiple differences in the coding region, compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AC092047, AK293548, BU681817
      Consensus CDS
      CCDS58829.1
      UniProtKB/Swiss-Prot
      P32241
      Related
      ENSP00000415371.2, ENST00000438259.6
      Conserved Domains (1) summary
      cl21561
      Location:55 → 174
      7tm_4; Olfactory receptor

    3. NM_001251884.2 → NP_001238813.1  vasoactive intestinal polypeptide receptor 1 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks an alternate exon in the 5' coding region and uses a downstream start codon, compared to variant 1. The resulting isoform (4) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AC092047, AK294609, AK298115, BU681817
      Consensus CDS
      CCDS58827.1
      UniProtKB/Swiss-Prot
      P32241
      UniProtKB/TrEMBL
      B4DNY6
      Related
      ENSP00000445701.1, ENST00000543411.5
      Conserved Domains (2) summary
      smart00008
      Location:14 → 81
      HormR; Domain present in hormone receptors
      pfam00002
      Location:91 → 336
      7tm_2; 7 transmembrane receptor (Secretin family)

    4. NM_001251885.2 → NP_001238814.1  vasoactive intestinal polypeptide receptor 1 isoform 5

      See identical proteins and their annotated locations for NP_001238814.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks an alternate internal segment in the 5' coding region and uses a downstream start codon, compared to variant 1. The resulting isoform (5z) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AC092047, AK298115, BU681817
      UniProtKB/TrEMBL
      B4DNY6
      Conserved Domains (2) summary
      smart00008
      Location:32 → 101
      HormR; Domain present in hormone receptors
      pfam00002
      Location:112 → 357
      7tm_2; 7 transmembrane receptor (Secretin family)

    5. NM_004624.4 → NP_004615.2  vasoactive intestinal polypeptide receptor 1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_004615.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC092047, BU681817, DA200439, L13288, X75299
      Consensus CDS
      CCDS2698.1
      UniProtKB/Swiss-Prot
      A5JUT9, B3KPV1, B4DEB5, B4DGI4, F5H1F5, G3V0I1, P32241, Q15871, Q6P2M6
      Related
      ENSP00000327246.4, ENST00000325123.5
      Conserved Domains (2) summary
      smart00008
      Location:59 → 128
      HormR; Domain present in hormone receptors
      pfam00002
      Location:139 → 384
      7tm_2; 7 transmembrane receptor (Secretin family)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      42489299..42537568
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005265437.3 → XP_005265494.1  vasoactive intestinal polypeptide receptor 1 isoform X1

      Conserved Domains (2) summary
      smart00008
      Location:59 → 128
      HormR; Domain present in hormone receptors
      pfam00002
      Location:138 → 383
      7tm_2; 7 transmembrane receptor (Secretin family)

    2. XM_005265439.3 → XP_005265496.1  vasoactive intestinal polypeptide receptor 1 isoform X2

      Conserved Domains (2) summary
      smart00008
      Location:14 → 81
      HormR; Domain present in hormone receptors
      pfam00002
      Location:92 → 337
      7tm_2; 7 transmembrane receptor (Secretin family)

    3. XM_011534080.3 → XP_011532382.1  vasoactive intestinal polypeptide receptor 1 isoform X3

      Conserved Domains (3) summary
      smart00008
      Location:59 → 128
      HormR; Domain present in hormone receptors
      cd14964
      Location:142 → 166
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:139 → 337
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    4. XM_047448850.1 → XP_047304806.1  vasoactive intestinal polypeptide receptor 1 isoform X4

    5. XM_047448851.1 → XP_047304807.1  vasoactive intestinal polypeptide receptor 1 isoform X5

    RNA

    1. XR_007095725.1 RNA Sequence

      Related
      ENST00000436487.5

    2. XR_940500.3 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      42507314..42555561
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054347745.1 → XP_054203720.1  vasoactive intestinal polypeptide receptor 1 isoform X1

    2. XM_054347746.1 → XP_054203721.1  vasoactive intestinal polypeptide receptor 1 isoform X2

    3. XM_054347747.1 → XP_054203722.1  vasoactive intestinal polypeptide receptor 1 isoform X3

    4. XM_054347748.1 → XP_054203723.1  vasoactive intestinal polypeptide receptor 1 isoform X4

    5. XM_054347749.1 → XP_054203724.1  vasoactive intestinal polypeptide receptor 1 isoform X5

    RNA

    1. XR_008486791.1 RNA Sequence

    2. XR_008486792.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32241.1 GenPept UniProtKB/Swiss-Prot:P32241

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